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WO/2016/144016A1 |
The present invention relates to a method for preparing biosugar and quercetin by using onion skins and, more particularly, to a method for preparing biosugar and quercetin, comprising: extracting biosugar from a hydrolysate produced by ...
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WO/2016/141243A1 |
There are provided, inter alia, methods and reagents for labeling nucleic acids.
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WO/2016/141207A1 |
The present disclosure relates to the biosynthesis of indigoid dye precursors and their conversion to indigoid dyes. Specifically, the present disclosure relates to methods of using polypeptides to produce indigoid dye precursors from in...
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WO/2016/136508A1 |
The present invention provides a method for producing 2-aza-8oxohypoxanthine, comprising the steps of: reacting 2-azahypoxanthine with a microorganism to produce 2-aza-8oxohypoxanthine; and isolating 2-aza-8oxohypoxanthine from a reactio...
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WO/2016/130412A1 |
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzy...
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WO/2015/157719A9 |
The present disclosure relates to processes that combine microbial production of organic intermediates and subsequent synthetic transformation to provide compounds of industrial value, including compounds used in fragrances.
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WO/2016/109769A1 |
Provided herein are biocatalysts and systems thereof for pterin-dependent enzymes and pathways and methods of making and using the same. Provided herein in some embodiments are biocatalysts having a pterin source and a pterin-dependent e...
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WO/2016/071505A9 |
The invention provides a genetically modified micro-organism comprising one or more transgene for the production of one or more of the flavonoids garbanzol, resokaempferol and fisetin. The micro-organism may be a bacterial or yeast cell ...
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WO/2016/104437A1 |
A method that comprises culturing a C1 compound-assimilating bacterium and/or yeast, said bacterium and/or yeast being a methylotroph, using a medium containing a C1 compound and/or glycerol as a carbon source to thereby produce EGT.
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WO/2016/102281A1 |
The invention relates to a method for producing a compound according to general formula (I), wherein R is H or C1-C6 alkyl, by reaction of at least one compound of formula (II), wherein R has the the same meaning as in formula (I) and wh...
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WO/2016/101720A1 |
Provided is a method for preparing Stallimycin. The method comprises: streptomycete ferments in a fermentation medium containing a carbon source, a nitrogen source and 3-hydroxy-4-amino-butyric acid, and vegetable oil is added to the fer...
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WO/2016/084886A1 |
Provided are: a novel method for manufacturing a germination-treated plant seed suitable for the production of a large quantity of phytoalexin; a method for manufacturing a raw seed for germination induction to be used in the manufacturi...
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WO/2016/086015A1 |
Methods are provided for carrying out carbene transfer transformations such as olefin cyclopropanation reactions, carbene heteroatom-H insertion reactions (heteroatom = N, S, Si), sigmatropic rearrangement reactions, and aldehyde olefina...
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WO/2016/085987A1 |
The invention relates to a process comprising reacting mevalonic acid, or a solution comprising mevalonic acid, to yield a first product or first product mixture, optionally in the presence of a solid catalyst and/or at elevated temperat...
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WO/2016/076159A1 |
A method for manufacturing cis-5-hydroxy-L-pipecolic acid, characterized in that cis-5-hydroxy-L-pipecolic acid is produced by causing 2-oxoglutarate-dependent L-pipecolic acid hydroxylase to act on L-pipecolic acid, the 2-oxoglutarate-d...
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WO/2016/075302A1 |
The invention relates to recombinant microorganisms and methods for producing manoyl oxide.
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WO/2016/077800A1 |
This document describes biochemical pathways for producing 6-hydroxyhexanoic acid using a polypeptide having ß-ketothiolase activity to form a 3-oxo-6-hydroxyhexanoyl-CoA intermediate. 6-hydroxyhexanoic acid can be enzymatically convert...
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WO/2016/070885A1 |
The invention discloses novel methods for biosynthesis of forskolin and other oxidised 13R-MOs. Oxidised 13R-MO may be valuable on its own account or as precursors for production of forskolin. In particular, the invention provides method...
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WO/2016/065425A1 |
The present disclosure relates to a method of preparing heteropolycyclic compounds. In some embodiments, the heteropolycyclic compounds are prepared by Pictet-Spengler reaction using a Pictet-Spenglerase biocatalyst and the aldehyde subs...
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WO/2016/064619A1 |
Disclosed are a variety of amphoteric ester sulfonates of formula 1, including 3-(N,N-dimethyl-cocoylpropylammonio-1-yl)-2-hydroxypropanesu
lfonate. These amphoteric ester sulfonates can be advantageously prepared in high yield and purit...
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WO/2016/050690A1 |
The present invention relates to a novel method for cyclizing geranyllinalool of formula (I) using the squalene-hopene cyclase (Zm-SHC) originating from Zymomonas mobilis or a cyclase of at least 80% sequence identity to Zm-SHC, and to c...
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WO/2016/050656A1 |
A method is proposed for producing flavonoids, comprising the steps: (a) providing of a transgenic microorganism, containing (i) a first nucleic acid section (A), comprising or consisting of a gene coding for a CYP450 oxidase, (ii) a sec...
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WO/2016/048048A1 |
The present invention relates to a novel ε-caprolactam converting enzyme and, more specifically, to: a novel ε-caprolactam converting enzyme for converting aminocaproic acid into ε-caprolactam; and a method for preparing ε-caprolacta...
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WO/2016/041500A1 |
A process for producing the gardenia blue pigment is provided. The process is easy to operate and suitable for industry and the obtained gardenia blue pigment is bright and suitable for industrial application.
