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WO/1999/067289A1 |
A method of enhancement of growth factors including PDGF, which enables them to be used in the treatment of bone fractures and wounds in the future. The more efficient production of growth factors in this invention can be applied as a th...
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WO/1999/064615A1 |
A novel method is provided for delivering nucleic acid molecules to the cells of an organism by pulse voltage delivery. The method involves the combination of formulated nucleic acid molecules with devices for injecting the molecules by ...
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WO/1999/061594A2 |
The invention relates to a method and a device for treating (permeating and/or fusing) biological objects. Said biological objects are placed in an ambient medium and exposed to an electrical field produced by at least two electrodes for...
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WO/1999/059695A1 |
Provided is a magnetic separation device comprising a container having one or more outer surfaces; at least one magnetic sheet; and a physical coupler that is used to detachably secure the container to the magnetic sheet. A method of usi...
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WO/1999/060168A1 |
A method and apparatus for thermally inducing a reaction, such as a polymerase chain reaction or other temperature-sensitive transformation of biological systems are provided. Electromagnetic energy is applied to a target (51, 60) to pro...
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WO/1999/058637A2 |
Disclosed is a device for targeted exposure of a biological sample, preferably a biological cell material, to sound waves, comprising a sample container in which the biological sample is found in suspended form and an electroacoustic con...
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WO/1999/058163A1 |
A sterilization apparatus and method provides within enclosure (1) a low energy modulated magnetic field, generated by coils (3) into which is directed a fine mist or vapor of a sterilizing fluid from nozzle (9) for producing free radica...
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WO/1999/054444A2 |
The present invention relates to methods for increasing the efficiency of transformation of cycling cells, the methods comprising synchronizing cells at a first stage of the cell cycle, and transforming the cells at a second stage of the...
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WO/1999/046361A1 |
Techniques for regulating membrane denaturation reactions without resort to any physical shear force. Namely, a method which comprises reacting a stimulus (light, etc.) with a compound which is activated by this stimulus on a membrane su...
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WO/1999/045372A1 |
Fast lysis of a single cell (46) or cellular component thereof is performed by generating a shock wave in a medium in which the cell (46) or cellular component thereof is positioned. The cell (46) or cellular component thereof is either ...
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WO/1999/043790A1 |
An apparatus and method for illuminating a fluid having photosensitive material therein comprising a surface and a roller separated from the surface by a space. The space is adapted to receive a flexible container therein. The flexible c...
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WO/1999/038612A1 |
The present invention comprises devices and methods for performing channel-less separation of cell particles by dielectrophoresis, DC high voltage-pulsed electronic lysis of separated cells, separation of desired components from crude mi...
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WO/1999/032604A1 |
The present invention provides an isolated linoleate isomerase and its nucleic acid and amino acid sequence. The present invention also provides a method for producing CLA from an oil using an immobilized bacterial cell or an isolated li...
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WO1999015638B1 |
A system and method for processing a lipid membrane bound structure, the method comprising the steps of providing the structure to be processed in a liquid medium; and heating the liquid medium containing the structure at a rate and thro...
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WO/1999/025816A1 |
A micromachined cell lysis device with electrodes that are spaced by less than 10 $g(m)m from one another. The cells are attracted to the space between the electrodes and then lysed.
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WO/1999/024110A1 |
The invention relates to a method for permeabilisation of a cell structure consisting of a single cell, an intracellular structure or an organelle comprising the following steps: (a) microelectrodes, preferably two carbon fibre electrode...
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WO/1999/018116A1 |
This invention relates to a method of screening for compounds that modulate gene expression, particularly those which lower gene expression.
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WO/1999/013719A1 |
Complexes comprising a nucleic acid molecule and a conjugated peptide nucleic acid (PNA). The PNA may be labeled or conjugated to a protein, peptide, carbohydrate moiety or receptor ligand. These complexes are used to transfect cells to ...
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WO/1999/011771A1 |
The present invention involves methods and devices which enable discrete objects having a conducting inner core, surrounded by a dielectric membrane to be selectively inactivated by electric fields via irreversible breakdown of their die...
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WO/1998/056893A1 |
The object of the invention is to provide a method and apparatus for treating membrane containing material with electrical fields and with an added treating substance. With the method, a plurality of electrodes (121-128) are arrayed arou...
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WO/1998/055605A1 |
A method of destroying cells selected for destruction within a host body with little to no collateral damage to healthy surrounding tissue utilizes ultrasonic energy to effect resonant destruction of intracellular components within the c...
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WO/1998/054306A1 |
The invention concerns a method for isolating a nucleic and/or protein intracellular substance, from a cell sample suspended in a liquid, comprising the following steps: exposing the sample to at least an electric pulse, whereof at least...
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WO/1998/049281A1 |
The present invention provides a method for treating a viral infection in a subject in need of such treatment comprising administering to the subject a photosensitizer formulated in a liposome carrier, and exposing the subject to light a...
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WO/1998/048621A1 |
The present invention provides methods for reducing the level of infectious virus contained in red blood cell compositions. The methods comprise the steps of contacting the composition with a photosensitizer formulated in a liposome carr...
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WO/1998/045418A1 |
This invention presents a method of improving enzymatic degradation of lignocellulose, as in the production of ethanol from lignocellulosic material, through the use of ultrasonic treatment. The invention shows that ultrasonic treatment ...
