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WO/2018/071564A1 |
Disclosed herein are methods and compositions for the production of L-3,4- dihydroxyphenylalanine from a bacteria.
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WO/2018/055563A1 |
The present invention relates to a method for heterologously expressing an ornithine acyl-ACP N-acyltransferase in a microorganism, wherein the expression of the ornithine acyl-ACP N-acyltransferase protein catalyses the synthesis of lys...
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WO/2018/056305A1 |
[Problem] To provide a novel method for producing L-cysteine as a substitute for the existing fermentation methods. More specifically, provided is a method for producing L-cysteine with the combined use of heat-resistant enzymes. In part...
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WO/2018/050300A1 |
The invention relates to a polysaccharide-oxidizing composition comprising a polysaccharide-oxidizing enzyme wherein, when the said polysaccharide-oxidizing enzyme is compared to the reference polypeptide of SEQ ID NO. 1 as described in ...
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WO/2018/040469A1 |
A method for producing L-lysine by fermentation, comprising modifying a gene for coding an NCBI reference sequence NP_601029.1 and/or NP_599350.1 on a Corynebacterium bacterial chromosome to enable the activity and/or expression quantity...
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WO/2018/042460A1 |
The present invention discloses sulphur functionalized polyurea composite of Formula (I) and Formula (II) that provides an insoluble solid support for effective removal of metal residues from solvent streams and other reservoirs and to t...
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WO/2018/042841A1 |
A SAMe-containing material having a high SAMe content can be obtained by a method which comprises: a heating/dissolving step for supplying water and brown sugar to a culture tank and dissolving the brown sugar by heating; a culture step ...
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WO/2018/041639A1 |
The invention relates to a method for producing an N-acyl- or N-sulfonyl-α-aminonitrile, comprising the following steps: a) condensation of an N-acyl- or N-sulfonyl-α-aminoaldehyde with hydroxylamine to obtain an aldoxime, and b) dehyd...
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WO/2018/039495A1 |
This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canoni...
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WO/2018/037833A1 |
Provided is a method of producing poly-gamma-glutamic acid by culturing Bacillus subtilis identified by deposit number NITE BP-02276, deposit number NITE BP-02277, deposit number NITE BP-02278, deposit number NITE BP-02279, deposit numbe...
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WO/2018/035249A1 |
The present disclosure relates to compositions and methods for producing stereoisomerically pure aminocyclopropanes.
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WO/2018/032240A1 |
Provided herein is a genetically modified host cell comprising a heterologous nucleic acid encoding a biofilm dispersal polypeptide that decreases intracellular c-di-GMP levels and enhances the production of lysine and lysine derivatives...
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WO/2018/029282A1 |
Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to have reduced levels or activity of one or more alcohol dehydrogenases or aldehyde reductases thereby increasing the production of benzylisoqui...
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WO/2018/030507A1 |
The present invention provides a production method for an L-amino acid such as L-lysine. An L-amino acid is produced by culturing, in a culture medium, bacteria having L-amino acid producing ability, bacteria that have been modified to h...
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WO/2018/029097A1 |
The present invention relates to a method for synthesising amides that is of general applicability. The method may be performed in vitro or in vivo. Cell lines for use in the in vivo methods also form aspects of the invention. The method...
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WO/2018/022613A1 |
This disclosure describes methods for regulating the biosynthesis of pimelic acid, 7-arninoheptanoate, 7-hydroxyheptanoate, heptamethyJenediamine, 7-aminoheptanol, or 1,7-heptanedioi by channeling increased flux through the biosynthesis ...
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WO/2018/019867A1 |
The present invention relates to a compound of general formula (I). The present invention also relates to a method of producing N-acetyl homoserine and/or derivatives thereof, the method comprising contacting at least one recombinant cel...
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WO/2018/018569A1 |
Provided is a method for increasing production of an L-arginine by knocking-out a flavoprotein reductase. A Corynebacterium crenatum SDNN403 genome is used as a template. Overlap extension PCR is used to acquire a missing gene fragment o...
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WO/2018/022440A2 |
This disclosure relates to genome-scale attenuation or knockout strategies for directing carbon flux to certain carbon based building blocks within the 7-aminoheptanoic acid (7-AHA) and 6-aminohexanoic acid (6-AHA) biosynthesis pathways,...
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WO/2018/020380A1 |
The present invention provides process for preparation of enantiomerically pure (R)-3- aminobutan-1-ol (I) by treating 4-hydroxybutan-2-one (II) with transaminase enzyme and use of enantiomerically pure (R)-3-aminobutan-1-ol (I) in the p...
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WO/2018/020012A1 |
The present invention generally relates to industrial microbiology, and specifically to the production of biochemical compounds, such as L-serine, L-tyrosine, mevalonate and their derivatives, and recombinant polypeptides using genetical...
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WO/2018/016873A1 |
The present invention relates to a novel polypeptide of acyltransferase or a microorganism comprising the same; a composition for preparing N-acetyl-L-methionine comprising the polypeptide or microorganism; and a method for preparing N-a...
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WO/2018/009315A1 |
Systems and methods for producing ammonia are described. In one embodiment, hydrogen, carbon dioxide, and nitrogen are dissolved in a solution. A glutamine synthetase inhibitor and autotrophic diazotroph bacteria are also placed in the s...
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WO/2018/007599A1 |
The present invention relates to an improved method for the fermentative production of stable isotope labeled metabolites in a microorganism, particularly stable isotope labeled amino acids, stable isotope labeled monosaccharides, stable...
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WO/2018/000089A1 |
Polynucleotides and polypeptides useful in the manufacture of a class of chemical compounds known as alkaloids are provided. The polynucleotides and polypeptides may be used to synthesize alkaloids, including reticuline, thebaine and mor...
