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WO/2018/185709A9 |
The present disclosure relates to compositions, nucleic acid constructs, methods and kits thereof for cell induction or reprogramming cells to the dendritic cell state or antigen presenting cell state, based, in part, on the surprisingly...
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WO/2019/159934A1 |
Provided are a fusion protein for measuring the quantity or quality of modified HDL, the fusion protein being a lipid-free standard having good long-term storability, and a method for accurately, reproducibly, and reliably measuring high...
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WO/2019/160419A1 |
The present invention relates to a tripodal squaramide-based monomer based monomer according to formula (I) for the formation of supramolecular polymers: wherein T represents a central atom; n is an integer of from 4 to 12; and R1 is a g...
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WO/2019/161143A1 |
Methods for improving the efficiency and productivity of hybrid corn seed production are provided herein. Various methods to improve the transfer of pollen from male corn plants to female corn plants, and thus increase yield, are provide...
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WO/2019/161271A1 |
The disclosure provides a method of generating modified T cells from engineered stem cells for use in an autologous or allogeneic setting for engineered immunotherapy. The knockout of endogenous TCR or HLA expression allows for engineeri...
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WO/2019/157691A1 |
The present invention provides a recombinant chimeric antigen receptor (CAR) gene, a vector comprising same, a CAR-T cell and use thereof. The recombinant CAR gene comprises a nucleic acid sequence encoding the following portions: an ant...
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WO/2019/158724A1 |
A subject of the invention is an infusible three-dimensional network of crosslinked-polymer fibres, suitable as a cell support, and in particular characterized in that the diameter of said fibres is between 0.1 and 1.5 μm, the size of t...
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WO/2019/159084A1 |
Described herein are methods to affect binding by a multivalent binding molecule to a FZD receptor and a Wnt co-receptor on a cell wherein binding by the multivalent binding molecule to both FZD receptor and co-receptor on the cell activ...
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WO/2019/160148A1 |
The purpose of the present invention is to provide: a cell aggregate containing dopamine-producing neural precursor cells suitable for transplantation; a mixture thereof; and a method for preparing the same. This cell aggregate contains ...
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WO/2019/160193A1 |
The present invention relates to a method for preparation of human pluripotent stem cell-derived functional cardiomyocytes through cell differentiation and maturation, the method comprising: a culturing step of seeding and culturing huma...
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WO/2019/112899A8 |
Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs. The derivative cells provided herein have stable and functional g...
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WO/2019/140116A3 |
This disclosure provides, among other things, amplifiable nucleic acid constructs for expressing a gene of interest in a cell, e.g., an erythroid cell. The amplifiable nucleic acid construct may contain the gene of interest and an RNA-de...
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WO/2019/160299A1 |
The present invention relates to a composition for promoting the efficiency of somatic cell replication, comprising endothelin as an active ingredient. When somatic cells are treated with the composition of the present invention, H3K9me3...
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WO/2019/158539A1 |
The invention relates to a method for preparing an irradiated platelet lysate, comprising the following steps: provision of a platelet lysate in order to obtain a starting platelet lysate, said starting platelet lysate comprising (i) pla...
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WO/2019/159558A1 |
The purpose of the present invention is to provide an apparatus for exchanging cell nuclei. An apparatus for exchanging cell nuclei, which is an apparatus for producing a cell having the cell nucleus of a first cell and containing the ce...
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WO/2019/161048A1 |
A network of neurospheres (NNet) mimicking the small-world hierarchic-modular architecture of mammalian brains, created by synthetically building a network of inter-connected individual brain microphysiological systems (MPSs).
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WO/2019/160099A1 |
Provided is a peptide which comprises 10-45 amino acids containing: an amino acid sequence KILQQSRIVQX (wherein X is nil or represents S); an amino acid sequence consisting of 10 or more consecutive amino acids in an amino acid sequence ...
