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WO/2019/010194A1 |
A method and system of delivering a charged cargo, such as a biomolecule, to a target structure, such as cells, exosomes, other vesicles or micelles, using an electroactive porous membrane. This method comprises contacting an electroacti...
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WO/2019/008225A1 |
The present invention relates to a method for producing a cell culture of a plant of the family Betulaceae, said method comprising two stages, where in the first stage birch callus line is cultured in a liquid medium comprising a medium ...
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WO/2019/004795A2 |
The present invention relates to a method for assessing validity of a cell therapy product. An expression level of TGF-β and/or TSP-1 in: (a) a 1st population of mammal cells transformed with TGF-β; and (b) a 2nd population of mammal c...
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WO/2018/232045A1 |
An acoustic standing wave is utilized to separate components from a multi- component fluid, such as oil from an oil-water mixture, or cells entrained in a fluid, in a fluid flow scheme with an acoustophoresis device. For example, the flo...
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WO/2018/225403A1 |
This cell culturing method is characterized by irradiating cells with infrared radiation while maintaining the temperature of the cells.
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WO/2018/221954A1 |
The present disclosure relates to a method of delivering target materials into extracellular vesicles including exposing the target materials and the extracellular vesicles to extracorporeal shockwaves, a method of preparing target mater...
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WO/2018/200830A1 |
Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the sup...
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WO/2018/192156A1 |
An ultra-remote intelligent diagnosis and treatment system for diabetes comprises an in-vivo implantable LED and a hydrogel transplant carrier containing a photo-controlled engineered cell, which is formed from a hydrogel-coated engineer...
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WO/2018/191534A1 |
Disclosed herein is a housing for a filter array, comprising: a first (e.g., upper) susface, a second (e.g., lower) surface, and a periphery, which are configured to house (e.g., enclose) a filter array comprising a plurality of filters;...
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WO/2018/191180A1 |
The present invention provides a method for measuring the amount of absorbance of a sample in a microcapillary based on measuring the absorbance in the sample.
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WO/2018/187840A1 |
The present invention relates to cell culture and the use of nanorods comprising a plasmonic metamaterial for facilitating detachment of cells from the cell culture. These substrates are optically responsive and capable of stimulating pl...
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WO/2018/183851A1 |
The present invention relates to methods of providing sequence specificity to in situ genome imaging at the level of the electron microscope (EM).
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WO/2018/161063A1 |
Methods of inducing functional maturation of immature cardiomyocytes derived from induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) by electrically pacing the immature cardiomyocytes according to a pulse profile that...
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WO/2018/160496A1 |
Disclosed herein are various embodiments relating to methods of producing iMGLs, for example, from pluripoteiit stem cells (PSCs), methods of using iMGLs, and compositions of iMGLs. Also disclosed herein are methods to study various neur...
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WO/2018/146854A1 |
Provided is a cell treatment device that can treat cells that are in a cell culture vessel. This cell treatment device 100 is characterized by including a first region 1, a second region 3, and a third region 5, the first region 1 and th...
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WO/2018/146855A1 |
Provided is a cell treatment device that can treat cells that are inside a cell culture vessel. This cell treatment device 100 is characterized by including a first region 1, a second region 3, and a third region 5, the first region 1 an...
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WO/2018/148520A1 |
In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for remotely-controlled and non-invasive manipulation of genetic processes in live cells, e.g., for monitoring physiologic pr...
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WO/2018/136670A1 |
Disclosed embodiments include illustrative piezoelectric element array assemblies, methods of fabricating a piezoelectric element array assembly, and systems and methods for shearing cellular material. Given by way of non-limiting exampl...
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WO/2018/131936A1 |
According to one embodiment, a virus inactivation kit can comprise: a tube for accommodating a sample containing viruses; a chamber comprising an inner space for accommodating the tube; and at least one light emitting module arranged on ...
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WO/2018/124450A1 |
The present invention relates to a method for differentiating of 3D dopaminergic midbrain organoids by using specific electromagnetic waves. The method can significantly enhance the efficiency of production of dopamine neuron 3D differen...
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WO/2018/105748A1 |
The present invention addresses the problem of providing a method which enables the introduction of a foreign substance into a single cell with high efficiency and easily and is less likely to be influenced by the damage of the cell. A c...
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WO/2018/102070A3 |
In some aspects, the present disclosure provides a method of bioelectric production of organic compounds such as acetate. In further aspects, the present disclosure also provides methods of producing a hydrocarbon based fuel using C02 as...
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WO/2018/091396A1 |
The present invention relates to improved yeast transformation of yeast cells and yeast cell libraries transformed thereby. More specifically, the present invention relates to the transformation of yeast by electroporation.
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WO/2018/091876A1 |
A device for the preparation of samples for constituent analysis is provided. The device comprises a conductive body has a first face and a second face separated by a gap. A channel for containing a sample runs through the gap. The condu...
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WO/2018/085895A1 |
The present invention relates to sensors and methods for detecting bacterial proteases in a sample. In particular, the present invention relates to sensors and methods for detecting Pseudomonas spp. protease activity in a sample. The sen...
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WO/2018/088639A1 |
The present invention provides a method for differentiating neural stem cells. The present invention provides a condition for optimized differentiation of neural stem cells into neurons by using a patterned hydrogel.
