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WO/2020/071665A3 |
The present invention relates to an exosome for extending telomeres of cells, a composition comprising same, and a preparation method therefor and, more particularly, to an exosome for extending telomeres of cells, the exosome comprising...
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WO/2020/086701A1 |
Compositions and methods for reducing nucleotide oxidation during electroporation, specifically the use of free radical scavengers to reduce electroporation-induced oxidation, are described. Compositions and methods for enhancing transfe...
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WO/2020/080920A2 |
The present invention pertains to a method for overexpressing target genes and/or reprogramming cells, the method comprising: (a) obtaining transformed cells by introducing a vector into which a promoter and target genes have been insert...
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WO/2012/145019A8 |
Provided are methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.
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WO/2020/071663A1 |
Disclosed is a method for producing exosomes having effects of skin regeneration and wound healing, comprising the steps of: providing ultrasonic stimulation directly or indirectly to cells; culturing a mixture of the cells and a medium ...
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WO/2020/071652A1 |
Disclosed are a method for extending the telomeres of cells and cells having telomeres extended by physical stimuli, the method comprising the steps of: providing direct or indirect physical stimuli for cells; and incubating a mixture of...
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WO/2020/071665A2 |
The present invention relates to an exosome for extending telomeres of cells, a composition comprising same, and a preparation method therefor and, more particularly, to an exosome for extending telomeres of cells, the exosome comprising...
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WO/2020/071662A1 |
Disclosed is a method for preparation of exosomes having a hair regeneration effect, the method comprising the steps of: providing direct or indirect ultrasonic stimuli for cells; incubating a mixture of the cells and a medium for a pred...
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WO/2020/070288A1 |
The inventors has developed a recombinant molecular system, named OptoFab, allowing the accurate control of the agonistic properties of an antibody-derived Fab fragment in time and in space using specific wavelengths of light. It consist...
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WO/2020/030037A1 |
Provided is the use of a nanosecond pulsed electric field in improving cell stemness. Specifically, applying a nanosecond pulsed electric field to cells, especially stem cells, can effectively increase the expression level of stemness ge...
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WO/2020/022382A1 |
A cell stimulation method that controls cell proliferation by stimulating cells without damaging the cells, by applying an AC electric field to the cells placed in an environment in which proliferation is possible.
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WO/2020/010394A1 |
The present disclosure provides a method of dispersing agglomerated material in a preparation comprising influenza proteins. The method comprises subjecting the preparation to sonication.
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WO/2020/008606A1 |
An ultrasonic vibrator (10) radiates ultrasonic waves toward a culture solution (3) retained together with cells (2) in a culture container (1). An acquisition unit acquires information indicating the state of sedimentation of cells (2) ...
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WO/2020/000525A1 |
Disclosed is a cell sorting device, comprising a fluid pipe (1), a cell sorting unit (2), a cell delivery unit (3) and a magnetic field assembly (4). The cell sorting unit (2) comprises at least one cell sorting chamber (21), the fluid p...
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WO/2019/232416A1 |
The present disclosure describes both compositions and methods that provide an agent encapsulated within a biopolymer. The methods as provided herein produce a spray-dried composition that exhibit enhanced yield and survivability of the ...
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WO/2019/229722A1 |
The current subject matter provides a cell engineering platform of a diagnostic and clinical use scale for vector -free and/or viral delivery of payload/cargo compounds and compositions into non-adherent cells, lire platform achieves del...
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WO/2019/231243A1 |
The present invention relates to a feeder cell expressing OX40L and a method for culturing natural killer cells using same. When the feeder cell expressing OX40L according to the present invention is co-cultured together with peripheral ...
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WO/2019/227060A1 |
The disclosure provides compositions and methods for infecting a legume plant and/or increasing the yield of a legume plant by providing a population of light-activated, nitrogen-fixing bacteria by illuminating a population of nitrogen-f...
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WO/2019/226926A1 |
Some embodiments herein include methods of ameliorating, inhibiting, reducing, treating, slowing the progression of, or preventing a decline in respiratory function associated with a neurological disease of a patient, for example amyotro...
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WO/2019/222333A1 |
Disclosed herein are devices, apparatuses and methods for generating self-sustaining gaseous and non-gaseous gradients across a cell support structure and for culturing one or more cells or tissues under hypoxic conditions. Methods of ge...
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WO/2019/220025A1 |
The present invention relates to the field of converting algal biomass. The present invention relates to a method for obtaining fat-soluble and water-soluble compounds from a biomass of eukaryotic or prokaryotic microalgae (cyanobacteria...
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WO/2019/203894A1 |
Articles, systems, and methods in which electromagnetic energy is converted to heat (e.g., for the purpose of inducing or inhibiting phase change of a material disposed over a surface) are generally described.
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WO/2019/173800A1 |
A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.
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WO/2019/164928A1 |
Disclosed herein are multi-cuvette cartridges (130, 222), flow cells (245, 342), and electrical pulse systems (100) for treatment of large volumes of biological samples with pulsed electric fields. The multi-cuvette cartridges systems ma...
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WO/2019/074455A3 |
The invention is about a centrifuge device with photobiostimulation effect in order to obtain growth factors from the person's own blood to be used for the acceleration of wound healing and for the treatment of open and closed wounds of ...
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WO/2019/140019A1 |
A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.
