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WO/2013/071440 |
Methods and products (e.g., recombinant proteins) are described for increasing frataxin expression/levels in a cell, as well as uses of such methods and products, for example for the treatment of Friedreich ataxia in a subject suffering ...
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WO/2013/073699 |
Provided is DNA for a glycoalkaloid biosynthase derived from a plant belonging to the genus Solanaceae, such as potato. A protein having the activity of a glycoalkaloid biosynthase derived from a plant belonging to the genus Solanaceae, ...
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WO/2013/074163 |
This invention provides methods of detecting and quantifying target nucleic acids in samples in multiplexed single chamber reactions. Consumables incorporating chambers optimized to reduce signal background proximal to high efficiency ar...
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WO/2013/075140 |
Auto-recognizing therapeutic R/DNA chimeric nanoparticles (R/DNA NP) are described that are pairs of DNA/RNA hybrids where the DNA molecules have complementary toehold sequences that promote the re- association of the R/DNA NPs when mixe...
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WO/2013/073760 |
The present invention relates to a novel gene derived from a mud flat metagenome, and to a novel protein obtained therefrom showing the coactivity of phospholipase and lipase. Specifically, the novel gene isolated from the metagenome lib...
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WO/2013/073679 |
The present invention provides a method for efficiently producing (2R,4R)-monatin polyvalent metal salt crystals which have good sweetness characteristics and a high storage stability. More specifically, the present invention provides a ...
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WO/2013/073860 |
The present invention relates to a recombinant microorganism having genes introduced therein to code an acetyl-CoA synthases/carbon monoxide dehydrogenase complex (ACS/CODH) involved in a Wood-Ljungdahl pathway. The recombinant microorga...
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WO/2013/074974 |
One aspect of the present invention relates to double-stranded RNAi (dsRNA) duplex agent capable of inhibiting the expression of a target gene. The dsRNA duplex comprises one or more motifs of three identical modifications on three conse...
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WO/2013/074911 |
The present invention provides methods for light-dependent gene regulation using a light-responsive DNA-binding protein. Also provided are related nucleic acid molecules, and protein molecules, such as those encoding or comprising the li...
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WO/2013/072587 |
The invention relates to the use of fibromodulin and lumican, in particular the active fragments thereof, for increasing muscle mass, in particular in the treatment of muscular dystrophy.
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WO/2013/073667 |
The present invention pertains to a material delivery carrier for extracellular matrix-producing cells in the intestines, the carrier comprising a retinoid as a targeting agent, as well as to an intestinal fibrosis treatment agent using ...
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WO/2013/074438 |
More than 2% of adults harbor a pancreatic cyst, a subset of which progress to invasive lesions with lethal consequences. To assess the genomic landscapes of neoplastic cysts of the pancreas, we determined the exomic sequences of DNA fro...
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WO/2013/073041 |
[Problem] With respect to a method for evaluating the activity of the condition and progression of rheumatoid arthritis disease, to find a simple biomarker with high reproducibility, and to provide an effective evaluation method. [Soluti...
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WO/2013/074833 |
Disclosed is an efficient and scalable method for targeted resequencing and variant identification of nucleic acids such as genomic DNA found in single stranded, fragmented form, such as in a clinical sample of formalin- fixed, paraffin-...
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WO/2013/074601 |
A category of γΡΝΑ miniprobes and chimeric γΡΝΑ probes is especially useful for detecting RNA and telomeric DNA in a cell sample. In particular, the probes can be used to deliver fluorescent dyes to the telomeres, allowing direct...
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WO/2013/074489 |
In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are connected by a polymer linker, e.g., polypep...
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WO/2013/073576 |
The purpose of the present invention is to develop and provide a nucleic acid molecule which can inhibit the activity of an target RNAi molecule specifically and with high efficiency and can be produced safely at low cost. Provided is a ...
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WO/2013/071883 |
Provided are isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods ...
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WO/2013/075079 |
Methods and systems for selectively amplifying a target DNA sequence in the presence of non-target DNA sequence in a sample, comprising: contacting the sample with an oligonucleotide system under hybridization conditions to form a reacti...
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WO/2013/073219 |
The purpose of the present invention is to develop a method for producing a large amount of an insoluble aggregate that is equivalent to an insoluble aggregate formed in the brain of a patient. A method for producing an insoluble aggrega...
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WO/2013/073545 |
A medicine for the effective treatment and/or improvement of sepsis in patients suffering from severe sepsis who have damage to one or more organs and the International Normalized Ratio (INR) value of a blood sample of whom is higher tha...
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WO/2013/071876 |
The present invention provides a method for constructing a high-throughput sequencing library, which comprises:fragmenting the genomic DNA, repairing end of the DNA fragments, adding base A to the 3' end, connecting the DNA fragments hav...
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WO/2013/074999 |
Disclosed herein are enhanced polypeptides, polynucleotides encoding these polypeptides, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-bi...
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WO/2013/074785 |
A process for detecting norovirus nucleic acid in a sample is provided including producing an amplification product by amplifying a norovirus nucleotide sequence using a forward primer of SEQ ID NO: 1, 4, or 10 and a reverse primer of SE...
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WO/2013/074857 |
The invention generally relates to a novel method and related compositions for detecting and analyzing cancers. More particularly, the invention relates to unique methods, compositions and assays useful for diagnosing and measuring the p...