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WO/2016/034751A1 |
Diseases and pests pose a serious problem in the field of agriculture. The present invention proposes a new compound of formula (I) having biocidal activity, isolated from the fermentation product of endophyte fungi of the Guignardia sp ...
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WO/2016/030828A1 |
The present invention provides an apparatus and methods for simultaneously producing different compounds in various ratios under set conditions.
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WO/2016/026048A1 |
Methods that may be used for the manufacture of a class of chemical compounds known as morphinans, including neopine, are provided. Compositions useful for the synthesis of morphinans, including neopine, are also provided.
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WO/2016/025692A1 |
A repeat expansion in C90RF72 causes frontotemporal dementia and amyotrophic lateral sclerosis (c9FTD/ALS). RNA of the expanded repeat (r(GGGGCC)exp) forms nuclear foci or undergoes repeat-associated non-ATG (RAN) translation producing "...
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WO/2016/008883A1 |
The present invention relates to a process for producing a monoterpene and to a cyanobacterial cell for the production of a monoterpene.
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WO/2016/008332A1 |
Provided are a method for improving the heterologous synthesis of Escherichia coli into polyketides and use of same. Particularly, the present invention weakens the expression of 72 genes in host bacteria such as sucC and talB, thus dram...
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WO/2016/006856A1 |
The present invention relates to a recombinant microorganism producing quinolinic acid - in particular, a microorganism producing quinolinic acid and having a protein of SEQ ID NO: 1, the activity of which is reduced or removed, and to a...
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WO/2015/196275A1 |
Nucleic acid molecules from cannabis have been isolated and characterized and encode polypeptides having cannabichromenic acid synthase activity. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds. ...
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WO/2015/192233A1 |
Methods that may be used for the manufacture of the chemical compound (S)- norcoclaurine, (S)-norIaudanosoline, and (S)-norcoclaurine or [S]- norlaudanosoline synthesis intermediates are provided. (S)-Norcoclaurine, (S)- norlaudanosoline...
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WO/2015/195535A2 |
The present invention provides a method of producing lysergic acid and other ergot alkaloids by genetic modification of a fungus. A strain of fungus comprising Aspergillus fumigatus (A. fumigatus) and expressing one or more genes of the ...
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WO/2015/195654A1 |
This document describes biochemical pathways for producing 2,3-dehydroadipyl-CoA methyl ester from precursors such as 2-oxoglutarate using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase and a CoA ligas...
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WO/2015/177674A1 |
Provided are polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising the polynucleotides. Also provided are methods for the pro...
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WO/2015/177189A1 |
The present invention is directed to a process for self-sufficient hydrolysis of lignocellulosic material. In an additional aspect, the present invention is directed to a process for the production of an organic product and the organic p...
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WO/2015/179621A2 |
The present disclosure relates to a new class of cytokinin biosynthetic enzymes, cytokinin synthases, which have two domains: an isopentenyl transfer (IPT)-like domain and a cytokinin nucleotide phosphoribohydrolase (PRH)-like domain. Th...
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WO/2015/175698A1 |
This document describes biochemical pathways for producing adipyl-[acp] and either hexanoic acid or acetic acid from a long chain acyl-[acp] such as dodecanoyl-[acp] or octanoyl-[acp] using a polypeptide having pimeloyl-[acp] synthase ac...
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WO/2015/165957A1 |
The invention relates to a method for transforming levoglucosenone into 4-hydroxymethyl butyrolactone or 4-hydroxymethyl butenolide, comprising a step involving the oxidation of the levoglucosenone, or dihydrolevoglucosenone obtained by ...
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WO/2015/164960A1 |
Novel methods that may be used for the manufacture of plant alkaloid compounds and novel polynucleotide compounds are provided. The plant alkaloid compounds are useful as medicinal compounds.
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WO/2015/162175A1 |
Method for the production of the anticancer nucleoside clofarabine in high yield, the method comprising the preparation of 2- chloroadenosine by enzymatic transglycosylation between 2- chloroadenine and nucleosides, benzoylation, isomeri...
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WO/2015/156739A1 |
The present disclosure provides for a polypeptide scaffold capable of identifying and developing polyketide synthase enzymes. Moreover, the polypeptide of the present disclosure is utilized in methods for screening to verify the activity...
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WO/2015/143381A2 |
The present invention provides methods for producing a product of one or more enzymatic pathways. The pathways used in the methods of the invention involve one or more conversion steps such as, for example, an enzymatic conversion of gul...
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WO/2015/140315A2 |
The present invention relates to a method for obtaining at least one microbial secondary metabolite or a derivative thereof, the method comprising the step of heterologous expression of at least one synthetase of said secondary metabolit...
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WO/2015/128552A1 |
The invention relates to a method for producing lactones from a strain of Aureobasidium pullulans. The invention is characterized in that the method includes the following steps, according to which: a preculture of the Aureobasidium pull...
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WO/2015/125849A1 |
Provided is a bacteriochlorophyl b-producing variant obtained by deleting the bciA gene and bchY and/or bchZ gene inherent to a photosynthetic bacterium which produces bacteriochlorophyl a, and performing a manipulation so as to express ...
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WO/2015/121488A1 |
A process for the microbial synthesis of migalastat, specifically a process for the production of migalastat comprising culturing a microorganism under conditions such that at least one imino sugar is produced and detecting and/or isolat...
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WO/2015/119261A1 |
The purpose of the present invention is to provide a novel process whereby rosuvastatin calcium and an intermediate thereof which each have a high purity can be efficiently produced at low cost. This process efficiently produces high-pur...
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WO/2015/113569A1 |
The invention described materials and methods for producing oxidised 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R- MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 ...
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