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WO/2018/127143A1 |
The invention provides a highly active S-cyanohydrin lyase obtained by mutating an amino acid residue at position 103 of a wild-type cassava S-cyanohydrin lyase. The mutation can significantly increase an expression of a mutant enzyme in...
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WO/2018/124440A2 |
The present application relates to novel mutant polypeptide having isopropylmalate synthase activity, a polynucleotide coding for the same, a microorganism including the polypeptide, and a method for producing L-leucine by culturing the ...
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WO/2018/124247A1 |
A nitrile hydratase that is derived from Pseudonocardia thermopila and has an α subunit and a β subunit, wherein a specific amino acid residue has been substituted for the amino acid residue in at least one position selected from the g...
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WO/2018/124475A2 |
The present invention relates to a recombinant microorganism having a xenogeneic gene introduced thereto and a method for producing a useful material from formic acid and carbon dioxide using the microorganism. The present invention prov...
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WO/2018/120025A1 |
The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms gene...
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WO/2018/122511A1 |
The invention relates to the field of organic polysulphides, more particularly to a method for synthetising functionalised organic polysulphides of formula (I): R2-X-(NR1R7)C*H-(CH2)n-Sa-(CH2)n-C*H(NR1R7)-X-R2, in which the various subst...
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WO/2018/124778A1 |
The present application relates to a microorganism producing O-phosphoserine and a method for producing O-phosphoserine, cysteine or a cysteine derivative using same.
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WO/2018/124533A1 |
The present application relates to a Corynebacterium sp. microorganism for producing L-lysine and a method for producing L-lysine by using the same.
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WO/2018/120026A1 |
The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms gene...
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WO/2018/116203A1 |
The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, ...
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WO/2018/114841A1 |
The present invention relates to a process for preparing aminobenzoic acid or an aminobenzoic acid conversion product, comprising the steps of: (I) providing an aqueous solution of aminobenzoic acid using a fermentation process; (II) ads...
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WO/2018/115538A1 |
The invention relates to a method for obtaining biogenic polyamines from a protein material with a protein richness of approximately 10% by weight, the method including the following steps: (i) performing hydrolysis of a protein material...
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WO/2018/114575A1 |
The present invention relates to a method for the enzymatic reduction of cystine to cysteine comprising contacting cystine with a reduction solution comprising: (i) an active glutathione reductase (EC1.8.1.7); (ii) a cofactor; and (iii) ...
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WO/2018/104143A1 |
The present invention relates to a method for the biocatalytic synthesis of proteinogenic L-amino acids, such as L-alanine, L-valine, L-methionine, L-leucine, L-isoleucine or L-phenylalanine from a respective aldehyde and carbon dioxide ...
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WO/2018/099452A1 |
Disclosed is a L-isoleucine-producing Corynebacterium glutamicum fermentation medium, comprising a basal medium and a growth factor, wherein the growth factor consists of choline, betaine and vitamin B6, and the contents of each ingredie...
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WO/2018/090288A1 |
Provided is an engineering bacteria synthesizing α-aminobutyric acid, wherein the preparation method is: after the tandem of L-threonine deaminase, L-amino acid dehydrogenase and a dehydrogenase gene for providing cofactor NADH circulat...
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WO/2018/093033A1 |
The present application relates to an L-lysine producing microorganism, and a method for producing L-lysine using the same.
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WO/2018/088434A1 |
The purpose of the present invention is to provide a novel method for producing an N-succinyl-hydroxy-D-amino acid and/or a hydroxy-D-amino acid. A method for producing an N-succinyl-hydroxy-D-amino acid, said method comprising step (A) ...
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WO/2018/082030A1 |
Provided are a proline hydroxylase and an application thereof. The proline hydroxylase includes (a) a protein having the amino acid sequence as shown in SEQ ID NO: 2; (b) a protein in which the amino acid sequence as shown in SEQ ID NO: ...
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WO/2018/077159A1 |
Disclosed is a method for modifying an amino acid attenuator, a type of amino acid attenuator mutants, engineered bacteria generated on the basis of the amino acid attenuator mutants, and use of the engineered bacteria. Further disclosed...
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WO/2018/079685A1 |
A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective ...
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WO/2018/079686A1 |
A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective ...
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WO/2018/081221A1 |
A process for preparing Propamocarb is presented. The preparation of Propamocarb (propyl 3-(dimethylamino)propylcarbamate) from 3- dimethylaminopropylamine and dipropyl carbonate is performed using an enzyme catalyst. In certain embodime...
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WO/2018/075670A1 |
A method of demethylizing an opioid to a nor-opioid is provided. The method comprises contacting an opioid with at least one enzyme. Contacting the opioid with the at least one enzyme converts the opioid to a nor-opioid. A method of conv...
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WO/2018/071564A1 |
Disclosed herein are methods and compositions for the production of L-3,4- dihydroxyphenylalanine from a bacteria.
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WO/2018/055563A1 |
The present invention relates to a method for heterologously expressing an ornithine acyl-ACP N-acyltransferase in a microorganism, wherein the expression of the ornithine acyl-ACP N-acyltransferase protein catalyses the synthesis of lys...
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WO/2018/056305A1 |
[Problem] To provide a novel method for producing L-cysteine as a substitute for the existing fermentation methods. More specifically, provided is a method for producing L-cysteine with the combined use of heat-resistant enzymes. In part...