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WO/2019/140294A1 |
In some embodiments, methods of stimulating fluid intake in a subject in need thereof are described. The methods can comprise stimulating a nitric oxide synthase (nNOS)-positive neuron of the median preoptic nucleus (MnPO). In some embod...
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WO/2019/135843A1 |
Microparticles and nanoparticles made of various materials that are used in various configurations are disclosed. Such particles can also contain various types of materials as payloads to be used in the separation, segregation, different...
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WO/2019/131505A1 |
The present invention provides: a method for introducing a protein into fungal cells, comprising introducing a target protein into fungal protoplast by means of electroporation in a buffer that contains the target protein and a tonicity ...
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WO/2019/129953A1 |
The present invention relates to the processing of a fluid containing single-cell or multi-cell organisms, such as bacteria, yeasts, fruit and vegetables or pieces of fruit and vegetables, for the purposes of juice extraction and/or deco...
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WO/2019/113930A1 |
An ultrasonic microbubble cell stimulation device and an operation method thereof. The ultrasonic microbubble cell stimulation device comprises: a culture plate (11), a positioning frame (12), and a base (13). The culture plate (11) is i...
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WO/2019/113054A1 |
The systems and methods described herein include the use of Giant Plasma Membrane Vesicles (GPMVs) derived from cells expressing SPASM sensors (e.g., SPASM GPCR sensors). Herein provided are giant plasma membrane vesicle (GPMV) sensors c...
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WO/2019/097500A1 |
A photoreactor for cell assay and array chemical and biochemical reactions has a reaction chamber an input aperture, and a lamp. A specimen receptacle with a reflective surface is positioned within the reaction chamber. The lamp has a li...
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WO/2019/084624A1 |
A method and device for transfecting a cell to introduce an exogenous material into the cell. The method includes exposing the cell to a region of unsteady flow in the presence of an electric field to encourage introduction of the exogen...
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WO/2019/081260A1 |
The invention relates to a system (100) and to a method (500) for monitoring a vibration-transmitting unit (300), in particular a sonotrode (300), for applying mechanical vibrations to a device (200) for exciting a liquid (210) located i...
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WO/2018/222025A3 |
The present invention provides a method for increasing replication of human infection type noroviruses. The present invention allows a study associated with the infection and diseases of noroviruses to be peformed by culturing and prolif...
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WO/2019/071328A1 |
The present invention relates to an improved process of enzymatic starch hydrolysis in the alcohol industry, with an increase in converted sugar production yield and hydrolysis reaction speed. During the enzymatic starch hydrolysis, the ...
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WO/2019/068061A1 |
In an illustrative embodiment, automated multi-module cell editing instruments comprising one or more flow-through electroporation devices or modules are provided to automate genome editing in live cells.
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WO/2019/068062A1 |
In an illustrative embodiment, automated instruments comprising one or more flow- through electroporation devices or modules are provided to automate transformation of nucleic acids in live cells.
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WO/2019/059936A1 |
An electroporation system may include a well plate, a dispenser and a dispenser-well positioning system. The well plate may include wells, each of the wells including an interior, a first electrode adjacent the interior and a second elec...
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WO/2019/004795A3 |
The present invention relates to a method for assessing validity of a cell therapy product. An expression level of TGF-β and/or TSP-1 in: (a) a 1st population of mammal cells transformed with TGF-β; and (b) a 2nd population of mammal c...
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WO/2019/060558A1 |
The present invention provides an isolated cell composition suitable for adoptive immunotherapy, as well as methods of manufacturing the cell compositions and methods of treatment with the cell compositions. The composition comprises, in...
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WO/2018/218085A3 |
Provided herein are methods and systems for bio-printing of three-dimensional organs and organoids. Also provided herein are bio-printed three-dimensional organs and organoids for use in the generation and/or the assessment of immunologi...
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WO/2019/046483A1 |
Aspects of the present disclosure describe systems, methods, and structures for acoustic wave-based separation of particulates in a fluidic flow. Illustrative systems, methods, and structures according to aspects of the present disclosur...
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WO/2019/046304A1 |
An intracellular delivery system and method are provided. The intracellular delivery system comprises a laser-activated surface and cells positioned at a distance from the laser- activated surface. A laser provided a laser pulse that is ...
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WO/2019/044804A1 |
The present invention addresses the problem of recovering, in an simple and inexpensive manner, an entire single cell or cell sheet that has been cultured. The cell production method according to an embodiment of the present invention in...
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WO/2019/036232A1 |
A well for electrically stimulating at least one cell. The well includes a bottom portion and comprises an adaptive electrode arrangement for introducing an electric field into the well. The adaptive electrode arrangement includes a pair...
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WO/2018/115973A3 |
The invention provides a solution to the problem of transfecting non-adherent cells. Devices and delivery compositions containing ethanol and an isotonic salt solution are used for delivery of compounds and compositions to non-adherent c...
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WO/2019/025668A1 |
The present invention relates to a method for keeping chlorella alive and fresh for consumption thereof. According to the invention, such a method is characterised in that it involves exposing a chlorella concentrate (24), comprising bet...
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WO/2019/010194A1 |
A method and system of delivering a charged cargo, such as a biomolecule, to a target structure, such as cells, exosomes, other vesicles or micelles, using an electroactive porous membrane. This method comprises contacting an electroacti...
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