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WO/2019/055498A1 |
The present invention provides enzymes that have been optimized by implementation of Protein Repair One Stop Shop (PROSS), an algorithm that generates protein design(s) for enhanced stability without changing either enzymatic properties ...
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WO/2019/051069A1 |
The invention is directed to a process for producing one or more fermentation product in a multi-stage process including an inoculation reactor and at least one bioreactor. The inoculation reactor is fed a C1-containing gaseous substrate...
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WO/2019/048438A1 |
Method of obtaining a compound and corresponding apparatus. The method comprises adding a substrate (14) to a medium (132) comprised in a reactor (13, 33), and reacting the substrate in the reactor to form the compound. A first stream (1...
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WO/2019/043186A1 |
The present invention relates to a method for producinga chiral amine, performing a transamination reaction of a prochiral amino acceptor and an amino donor in a first solution in the presence of a transaminase, thereby forming a chiral ...
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WO/2019/039544A1 |
The present invention provides: a compound having a structure represented by general formula (1) (in the formula, n is 2-100, P represents a (C1-C5) alkylene group substituted with one amino group, Q is general formula (2) (in general fo...
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WO/2019/035612A1 |
The present application relates to a microorganism producing a mycosporine-like amino acid and a mycosporine-like amino acid production method using the same microorganism. Being enhanced in the productive potential of mycosporine-like a...
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WO/2019/031575A1 |
An enzyme having features (a) and (b). (a) Has D-amino acid reversible dehydrogenating activity. (b) Is a hexamer of a polypeptide having an amino acid sequence that identifies at least 80% with a SEQ ID No. 2 amino acid sequence.
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WO/2019/030808A1 |
Provided is a microorganism which is plasmid-free and has improved productivity. In one aspect, the present disclosure relates to a transgenic microorganism belonging to the genus Escherichia, in which at least five genes shown below are...
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WO/2019/031574A1 |
An enzyme having features (a) and (b). (a) Has D-amino acid reversible dehydrogenating activity. (b) Is a hexamer of a polypeptide having an amino acid sequence that identifies at least 80% with a SEQ ID No. 2 amino acid sequence.
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WO/2019/024706A1 |
An aspartase variant, a preparation method therefor, and an application thereof are provided. The amino acid sequence of the aspartase variant has 96% or higher identity with sequence 2 in the sequence listing, comprises T187I and N326C ...
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WO/2019/023796A1 |
Disclosed are methods for converting an alkaloid substrate compound into a N- alkylated alkaloid product compound in the presence of an alkyl donor compound and catalytic quantities of an N-alkyltransferase enzyme capable of converting t...
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WO/2019/027267A2 |
The present application relates to an ATP phosphoribosyltransferase (HisG) protein, and a histidine production method using same.
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WO/2019/022375A1 |
Provided are: an L-lysine-producing microorganism having been transformed with a polynucleotide comprising an L-lysine-inducible promoter; and a method for producing L-lysine by using the same.
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WO/2019/017706A2 |
The present application relates to a genus Corynebacterium microorganism producing putrescine and a method for producing putrescine using the same
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WO/2019/011236A1 |
Use of a stereoselective transaminase in the asymmetric synthesis of a chiral amine. In particular, provided is use of a polypeptide in the production of a chiral amine or a downstream product using a chiral amine as a precursor. Further...
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WO/2019/011946A1 |
The present invention relates to the field of bio-production of threonine. The inventors have conceived genetically modified yeasts, having an increased ability to produce threonine, as compared to the parent yeasts.
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WO/2019/012525A3 |
The present invention provides anti-microbial compositions comprising a hydroxycinnamic acid and related conjugates, analogues and derivatives, and methods of use thereof for enhancing production of anti-microbial agents in bacteria as w...
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WO/2019/012525A2 |
The present invention provides anti-microbial compositions comprising a hydroxycinnamic acid and related conjugates, analogues and derivatives, and methods of use thereof for enhancing production of anti-microbial agents in bacteria as w...
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WO/2019/013569A1 |
The present application relates to a microorganism expressing active D-proline reductase.
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WO/2019/011948A1 |
The present invention relates to the field of bio-production of metabolites, and in particular of metabolites produced by a microorganism using more particularly oxaloacetate as substrate or co-substrate upstream in the biosynthesis path...
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WO/2019/011942A1 |
The present invention relates to the field of bio -production of methionine and/or of its derivatives thereof, and in particular of bio-production of methionine and/or of its derivatives thereof from a reduced source of sulfur, such as M...
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WO/2019/011945A1 |
The present invention relates to the field of bio-production of metabolites, and in particular of metabolites produced by a microorganism using oxaloacetate, pyruvate and/or acetyl-CoA as substrate or co-substrate upstream in the biosynt...
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WO/2019/013532A2 |
The present application relates to a novel acetohydroxy acid synthetase mutant, and a method for producing a microorganism comprising the same or an L-branched chain amino acid using the same.
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WO/2019/011194A1 |
A bio-enzyme for catalyzing synthesis of phosphatidylserine, a preparation method therefor and application thereof. The bio-enzyme is an amino acid sequence represented by SEQ ID NO: 2. The preparation of the bio-enzyme comprises: first ...
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WO/2019/006700A1 |
Provided are a Bacillus subtilis strain JSC-137 producing 5-hydroxytryptophan and a method for producing 5-hydroxytryptophan by using the same with tryptophan as a substrate. The Bacillus subtilis strain JSC-137 has a collection number o...
