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Matches 1 - 50 out of 114,517

Document Document Title
WO/2019/078278A1
Provided is a method for producing pluripotent stem cells to be differentiated into cardiomyocytes, said method comprising: (1) culturing pluripotent stem cells on a weakly cell-adhesive substrate so as to form a dome-shaped colony; and ...  
WO/2019/075562A1
The present disclosure relates to an endogenous Retrovirus K protein (ERVK) with an alternative envelope protein titled CTXLP. Said CTXLP peptide is represented by the sequences set forth in SEQ ID NO: 1. Additionally, antibodies that sp...  
WO/2019/079681A1
The present invention provides methods and systems which accommodate 3- dimensional adipocyte expansion to produce, e.g., mature adipocytes and synthetic adipose tissue with cellular properties of mature adult organisms, including cell s...  
WO/2019/075782A1
The present invention provides a method for rebuilding a marrow microenvironment in a testee whose marrow microenvironment is damaged. The method comprises: implanting a composition containing separated mesenchymal stromal cells (MSC) in...  
WO/2019/076486A1
The invention pertains to the field of adaptive cell immunotherapy. It provides with the genetic insertion of exogenous coding sequence(s) that help the immune cells to direct their immune response against infected or malignant cells. Th...  
WO/2019/075557A1
The present disclosure relates generally to enhance transfection efficiency of human pluripotent stem cells through the combinatorial effects of retinoic acid analogue (TTNPB) and Rho-associated kinase inhibitor (Y-27632), and PPARγ ago...  
WO/2019/078252A1
Provided that a human hemocyte-like cell group suited to erythrocyte-mediated infectious microorganisms such as viruses, bacteria, protozoa, etc., to be studied can be identified, the cell group can be prepared artificially and provided,...  
WO/2019/079034A1
The invention provides herein engineered regulatory T cells (Tregs), compositions thereof, and their methods of use. The Tregs described herein can be engineered to include, e.g., a chimeric antigen receptor (CAR), conferring increased s...  
WO/2019/078277A1
This chip (20) is equipped with micro flow channel units for hydro-dynamically classifying cells in a blood sample. In each of the micro flow channel units, a liquid flowing out from a sub flow channel into a main flow channel squeezes c...  
WO/2019/078781A1
Retinal photoreceptor progenitors and photoreceptors can be produced by differentiating human embryonic stem cells on a surface having a laminin matrix thereon made of two laminins. One laminin is laminin-521, and the other laminin is ei...  
WO/2019/079292A1
Some embodiments provide method of forming a three-dimensional tissue scaffold that includes extruding a bioink material through a nozzle onto a support while moving the nozzle relative to the support or moving the support relative to th...  
WO/2019/078342A1
The present disclosure addresses the problem of providing a method for selecting a pluripotent stem cell having directivity of differentiation to a cardiomyocyte. The problem can be solved by a method including (a) measuring the expressi...  
WO/2019/078587A1
The present invention relates to a composition for promoting osteogenesis or inducing chondrogenic differentiation and, more specifically, to a composition containing, as an active ingredient, a culture of chicken bone marrow-derived ost...  
WO/2019/078251A1
The adhesive according to the present invention includes nanoparticles, the surfaces of which are coated by a cationic water-soluble polymer. A cell structure in the present invention includes an alginic acid hydrogel in which a cell is ...  
WO/2019/078357A1
The present invention provides a method for measuring the amount of a molecule that is internalised into a cell, said method comprising: (i) a step for adding said molecule to a cell population derived from an internal organ, and incubat...  
WO/2019/027299A3
The present invention relates to a pharmaceutical composition for preventing or treating vascular disorders including a mesenchymal stem cell expressing a hepatocyte growth factor (HGF) protein as an active ingredient. This pharmaceutica...  
WO/2019/077628A1
The present invention relates to a process for modulating glycoform of recombinant glycoproteins by altering the trace element composition of a culture medium. Further, the present invention provides a culture medium supplemented with tr...  
WO/2019/076355A1
A method of modifying an upstream open reading frame (uORF) by genome editing technique to regulate gene expression.  
WO/2019/076386A1
Provided is a method for determining an ATR and ERK binding region, said method comprising the use of recombinant plasmid cell transfection and co-immunoprecipitation to determine an ERK kinase and ATR protein active region.  
WO/2019/079656A1
The present disclosure provides method and products for the selective enrichment of one population of DNA in a mixed sample comprising multiple populations of DNA. In some embodiments, the mixed sample comprises one or more populations o...  
WO/2019/079009A1
The invention provides methods of measuring the progression and effectiveness of a course of treatment of bladder cancer in a subject diagnosed with a bladder cancer, by applying a physiologically acceptable dye to the tumor and measurin...  
WO/2019/076508A1
The present invention relates to a method for the in vitro generation of skin, in particular of a skin model, thus obtained and its use for screening and testing of candidate substances and pharmaceutical compositions.  
WO/2019/078263A1
The present invention addresses the problem of providing a method for easily and efficiently preparing a functional and matured neuromuscular junction (NMJ) in vitro. This problem is solved by a method for producing an artificial neuromu...  
WO/2019/077062A1
The CAR-T cells described herein can provide highly effective therapies for diverse cancer types, e.g., solid cancers, hematological cancers, and metastatic forms thereof. Provided herein are methods of generating CAR-T cells, compositio...  
WO/2019/035901A9
The present disclosure relates, in general, to inhibiting signaling activity of STING (STimulator of INterferon Genes) in a subject having an ongoing immune response and use of constitutively active STING mutants to stimulate an immune r...  
