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WO/2018/045199A3 |
Described herein are nucleic acid-peptide capsule complexes or nanoparticles comprising pre-formed peptide capsules and nucleic acids bound the exterior surface of the capsule, such that the wrap around the capsule membrane. The peptide ...
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WO/2019/056015A3 |
A strong insulator fragment from foamy virus, which can be used to insulate expression of a transgene and reduce genotoxicity of integrating vectors comprising such. The insulator fragment can also be used in gene targeting constructs in...
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WO/2019/074292A2 |
The present invention relates to an expression cassette for a target protein, comprising a promoter, a polynucleotide coding for the target protein, an intron sequence, and a poly A sequence, an expression vector, and a transformant. The...
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WO/2019/075320A1 |
The present invention relates to a novel antisense transcript to the human SLC2A1 (Glutl) gene, variants and fragments thereof. This antisense transcript can be used to modulate Glutl expression and serve to restore Glutl, and as a thera...
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WO/2019/075028A1 |
The invention provides an animal feed composition comprising microbial α-amylase, for example, an animal feed composition comprising transgenic plant material comprising a microbial α-amylase (e.g., a thermostable microbial α-amylase)...
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WO/2019/073964A1 |
The present disclosure provides a technique whereby the influence of an endogenous TCR is eliminated in TCR gene transfer. A TCR gene is edited using a genome editing enzyme, said genome editing enzyme having one characteristic that amin...
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WO/2019/073954A1 |
A method for manufacturing a protein is provided. In the present invention, a target protein is manufactured by culturing, in a medium, Talaromyces cellulolyticus having the ability to produce the target protein, the Talaromyces cellulol...
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WO/2019/075295A1 |
Plant cell fate and development is altered by treating cells with cellular reprogramming factors. Embryogenesis inducing morphogenic developmental genes are used as cellular reprogramming factors, specifically comprising polypeptides or ...
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WO/2018/014041A3 |
Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of spinal muscular atrophy.
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WO/2019/075200A1 |
The present disclosure provides a split intein selectable marker system for the production and selection of transgenic cells.
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WO/2018/080324A9 |
A device is provided, comprising a cell trap comprising a plurality of micro-chambers, each micro-chamber configured to hold a cell. The device can further comprise a manipulator array comprising a plurality of manipulators, each manipul...
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WO/2019/073902A1 |
The present invention addresses the problem of providing a method which enables the noninvasive detection and isolation of droplets in which microorganisms have proliferated. The present invention relates to a detection method for detect...
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WO/2019/071471A1 |
The present invention provides a method for improving the loading of a nucleic acid on a solid support by contacting the solid support with a poloxamer-containing reagent. The present invention also provides a method for improving the st...
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WO/2019/072964A1 |
The present invention discloses novel recombinant multivalent non-pathogenic Marek's Disease virus constructs that encode and express foreign antigens from three or more avian viruses, along with methods of the use of the multivalent pou...
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WO/2019/075157A1 |
Disclosed herein are protein translation switches and conditional gene expression systems that are compatible with retroviral and lentiviral gene delivery. The linking of a protein translation switch to a 3' gene of interest suppresses t...
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WO/2019/075387A1 |
The present disclosure provides cotton plants with reduced gossypol levels in the seed, and in further embodiments provides cotton plants with increased gossypol levels in the leaves. Also provided are methods for reducing gossypol conte...
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WO/2019/074542A1 |
This invention pertains to mutant Cas9 nucleic acids and proteins for use in CRISPR/Cas endonuclease systems, and their methods of use. In particular, the invention pertains to an isolated mutant Cas9 protein, wherein the isolated mutant...
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WO/2019/074907A1 |
Recombinant cells and methods therefor are contemplated that allow for rapid and high titer production of recombinant viruses, and especially replication deficient Ad5 virus. In some preferred aspects, the host cell is modified to produc...
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WO/2019/074071A1 |
The present invention provides a nucleic acid molecule dimer that includes a first nucleic acid molecule having complementarity with at least part of a target nucleic acid molecule, and a second nucleic acid molecule having complementari...
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WO/2019/074046A1 |
[Problem] The purpose of the present invention is to provide a method for preparing a cell population containing numerous periodontal ligament stem cells, particularly epithelial stem cells from the periodontal ligament and/or periodonta...
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WO/2019/073973A1 |
The purpose of the present invention is to provide, in order to continue the rejection of malignant tumors over a long period of time, an enhancer for endogenous T-cells or B-cells having a memory function, and a malignant tumor recurren...
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WO/2019/071358A1 |
A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a...
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WO/2019/073072A1 |
A method for synthesizing a target double stranded (ds) polynucleotide having a predefined sequence, comprising a) providing an oligonucleotide library within an array device, which comprises a diversity of oligonucleotide library member...
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WO/2019/071668A1 |
Provided is an L-homoserine producing strain, which has a single and stable chromosome and does not contain any plasmids or other free DNA vectors. One or more genes related with L-threonine synthesis on the chromosome DNA are knocked ou...
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WO/2019/075053A1 |
The present invention relates to variants of porcine granulocyte colony stimulating factor (pG-CSF). The pG-CSF variants are useful in treating preventing or reducing the incidence of bacterial infections in swine. Methods of treating sw...
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WO/2019/073059A1 |
The invention generally concerns the production of defective Adenovirus helper viruses for producing a recombinant adeno-associated virus (rAAV), wherein the Adenovirus helper virus contains at least one mutation selected from (a) an ina...