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WO/2018/089690A1 |
A system includes a control device and a magnetic device coupled to the control device. The magnetic device is configured to inductively couple to a treatment target including one or more cells exposed to an agent, and includes one or mo...
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WO/2018/085817A1 |
Methods and devices are provided for reduced biased isolation of genetic materials from mixed microbial samples are provided.
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WO/2018/085542A1 |
In one aspect, the present invention provides methods of cell processing, which include placing at least one cell on or near a metalized surface having a plurality of projections. The cell(s) can be disposed on the substrate in a variety...
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WO/2018/083692A1 |
The present invention discloses a system and method for modulating protein expression in targeted microorganisms. The system comprises: (a) a plasma discharge source for discharging plasma to said microorganisms, said plasma comprising a...
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WO/2018/085781A3 |
Systems and methods for detecting and sequestering target analytes in a fluid sample. The system comprises a bulk specimen reservoir for receiving a liquid sample, along with paramagnetic materials operative to selectively bind to the ta...
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WO/2018/064463A1 |
Described herein are systems and methods of flow-through electroporation can comprise a chamber with a first and a second portion, wherein the first portion is configured to receive cells and the second portion is in fluid communication ...
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WO/2018/053485A1 |
The disclosure provides methods and apparatus for high speed and sterile sorting of heterogeneous populations of cells to isolate homogenous populations. In embodiments, the disclosure provides a micropore array and collection tray situa...
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WO/2018/045373A1 |
Provided are systems for analyzing cellular distribution in an engineered tissue sample, which optionally is a bioprinted organ or tissue sample. In some embodiments, the systems include an ultrasound imaging system and a processing unit...
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WO/2018/016217A1 |
It was found that a substance can be easily and highly efficiently introduced into a plant cell without causing any damage and regardless of the kind of plant and tissue from which the cell is derived, by treating the plant cell with pla...
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WO/2018/008779A1 |
The present invention provides a method for controlling the growth direction of neuron dendrites, and a neuron culture controlled by the method. According to the present invention, the growth direction of neuron dendrites can be controll...
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WO/2018/009836A1 |
Methods of acquiring cellular and tissue vibrational patterning to identify signatures capable to induce pluripotency and commitment towards defined lineages, as well as survival under hostile conditions (i.e. oxidative stress) in both h...
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WO/2017/210664A1 |
The invention, in some aspects, relates to polypeptide molecules and their encoding nucleic acid molecules and use of such molecules to target opsins to the soma of cells in which they are expressed. Compositions of the invention may be ...
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WO/2017/210334A8 |
Methods and apparatuses for cell electroporation are provided. An apparatus includes a fluid transport structure, such as a pipette, that includes an electroporation structure defining a flow path having a constriction. The fluid transpo...
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WO/2017/208589A1 |
A cell treatment system is constructed, which is equipped with: an imaging device for imaging a cell culture vessel for the purpose of killing undesired cells among cells cultured on the cell culture vessel to obtain cell aggregates each...
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WO/2017/210334A1 |
Methods and apparatuses for cell electroporation are provided. An apparatus includes a fluid transport structure, such as a pipette, that includes an electroporation structure defining a flow path having a constriction. The fluid transpo...
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WO/2017/197531A1 |
Devices, materials, compounds, systems, and processes for Cherenkov-Activated Nuclear-Targeted Photodynamic Therapy that involves generating Cherenkov light within the tissue of a target volume and using this light to activate photosensi...
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WO/2017/192760A1 |
Multi-stage acoustophoretic devices for continuously separating a second fluid or a particulate from a host fluid are disclosed. Methods of operating the multi-stage acoustophoretic devices are also disclosed. The systems include multipl...
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WO/2017/188516A1 |
The present invention relates to a method for preventing cancerization of normal cells due to low-dose irradiation. The method enables effective prevention of cancerization of normal cells by means of low-dose radiation which is innocuou...
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WO/2017/188517A1 |
The present invention relates to an apparatus, for inhibiting oncogene-induced malignant cancerization, comprising an irradiation unit which is for irradiating low-dose radiation on a subject and a method, for inhibiting oncogene-induced...
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WO/2017/176764A1 |
A system, device and method for electroporation of living cells and the introduction of selected molecules into the cells utilizes a fluidic system where living cells and biologically active molecules flow through a channel that exposes ...
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WO/2017/170771A1 |
The present application provides a method for introducing the Cas9 protein into the fertilized egg of a mammal, and involves stages for (a) placing a mixture comprising a fertilized egg and a solution containing the Cas9 protein between ...
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WO/2017/157874A1 |
Device (1) for stimulation of at least one cell (2), and/or for stimulation of at least one electrochemical reaction, comprising at least one semiconductor (3) that is configured to convert electromagnetic radiation (4) into a charge sep...
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WO/2017/155166A1 |
The present invention relates to a cell reprogramming method using imposition of a physical stimulation-mediated environmental transition. More specifically, by subjecting differentiated or non-differentiated cells to physical stimulatio...
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WO/2017/155167A1 |
The present invention relates to a cell reprogramming apparatus using energy which can promote an environmental transition, more specifically to a cell reprogramming apparatus applying energy, such as ultrasonic waves, laser or heat trea...
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