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WO/2004/050889 |
Disclosed is a method for the enzymatic synthesis of flavonoid esters and flavonoid derivatives, according to which a) a reaction medium containing an organic solvent, a glycosylated flavonoid or aglycone flavonoid, an acyl group donor, ...
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WO/2004/050684 |
Methods for improving secondary metabolite production by modulating certain genes involved in secondary metabolite production, including genes encoding CreA, AreA, GanB, Gna3, FadA, Gna1, Gpa1, RfeH, An09, PacC, Lys14, LovU, Ste7, Pde2, ...
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WO/2004/050795 |
Methods and compositions are disclosed for the preparation of free radical scavenging polymers and polymer films functionalized with antioxidants. Enzymatic and chemical tailoring of monomers with antioxidants followed by enzymatic polym...
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WO/2004/048590 |
The present invention relates to a process for producing a compound of formula (I); said process comprising the steps of: a) subjecting a compound of formula (II) to an enzymatic diastereomeric resolution in the presence of a suitable am...
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WO/2004/045600 |
The present invention relates to the finding of potentiality of aromatic polyketide intermediates in drug development and, in specific, use of these compounds in development of antiviral or anticancer medicines.
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WO/2004/046368 |
It is intended to provide a novel compound having an excellent antibacterial activity, a microorganism producing this compound, a process for producing the compound, a medicinal composition (in particular, an antibacterial agent) contain...
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WO/2004/044180 |
A method for the production of a polyketide by fermentation comprising the steps of growing a culture of a polyketide-producing organism at a pH value conducive to cell growth for a time sufficient to generate the producing culture, lowe...
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WO/2004/044211 |
The invention relates to cells and to a method for the production of R-$g(a)-liponic acid by fermentation. The inventive host organism strain, which is suitable for fermentative production of R-$g(a)-liponic acid, is characterized in tha...
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WO/2004/044214 |
A microorganism capable producing a substance FKI−1033 represented by the following formula: is cultured in a medium to accumulate the FKI−1033 in the culture medium and then the FKI−1033 is collected from the culture medium. Becau...
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WO/2004/044213 |
The invention provides a PHA copolymer including at least a 3-hydroxy-&ohgr -carboxyalkanoic acid represented by a formula (19) or (32) and simultaneously at least a unit represented by a formula (2) or a formula (3) in a molecule, a pre...
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WO/2004/040955 |
There is provided a microbiological one-step method for the manufacture of ascorbic acid. The method comprises use of the operon expressing 2-ketogluconate dehydrogenase in naturally occurring microorganisms and microorganisms transforme...
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WO/2004/039993 |
The present invention relates to a polynucleotide sequence encoding a pyranosone dehydratase. The present invention further relates to a method for producing transgenic plants which are resistant to pathogens, particularly fungal pathoge...
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WO/2004/034810 |
The invention relates to animal food additives containing a vitamin B6, a method for producing said additives, animal food compounds containing the inventive additive and a method for introducing said additives into the animal food compo...
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WO/2004/035760 |
Three gene clusters that together encode albicidin biosynthesis, the complete gene DNA sequences, and the deduced protein sequences for the enzymes and methods for using the DNA sequences are disclosed and discussed as well as methods fo...
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WO/2004/035010 |
The present invention features methods of producing B6 vitamers that involve culturing an organism overexpressing an enzyme that catalyzes a step in the biosynthesis of a B6 vitamer under conditions such that a B6 vitamer is produced. Th...
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WO/2004/033703 |
A novel macrophage foam cell formation inhibitor FKA−25 which is a substance inhibiting the formation of mouse−origin macrophage foam cells. Pseudobotrytis sp. FKA−25, which is a strain belonging to the genus Pseudobotrytis and cap...
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WO/2004/033702 |
Microorganisms belonging to the genus Streptomyces and being capable of producing K99−5278A, K99−5278B and K99−5278C, which are drugs efficacious against infection with so−called fungi such as molds and yeasts, are cultured in a ...
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WO/2004/029267 |
The present invention provides the use of Enzyme B of G. oxydans DSM 4025, as disclosed in EP 0 832 974 A2, in a process for producing L-ascorbic acid from L-gulose, L- galactose, L-idose or L-talose, or from L-gulono-1,4-lactone (and it...
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WO/2004/029268 |
The present invention provides a process for the production of vitamin C from different substrates like D-sorbitol, L-sorbose, L-sorbosone or L-gulose using a microorganism selected from the group consisting of Gluconobacter oxydans DS...