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WO/2018/050300A1 |
The invention relates to a polysaccharide-oxidizing composition comprising a polysaccharide-oxidizing enzyme wherein, when the said polysaccharide-oxidizing enzyme is compared to the reference polypeptide of SEQ ID NO. 1 as described in ...
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WO/2018/040469A1 |
A method for producing L-lysine by fermentation, comprising modifying a gene for coding an NCBI reference sequence NP_601029.1 and/or NP_599350.1 on a Corynebacterium bacterial chromosome to enable the activity and/or expression quantity...
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WO/2018/045376A3 |
Provided herein are compositions and methods for generating polypeptides using non-natural amino acids (nnAAs) and genetic machinery, wherein the modified polypeptides, such as therapeutic polypeptides, bind to albumin, such as serum alb...
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WO/2018/042460A1 |
The present invention discloses sulphur functionalized polyurea composite of Formula (I) and Formula (II) that provides an insoluble solid support for effective removal of metal residues from solvent streams and other reservoirs and to t...
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WO/2018/042841A1 |
A SAMe-containing material having a high SAMe content can be obtained by a method which comprises: a heating/dissolving step for supplying water and brown sugar to a culture tank and dissolving the brown sugar by heating; a culture step ...
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WO/2018/041639A1 |
The invention relates to a method for producing an N-acyl- or N-sulfonyl-α-aminonitrile, comprising the following steps: a) condensation of an N-acyl- or N-sulfonyl-α-aminoaldehyde with hydroxylamine to obtain an aldoxime, and b) dehyd...
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WO/2018/039495A1 |
This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canoni...
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WO/2018/037833A1 |
Provided is a method of producing poly-gamma-glutamic acid by culturing Bacillus subtilis identified by deposit number NITE BP-02276, deposit number NITE BP-02277, deposit number NITE BP-02278, deposit number NITE BP-02279, deposit numbe...
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WO/2018/035249A1 |
The present disclosure relates to compositions and methods for producing stereoisomerically pure aminocyclopropanes.
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WO/2018/032240A1 |
Provided herein is a genetically modified host cell comprising a heterologous nucleic acid encoding a biofilm dispersal polypeptide that decreases intracellular c-di-GMP levels and enhances the production of lysine and lysine derivatives...
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WO/2018/029282A1 |
Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to have reduced levels or activity of one or more alcohol dehydrogenases or aldehyde reductases thereby increasing the production of benzylisoqui...
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WO/2018/030507A1 |
The present invention provides a production method for an L-amino acid such as L-lysine. An L-amino acid is produced by culturing, in a culture medium, bacteria having L-amino acid producing ability, bacteria that have been modified to h...
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WO/2018/029097A1 |
The present invention relates to a method for synthesising amides that is of general applicability. The method may be performed in vitro or in vivo. Cell lines for use in the in vivo methods also form aspects of the invention. The method...
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WO/2018/022613A1 |
This disclosure describes methods for regulating the biosynthesis of pimelic acid, 7-arninoheptanoate, 7-hydroxyheptanoate, heptamethyJenediamine, 7-aminoheptanol, or 1,7-heptanedioi by channeling increased flux through the biosynthesis ...
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WO/2018/019867A1 |
The present invention relates to a compound of general formula (I). The present invention also relates to a method of producing N-acetyl homoserine and/or derivatives thereof, the method comprising contacting at least one recombinant cel...
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WO/2018/018569A1 |
Provided is a method for increasing production of an L-arginine by knocking-out a flavoprotein reductase. A Corynebacterium crenatum SDNN403 genome is used as a template. Overlap extension PCR is used to acquire a missing gene fragment o...
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WO/2018/022440A2 |
This disclosure relates to genome-scale attenuation or knockout strategies for directing carbon flux to certain carbon based building blocks within the 7-aminoheptanoic acid (7-AHA) and 6-aminohexanoic acid (6-AHA) biosynthesis pathways,...
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WO/2018/020380A1 |
The present invention provides process for preparation of enantiomerically pure (R)-3- aminobutan-1-ol (I) by treating 4-hydroxybutan-2-one (II) with transaminase enzyme and use of enantiomerically pure (R)-3-aminobutan-1-ol (I) in the p...
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WO/2018/020012A1 |
The present invention generally relates to industrial microbiology, and specifically to the production of biochemical compounds, such as L-serine, L-tyrosine, mevalonate and their derivatives, and recombinant polypeptides using genetical...
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WO/2018/016873A1 |
The present invention relates to a novel polypeptide of acyltransferase or a microorganism comprising the same; a composition for preparing N-acetyl-L-methionine comprising the polypeptide or microorganism; and a method for preparing N-a...
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WO/2018/009315A1 |
Systems and methods for producing ammonia are described. In one embodiment, hydrogen, carbon dioxide, and nitrogen are dissolved in a solution. A glutamine synthetase inhibitor and autotrophic diazotroph bacteria are also placed in the s...
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WO/2018/007599A1 |
The present invention relates to an improved method for the fermentative production of stable isotope labeled metabolites in a microorganism, particularly stable isotope labeled amino acids, stable isotope labeled monosaccharides, stable...
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WO/2018/000089A1 |
Polynucleotides and polypeptides useful in the manufacture of a class of chemical compounds known as alkaloids are provided. The polynucleotides and polypeptides may be used to synthesize alkaloids, including reticuline, thebaine and mor...
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