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WO/2018/190398A1 |
According to the present invention, it becomes possible to produce theanine with high efficiency without requiring adding ethylamine from the outside and without accumulating or remaining ethylamine as a by-product, by using a microorgan...
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WO/2018/185084A1 |
The present invention relates to a method of producing vinylglycine and/or derivatives thereof, the method comprising, - contacting glutamic acid and/or derivatives thereof with an electrolysis medium; and - subjecting the glutamic acid ...
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WO/2018/181774A1 |
The purpose of the present invention is to provide a novel enzymatic protein that makes it possible to produce an optically active β-hydroxy amino acid. The present invention solves the aforementioned problem by providing a monooxygenas...
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WO/2018/182361A1 |
The present invention relates to a method for preparing a bacteria mutant strain, comprising the steps of: (a) primarily transforming a normal bacteria into an enzyme-expressing vector which has temperature sensitivity or antibiotic sens...
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WO/2018/171488A1 |
Provided is a method for screening a corynebacterium constitutive expression vector promoter on the basis of transcriptome sequencing; and further provided are the corynebacterium constitutive expression vector promoter screened on the b...
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WO/2018/168525A1 |
The present invention provides a polyamine-rich yeast mutant that is mutated in comparison to the Sake yeast kyokai No. 7 in that, in the amino acid sequence of any one of leucine synthase, aconitic acid synthase, S-adenosyl-L-methionine...
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WO/2018/165325A1 |
Provided herein are methods for producing an organoboron product. The methods include combining a boron-containing reagent and a carbene precursor in the presence of a heme protein, e.g., a cytochrome c, a cytochrome P450, a globin, a pr...
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WO/2018/157942A1 |
Process of cell-free synthesis of a target protein, comprising at least the following steps: a. providing at least one precursor of an amino-acid, a cell-free extract comprising means for transforming said precursor of an amino-acid into...
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WO/2018/160103A1 |
A group of inventions relates to biotechnology, in particular a method for producing L-asparaginic acid. For this purpose, a recombinant strain of Escherichia coli that produces aspartase was produced by introducing a recombinant plasmid...
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WO/2018/152918A1 |
Provided is an L-homoserine-producing bacterial strain. One or more genes of the bacterial strain related to an L-homoserine metabolic pathway are knocked out or weakened, and/or one or more genes related to the L-homoserine metabolic pa...
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WO/2018/144965A1 |
Microorganisms and bioprocesses are provided that convert gaseous substrates, such as renewable H2 and waste CO2 producer gas, or syngas into high-protein biomass that may be used directly for human nutrition, or as a nutrient for plants...
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WO/2018/127143A1 |
The invention provides a highly active S-cyanohydrin lyase obtained by mutating an amino acid residue at position 103 of a wild-type cassava S-cyanohydrin lyase. The mutation can significantly increase an expression of a mutant enzyme in...
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WO/2018/124440A3 |
The present application relates to novel mutant polypeptide having isopropylmalate synthase activity, a polynucleotide coding for the same, a microorganism including the polypeptide, and a method for producing L-leucine by culturing the ...
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WO/2018/124440A2 |
The present application relates to novel mutant polypeptide having isopropylmalate synthase activity, a polynucleotide coding for the same, a microorganism including the polypeptide, and a method for producing L-leucine by culturing the ...
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WO/2018/124247A1 |
A nitrile hydratase that is derived from Pseudonocardia thermopila and has an α subunit and a β subunit, wherein a specific amino acid residue has been substituted for the amino acid residue in at least one position selected from the g...
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WO/2018/124475A2 |
The present invention relates to a recombinant microorganism having a xenogeneic gene introduced thereto and a method for producing a useful material from formic acid and carbon dioxide using the microorganism. The present invention prov...
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WO/2018/120025A1 |
The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms gene...
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WO/2018/124475A3 |
The present invention relates to a recombinant microorganism having a xenogeneic gene introduced thereto and a method for producing a useful material from formic acid and carbon dioxide using the microorganism. The present invention prov...
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WO/2018/122511A1 |
The invention relates to the field of organic polysulphides, more particularly to a method for synthetising functionalised organic polysulphides of formula (I): R2-X-(NR1R7)C*H-(CH2)n-Sa-(CH2)n-C*H(NR1R7)-X-R2, in which the various subst...
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WO/2018/124778A1 |
The present application relates to a microorganism producing O-phosphoserine and a method for producing O-phosphoserine, cysteine or a cysteine derivative using same.
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WO/2018/124533A1 |
The present application relates to a Corynebacterium sp. microorganism for producing L-lysine and a method for producing L-lysine by using the same.
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WO/2018/120026A1 |
The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms gene...
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WO/2018/116203A1 |
The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, ...
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WO/2018/114841A1 |
The present invention relates to a process for preparing aminobenzoic acid or an aminobenzoic acid conversion product, comprising the steps of: (I) providing an aqueous solution of aminobenzoic acid using a fermentation process; (II) ads...
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WO/2018/115538A1 |
The invention relates to a method for obtaining biogenic polyamines from a protein material with a protein richness of approximately 10% by weight, the method including the following steps: (i) performing hydrolysis of a protein material...
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WO/2018/114575A1 |
The present invention relates to a method for the enzymatic reduction of cystine to cysteine comprising contacting cystine with a reduction solution comprising: (i) an active glutathione reductase (EC1.8.1.7); (ii) a cofactor; and (iii) ...