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WO/2019/074737A1 |
This disclosure concerns nucleic acid molecules and methods of use thereof for control of pathogens through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in pathogens. The disclosure also conc...
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WO/2019/072596A1 |
ThermoCas9 is identified and characterized from the thermophilic bacterium Geobacillus thermodenitrificans T12. Experiments show how in vitro ThermoCas9 is active between 20 and 70 °C, has stringent PAM-preference at lower temperatures...
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WO/2019/074841A1 |
ABSTRACT Compositions and methods are provided for modification of a target sequence in the genome of a cell. The methods and compositions employ a cascade system and guide polynucleotide to provide an effective system for targeting, bin...
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WO/2019/073965A1 |
The present disclosure provides a technique for producing regulatory T cells specific to a desired antigen. Regulatory T cells specific to an antigen are produced by a method that includes: a step for identifying a T cell receptor (TCR) ...
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WO/2019/074110A1 |
The present invention provides a novel single-stranded nucleic acid molecule, and a production method therefor. The present invention is related to a production method for a single-stranded nucleic acid molecule represented by general fo...
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WO/2019/073960A1 |
The present invention provides a method for producing a somatic cell chimera using pluripotent cells which have been genetically manipulated so as to not differentiate into specific cell types. In particular, the present invention provid...
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WO/2019/074089A1 |
The present invention provides a rebaudioside M-rich-type nontransgenic stevia plant body which contains rebaudioside M in a larger amount compared with a wild-type stevia species. The present invention also provides: a method for produc...
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WO/2019/075327A1 |
This disclosure relates to methods and compositions for treating cancers, e.g., Merkel cell carcinoma. The methods involve, e.g., administering to a subject in need thereof an effective amount of a lysine specific demethylase 1 (LSD1) in...
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WO/2019/075098A1 |
The present disclosure provides ribonucleic acids that provide for translation stalling. The present disclosure provides ribosome/nucleic acid complexes comprising the ribonucleic acids, as well as ribosome/nucleic acid/nascent chain pol...
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WO/2019/072055A1 |
Provided is a composition for gene therapy or transfection, comprising a nucleic acid, a natural polyphenol, and a cationic molecule. The natural polyphenol comprises multiple phenolic hydroxyl groups, and has a free radical scavenging, ...
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WO/2019/074091A1 |
Provided is a primer pair of primers for methicillin-resistant gene detection for the purpose of achieving highly sensitive methicillin-resistant gene detection. Said primer pair comprises a combination of SEQ ID NO:3 and SEQ ID NO:7, a ...
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WO/2019/073018A1 |
The present invention relates to methods for identifying improved stereodefined phosphorothioate oligonucleotide variants of antisense oligonucleotides utilising sub-libraries of partially stereodefined oligonucleotides. The methods allo...
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WO/2018/053451A8 |
The inventive technology relates to novel paratransgenic strategies for the control of pathogens. The inventive technology may specifically include a novel paratransgenic system configured to deliver one or more inhibitory RNA molecules ...
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WO/2019/075385A1 |
Provided are T cell receptors (TCR) and TCR variable regions that can selectively bind SLC45A2. The TCR may be utilized in various therapies, such as autologous cell transplantation, to treat a cancer, such as a cutaneous melanoma, uveal...
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WO/2019/075182A1 |
The invention is related to preparation of botulinum toxin A6 and methods of use.
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WO/2019/075159A1 |
Methods of genetically modifying microorganisms using advanced genome editing are disclosed. Methods of modifying the genome of these microorganisms for point mutations, deletions, and DNA insertions are also disclosed. Further, inhibiti...
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WO/2019/073058A1 |
The present invention relates to an antagonist of the Two-Pore Domain Potassium Channel (TASK- 1) K2P3.1 for use in the prevention and/or treatment of cardiac arrhythmia in a subject. The invention also relates to a nucleic acid molecule...
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WO/2019/074980A1 |
The present invention relates to methods for expanding a stem cell population, as well as other cell populations. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell and/or other ce...
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WO/2019/072081A1 |
The present invention provides a microorganism. The microorganism comprises the following features: over-expressing at least one selected from the following genes: PAH1, DGA1, OLE1, ACC1**, ACCA2, ACCB, ACCE, DGAT, LPPβ, OLE1A, OLE1B, O...
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WO/2019/074598A1 |
The present invention relates generally to methods of molecular biology and gene silencing to control pests.
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WO/2019/074461A2 |
The present invention relates to a marker developed for Tm-22 (Tm2a) gene which provides resistance against tomato mosaic virus and relates to the kits comprising said marker and relates to the usage of said marker in the detection of th...
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WO/2019/074891A1 |
Described herein are methods and compositions related to the treatment or prevention of an inflammatory disease via administration of an agent that inhibits a long noncoding RNA (lnc-RNA) expressed in a macrophage to a subject in need th...
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WO/2019/075357A1 |
Among other things, the present disclosure provides technologies for altering splicing, particularly for increasing inclusion of exons in splicing products. In some embodiments, the present disclosure provides SMN2 oligonucleotides, comp...
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WO/2019/072883A1 |
The present invention concerns a genetically modified microorganism for the production of a derivative of 4-hydroxy-2-ketobutyrate selected in the group consisting of 1,3- propanediol, 3-hydroxypropionaldehyde, 3-hydroxypropionate and 2,...
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