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WO/2019/006701A1 |
A Bacillus licheniformis strain JSC-69 producing 5-hydroxytryptophan and having a collection number of CGMCC NO: 13533 and a method for producing 5-hydroxytryptophan by using the Bacillus licheniformis strain. The Bacillus licheniformis ...
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WO/2019/006723A1 |
Provided is a mesophilic microorganism host cell that produces lysine, and is genetically modified to express a thermophilic lysine decarboxylase and to overexpress one or more lysine biosynthesis polypeptides. And provided are methods o...
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WO/2019/008110A1 |
The present invention relates to the preparation of amines from aldehydes and ketones by reductive amination with enzymes having a reductive aminase activity on aldehydes and ketones devoid of any carboxyl group gamma of the carbonyl gro...
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WO/2019/004780A2 |
The present application relates to an O-succinyl homoserine transferase mutant, a polynucleotide for coding same, a microorganism comprising the mutant, and a method for producing O-succinyl homoserine using the microorganism.
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WO/2019/004778A2 |
The present application relates to an aspartokinase mutant, a microorganism including the mutant, and a method for production of an aspartate-derived L-amino acid or homoserine derivative, using the microorganicm.
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WO/2019/004234A1 |
The present invention addresses the problem of providing a simple method for producing ergothioneine. Provided is an ergothioneine production method characterized by comprising a step for culturing a microorganism belonging to the genus ...
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WO/2019/004779A2 |
The present application relates to an O-succinyl homoserine transferase mutant, a polynucleotide for coding same, a microorganism comprising the mutant, and a method for producing O-succinyl homoserine using the microorganism.
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WO/2018/230977A1 |
The present application relates to a novel polypeptide having an ability to discharge an ornithine-based product, and a method for producing an ornithine-based product using same.
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WO/2018/230978A1 |
The present application relates to a novel polypeptide having an ability to discharge an ornithine-based product, and a method for producing an ornithine-based product using same.
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WO/2018/229208A1 |
A method for producing a compound of formula (III) or a salt thereof, wherein said process comprises the following steps: (a) forming a mixture comprising a compound of formula (II) by adding an organocatalyst to a compound of formula (I...
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WO/2018/228247A1 |
Disclosed in the present application are a method for producing an enzymatic reaction by using adenosine to replace adenosine triphosphate (ATP) and an application thereof. The method comprises the following steps: (1) in an enzymatic re...
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WO/2018/220228A1 |
The method relates to the production of dialdehyde dioxime precursors corresponding to medium chain linear α-, ω-dinitriles by means of an enzymatic conversion.
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WO/2018/219107A1 |
Provided are engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed are developed through directed evolution based on ...
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WO/2018/219619A9 |
The invention relates to a method of producing a modified non-ribosomal peptide, e.g. a modified microcystin and/or modified nodularin (together CA), comprising the steps of: a) growing a modified non-ribosomal peptide producing cyanobac...
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WO/2018/219619A1 |
The invention relates to a method of producing a modified non-ribosomal peptide, e.g. a modified microcystin and/or modified nodularin (together CA), comprising the steps of: a) growing a modified non-ribosomal peptide producing cyanobac...
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WO/2018/217168A1 |
This invention relates to the bioproduction of substituted or unsubstituted phenylacetaldehyde, 2-phenylethanol, phenylacetic acid or phenylethylamine by subjecting a starting material comprising glucose, L-phenylalanine, substituted L-p...
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WO/2018/212626A1 |
The present invention relates to a recombinant microorganism having an enhanced ability to produce heme, coproporphyrin III (Copro III), and uroporphyrin III (Uro III), and a method for producing heme, coproporphyrin III, and uroporphyri...
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WO/2018/213796A1 |
The disclosure relates to host cells having altered NADPH availability, allowing for increased production of compounds produced using NADPH, and methods of use thereof. NADPH availability is altered by one or more of: expressing an alter...
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WO/2018/211051A1 |
The present invention is directed to microbial production of nicotinamide mononucleotide using a genetically modified fungus.
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WO/2018/209563A1 |
Provided are CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. Methods of generating such mutant polypeptides, microorganisms genetically modified to overexpress the mu...
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WO/2018/210359A1 |
The invention relates to pyruvate carboxylase and a pyruvate carboxylase-encoding DNA, a plasmid containing said DNA and a microorganism for the production thereof, and to methods for the production of products the biosynthesis of which ...
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WO/2018/206027A1 |
It has been determined that the yeast Kazachstania slooffiae, which occurs endemically in hog-gut, is capable of utilising a plurality of L-amino acids, peptone, ammonium sulfate or urea as an individual N-source and in so doing, does no...
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WO/2018/202688A1 |
The present invention relates to a process for preparing a natural flavor base and a flavor base obtainable by such process. A further aspect of the invention is a method for providing a natural pistachio, a natural malty, a natural hone...
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WO/2018/202683A1 |
The present invention relates to a process for preparing a natural flavor base and a flavor base obtainable by such process. A further aspect of the invention is a method for providing a natural malty, a natural tropic fruit, a natural c...
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WO/2018/202686A1 |
The present invention relates to a process for preparing a natural flavor base and a flavor base obtainable by such process. A further aspect of the invention is a nnethod for providing a natural milky, a natural caramel, a natural pop-c...
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