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WO/2005/054491 |
A process for producing (R)-tetrahydrothiophen-3-ol, comprising the step (A) of incubating tetrahydrothiophen-3-one in the presence of a preparation of strain belonging to the genus Penicillium, the genus Aspergillus or the genus Strepto...
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WO/2005/053678 |
Therapeutic or preventive agents for ischemic neuropathy containing as the active ingredient compounds represented by the general formula [2]: wherein R1 and R4 are each independently hydrogen, carboxy, or alkoxycarbonyl; and R2 and R5 a...
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WO/2005/054266 |
14-membered macrolide compounds such as erythromycins are provided with functional groups at the 14- and/or 15-position by providing a 14-membered aglycone template and feeding it to a strain capable of hydroxylating it at the 14 and/or ...
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WO/2005/054186 |
The present invention relates to methods of preparing a stereoisomerically enriched compound of formula (I), wherein R6 is hydrogen, comprising treating a compound of formula (I), wherein R6 is chosen from C1-C10 alkyl, C2-C10 alkenyl, C...
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WO/2005/054186 |
The present invention relates to methods of preparing a stereoisomerically enriched compound of formula (I), wherein R6 is hydrogen, comprising treating a compound of formula (I), wherein R6 is chosen from C1-C10 alkyl, C2-C10 alkenyl, C...
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WO/2005/054250 |
The invention relates to tricyclacetalactonin, preparation and use there of. Said tricyclacetalactonin is prepared from Streptomyces albogriseolus of A2-2002. As being proved by the experiments, said compounds can be used as cell cycle i...
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WO/2005/052152 |
It is intended to provide a DNA participating in the hydroxylation of a macrolide compound 11107B and a novel method of producing a macrolide compound 11107D. More specifically speaking, a DNA participating in the biological conversion o...
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WO/2005/047275 |
The invention relates to 2-phenyl-benzofuran compounds of formula (I), which are formed by the microorganism Aspergillus flavipes ST003878 (DSM 15290) during fermentation, to a method for the production thereof and to their use as medica...
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WO/2005/047509 |
The present invention relates to Mycobacterium ulceran virulence plasmid, pMUM001 and particularly to a cluster of genes carried by this plasmid that encode polyketide synthases (PKSs) and polyketide-modifying enzymes necessary and suffi...
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WO/2005/044803 |
The invention relates to bengamide derivatives which are formed by the micro-organism Myxococcus virescens ST200611 (DSM 15898), during fermentation, to the use thereof for the treatment of cancer, to medicaments containing bengamide der...
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WO/2005/045051 |
The present invention relates to a method for de-glycosylation of baicalin to produce baicalein by treating the baicalin with an enzyme having beta-glucuronidase activity under conditions such that baicalin is converted to baicalein.
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WO/2005/042757 |
The present invention relates to a method for preparing a Sohporae Fructus extract containing isoflavone. More particularly, the present invention relates to a method for preparing a Sohporae Fructus extract containing isoflavone in high...
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WO/2005/042756 |
Methods and compositions that can be used to make monatin or salt thereof from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclose...
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WO/2005/042720 |
Disclosed are strains of Vibrio sp bacteria that produce kahalalides or derivatives thereof, methods of isolating said strains, and 16S rRNA sequences useful in identifying kahalalides producing bacteria.
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WO/2005/042720 |
Disclosed are strains of Vibrio sp bacteria that produce kahalalides or derivatives thereof, methods of isolating said strains, and 16S rRNA sequences useful in identifying kahalalides producing bacteria.
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WO/2005/040373 |
Polyacrylamide beads containing encapsulated cells were prepared by a process comprising the steps of (i) providing an aqueous solution of a mixture of acrylic monomers, (ii) providing a suspension of cells in an aqueous solution of a pe...
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WO/2005/040107 |
The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.
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WO/2005/040107 |
The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.
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WO/2005/038009 |
The invention relates to a new microorganism Streptomyces glaucescens MTCC 5115 and a process for producing the immunosuppressant agent, tacrolimus (FK-506) utilizing the new microorganism Streptomyces glaucescens MTCC 5115. The inventio...
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WO/2005/038036 |
The invention relates to a method for hydrolysing fluorinated epoxy comprising one or several CF3 groups consisting in treating an epoxy in the presence of a protein exhibiting epoxy hydrolysis (EH) activity with respect to CF3 epoxies i...
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WO/2005/037813 |
The invention relates to a new compound, to the preparation thereof, and to the use of which in the preparation of a drug as a calcium antagonist of L type channel. The compound of the invention is very important in the treatment of hear...
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WO/2005/038008 |
The present invention relates to a method for preparing a fermentation product of soybean having an enhanced content of #-aminobutyric acid and phytoestrogens by using the Bifidobacterium breve K-110, said method comprising the steps of ...
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WO/2005/033076 |
This invention relates to a method of preparing (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine, a key intermediate compound for the synthesis of certain inhibitor compounds, including the step of enzyme catalysed enantioselective esterific...
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WO/2005/033305 |
A process for producing an intermediate of alkaloid biosynthesis, comprising inhibiting the expression of an enzyme using a target alkaloid biosynthesis intermediate as a substrate by the employment of RNAi method in an alkaloid producin...
