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WO/2018/161135A1 |
The present invention describes i) the construction of synthetic genes for components of a recombinant fibrin glue: fibrinogen A, fibrinogen B, fibrinogen G, factor XIIIA, prothrombin, ecarin and ERp57; ii) the expression of said genes i...
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WO/2018/164712A1 |
The present invention is a DNA expression vector comprising: a toxP; a mutant toxO that blocks Fe-mediated regulation of gene expression; and a DNA sequence encoding a protein, wherein the toxP and the mutant toxO regulate expression of ...
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WO/2018/164275A1 |
The purpose of the present invention is to provide a novel antisense oligonucleotide and a composition for the prevention or treatment of glycogen storage disease type Ia. Provided is an antisense oligonucleotide that: hybridizes the pre...
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WO/2018/162748A1 |
The present invention relates to vectors and compositions for the treatment of glycogen storage disease III.
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WO/2018/164186A1 |
The present invention provides: a nucleic acid having an activity to inhibit the expression of MASP2; a pharmaceutical composition containing the nucleic acid; and a prophylactic or therapeutic agent for autoimmune diseases including APS...
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WO/2018/165417A1 |
The present invention provides methods for determining bone growth velocity comprising: (a) measuring an amount of a collagen X marker in a sample obtained from a subject in need thereof; and (b) comparing the amount of collagen X marker...
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WO/2018/165194A1 |
Provided herein are engineered cells and methods for engineering cells to deliver a therapeutic agent, e.g., a small molecule, peptide or other drug, to a cell or tissue to be treated.
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WO/2018/162892A1 |
The present invention relates to methods or assays for detecting proteins or molecules of interest in a sample. Aptamers specific to the protein of interest are obtained and are then incubated with the sample. If the protein of interest ...
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WO/2018/162329A1 |
In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have bee...
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WO/2018/165091A1 |
Compositions and methods for conferring herbicide tolerance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions include polynucleotides encoding herbicide tolerance polypeptides, vectors comprising those polynu...
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WO/2018/162450A1 |
The invention relates to new immunostimulatory compositions that comprise conjugates based on the protein CIRP and polypeptides or proteins for stimulation of Antigen Presenting Cells such as dendritic cells. The conjugates may be direct...
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WO/2018/165328A1 |
Disclosed herein are compositions, methods, and systems for the purification and/or detection of recombinant and other proteins. In some embodiments, compositions may comprise recombinant protein with one or more sequences having substan...
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WO/2018/161141A1 |
The present invention relates to methods for identifying and validating gene products from the Cryptococcus fungus as effective targets for therapeutic drug screening. The use of five genes identified in Cryptococcus, responsible for the...
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WO/2018/162612A1 |
Conversion of organic educts, in particular biomass feedstock, into useful organic compounds via pyrolysis and biocatalysts.
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WO/2018/161921A1 |
Provided is a method for epigenetically manipulating plant phenotypic plasticity: quantitatively replacing a methylation site of a target gene by means of a degenerate codon, and carrying out a transgenic operation by means of designing ...
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WO/2018/165198A1 |
Provided herein are engineered cells and methods for engineering cells to deliver a therapeutic agent, e.g., a small molecule, peptide or other drug, to a cell or tissue to be treated.
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WO/2018/165259A1 |
Presented herein are plants with altered photorespiratory characteristics. Disruption of transport proteins involved in shuttling glycolate and/or glycerate results in reductions in photosynthetic rates, reduced plant growth and alterati...
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WO/2018/165062A1 |
This invention relates to inhibition of the complement signaling using an C5 antibody. Specifically, the invention relates to methods of treating a complement- mediated disease or complement-mediated disorder in an individual by contacti...
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WO/2018/165504A1 |
Provided herein are systems, compositions, kits, and methods for the suppression of pain (e.g., chronic pain). Genes encoding ion channels (e.g., SCN9A) responsible for the propagation pain signals in neurons (e.g., DRG neurons) may be e...
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WO/2018/165541A1 |
Described are compounds and methods useful in the treatment of Fuchs' Endothelial Corneal Dystrophy (FECD).
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WO/2018/164190A1 |
The present invention pertains to a synthetic fibroin fiber which contains a modified fibroin and for which a shrinkage rate, defined by the formula below, exceeds 7%. Shrinkage rate = {1 − the length of a synthetic fibroin fiber which...
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WO/2018/162330A1 |
In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have bee...
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WO/2018/164747A1 |
The present invention relates, in some aspects, to the production of steviol glycoside rebaudioside D4 through the use of rebaudioside E. In some aspects, the invention relates to mutant CPl enzymes, mutant HVl enzymes as well as host ce...
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WO/2018/162517A1 |
Herein are provided a method for producing a multispecific antibody comprising the steps of providing a mammalian cell expressing the antibody, transfecting said mammalian cell with an expression vector comprising an expression cassette ...
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WO/2018/162376A1 |
Herein is reported a method for selecting a variant of a parental antibody variable domain encoding nucleic acid, wherein the parental antibody variable domain amino acid sequence encoded by said encoding nucleic acid has at least one de...
