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WO/2019/084624A1 |
A method and device for transfecting a cell to introduce an exogenous material into the cell. The method includes exposing the cell to a region of unsteady flow in the presence of an electric field to encourage introduction of the exogen...
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WO/2019/081260A1 |
The invention relates to a system (100) and to a method (500) for monitoring a vibration-transmitting unit (300), in particular a sonotrode (300), for applying mechanical vibrations to a device (200) for exciting a liquid (210) located i...
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WO/2018/222025A3 |
The present invention provides a method for increasing replication of human infection type noroviruses. The present invention allows a study associated with the infection and diseases of noroviruses to be peformed by culturing and prolif...
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WO/2019/071328A1 |
The present invention relates to an improved process of enzymatic starch hydrolysis in the alcohol industry, with an increase in converted sugar production yield and hydrolysis reaction speed. During the enzymatic starch hydrolysis, the ...
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WO/2019/068061A1 |
In an illustrative embodiment, automated multi-module cell editing instruments comprising one or more flow-through electroporation devices or modules are provided to automate genome editing in live cells.
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WO/2019/068062A1 |
In an illustrative embodiment, automated instruments comprising one or more flow- through electroporation devices or modules are provided to automate transformation of nucleic acids in live cells.
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WO/2019/059936A1 |
An electroporation system may include a well plate, a dispenser and a dispenser-well positioning system. The well plate may include wells, each of the wells including an interior, a first electrode adjacent the interior and a second elec...
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WO/2019/004795A3 |
The present invention relates to a method for assessing validity of a cell therapy product. An expression level of TGF-β and/or TSP-1 in: (a) a 1st population of mammal cells transformed with TGF-β; and (b) a 2nd population of mammal c...
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WO/2019/060558A1 |
The present invention provides an isolated cell composition suitable for adoptive immunotherapy, as well as methods of manufacturing the cell compositions and methods of treatment with the cell compositions. The composition comprises, in...
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WO/2018/218085A3 |
Provided herein are methods and systems for bio-printing of three-dimensional organs and organoids. Also provided herein are bio-printed three-dimensional organs and organoids for use in the generation and/or the assessment of immunologi...
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WO/2019/046483A1 |
Aspects of the present disclosure describe systems, methods, and structures for acoustic wave-based separation of particulates in a fluidic flow. Illustrative systems, methods, and structures according to aspects of the present disclosur...
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WO/2019/046304A1 |
An intracellular delivery system and method are provided. The intracellular delivery system comprises a laser-activated surface and cells positioned at a distance from the laser- activated surface. A laser provided a laser pulse that is ...
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WO/2019/044804A1 |
The present invention addresses the problem of recovering, in an simple and inexpensive manner, an entire single cell or cell sheet that has been cultured. The cell production method according to an embodiment of the present invention in...
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WO/2019/036232A1 |
A well for electrically stimulating at least one cell. The well includes a bottom portion and comprises an adaptive electrode arrangement for introducing an electric field into the well. The adaptive electrode arrangement includes a pair...
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WO/2019/025668A1 |
The present invention relates to a method for keeping chlorella alive and fresh for consumption thereof. According to the invention, such a method is characterised in that it involves exposing a chlorella concentrate (24), comprising bet...
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WO/2019/010194A1 |
A method and system of delivering a charged cargo, such as a biomolecule, to a target structure, such as cells, exosomes, other vesicles or micelles, using an electroactive porous membrane. This method comprises contacting an electroacti...
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WO/2019/008225A1 |
The present invention relates to a method for producing a cell culture of a plant of the family Betulaceae, said method comprising two stages, where in the first stage birch callus line is cultured in a liquid medium comprising a medium ...
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WO/2019/004795A2 |
The present invention relates to a method for assessing validity of a cell therapy product. An expression level of TGF-β and/or TSP-1 in: (a) a 1st population of mammal cells transformed with TGF-β; and (b) a 2nd population of mammal c...
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WO/2018/232045A1 |
An acoustic standing wave is utilized to separate components from a multi- component fluid, such as oil from an oil-water mixture, or cells entrained in a fluid, in a fluid flow scheme with an acoustophoresis device. For example, the flo...
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WO/2018/225403A1 |
This cell culturing method is characterized by irradiating cells with infrared radiation while maintaining the temperature of the cells.
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WO/2018/221954A1 |
The present disclosure relates to a method of delivering target materials into extracellular vesicles including exposing the target materials and the extracellular vesicles to extracorporeal shockwaves, a method of preparing target mater...
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WO/2018/200830A1 |
Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the sup...
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WO/2018/192156A1 |
An ultra-remote intelligent diagnosis and treatment system for diabetes comprises an in-vivo implantable LED and a hydrogel transplant carrier containing a photo-controlled engineered cell, which is formed from a hydrogel-coated engineer...
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WO/2018/191534A1 |
Disclosed herein is a housing for a filter array, comprising: a first (e.g., upper) susface, a second (e.g., lower) surface, and a periphery, which are configured to house (e.g., enclose) a filter array comprising a plurality of filters;...
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WO/2018/191180A1 |
The present invention provides a method for measuring the amount of absorbance of a sample in a microcapillary based on measuring the absorbance in the sample.
