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WO/2012/061776 |
Methods for production of virus particles with simplified glycosylation on structural or surface proteins are provided. When used as targets for vaccine production, the conserved nature of such sites generates vaccines that are less sens...
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WO/2012/060120 |
The purpose of the present invention is to provide a novel protein that shows specific localization in fat droplets. The present invention provides: (A) a protein in which the N-terminus of a polypeptide (b), which comprises the amino ac...
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WO/2012/061810 |
The present invention relates to oligonucleotides with base modified nucleosides for enhancement of binding affinity.
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WO/2012/059069 |
The present invention provides isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also provides nucleic acid constructs, vectors, and host cells comprising the po...
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WO/2012/058714 |
The present invention relates to genetically modified plants of the species Papaver bracteatum wherein the type or amount of one or more alkaloids produced by the plants has been modified. Specifically, the genetically modified plants ha...
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WO/2012/059217 |
The present invention relates to a vector including: (i) an inverted terminal repeat (ITR) nucleotide sequence at the 5' position; (ii) a nucleotide sequence functionally bonded to a promoter at the central position, said nucleotide sequ...
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WO/2012/060473 |
Provided is a method of improving the efficiency of iPS cell establishment, comprising bringing one or more factors selected from the group consisting of proteins belonging to cyclin D family and nucleic acids that encode the same into c...
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WO/2012/061513 |
This disclosure concerns compositions and methods for identifying the SCN resistant phenotype in soybean. In some embodiments, the disclosure concerns methods for performing marker assisted breeding and selection of plants carrying one o...
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WO/2012/061105 |
IDH1 gene-defective cell lines (e.g., IDH1R132H heterozygous) have been made from a robust cell line, HCT116. The IDH1 gene-defective cell lines can be used to determine the effect of IDH1R132H on cell biology, tumorigenesis, and cellula...
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WO/2012/059243 |
The present invention relates to compositions, methods, and uses involving the modulation of K4 protein activity, especially in the treatment of various diseases and in the enhancement of vaccination regimens. The invention relates to po...
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WO/2012/061719 |
Provided herein are DNA origami devices useful in the targeted delivery of biologically active entities to specific cell populations.
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WO/2012/060596 |
The present invention relates to an apparatus and method for simultaneously detecting various types of target nucleic acids in real time, whereby various types of target nucleic acids can be simultaneously detected in real time to allow ...
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WO/2012/061726 |
Provided are compositions and methods for sequencing a target polynucleotide that has been used to generate an elongated polynucleotide having a plurality of segments, each segment corresponding to one of the nucleic acid residues of the...
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WO/2012/059053 |
The present invention provides isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also provides nucleic acid constructs, vectors, and host cells comprising the po...
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WO/2012/060705 |
The present invention relates generally to the field of plant molecular biology and plants, especially genetically altered or genetically evolved plants, plant parts, progeny, subsequent generations and reproductive material having cells...
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WO/2012/061443 |
This invention describes a protein nanoparticle system for targeting siRNA or other drugs into tumors. The basis of the protein system is elastin-like peptides that self-assemble once exposed to the nucleic acid of the siRNA. Specific ta...
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WO/2012/060840 |
The invention provides methods and compositions for identifying compounds that can enhance plant resistance to stress.
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WO/2012/061225 |
The present invention relates to nucleic acid amplification assays for the detection of nucleic acid sequences of Gardnerella vaginalis. The present invention provides oligonucleotides that are complementary or that anneal to nucleic aci...
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WO/2012/059593 |
The present invention stems from the finding that the interaction between the β2 adrenoceptor (β2ΑΡ) and type IV pilus-associated proteins initiates a process leading to the opening of the blood-brain barrier. The invention therefore...
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WO/2012/060489 |
The present invention relates to a recombinant microorganism containing a Cornebacterium induced novel indole oxygenase gene, and a method for preparing indirubin using same, and more particularly, to a method for preparing an indigoid c...
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WO/2012/060407 |
Provided are a gene switch and gene circuit selection method, and an expression vector used in the selection method, characterized by using, as a selector, an expression vector containing at least a gene sequence, the expression of which...
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WO/2012/058730 |
Provided is a Wheat grain (Triticum aestivum) comprising an embryo, starch and one, two or three SBEIIa proteins, said embryo comprising two identical alleles of an SBEIIa-A gene, two identical alleles of an SBEIIa-B gene and two identic...
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WO/2012/060635 |
The present invention provides a polynucleotide including a gene which is related to the metabolism of isoflavone, and especially a single-nucleotide polymorphism (SNP) that is induced from a gene which is on the signaling path of NF-κB...
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WO/2012/061828 |
The invention provides an expression system for producing Caveolin-1 in neuronal cells or neural stem cells comprising a neuron-specific regulatory element and a nucleic acid sequence encoding Caveolin-1.
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WO/2012/061653 |
Provided herein are metabolically modified microorganisms characterized by having an increased keto-acid flux when compared with the wild-type organism and comprising at least one polynucleotide encoding an enzyme that when expressed res...
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WO/2012/061405 |
Disclosed herein are PNA probes, or PNA probe sets and their use as well as kits useful for the analysis of certain Oxalobacter species and/or strain(s) present in a sample of interest. Probe sequences may sequence that are at least abou...