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WO/2018/161798A1 |
The present invention belongs to the technical field of biomedicine. Provided are an improved anti-VEGFR-2 monoclonal antibody and an application thereof. By a computer-aided simulation design, a novel phage antibody library was designed...
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WO/2018/164293A1 |
The present invention relates to: a method for controlling plant resistance to environmental stress by transforming plant cells with a recombinant vector comprising a gene coding for an Oryza sativa-derived rice outermost cell-specific g...
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WO/2018/161825A1 |
Provided is a recombinant Herpes simplex virus. The recombinant Herpes simplex virus does not express functional ICP0 protein and ICP34.5 protein; but expresses functional UL43 protein, functional UL41 protein (i.e. vhs protein), functio...
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WO/2018/161872A1 |
Provided are an anti-B7-H3 antibody, an antigen-binding fragment thereof, and a pharmaceutical composition comprising the antibody or the antigen-binding fragment. Also provided is a use of the antibody or the antigen-binding fragment in...
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WO/2018/164214A1 |
The purpose of the present invention is to provide an auxin derivative capable of efficiently exerting a desired effect while reducing undesired effects. A compound represented by general formula (1) which has specific substituent(s) at ...
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WO/2018/164457A1 |
Provided is a dielectric calibration technique using C2cl endonuclease. The dielectric calibration technique is characterized by being especially applicable to eukaryotic cells, for example, to mammalian cells.
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WO/2018/165635A1 |
The disclosure relates to filtering devices, capture devices and their uses to isolate nucleic acids from exosome and/or vesicles.
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WO/2018/164195A1 |
Disclosed is a method for producing a purified protein, comprising: a step for raising pH of an acidic aqueous protein solution containing a target protein, impurities, acidic compound, and water for dissolving the foregoing, thereby pre...
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WO/2018/162750A1 |
A recombinant construct comprising a nucleotide sequence of SEQUENCE ID NO. 1 or a functional variant or functional fragment thereof is provided. Also provided are plant cells transformed with the gene and plant material, including plant...
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WO/2018/163800A1 |
The present invention provides a method for screening for a flavor material having a marine note. The screening method according to the present invention is a method for screening for a candidate compound having a marine note among from ...
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WO/2018/165309A1 |
Provided herein is technology relating to the detection of analytes and particularly, but not exclusively, to methods, systems, compositions, and kits for detecting analytes such as nucleic acids, proteins, small molecules, and other mol...
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WO/2018/162469A1 |
The first object of the invention is directed to a genetic engineering process of plant comprising bast fibres, comprising the steps of (a) identification of the bast fibre promoter; and (b) amplification of the bast fibre promoter. Said...
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WO/2018/165564A1 |
The present invention provides morpholino modified oligomeric compounds having at least one monomer subunit having Formula III, compounds having Formula I useful for making certain of the morpholino modified oligomeric compounds and meth...
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WO/2018/162702A1 |
The present invention relates to nuclease protein fusions for enhancing genome editing by homology-directed transgene integration (HDI). The inventors found that the rate of HDI mediated by the CRISPR/Cas9 system may be substantially imp...
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WO/2018/165293A1 |
The present disclosure relates to compounds, compositions, and methods for the inducing neurodegenerative disease pathologies. In one aspect, disclosed herein is a nucleotide sequence encoding a chimeric polypeptide, comprising: a first ...
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WO/2018/164189A1 |
Disclosed is a method for producing a protein molded article, comprising the steps of: preparing a protein solution which contains a protein, a reactive compound and a solvent to which the protein and the reaction compound are dissolved,...
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WO/2018/164174A1 |
An epithelial tissue stem cell derived from an adult, said epithelial tissue stem cell lacking at least one cancer suppressor gene.
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WO/2018/165536A1 |
The present invention provides constructs comprising modified riboswitches to regulate expression of a transgene within a subject. Methods of treating a disease, specifically an eye disease, are also contemplated.
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WO/2018/165528A1 |
The present disclosure relates to compositions and methods for treating cancers using antisense (AS) nucleic acids directed against Insulin-like Growth Factor 1 Receptor (IGF-IR). The AS may be administered to the patients systemically, ...
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WO/2018/165629A1 |
Some aspects of this disclosure provide compositions, strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g...
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WO/2018/165249A1 |
The disclosure provides compositions and methods to transform and edit the genome of plants and to measure heritable genetic modifications.
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WO/2018/164021A1 |
The present invention relates to a contracted synthetic fibroin fiber comprising modified fibroin, wherein the contraction percentage defined by the following equation exceeds 7%. Contraction percentage={1-(length of contracted synthetic...
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WO/2018/165547A1 |
Described herein are FasL-engineered biomaterials, as well as methods of making and using such FasL-engineered biomaterials, such as for immunomodulation, such as for inducing immunosuppression and specific immune tolerance, such as for ...
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WO/2018/165034A1 |
The present invention relates to methods for treating cancer through combination therapy with a TRP channel antagonist and standard-of-care cancer agents.
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WO/2018/164948A1 |
The present invention provides self-directed polynucleotide switches capable of turning on or turning off the expression of a transgene in mammalian cells from a vector in the presence of Cpfl. Also provided in the invention are methods ...
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