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WO/2018/003652A1 |
A compound used in the conventional enzymatic reactions and mass spectrometry methods needs to be altered with respect to the structure thereof as a substrate compound, such as the length of an alkyl chain contained therein, depending on...
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WO/2017/223569A1 |
The present invention provides for a composition comprising: (a) a first host cell capable of producing L-DOPA; and (b) a modified host cell is capable of converting L-DOPA into hydroxytyrosol (HTy); wherein any one or both of the first ...
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WO/2017/216362A1 |
Described are methods for producing cannabinoid prodrugs using enzyme-catalysed synthesis / chemical modifications as well as methods for formulating such prodrugs in a pharmaceutically acceptable form and their use as therapeutic agents...
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WO/2017/213758A1 |
The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered prolin...
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WO/2017/213114A1 |
Provided are a method for producing flavor ingredients such as diallyl sulfide (ALS) and diallyl disulfide (ALDS), and a technology related to such method. Flavor ingredients such as diallyl sulfide (ALS) and diallyl disulfide (ALDS) are...
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WO/2017/213327A1 |
The present invention relates to a Bacillus subtilis EE5 strain useful for the production of natto with a high content of polyamine, a culture fermented with the same, and a method for producing polyamine by using the same. The Bacillus ...
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WO/2017/198147A1 |
A method for fermentation-production of a pentanediamine, comprising: culturing a cell expressing a lysine decarboxylase to obtain a whole cell fermentation broth comprising a pentanediamine; and extracting the pentanediamine from the wh...
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WO/2017/197887A1 |
An Escherichia coli JLTrp strain and application thereof in L-tryptophan synthesis. The strain has a culture collection number of CGMCC No.7.217 and is resistant against multiple antibiotics. The method using the strain for fermentation-...
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WO/2017/199200A1 |
The invention relates to a bacterial strain of Rhodococcus biphenylivorans named Palladio 22 and registered at the BCCM-LMG Bacteria Collection under registration number LMG P-29520. The invention also relates to a method for the product...
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WO/2017/195873A1 |
The present invention relates to a yeast cell of Yarrowia lipolytica, a cell culture product thereof or an extract of the same. The aforesaid yeast cell, cell culture product and extract of the same are characterized by containing L-hydr...
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WO/2017/195870A1 |
The yeast cell, cell culture product and extract of the same according to the present invention are a cell of at least one kind of yeast selected from the group consisting of Kodamaea ohmeri, Metschnikowia reukaufii, Meyerozyma caribbica...
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WO/2017/191195A1 |
There is provided a method of producing at least one unsaturated amino acid from at least one amino acid comprising at least two carbonyl groups, the method comprising (a) contacting a recombinant microbial cell with a medium comprising ...
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WO/2017/186685A1 |
A method for preparing an aqueous polyacrylamide solution is disclosed. The method comprises: hydrating acrylonitrile in water in presence of a biocatalyst capable of converting acrylonitrile to acrylamide so as to obtain an acrylamide s...
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WO/2017/186026A1 |
Provided is a method for constructing engineered corynebacterium glutamicum bacteria having a high production of L-lysine. The engineered bacteria are constructed by deactivating the NCgl1221 gene of corynebacterium glutamicum, and the n...
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WO/2017/188355A1 |
The present invention relates to synthesis methods for cysteine with an isotopically labeled sulfur atom and a cysteine derivative. The present invention also relates to a kit for use in the synthesis methods. The present invention makes...
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WO/2017/180889A1 |
Methods, systems, and compositions for detecting molecule aggregation, folding, or interactions featuring comparing the amount of labeling of a molecule of interest, such as a protein, in a test sample with an amount of labeling in a con...
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WO/2017/176277A1 |
The present invention describes an approach to produce taurine or increase hypotaurine or taurine production in prokaryotes or eukaryotes. More particularly, the invention relates to genetic transformation of organisms with algal, microa...
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WO/2017/169275A1 |
The present invention addresses the problem of providing a method for culturing a microorganism, whereby the microorganism can adapt to an inhibitor and thus fermentation inhibition can be sufficiently decreased, and a method for produci...
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WO/2017/167866A1 |
Described herein are recombinant microbial host cells comprising biosynthetic pathways and their use in producing oxidation products and downstream products, e.g., melatonin and related compounds, as well as enzyme variants, nucleic acid...
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WO/2017/167803A1 |
The present invention relates to a method for producing a polyacrylamide solution having increased viscosity. In particular, the present invention is related to the separation of a biocatalyst from an aqueous acrylamide solution prepared...
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WO/2017/160042A1 |
The present application relates to an L-histidine producing Corynebacterium glutamicum variant and a method for producing L-histidine, using the same.
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WO/2017/159976A1 |
The present application relates to a putrescine-producing microorganism in which the activity of formate dehydrogenase is activated, and a method for producing putrescine using the same.
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WO/2017/154955A1 |
The present invention is a glucose composition characterized by containing, as equivalents in an aqueous solution of said composition having a glucose concentration of 100 g/L, 0-25 g/L of xylose, 0.1-10 g/L of acetic acid, 0.15-2.0 g/L ...
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WO/2017/148357A1 |
The present invention relates to a sacubitril intermediate and a preparation method thereof. The sacubitril intermediate can be prepared by subjecting a compound to a deprotection reaction. The intermediate can be used as a raw material ...
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WO/2017/150560A1 |
Provided are a method for obtaining an HNL gene and HNL derived from a millipede other than Chamberlinius hualienensis, and preparing a practically useable amount of HNL; and a method for producing optically active cyanohydrin using this...
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