WO/2019/079772A1
Systems and methods to genetically modify B cells to express selected antibodies are described. The systems and methods can be used to: obviate the need for classical vaccinations; provide protection against infectious agents for which n...  
WO/2019/079259A1
This disclosure relates to the use of DNA methyltransferase inhibitors, alone or in combination with Aurora kinase inhibitors, to treat muscle cells isolated from contractured muscles or to prepare isolated and treated muscle cell compos...  
WO/2019/078783A1
Retinal progenitors and mature photoreceptor cells can be produced by differentiating human embryonic stem cells on a surface having a laminin matrix thereon made of two laminins. One laminin is laminin-521, and the other laminin is eith...  
WO/2019/078296A1
Provided is an HLA-A24-restricted epitope peptide derived from methothelin. More specifically, provided are a peptide comprising an amino acid sequence AFYPGYLCSL (SEQ ID NO: 15), a polynucleotide encoding the peptide represented by SEQ ...  
WO/2019/077162A1
The present invention relates to a method for identifying molecules promoting or inhibiting dopaminergic neuronal differentiation and/or death of dopaminergic neurons in a three-dimensional cell culture. Furthermore, the present inventio...  
WO/2019/076591A1
The application discloses a method for obtaining MSC-derived cells with improved transplantation properties from MSC, the method comprising a cell size reduction step, wherein said cell size reduction step is characterized by contacting ...  
WO/2019/075556A1
Systems and methods for the monitoring of G protein activation at various cell compartments, such as the plasma membrane and the endosomes, and in a Gα protein subunit family-selective manner are described. These systems and methods als...  
WO/2019/079249A1
Chimeric antigen receptors (CARs) containing CD22 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the CARsare also ...  
WO/2019/076489A1
The invention pertains to the field of adaptive cell immunotherapy. It provides with the genetic insertion of exogenous coding sequence(s) into genetically engineered immune cells to prevent cytokine release syndrome to arise during the ...  
WO/2019/076149A1
Provided are a universal CAR-T cell, a preparation method therefor and an application thereof. In the universal CAR-T cell, the functions of a T cell antigen receptor (TCR) and major histocompatibility complexes (MHC I and MHC II) in the...  
WO/2019/027298A3
The present invention relates to a pharmaceutical composition comprising mesenchymal stem cells expressing TRAIL and CD as an effective ingredient for prevention or treatment of cancer. A pharmaceutical composition comprising TRAIL- and ...  
WO/2019/050350A3
The present invention relates to a stem cell-derived Sertoli-like cell, a preparation method therefor, and a use thereof. According to one embodiment, Sertoli-like cells can be obtained on mass scale because of the differentiation thereo...  
WO/2019/071297A1
An apparatus for removing fluid from a cell culture comprising the fluid and one or more multicellular spheroids, the apparatus comprising: a body having an conduit terminating at an opening; and a filter extending across the opening, th...  
WO/2019/073964A1
The present disclosure provides a technique whereby the influence of an endogenous TCR is eliminated in TCR gene transfer. A TCR gene is edited using a genome editing enzyme, said genome editing enzyme having one characteristic that amin...  
WO/2018/064440A8
The described invention provides a well plate-based perfusion culture model of endosteal-, extracellular matrix (ECM)- and endothelial- myeloma interactions and patient-specific methods for selecting treatment for and assessing drug resi...  
WO/2019/075397A1
A cardiac patch for treatment of a mammalian heart including perfu sable vessels embedded integratedly between two layers of anisotropically oriented myocardial fibers. The cardiac patch is made using a dual 3D bioprinting technique usin...  
WO/2019/075055A1
Provided are methods of producing an isolated population of T cells for adoptive cell therapy, the method comprising culturing isolated T cells in vitro in the presence of a p38 mitogen activated protein kinase (p38 MAPK) inhibitor, wher...  
WO/2019/075166A2
The present invention provides hollow microcarriers for cell culture. The hollow microcarriers form a shell around a hollow interior and can be opened to permit cell infiltration or harvesting. The hollow microcarriers protect cells from...  
WO/2019/075057A1
Provided are methods and compositions for inducing the reprogramming of a non-pluripotent to an iPSC having desirable properties using a vector system providing transient and temporal expression of transgenes that are short-lived. Also p...  
WO/2019/074046A1
[Problem] The purpose of the present invention is to provide a method for preparing a cell population containing numerous periodontal ligament stem cells, particularly epithelial stem cells from the periodontal ligament and/or periodonta...  
WO/2019/075101A1
Provided herein are ex vivo derived tissues generated from adipose-derived stem cells, as well as methods of making and using the same. Also provided herein are methods for repairing or healing damaged tissues or organs and for treating ...  
WO/2019/073951A1
Provided is a method for preparing hepatocytes or cells that can be differentiated into hepatocytes from pluripotent stem cells for the purpose of preparing mature hepatocytes that are similar in many respects to primary cultured hepatoc...  
WO/2018/124888A9
The present disclosure provides a method of transportation for a structured synthetic tissue cultured in vitro comprising transporting the said tissue in part or all of the manufacturing device, such that the tissue is essentially untouc...  
WO/2019/073973A1
The purpose of the present invention is to provide, in order to continue the rejection of malignant tumors over a long period of time, an enhancer for endogenous T-cells or B-cells having a memory function, and a malignant tumor recurren...  
WO/2019/071358A1
A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a...  

Matches 1 - 50 out of 114,517