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Matches 1 - 50 out of 240,812

Document Document Title
WO/2018/009869A1
Provided herein are genetically engineered cells containing one or more modulated metabolic genes, where the expression of the modulated metabolic gene(s) can be greater than that of an unmodified control. Also provided herein are method...  
WO/2018/009553A1
Methods for treating glaucoma and/or Fas ligand-dependent inflammatory conditions in a subject using soluble Fas ligand (sFasL) or a fragment thereof, which may be rAAV- mediated delivery of sFasL or a fragment thereof to a subject.  
WO/2018/009466A1
The present invention provides highly active locked nucleic acid cyclic -dinucleotide (LNA-CDN) immune stimulators that activate DCs via the cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the LNA-CDN...  
WO/2018/006750A1
Provided is a secretory protein sDSS1 of a higher primate. The protein can be detected in human blood serum and cerebrospinal fluid. The sDSS1 protein can bind, under non-enzymatic conditions, with an oxidized protein to form a polymer, ...  
WO/2018/008740A1
The present invention provides a method for judging the onset possibility of large bowel cancer in a human ulcerative colitis patient, etc. The method comprises a measurement step for measuring methylation ratios at one or more CpG sites...  
WO/2018/009246A1
The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.  
WO/2018/007475A1
The current invention provides antisense splice-switching oligonucleotides with improved characteristics that enhance clinical applicability for treating, ameliorating, preventing, and/or delaying neuromuscular disorders, such as DMD.  
WO/2018/008750A1
Provided are a method for screening agents for the prevention or treatment of diseases caused by interleukin 6, interleukin 13, TNF, G-CSF, CXCL1, CXCL2, or CXCL5 and an agent for the prevention or treatment of diseases caused by interle...  
WO/2018/009806A1
This application discloses methods for fermenting recombinant Trichoderma reesei comprising a heterologous invertase gene, using sucrose as carbon source.  
WO/2018/009809A1
Compositions, methods and kits are provided. The compositions, methods and kits are for assembly of series of DNA segments in yeast using homologous recombination. The assembled DNA segments are maintained episomally. Yeast made using th...  
WO/2018/009696A1
Disclosed herein are methods and kits for identifying a subject as having colon cancer. Also provided herein are methods and kits for determining the prognosis of a subject having colon cancer and for determining the progression of colon...  
WO/2018/009770A1
A synthetic, cognitive cell, system, and method for automatically generating an output based on an environmental input is disclosed. The cognitive cell includes an operator including chemical agents, and a coded chemical including polyme...  
WO/2018/009847A1
The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.  
WO/2018/006824A1
A BLyS antibody, preparation method therefor and application thereof, the BLyS antibody comprising one or more of a heavy chain CDR1, a heavy chain CDR2 and a heavy chain CDR3 of a heavy chain variable region of the BLyS antibody, and/or...  
WO/2018/009814A1
Codon optimized nucleic acid sequences for RDH12 are provided, as well as recombinant viral vectors, such as AAV, expression cassettes, proviral plasmids or other plasmids containing the codon optimized sequence for functional RDH12. Rec...  
WO/2018/006881A1
A recombinant receptor and an application thereof. The recombinant receptor comprises: a cellular immune-checkpoint molecular segment; an immune stimulator molecular segment; and a T-cell receptor zeta chain.  
WO/2018/008083A1
The present invention has been conceived for the purpose of providing a new DNA detecting method and an apparatus therefor. In other words, provided is a DNA detecting method including: a step for manufacturing droplets by adding, to oil...  
WO/2018/007526A1
The present invention relates to the use of transcriptional activators from prokaryotic organisms for use in eukaryotic cells, such as yeast as sensors of intracellular and extracellular accumulation of a ligand or metabolite specificall...  
WO/2018/008979A1
The present invention relates to a recombinant vector for producing pinostilbene or pterostilbene, a transformant for producing pinostilbene or pterostilbene, and a method for producing pinostilbene or pterostilbene. The use of the recom...  
WO/2018/009600A2
The invention provides methods for improving plant yield, biomass accumulation and stress tolerance. According to the invention applications have discovered that a novel AP2-like transcription factor MPG1, which when modulated impacts gr...  
WO/2018/006882A1
Provided in the present invention is an antibody for anti-claudin 18A2 and an immune effector cell targeting claudin 18A2. Also provided are methods for inducing cell death and treating tumours.  
WO/2018/009506A1
A DNA construct containing an erythroid lineage-specific promoter operably linked to a nucleotide coding sequence of interest and a method of using the same in the prevention or treatment of a hematopoietic disorder such as a hemoglobino...  
WO/2018/009541A1
RNA virus vectors comprising a gene encoding the DNA-dependent activator of interferon-regulatory factors (DAI) protein, and optionally further comprising a gene encoding the receptor-interacting serine/threonine-protein kinase 3 (RIPK3)...  
WO/2018/009632A1
An altered RuBisCO activase (RCA) a-isoform lacking redox activity at its carboxy terminus and genetically altered plants that encode an altered RCA α-isoform having an altered DNA at its 3 ' end (or the exon that encodes the redox-sens...  
WO/2018/007976A1
The present application provides materials and methods for treating a patient with one or more conditions associated with SCN10A whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing ...  