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WO/2018/104143A1 |
The present invention relates to a method for the biocatalytic synthesis of proteinogenic L-amino acids, such as L-alanine, L-valine, L-methionine, L-leucine, L-isoleucine or L-phenylalanine from a respective aldehyde and carbon dioxide ...
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WO/2018/099452A1 |
Disclosed is a L-isoleucine-producing Corynebacterium glutamicum fermentation medium, comprising a basal medium and a growth factor, wherein the growth factor consists of choline, betaine and vitamin B6, and the contents of each ingredie...
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WO/2018/090288A1 |
Provided is an engineering bacteria synthesizing α-aminobutyric acid, wherein the preparation method is: after the tandem of L-threonine deaminase, L-amino acid dehydrogenase and a dehydrogenase gene for providing cofactor NADH circulat...
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WO/2018/093033A1 |
The present application relates to an L-lysine producing microorganism, and a method for producing L-lysine using the same.
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WO/2018/088434A1 |
The purpose of the present invention is to provide a novel method for producing an N-succinyl-hydroxy-D-amino acid and/or a hydroxy-D-amino acid. A method for producing an N-succinyl-hydroxy-D-amino acid, said method comprising step (A) ...
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WO/2018/082030A1 |
Provided are a proline hydroxylase and an application thereof. The proline hydroxylase includes (a) a protein having the amino acid sequence as shown in SEQ ID NO: 2; (b) a protein in which the amino acid sequence as shown in SEQ ID NO: ...
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WO/2018/077159A1 |
Disclosed is a method for modifying an amino acid attenuator, a type of amino acid attenuator mutants, engineered bacteria generated on the basis of the amino acid attenuator mutants, and use of the engineered bacteria. Further disclosed...
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WO/2018/079685A1 |
A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective ...
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WO/2018/079686A1 |
A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective ...
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WO/2018/081221A1 |
A process for preparing Propamocarb is presented. The preparation of Propamocarb (propyl 3-(dimethylamino)propylcarbamate) from 3- dimethylaminopropylamine and dipropyl carbonate is performed using an enzyme catalyst. In certain embodime...
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WO/2018/075670A1 |
A method of demethylizing an opioid to a nor-opioid is provided. The method comprises contacting an opioid with at least one enzyme. Contacting the opioid with the at least one enzyme converts the opioid to a nor-opioid. A method of conv...
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WO/2018/071564A1 |
Disclosed herein are methods and compositions for the production of L-3,4- dihydroxyphenylalanine from a bacteria.
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WO/2018/055563A1 |
The present invention relates to a method for heterologously expressing an ornithine acyl-ACP N-acyltransferase in a microorganism, wherein the expression of the ornithine acyl-ACP N-acyltransferase protein catalyses the synthesis of lys...
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WO/2018/056305A1 |
[Problem] To provide a novel method for producing L-cysteine as a substitute for the existing fermentation methods. More specifically, provided is a method for producing L-cysteine with the combined use of heat-resistant enzymes. In part...
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WO/2018/050300A1 |
The invention relates to a polysaccharide-oxidizing composition comprising a polysaccharide-oxidizing enzyme wherein, when the said polysaccharide-oxidizing enzyme is compared to the reference polypeptide of SEQ ID NO. 1 as described in ...
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WO/2018/040469A1 |
A method for producing L-lysine by fermentation, comprising modifying a gene for coding an NCBI reference sequence NP_601029.1 and/or NP_599350.1 on a Corynebacterium bacterial chromosome to enable the activity and/or expression quantity...
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WO/2018/045376A3 |
Provided herein are compositions and methods for generating polypeptides using non-natural amino acids (nnAAs) and genetic machinery, wherein the modified polypeptides, such as therapeutic polypeptides, bind to albumin, such as serum alb...
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WO/2018/042460A1 |
The present invention discloses sulphur functionalized polyurea composite of Formula (I) and Formula (II) that provides an insoluble solid support for effective removal of metal residues from solvent streams and other reservoirs and to t...
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WO/2018/042841A1 |
A SAMe-containing material having a high SAMe content can be obtained by a method which comprises: a heating/dissolving step for supplying water and brown sugar to a culture tank and dissolving the brown sugar by heating; a culture step ...
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WO/2018/041639A1 |
The invention relates to a method for producing an N-acyl- or N-sulfonyl-α-aminonitrile, comprising the following steps: a) condensation of an N-acyl- or N-sulfonyl-α-aminoaldehyde with hydroxylamine to obtain an aldoxime, and b) dehyd...
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WO/2018/039495A1 |
This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canoni...
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WO/2018/037833A1 |
Provided is a method of producing poly-gamma-glutamic acid by culturing Bacillus subtilis identified by deposit number NITE BP-02276, deposit number NITE BP-02277, deposit number NITE BP-02278, deposit number NITE BP-02279, deposit numbe...
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WO/2018/035249A1 |
The present disclosure relates to compositions and methods for producing stereoisomerically pure aminocyclopropanes.
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WO/2018/032240A1 |
Provided herein is a genetically modified host cell comprising a heterologous nucleic acid encoding a biofilm dispersal polypeptide that decreases intracellular c-di-GMP levels and enhances the production of lysine and lysine derivatives...
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