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WO/2019/154437A1 |
Provided is an SgRNA combination, comprising an SgRNA specifically targeting the GGTA1 gene, an SgRNA specifically targeting the CMAH gene and an SgRNA specifically targeting the β4GalNT2 gene. Also provided is a CRISPR/Cas9 vector comb...
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WO/2019/132510A3 |
The present invention relates to a recombinant yeast in which an organelle is mutated by gene manipulation and a method for production of various isopreonoids by using the same. When a metabolic pathway of the useful product isoprenoid i...
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WO/2019/076891A3 |
Disclosed are double stranded RNA molecules that are toxic to hemipteran insects. In particular, interfering RNA molecules capable of interfering with pest target genes and that are toxic to the target pest are provided. Further, methods...
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WO/2019/154939A1 |
The present invention relates to hybrid transcription regulatory elements to drive gene expression, in particular hybrid promoters, designed by the fusion of at least two transcription regulatory elements with different tissue selectivit...
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WO/2019/154313A1 |
An isolated CD19-binding chimeric antigen receptor, a CRISPR-Cas9 system-based method for knocking out TRAC, B2M and PD-1 genes in T cells in vitro, crRNA used in the method, gene knockout T cells obtained according to the method, and a ...
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WO/2019/154285A1 |
A no-label reagent combination for gene editing, comprising: (i) a first nucleic acid construct, or a first vector containing the first nucleic acid construct; and (ii) a second nucleic acid construct, or a second vector containing the s...
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WO/2019/157034A1 |
The disclosure provides DNA library preparation methods that do not require a purification between adapter ligation and PCR amplification. Adaptors are added to DNA fragments to form oligonucleotide extension products and the oligonucleo...
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WO/2019/157087A1 |
Methods for predicting response to immunotherapy and selecting immunotherapy for treating cancer, e.g., cancer of epithelial origin, in a subject.
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WO/2019/156115A1 |
The purpose of the present invention is to provide a vector, a promoter and miRNA for the same, and a pharmaceutical composition including the vector, whereby expression of the PLP1 gene can be suppressed specifically in oligodendrocytes...
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WO/2019/118638A3 |
The present invention relates to RNAi constructs for reducing expression of the PNPLA3 gene. Methods of using such RNAi constructs to treat or prevent liver disease, nonalcoholic fatty liver disease (NAFLD) are also described.
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WO/2019/157324A1 |
Described herein are engineered nucleases comprising mutations in the cleavage domain (e.g., FokI or homologue thereof) and/or DNA binding domain (zinc finger protein, TALE, single guide RNA) such that on-target specificity is increased.
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WO/2019/153633A1 |
Provided are an alcohol dehydrogenase mutant and an application thereof in synthesis of diaryl chiral alcohol, belonging to the technical field of the biological engineering. The alcohol dehydrogenase mutant has good catalytic activity a...
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WO/2019/155969A1 |
The present invention addresses the problem of providing: an enzyme agent useful in reducing purine bodies, in particular in beer and beer-like drinks; and use thereof. Provided is a nucleosidase agent characterized by the activity ratio...
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WO/2019/124782A3 |
In a method for producing acetoin, butanediol, or butanol from ethanol according to the present invention, a cell-free catalysis method was used by designing an artificial synthetic pathway so that proteins of NOX, EtDH, FLS, BDH, and DD...
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WO/2019/157173A1 |
Described herein are plants, plant seeds, and plants cells that are modified to express particular types of cellulose synthase enzymes (but not CesA3, CesA9, or CesA7 enzymes). Such plants, plant seeds and plant cells can be cotton, flax...
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WO/2019/156152A1 |
The present disclosure relates to: a nucleic acid that includes a gene expression control sequence that can control the expression of a target gene in coryneform bacteria; bacteria into which the nucleic acid has been introduced; a metho...