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WO/1998/042356A1 |
A method is presented to remove contaminating tumor cells from a cell population. The method includes labeling individual tumor cells in the population and then killing them with a high energy laser beam. The laser is focused so that it ...
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WO/1998/040105A1 |
The present invention describes a method for the selection and temporal expression of heterologous genes. The invention consists of methods to obtain selective and temporal expression of heterologous genes in target tissues. Promoters in...
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WO/1998/038876A1 |
The invention relates to a method of regulating microorganism activity, particularly of controlling the growth of microorganisms by subjecting the microorganism to low-power laser irradiation at a certain wavelength. The invention also r...
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WO/1998/038293A1 |
A method and apparatus for the fraction sorting of cells is provided. The invention includes a dispensing device, aspirating device, flow channel and a magnetic assembly. A first fractional sorting device includes a dipole fractional cel...
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WO/1998/024490A1 |
An improved electrode for use in generating an electrical field in a saline solution is provided. In particular, a continuous crystalline metal nitride coated electrode is provided for use in a variety of saline solution applications, su...
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WO/1998/015641A1 |
The invention concerns a method for preparing a composition containing at least one heat sensitive substance and at least one binder. The method consists in drying a composition containing at least one heat sensitive substance and at lea...
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WO/1998/010277A1 |
Systems and methods for the electronic sample preparation of biological materials utilize the differential charge-to-mass ratio and/or the differential affinity of sample constituents to separation materials for sample preparation. An in...
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WO/1997/032483A1 |
A method for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2 �C at a rate which exceeds a relaxation rate of a cellular membrane of that organism, u...
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WO/1997/020210A1 |
A process and control device is disclosed for the location-selective and/or type-selective control of the position and/or position modification of suspended particles in a multi-electrode system using polarisation forces induced in the p...
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WO/1997/016545A1 |
Methods and support systems are provided for modifying the regeneration, differentiation, or function of cells. In one embodiment, electrically conducting biocompatible polymers may be used alone or in combination with a polymeric suppor...
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WO/1996/039816A1 |
Viral and bacterial contaminants present in biological solutions are inactivated by mixing one of a novel class of photosensitizer with said solution and irradiating the mixture. Quinoline and quinolone compounds are useful as photosensi...
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WO/1996/039799A1 |
The present invention relates, in general, to a method of stimulating microbial activity and composition suitable for use therein and, in particular, to a composition capable of stimulating plant growth and to a method of preparing such ...
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WO/1996/039493A1 |
Chemical and biological systems can be altered, enhanced or suppressed, in a precisely controllable manner by exposure to a predetermined combination of AC and DC magnetic fields. The flux density of the DC magnetic field can be minimize...
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WO/1996/024360A1 |
A method of increasing delivery of a compound from an exterior region (18) to an interior region of a cell (20) without causing substantial lethality to the cell. The method includes the steps of first providing the compound in the exter...
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WO/1996/022359A1 |
The present invention relates to a composition capable of stimulating plant growth and to a method of preparing such a composition. A culture is prepared by exposing the culture obtained from a starting culture of gastrointestinal microo...
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WO/1995/024969A1 |
An apparatus and method for performing a magnetic cell separation process using paramagnetic beads, and having multiple steps or activitites which are required to complete the process successfully includes using a programmable machine (1...
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WO/1995/023211A1 |
A method and apparatus for incorporating macromolecules into membrane vesicles, cells or tissue by electroporation is presented. The method involves the steps of: a) applying a train of low unipolar or alternating voltage pulses to the m...
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WO/1995/020961A1 |
Disclosed is an improved process for irradiating cell-containing compositions, especially, red cell-containing compositions, wherein vitamin E or a derivative thereof is added to the cell-containing composition prior to, during or after ...
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WO/1995/006129A2 |
A method for delivering to a target cell in a population of cells a biologically active agent comprising the steps of exposing the population of cells to a complex comprising the biologically active agent and a ligand capable of binding ...
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WO/1995/003814A1 |
Methods and pharmaceutical compositions for improving the effectiveness of radiation therapy for treating a subject having an internal solid tumor malignancy are disclosed. The methods include irradiating the tumor to release tumor-deriv...
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WO/1995/003417A2 |
A method of transforming slow-growing mycobacteria, such as M. bovis BCG, M. leprae, M. tuberculosis, M. avium, M. intracellulare and M. africanum; a method of manipulating genomic DNA of slow-growing mycobacteria through homologous reco...
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WO/1994/028120A1 |
The present invention concerns the product produced by inactivating exracellular or intracellular pathogenic virus in a biological composition without incurring substantial disruption or inactivation of cells and without significant loss...
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WO/1994/023594A1 |
Phaffia rhodozyma strains are described which produce greater than 3,000 ppm astaxanthin based on dry yeast solids when cultivated in a volume of nutrient medium of at least about 1,500 liters and containing in excess of 4 percent, prefe...
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WO/1994/021117A1 |
The present invention relates to a method and apparatus for the encapsulation of biologically-active substances in red blood cells, characterized by an optionally automated, continuous-flow self-contained electroporation system (10), as ...
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WO/1994/016821A1 |
Particles are subjected to travelling wave field migration (TWFM) to migrate the particles over an array of microelectrodes. Altered particles are produced by treating original particles in such a way so as to alter their TWFM characteri...
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