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WO/2018/187840A1 |
The present invention relates to cell culture and the use of nanorods comprising a plasmonic metamaterial for facilitating detachment of cells from the cell culture. These substrates are optically responsive and capable of stimulating pl...
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WO/2018/183851A1 |
The present invention relates to methods of providing sequence specificity to in situ genome imaging at the level of the electron microscope (EM).
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WO/2018/161063A1 |
Methods of inducing functional maturation of immature cardiomyocytes derived from induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) by electrically pacing the immature cardiomyocytes according to a pulse profile that...
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WO/2018/160496A1 |
Disclosed herein are various embodiments relating to methods of producing iMGLs, for example, from pluripoteiit stem cells (PSCs), methods of using iMGLs, and compositions of iMGLs. Also disclosed herein are methods to study various neur...
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WO/2018/146854A1 |
Provided is a cell treatment device that can treat cells that are in a cell culture vessel. This cell treatment device 100 is characterized by including a first region 1, a second region 3, and a third region 5, the first region 1 and th...
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WO/2018/146855A1 |
Provided is a cell treatment device that can treat cells that are inside a cell culture vessel. This cell treatment device 100 is characterized by including a first region 1, a second region 3, and a third region 5, the first region 1 an...
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WO/2018/148520A1 |
In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for remotely-controlled and non-invasive manipulation of genetic processes in live cells, e.g., for monitoring physiologic pr...
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WO/2018/136670A1 |
Disclosed embodiments include illustrative piezoelectric element array assemblies, methods of fabricating a piezoelectric element array assembly, and systems and methods for shearing cellular material. Given by way of non-limiting exampl...
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WO/2018/131936A1 |
According to one embodiment, a virus inactivation kit can comprise: a tube for accommodating a sample containing viruses; a chamber comprising an inner space for accommodating the tube; and at least one light emitting module arranged on ...
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WO/2018/124450A1 |
The present invention relates to a method for differentiating of 3D dopaminergic midbrain organoids by using specific electromagnetic waves. The method can significantly enhance the efficiency of production of dopamine neuron 3D differen...
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WO/2018/115973A3 |
The invention provides a solution to the problem of transfecting non-adherent cells. Devices and delivery compositions containing ethanol and an isotonic salt solution are used for delivery of compounds and compositions to non-adherent c...
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WO/2018/105748A1 |
The present invention addresses the problem of providing a method which enables the introduction of a foreign substance into a single cell with high efficiency and easily and is less likely to be influenced by the damage of the cell. A c...
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WO/2018/102070A3 |
In some aspects, the present disclosure provides a method of bioelectric production of organic compounds such as acetate. In further aspects, the present disclosure also provides methods of producing a hydrocarbon based fuel using C02 as...
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WO/2018/091396A1 |
The present invention relates to improved yeast transformation of yeast cells and yeast cell libraries transformed thereby. More specifically, the present invention relates to the transformation of yeast by electroporation.
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WO/2018/091876A1 |
A device for the preparation of samples for constituent analysis is provided. The device comprises a conductive body has a first face and a second face separated by a gap. A channel for containing a sample runs through the gap. The condu...
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WO/2018/085895A1 |
The present invention relates to sensors and methods for detecting bacterial proteases in a sample. In particular, the present invention relates to sensors and methods for detecting Pseudomonas spp. protease activity in a sample. The sen...
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WO/2018/088639A1 |
The present invention provides a method for differentiating neural stem cells. The present invention provides a condition for optimized differentiation of neural stem cells into neurons by using a patterned hydrogel.
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WO/2018/089690A1 |
A system includes a control device and a magnetic device coupled to the control device. The magnetic device is configured to inductively couple to a treatment target including one or more cells exposed to an agent, and includes one or mo...
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WO/2018/085817A1 |
Methods and devices are provided for reduced biased isolation of genetic materials from mixed microbial samples are provided.
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WO/2018/085542A1 |
In one aspect, the present invention provides methods of cell processing, which include placing at least one cell on or near a metalized surface having a plurality of projections. The cell(s) can be disposed on the substrate in a variety...
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WO/2018/083692A1 |
The present invention discloses a system and method for modulating protein expression in targeted microorganisms. The system comprises: (a) a plasma discharge source for discharging plasma to said microorganisms, said plasma comprising a...
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WO/2018/085781A3 |
Systems and methods for detecting and sequestering target analytes in a fluid sample. The system comprises a bulk specimen reservoir for receiving a liquid sample, along with paramagnetic materials operative to selectively bind to the ta...
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WO/2018/064463A1 |
Described herein are systems and methods of flow-through electroporation can comprise a chamber with a first and a second portion, wherein the first portion is configured to receive cells and the second portion is in fluid communication ...
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WO/2018/053485A1 |
The disclosure provides methods and apparatus for high speed and sterile sorting of heterogeneous populations of cells to isolate homogenous populations. In embodiments, the disclosure provides a micropore array and collection tray situa...
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WO/2018/045373A1 |
Provided are systems for analyzing cellular distribution in an engineered tissue sample, which optionally is a bioprinted organ or tissue sample. In some embodiments, the systems include an ultrasound imaging system and a processing unit...
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