WO/2018/008153A1
The present invention is a method for determining the possibility of the onset of colon cancer in human ulcerative colitis patients, wherein the method for determining the possibility of onset of colon cancer includes a measurement step ...  
WO/2018/009855A1
The present invention provides compositions and methods for treating cutaneous T-cell lymphoma (CTCL) with intralesional administration of one or more miR-155 inhibitors. In certain embodiments, the intralesional administration of one or...  
WO/2018/009520A1
The present invention relates to methods for improving at least one property of a microorganism host cell by repressing the expression of one or more genome target sequence of interest by CRISPR-inhibition as well as the resulting host c...  
WO/2018/007575A1
The present invention relates to a genomic sequences encoding for an attenuated mutant Zika virus. The inventors have introduced some specific substitutions at very specific positions in the epidemic genomic sequence for restoring some f...  
WO/2018/007873A1
We have found a way to make possible large-scale plasmid transfection using PEI to produce high titer viral vectors in fixed bed or adherent cell culture bioreactors by using PEI as a transfection agent, while avoiding formation of the P...  
WO/2018/009461A1
Provided are Listeria-based immunogeniccompositions comprising Wilms tumor protein (WT1) antigens and methods for treating and vaccinating against cancer and inducing an immune response against the same in a subject. Also provided herein...  
WO/2018/009709A1
Disclosed herein are methods and kits for identifying a subject as having lung cancer. Also provided herein are methods and kits for determining the prognosis of a subject having lung cancer and for determining the progression of lung ca...  
WO/2018/009707A1
Disclosed herein are methods and kits for identifying a subject as having esophagus cancer, pancreatic cancer, or stomach cancer. Also provided herein are methods and kits for generating the methylation profile of a biomarker associated ...  
WO/2018/009534A1
The presently disclosed subject matter provides compositions and methods comprising improvements of a CRISPR system (e.g. CRISPR associated (Cas) 9 (CRISPR-Cas9, non-Cas9 CRISPR systems). Such compositions may comprise modifications to t...  
WO/2018/009765A1
The present invention generally relates to systems and methods for determining RNA in blood or other fluids. In certain embodiments, blood or other fluids may be treated to isolate or separate RNA, for example, from DNA, cells, and other...  
WO/2018/007530A1
The invention relates to aptamers which specifically bind to fibrinogen and their use in the purification of said protein.  
WO/2018/007871A1
Materials and methods for treating a patient with Transthyretin Amyloidosis, both ex vivo and in vivo, are provided, and materials and methods for modulating the expression, function, or activity of a Transthyretin (TTR) gene in a cell b...  
WO/2018/007415A1
The present invention relates to an in vitro method for determining the transfection of a cell or group of cells, wherein said determination is performed spectroscopically. The determination comprises recording at least one Raman spectru...  
WO/2018/009457A1
Compositions and methods for using actin-based peptides to modulate cellular bioactivity, including modulation of cellular susceptibility to intracellular pathogens, such as bacteria and viruses.  
WO/2018/007263A1
The invention pertains to the field of adaptive cell immunotherapy. It aims at reducing the occurrence of translocations and cell deaths when several specific endonuclease reagents are used altogether to genetically modify primary immune...  
WO/2018/008617A1
The present invention specifies a glutathione-S-transferase that exhibits metabolic/detoxification activity on an isoxazoline derivative such as pyroxasulfone or the like. Provided is a transformed plant cultivation method that is charac...  
WO/2018/009024A1
The present invention relates to a recombinant vector system using a polynucleotide coding for a P domain of a coat protein (CP) derived from Turnip crinkle virus (TCV), and a use thereof. It is considered that when the recombinant vecto...  
WO/2018/009923A1
The present disclosure provides methods for genetically modifying lymphocytes and methods for performing adoptive cellular therapy that include transducing T cells and/or NK cells. The methods can include inhibitory RNA molecule(s) and/o...  
WO/2018/009050A1
The present invention relates to four CpRap2 genes isolated from Carica papaya, identified as CpRap2.4a, CpRap2.4b, CpRap2.1, CpRap2.10 and consisting of sequences SEQ. ID NO: 1, SEQ. ID NO: 2, SEQ. ID NO: 3 and SEQ. ID NO: 4, as well as...  
WO/2018/009702A1
Disclosed herein are methods and kits for identifying a subject as having leukemia. Also provided herein are methods and kits for determining a leukemia subtype in subject. Further provided herein are methods and kits for determining the...  
WO/2018/007980A1
The present application provides materials and methods for treating a patient with one or more conditions associated with SCN9A whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing a...  
WO/2018/006567A1
Provided is a high-efficiency method for linking a connector, the method comprising: using a type A DNA polymerase or a DNA polymerase Klenow fragment to process a DNA molecule so as to add a 3'dA protruding end; then linking the process...  
WO/2018/009663A1
Methods and compositions related to the engineering of a protein with L-cyst(e)ine degrading enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-y-lyase comprising one or more am...  
WO/2018/009562A1
Described herein are methods for treating a retinal degeneration in a subject, such as Leber's congenital amaurosis (LCA), retinitis pigmentosa (RP), and glaucoma. Also provided herein are methods of altering expression of one or more ge...  
WO/2018/009626A2
The present invention provides a method and means to change fatty acid and ultimately triacylglycerol production in plants and algae. Methods of the invention comprise the step of altering the activity levels of the committed step for de...  

Matches 1 - 50 out of 240,812