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WO/2019/156242A1 |
The present invention relates to a method for producing a recombinant protein using a recombinant cell in which the desired recombinant protein is expressed in the form of an insoluble material, the method being characterized in that the...
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WO/2019/157529A1 |
The present disclosure provides methods for analyte characterization from a single cell. The methods disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizi...
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WO/2019/153183A1 |
The present invention relates to the technical field of genetic engineering, and provides a monooxygenase mutant, a preparation method therefor and an application thereof. The monooxygenase mutant has any one of the amino acid sequences ...
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WO/2019/156511A1 |
Provided are a biological sample analysis method, an analysis chip and an analysis system comprising same, the method comprising the steps of: introducing structures for assisting the formation of bioreactors on a substrate; providing a ...
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WO/2018/152148A8 |
The present disclosure provides engineered modified strains of enterococcus faecalis (EF) that is able to produce bacteriocin but is inefficient at establishing long-term colonization of the GI track in an animal. Compositions comprising...
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WO/2019/153827A1 |
A method for preparing a liraglutide intermediate polypeptide GLP-1(7-37), comprising: constructing a recombinant liraglutide engineered bacteria, expressing a liraglutide intermediate fusion protein in the form of an inclusion body by m...
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WO/2019/157326A1 |
A CRISPR system is successfully used to modify the genomes of a gram-positive bacterium, such as a species of the Corynebacterium genus. Methods for modifying Corynebacterium species include single-nucleotide changes, creating gene delet...
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WO/2019/157130A1 |
Disclosed are nucleic acids and polypeptides which provide the co-expression of interleukin (IL)-21 and IL-15 by a host cell, each interleukin being bound to the cell membrane by a cell membrane anchor moiety. Also disclosed are related ...
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WO/2019/153899A1 |
Provided are a maize parthenogenetic haploid-induced gene ZmPLA1E and a use thereof. After a mutation occurs in a coding region of the ZmPLA1E gene, the ZmPLA1E gene can produce and significantly improve a parthenogenetic haploid-induced...
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WO/2019/155408A1 |
The present invention provides an anti-PD-1/anti-HER2 natural antibody structural heterodimeric bispecific antibody and a method of preparing the same. More particularly, the present invention provides a highly stable heterodimeric anti-...
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WO/2019/156054A1 |
In one embodiment, the present invention provides a new marker, method, kit, etc., with which it is possible to determine an MLH1 methylation group at high accuracy. In one embodiment, the present invention relates to a marker for mutL h...
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WO/2019/157531A1 |
The present disclosure provides oligomeric compound comprising a modified oligonucleotide having a central region comprising one or more modifications. In certain embodiments, the present disclosure provides oligomeric compounds having a...
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WO/2019/157522A1 |
Disclosed are modified plants and methods for producing modified plants having a modified 5'-untranslated region of small auxin upregulated protein flooding tolerance (SAUR_FT) gene. Modified plants disclosed herein have at least one of ...
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WO/2019/153200A1 |
Provided are an anti-PD-1/anti-HER2 natural antibody structure-like bispecific antibody in heterodimeric form and a preparation method therefor. The antibody can bind two target molecules simultaneously, and can be used for treating comp...
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WO/2019/156020A1 |
A manufacturing method for single-stranded RNA comprising a step for allowing an RNA ligase to act on a first single-stranded RNA with a phosphate group on the 5' end and a second single-stranded RNA with a hydroxyl group on the 3' end t...
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WO/2019/124932A3 |
The present application pertains to a Corynebacterium sp. microorganism producing L-arginine and a method using the same for producing L-arginine.
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WO/2019/156910A1 |
A method of characterizing a nucleic acid that includes steps of (a) contacting a primer-template nucleic acid hybrid with a polymerase and a mixture of nucleotides to produce an extended primer hybrid and to form a stabilized ternary co...