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WO/2013/071871 |
Provided are isolated polypeptides having cellobiohydrolase activity, catalytic domains and cellulose binding domains, and polynucleotides encoding the polypeptides, catalytic domains or cellulose binding domains. Also provided are nucle...
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WO/2013/072868 |
The invention relates to transgenic plants exhibiting increased cell wall content. In one embodiment, transgenic plants engineered to over-express fructokinase (FRK) or both FRK and sucrose synthase (SuSy) are provided. The FRK+SuSy doub...
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WO/2013/075132 |
The invention provides for therapeutic RNA switches comprising oligonucleotide sequences complementary to a trigger sequence, an antisense strand oligonucleotide, and a sense strand oligonucleotide complementary to a target nucleic acid ...
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WO/2013/075035 |
The present invention provides RNAi agents, e.g., double stranded RNAi agents, that target the transthyretin (TTR) gene and methods of using such RNAi agents for treating or preventing TTR- associated diseases.
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WO/2013/075131 |
Systems, devices, and methods for delivering a biological material into an organelle of a cell are provided. In one aspect, for example, a method for introducing biological material into an organelle of a cell can include bringing into p...
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WO/2013/073689 |
A polynucleotide for coding at least one polypeptide involved in pyripyropene biosynthesis, or a recombinant vector including the polynucleotide, is introduced into a plant body, thereby making it possible to provide a plant body introdu...
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WO/2013/074632 |
Disclosed are methods for identifying mismatched nucleotides such as SNPs in a DNA of interest. The methods entail a) preparing single stranded DNA fragments from one or more sources, allowing the fragments to re-anneal and form double s...
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WO/2013/073483 |
[Problem] To impart significantly improved myo-inositol producing capability, suitable for use in recombinant DNA techniques and synthetic biology methods, to a host microorganism that does not possess an endogenous myo-inositol biosynth...
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WO/2013/073774 |
The present invention relates to a nucleic acid gel matrix for the cell-free protein synthesis of a cell nucleus replicate which contains an X-type nucleic acid nanostructure, an expression plasmid containing a DNA fragment, transcriptio...
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WO/2013/072832 |
A method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a GRP (Growth Related Protein) polypeptide is provided. Plants having modulated expression of a nucleic acid encoding a ...
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WO/2013/073602 |
The purpose of the present invention is to develop and provide a method for efficiently producing a nucleic acid aptamer, in particular a DNA aptamer, having a higher specificity and a higher binding ability to a target than nucleic acid...
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WO/2013/073191 |
The present invention relates to a method for forecasting the onset risk of early delivery or abortion characterized by comprising measuring the activity or concentration of plasminogen activator inhibitor in the plasma. More specificall...
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WO/2013/072486 |
The present invention relates to a hydantoinase having an amino acid sequence selected from (i) or (ii), with (i) amino acid sequence selected from SEQ ID NO: 6-20 and SEQ ID NO: 73-119 (ii) amino acid sequence wherein in the amino acid ...
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WO/2013/071355 |
The present disclosure relates to a soluble CD52 glycoprotein and its use in treating diseases regulated by effector T-cells, for example autoimmune diseases such as type 1 diabetes. The present disclosure also relates to fusion proteins...
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WO/2013/073725 |
The present invention relates to a nanopore structure and to a base sequence determining device comprising same. More particularly, in the present invention, an oligonucleotide, both base sequences of which are bent in one direction arou...
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WO/2013/074916 |
The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising disrupted T cell receptor and/or HLA and comprising a chimeric antigen receptor. In certain embodiments, the compositions ar...
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WO/2013/073246 |
The present invention provides a method of producing a skeletal muscle cell from a pluripotent stem cell, which includes a step of expressing one or more exogenous factors selected from MyoD, Myf5 and nucleic acids encoding them on a plu...
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WO/2013/073653 |
Provided are: a novel protein-inducible eukaryotic cell which does not kill a host such as budding yeast and has a satisfactory decomposition ability; and a method for inducing proteolysis using the protein-inducible eukaryotic cell. A p...
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WO/2013/074927 |
Provided herein are methods for isolating cellular ribonucleic acid (RNA) from cells. The method includes suspending cells in an extraction solution comprising formamide; incubating the cells and formamide mixture; and pelleting cell deb...
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WO/2013/071356 |
The present invention relates to silk proteins which can be used to produce silk with a collagen-like structure, as well as nucleic acids encoding such proteins. The present invention also relates to recombinant cells and/or organisms wh...
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WO/2013/074885 |
A microfluidic apparatus, method, and associated applications utilize and apply to a formalin-fixed paraffin-embedded (FFPE) tissue sample and performing a liquid-liquid extraction to remove the paraffin from the tissue sample prior to a...
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WO/2013/073706 |
The purpose of the present invention is to improve the IVV (in vitro virus) synthesis efficiency and the stability of mRNA derived from screened cDNA in a cDNA display method to thereby improve the efficiency and reliability of the produ...
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WO/2013/074738 |
Ligand-specific HVEM variants, compositions comprising such variants, and methods of treating inflammatory diseases comprising administering such variants, are provided.
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WO/2013/073684 |
In the present invention, an isolated polynucleotide having a part or the whole of GFRA1 gene, a mutant GFRA1 protein or mRNA encoding mutant GFRA1 protein, each of which contain a GFRA1 function-deficient mutation, is used as a marker f...
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WO/2013/068692 |
The invention relates to an expression cassette for modifying the genome of bacteria, for example that of Escherichia coli, or for modifying a vector in a bacterial strain. The present invention also relates to a method for modifying the...
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