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WO/2019/160077A1 |
Provided is a method for producing, from a donor cell, a low-antigenic cell in which a rejection reaction in the case of allotransplantation to a recipient is reduced. The method includes: determining the donor cell and a human leukocyte...
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WO/2019/160978A1 |
Methods and systems for diagnosing, providing prophylaxis, and treating one or more age-related neurodegeneration or pathological cognitive impairment are provided. Provided are methods to protect against and/or reduce the severity of co...
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WO/2019/159149A1 |
A technique for producing an artificial biointerface involves providing a patterned microfluidic chip having: a chamber divided by a fluid-permeable fencing into a central region and two flanking channels; and at least 3 fluid paths, eac...
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WO/2019/161133A1 |
Provided herein are compositions, kits, and methods for manufacturing cells for adoptive cell therapy comprising (a) an engineered receptor, vector encoding an engineered receptor, or engineered immune cell expressing such engineered rec...
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WO/2019/160075A1 |
The present invention addresses the problem of sterilizing cyst nematodes, establishing an in-vitro mass propagation system for cyst nematodes, and providing sterilized cyst nematodes that allow evaluation tests such as an egg hatch assa...
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WO/2019/160829A1 |
Methods of expanding tumor infiltrating lymphocytes (TILs) in the presence of an adenosine A2A receptor (A2aR) antagonist, such as vipadenant, CPI-444 (ciforadenant), SCH58261, SYN115, ZM241385, SCH420814, a xanthine superfamily A2aR ant...
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WO/2019/158712A1 |
The present disclosure relates to allogeneic populations of mesenchymal stem/stromal cells and related compositions, which populations and compositions comprise cells pooled from multiple donors, and their use in therapy and/or preventio...
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WO/2019/158621A1 |
The present invention relates to a method for obtaining a spermatozoid cell population with improved fitness which comprises contacting the starting spermatozoid population with a binding agent recognizing the CD10 biomarker and isolatin...
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WO/2019/103436A9 |
The present invention relates to a composition for culturing NK cells and a method for culturing NK cells using the same. According to one aspect, in culturing of NK cells in peripheral blood monocytes, NK cells can be cultured in a medi...
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WO/2019/161243A1 |
The present technology relates to methods and compositions that provide for improved detection of target molecules in, for example, bioengineering.
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WO/2019/161400A1 |
Provided are compositions and methods for treating a subject having a primary immune deficiency (PID), for example who is suffering from a chronic viral, bacterial, or fungal infection, using autologous granulocytes, autologous lymphocyt...
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WO/2019/147979A3 |
Provided herein are compositions including peptide or nucleic acids encoding peptides and related methods for the treatment of angiogenic conditions such as cancer, vascular disorders such as cardiovascular disorders, and infectious dise...
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WO/2019/157597A1 |
A method of generating cells of the T cell lineage is provided comprising (a) culturing a sample comprising stem cells or progenitor cells with a Notch ligand conjugated to a suspension support and (b) isolating cells of the T cell linea...
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WO/2019/160059A1 |
Provided is a method for recycling s-adenosylmethionine that is characterized in that after s-adenosylmethionine is demethylated, s-adenosylmethionine is regenerated by converting s-adenosylmethionine from methionine obtained by transfer...
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WO/2019/158540A1 |
The invention relates to a method for preparing an irradiated platelet lysate, comprising the following steps: provision of a starting platelet lysate comprising (i) platelet factors including growth factors and (ii) plasma proteins incl...
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WO/2019/156180A1 |
A dissolution system for a poorly water-soluble organic compound, which is provided with: a container 1 that is capable of containing a gas which contains a poorly water-soluble organic compound that is in the form of a gas; and a spray ...
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WO/2019/157329A1 |
The present disclosure provides cell-based compositions for treating diabetes, methods for identifying cells that preferentially differentiate into endoderm cells, and methods for preparing insulin-producing pancreatic cells, as well as ...