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WO/2019/157504A1 |
This document relates to methods and materials for generating oilseed (e.g., pennycress) plants that have oil with reduced levels of polyunsaturated fatty acids (PUFAs) and/or increased levels of oleic acid. For example, oilseed plants h...
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WO/2019/157239A1 |
Provided herein, in certain embodiments, are plasmid expression vectors and methods of use of such vectors for either transient or stable integrated expression of transgenes in eukaryotic cells. The plasmid expression vectors provided he...
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WO/2019/154686A1 |
A eukaryotic host cell engineered to produce a heterologous protein of interest (POI), which cell is genetically modified to reduce production of at least one of three different endogenous host cell protein (HCP), and its use in a method...
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WO/2019/155016A1 |
The invention relates to a method of improving the efficiency of transduction of viral vectors into cells, wherein the method comprises administering to a cell an antimalarial agent and a viral vector. The invention also relates to a com...
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WO/2019/154249A1 |
Provided are a nitrilase mutant, a construction method therefor, and an application thereof in the synthesis of a pregabalin chiral intermediate. Brassica rapa nitrilase BrNIT and Arabidopsis thaliana nitrilase AtNIT are respectively use...
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WO/2019/157131A1 |
The disclosure relates to cell-permeable stabilized peptide modules and methods of use for e.g., cellular delivery of cargoes.
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WO/2019/154391A1 |
Provided are a chimeric antigen receptor, a NKG2D CAR-NK cell expressing the chimeric antigen receptor, a preparation method therefor and the use thereof. The chimeric antigen receptor comprises an antigen binding domain, a transmembrane...
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WO/2019/156395A1 |
The present invention relates to a lateral fluid separation-based DNA extraction device. A DNA extraction device according to an embodiment of the present invention may comprise: a sample pad for receiving a sample from which DNA is to b...
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WO/2019/157318A1 |
The present disclosure provides methods and compositions for tracking nucleic acid fragment origin by target-specific barcode tagging when original nucleic acid targets break into small fragments. Nucleic acid targets are captured in vit...
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WO/2019/154979A1 |
The present invention relates to oligonucleotides that are complementary to and modulate the expression of TMEM106B. The present invention further relates to conjugates of the oligonucleotide and pharmaceutical compositions and methods f...
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WO/2019/154189A1 |
A fibroblast growth factor 21 (FGF21) variant, further to a FGF21 variant fusion protein, a protein multimer, and use thereof are provided. The FGF21 variant, fusion protein and protein multimer can significantly improve the binding abil...
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WO/2019/157535A1 |
Disclosed herein are compositions and methods comprising extracellular vesicles comprising nucleic acid that target genes, leading to macrophage polarization of tumor associated macrophages. In certain embodiments, disclosed herein are m...
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WO/2019/156257A1 |
A method for determining a hyperexcitability in a subject comprising detecting a repeat expansion of TTTCA, TTTTA, or a complementary sequence thereof in a nucleic acid sample from the subject.
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WO/2019/154217A1 |
Provided are a Tripterygium wilfordii Cryptomeridiol synthase and a coding gene thereof. Also provided are a Tripterygium wilfordii Cryptomeridiol synthase and a coding gene, a engineered yeast contianing the Tripterygium wilfordii Crypt...
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WO/2019/153952A1 |
The present invention relates to an herbicide tolerance protein, an encoding gene thereof and use thereof, the herbicide tolerance protein comprising: a protein (a) having an amino acid sequence as shown in SEQ ID NO: 1, and having an al...
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WO/2019/153634A1 |
An alcohol dehydrogenase mutant and an application thereof in the synthesis of biaryl chiral alcohol. The alcohol dehydrogenase in the present invention is coupled to glucose dehydrogenase or formate dehydrogenase, and may be used for th...
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WO/2019/156251A1 |
The present invention provides a combination of: (1) a composition containing a living bacterium of Bacteroides vulgatus isolated from nature; and (2) a composition containing a living bacterium of Bacteroides dorei isolated from nature.
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