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WO/2005/030944 |
The present invention provides an enzyme that catalyzes the reaction producing piperitol from pinoresinol, and a reaction producing sesamin from piperitol. The invention also provides a gene that encodes such enzyme. Further, the inventi...
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WO/2005/026373 |
The present invention relates to a process for the preparation of enantiopure intermediates useful in the synthesis of valuable pharmaceutically active compounds, e.g. MAOB inhibitors, and to novel intermediates of formulae (I) and (II) ...
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WO/2005/025490 |
A novel family of cyclic polyene natural products isolated from marine actinomycete strain CNQ 140 is provided. This novel strain of actinomycetes was obtained from a previously unstudied population of marine actinomycetes that reside in...
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WO/2005/025490 |
A novel family of cyclic polyene natural products isolated from marine actinomycete strain CNQ 140 is provided. This novel strain of actinomycetes was obtained from a previously unstudied population of marine actinomycetes that reside in...
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WO/2005/026327 |
Polypeptides and domains of leptomycn polyketide synthase and the nucleic acids encoding them are provided. Methods to prepare leptomycin, leptomycin analogs, and leptomycin derivatives are described, as are methods to prepare other poly...
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WO/2005/023788 |
A microorganism belonging to Beauveria sp. and being capable of producing FKI-1366 substance A and/or FKI-1366 substance B and/or FKI-1366 substance C (Beauveria sp. FKI-1366, FERM BP-08459) is cultured in a medium and thus the FKI-1366 ...
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WO/2005/024025 |
Novel polyene polyketides, their pharmaceutically acceptable salts, prodrugs and derivatives have been found to have antibiotic activity. Formula (I) One method for obtaining the compounds is by cultivation of Amycolatopsis orientalis AT...
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WO/2005/021586 |
The invention provides a nucleic acid molecule comprising at least a functional fragment of the viomycin biosynthetic gene cluster, functional proteins encoded by the cluster, expression cassettes and recombinant host cells comprising a ...
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WO/2005/020883 |
A process of the large-scale fermentation of a highly productive ansamitocin-producing strains. A method for isolating crude ansamitocins. A method for purifying ansamitocins.
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WO/2005/019426 |
Domains of fostriecin polyketide synthase and modification enzymes and polynucleotides encoding them are provided. Methods to prepare fostriecin in pharmaceutically useful quantities are described, as are methods to prepare fostriecin an...
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WO/2005/016851 |
The invention relates to novel molecules and libraries thereof as well as methods for their production. Methods of producing the novel molecules include a. cleaving one or more of starting molecules into molecular subunits ; and b. assem...
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WO/2005/017099 |
The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the...
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WO/2005/017159 |
The present invention discloses an isolated polynucleotide molecule derived from a polynucleotide encoding a polypeptide having L-sorbosone dehydrogenase activity comprising a partial nucleotide sequence of at least 20 consecutive nucleo...
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WO/2005/017172 |
The present invention relates to a novel process for the production of L-ascorbic acid in high yields by using resting cells of a microorganism able to convert given carbon sources into vitamin C. The thus obtained vitamin C may be furth...
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WO/2005/017099 |
The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the...
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WO/2005/014839 |
The present invention relates to novel sweetener compositions comprising monatin and methods for making such compositions. The present invention also relates to sweetener compositions comprising specific monatin stereoisomers, specific b...
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WO/2005/014844 |
The present invention relates to L-gulose dependent vitamin C synthesis. More specifically, the present invention relates to a synthesis pathway of vitamin C, comprising the formation of GDP-L-gulose by GDP-mannose 3',5'-epimerase, and...
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WO/2005/014834 |
The invention relates to transgenic plant cells expressing nucleic acid molecules which encode polypeptides with expoxygenase activity wherein said cells naturally contain high levels of linoleic acid; plants comprising said cells and me...
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WO/2005/012498 |
Methods and materials for producing porphyrins are described. In particular, microorganisms that contain one or more exogenous nucleic acids are described that produce porphyrins in high yield.
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WO/2005/012498 |
Methods and materials for producing porphyrins are described. In particular, microorganisms that contain one or more exogenous nucleic acids are described that produce porphyrins in high yield.
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WO/2005/009391 |
Fermentation of a nutrient medium with a eubacterium Streptomyces sp. yields a novel antibacterial compound of structure (I).
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WO/2005/005618 |
The present invention related to the microorganism for producing pravastatin and the process for producing pravastatin using the microorganism. The Micropolyspora roseoalba CGMCC 0624 of the present invention has a stronger tolerance to ...
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WO/2005/003137 |
The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie wit...
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WO/2005/000042 |
It is intended to provide a composition containing a lactic acid-bacterium producing equol characterized by containing a lactic acid bacterium belonging to the genus Lactococcus that is capable of metabolizing at least one daidzein compo...
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WO/2005/001105 |
A method for producing monatin, characterized in that it comprises treating a liquid to be treated containing monatin and impurities with a non-polar resin containing an aromatic ring to thereby separate monatin from the liquid to be tre...
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WO/2004/110439 |
This invention relates to novel biologically active polyene oxazoles of Formula (I), their pharmaceutically acceptable salts and derivatives, and to methods of obtaining them. One method for obtaining the compounds is by cultivation of S...
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