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WO/2012/061306 |
The present invention provides methods of sensitizing lung cancer cells to paclitaxel and carboplatin and inhibiting the growth of lung cancer tumors in number and volume and increasing survival of lung cancer patients by employing a mod...
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WO/2012/061615 |
The invention provides methods for modifying lignin, cellulose, xylan, and hemicellulose content in plants, and for achieving ectopic lignification and, for instance, secondary cell wall synthesis in pith cells, by altered regulation of ...
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WO/2012/058768 |
The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g.CH2 and CH3) to accomplish selectivity between the various Fc receptors involved in modulating effector function, beyond those achievable with a nat...
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WO/2012/061146 |
Compositions and methods for generating platelets and methods of use thereof disclosed.
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WO/2012/059559 |
The present invention relates to plant genes involved in negative regulation of resistance to biotic and/or abiotic stress and uses thereof. More particularly, the present invention relates to plants comprising an inactivated MADS-box ge...
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WO/2012/058814 |
The present invention clones the second RNA recognition motif (RRM2) gene of FCA-γ gene in Brassica napus, and transforms the RRM2 domain gene into cotton by transgenic method. The transgenic line exhibits characteristics of yield incre...
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WO/2012/060025 |
The present invention addresses the problem of providing a vaccine which as yet has not been provided for the disease HHV-6B, which is the cause of exanthema subitum in infants, and the problem of providing an effective screening method ...
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WO/2012/061832 |
Artificial transposon sequences having code tags and target nucleic acids containing such sequences. Methods for making artificial transposons and for using their properties to analyze target nucleic acids.
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WO/2012/060389 |
Provided are: a transformant of yeast of the genus Schizosaccharomyces, which is capable of producing β-glucosidase; and a method for manufacturing the transformant of yeast of the genus Schizosaccharomyces. This transformant of yeast o...
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WO/2012/058762 |
A plant expression system and methods for expressing a protein of interest in a plant are provided. The plant expression system comprises a first nucleic acid sequence regulatory region sequence, operatively linked with a one or more tha...
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WO/2012/060666 |
The present invention relates to a method for producing hEGF(human epidermal growth factor) which has the same activity as the wild form, in high concentration and with a high degree of purity. More specifically, the invention relates to...
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WO/2012/060572 |
The present invention relates to a novel iturin biosynthesis gene, and a use thereof. More specifically, the present invention provides a novel iturin biosynthesis gene, wherein the iturin biosynthesis gene was cloned from Bacillus subti...
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WO/2012/059592 |
The present invention stems from the finding that the interaction between the β2 adrenoceptor (β2AR) and type IV pilus-associated proteins initiates a process leading to the opening of the blood-brain barrier. The invention therefore p...
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WO/2012/058919 |
A method for enhancing the rate of acid production of genetically engineered bacteria producing L-phenylalanine is provided, comprising: amplifying the whole phosphoenolpyruvate carboxykinase (pckA) gene by PCR and inserting the amplifie...
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WO/2012/059612 |
The present invention relates to a small interfering RNA (siRNA) specific for tumour necrosis factor-alpha (TNF-α), being 2'-0-methyl modified and there being attached thereto by a phosphodiester bond a group R in position 3', wherein R...
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WO/2012/059922 |
A method of engineering a plant having reduced acetylation in a cell wall is disclosed. The method comprising expressing in the plant cell wall at least one isolated heterologous polynucleotide encoding an acetylxylan esterase (AXE) enzy...
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WO/2012/059849 |
A method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a POI (Protein Of Interest) polypeptide is provided. Methods for the production of plants having modulated expression of...
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WO/2012/058868 |
Hepatocyte-like cells which express a Hnf polypeptide and a Foxa polypeptide, the method of generating the cells and the uses of the cells are provided.
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WO/2012/060323 |
Provided is a gene involved in the regulation of the amount of melanin in keratinocytes and the control of skin and hair color, said gene being selected from the group comprising the ATG7 gene, RAB11A gene, CLIP-170 gene, Rubicon gene, a...
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WO/2012/061432 |
The present application provides genetically modified fungal organisms that produce enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to glucose, enzyme mixtures produced by the genetically modified fungal organisms, ...
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WO/2012/059224 |
The present invention describes methods and pharmaceutical compositions for the treatment of cancer in mammals, more particularly in human subjects. More specifically, the invention concerns anti-tumor vaccines based upon plasmid DNA and...
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WO/2012/059223 |
The present invention relates to a method and to vectors for the immortalisation of cells independent of their type. It further relates to a cell or a cell line produced with the method or the vectors of the invention. The invention also...
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WO/2012/061075 |
Hematopoietic stem cells (HSCs) are programmed to generate induced pluripotent stem cells (iPSCs) that express anti-HIV polynucleotides including a CCR5 shRNA and a human/rhesus chimeric TRIM5? gene and optionally a Tar decoy. Upon direc...
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WO/2012/060109 |
The present invention provides a method of examining polycystic kidney disease or a complication of polycystic kidney disease using a gene(s) selected from the group consisting of NTNG1, POSTN, TNC, KAL1, BST1, ACAT2, INSIG1, SCD, HSD3B1...
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