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WO/2019/094550A8 |
The present invention provides methods of treating neurodegenerative diseases, comprising administering agents that block dendritic cells from entering the brain from the blood. The present invention further describes methods for detecti...
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WO/2019/156216A1 |
By using a drug that activates the cell cycle, such as a retinoic acid receptor agonist, a phosphatidylinositol 3-kinase (PI3K) inhibiting agent, or an isocitrate dehydrogenase 1 (IDH1) inhibiting agent, cardiomyocytes can be made to pro...
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WO/2019/157530A1 |
Methods for synthesizing a hydrogel are disclosed. The method includes the steps of: (a) dissolving effective amounts of a monomer, a crosslinker, and a photoinitiator in deionized water, wherein the overall concentration is about 200mg/...
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WO/2019/157440A1 |
The present disclosure generally relates to novel chimeric antigen receptors ("CARs"), modified regulatory T cells ("Tregs") expressing such CARs and/or Tregs which are engineered to express neurodegenerative disease modifying molecules,...
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WO/2019/156926A1 |
Some embodiments provided herein relate to methods and compositions for making genetically modified T cells. In some such embodiments, CD4+ and CD8+ T cells are cultured in a single serum-free volume. In some embodiments, co-cultured CD4...
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WO/2019/154315A1 |
An anti-B7-H4 antibody, an antigen-binding fragment thereof and pharmaceutical use thereof. A chimeric antibody and a humanized antibody comprising a CDR region of the anti-B7-H4 antibody, a pharmaceutical composition comprising the anti...
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WO/2019/155474A1 |
The invention relates to cancer immunotherapy, particularly to improved therapeutic modalities involving specifically modulating the expression and/or activity of SLAMF6 splice variants. More specifically, embodiments of the invention pr...
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WO/2019/154963A1 |
The present invention relates to a method for generating an ex vivo skin sample being capable of developing scar. Further, the present invention comprises a method for screening for a compound which modulates scar development. Additional...
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WO/2019/157524A1 |
The present disclosure provides binding proteins, including TCRs, that specifically bind human cyclin A1 (CCNA1), host cells expressing such antigen specific binding proteins, nucleic acids encoding the same, and compositions for use in ...
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WO/2019/154391A1 |
Provided are a chimeric antigen receptor, a NKG2D CAR-NK cell expressing the chimeric antigen receptor, a preparation method therefor and the use thereof. The chimeric antigen receptor comprises an antigen binding domain, a transmembrane...
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WO/2019/156032A1 |
Provided are a method and kit which are for culturing hair follicle's epithelial stem cells and which can grow a large amount of hair follicle's epithelial stem cells with hair regeneration capability thereof maintained. This method for ...
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WO/2019/155288A1 |
Current invention relates to a polynucleotide encoding activating chimeric receptors comprising engineered Natural Killer Group 2 member C (NKG2C) having enhanced affinity for HLA class I histocompatibility antigen alpha chain E (HLA-E)/...
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WO/2019/154217A1 |
Provided are a Tripterygium wilfordii Cryptomeridiol synthase and a coding gene thereof. Also provided are a Tripterygium wilfordii Cryptomeridiol synthase and a coding gene, a engineered yeast contianing the Tripterygium wilfordii Crypt...
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WO/2019/153952A1 |
The present invention relates to an herbicide tolerance protein, an encoding gene thereof and use thereof, the herbicide tolerance protein comprising: a protein (a) having an amino acid sequence as shown in SEQ ID NO: 1, and having an al...
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WO/2019/157356A1 |
Disclosed herein is a bioreactor system that allows active perfusive flow through a porous support medium enabling 3D growth of biological samples. In some embodiments, the system comprises a sample well filled with a three-dimensional (...
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WO/2019/153032A1 |
A method of isolating fetal trophoblastic cells from a suitable biological sample is disclosed. The method comprises: providing a suitable biological sample comprising fetal trophoblastic cell population within a population of other cell...
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