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WO/2004/029264 |
The present invention provides a process for the production of L-aldonolactone from L-aldohexose, especially for producing L-gulono-1,4-lactone or L-gulonic acid from L-gulose and producing L-galactono-1,4-lactone or L-galactonic acid fr...
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WO/2004/029228 |
Disclosed is a recombinant microorganism of the genus Sinorhizobium which is transformed with a vector containing pyridoxol 5'-phophate synthase gene and D-erythrose 4-phosphate dehydrogenase gene, and being capable of producing vitamin B6.
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WO/2004/029252 |
Disclosed is an isolated DNA encoding vitamin B6 phosphate phosphatase selected from the group consisting of: (a) a DNA sequence represented in SEQ ID NO:9; (b) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosp...
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WO/2004/029271 |
Disclosed is a recombinant microorganism being capable of producing vitamin B6, wherein said microorganism carries extra genes which code for an enzyme combination selected from: i) erythrose 4-phosphate dehydrogenase and 1-deoxy-D-xylul...
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WO/2004/029269 |
The present invention relates to a process for the production of vitamin C from L sorbosone using an aldehyde dehydrogenase which is isolated from Gluconobacter oxydans DSM 4025 (FERM BP-3812), said enzyme having the following physicoche...
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WO/2004/029270 |
Disclosed is a mutant of a recombinant microorganism of the genus Sinorhizobium capable of producing vitamin B6 having a recombinant plasmid with pdxJ gene that acquired histidine requirement of glycine resistance, or its combination the...
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WO/2004/027075 |
The invention provides novel aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and compositions comprising these side cha...
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WO/2004/027075 |
The invention provides novel aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and compositions comprising these side cha...
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WO/2004/027055 |
It is intended to provide a novel polypeptide capable of efficiently producing (R)-N-benzyl-3-pyrrolidinol, a polynucleotide encoding the same and a method of using the same. Namely, a polypeptide having the following physicochemical pro...
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WO/2004/027074 |
A process for preparing a rutin-enriched composition from plant biomass comprises extraction with an aqueous solution, and precipitation. An enzyme preparation, such as naringinase, is used for the transformation of rutin to higher value...
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WO/2004/026254 |
The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption ont...
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WO/2004/024928 |
The invention concerns transformed plants, in particular transformed plants producing larger amounts of plastoquinones, tocotrienols and tocophenols, than non-transformed identical plants. The invention also concerns a method for produci...
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WO/2004/022767 |
The present invention provides a novel method for producing compound of Formula (I) or any of its salt form, by solid state fermentation, optionally using fed-batch technique by culturing microorganisms capable of producing the compound ...
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WO/2004/022766 |
A process for easily producing an L-&agr -methylcysteine derivative or its salt, which is useful as a drug intermediate, from a cheap easily procurable raw material through an enzymatic D-stereoselective hydrolysis of racemic 5-halomethy...
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WO/2004/022586 |
The invention relates to an ss-DNA molecule, a ds-DNA molecule, an RNA, a vector, the use of the same, and a cell, especially for expressing tubulysin genes.
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WO/2004/018466 |
The present invention is directed to a method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives.
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WO/2004/018672 |
By using novel aldolases originating in microorganisms belonging to the genera Pseudomonas, Erwinia, Flavobacterium and Xanthomonas, 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid, which is useful as an intermediate in the synthesis o...
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WO/2004/015119 |
This invention relates to processes for the preparation of ansamitocins, in particular ansamitocins that can be converted to maytansinol.
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WO/2004/013332 |
The present invention relates to a method for converting a carbon-containing substrate of an NAD(P)H-dependent enzyme. A lactic acid bacterium which expresses the NAD(P)H dependent enzyme is used for the conversion. In this way more than...
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WO/2004/013297 |
Disclosed are strains of actinomycetes that produce manzamines or derivatives thereof, methods of isolating said strains, and a 16S rRNA useful in identifying manzamine-producing bacteria.
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WO/2004/013342 |
Novel substances of compounds PF1237A, PF1237B and PF1237M exhibiting antifungal activity; a process for producing these novel compounds through culturing of PF1237 producing strain belonging to the genus Fusarium; and an antifungal agen...
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WO/2004/013079 |
Ketocampholenic acid derivatives, their use, and methods of preparing these derivatives are described. In one aspect, novel derivatives of 2-oxo-4,5,5-trimethylcyclopent-3-enylacetic acid (herein further referred as ketocampholenic acid ...
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WO/2004/011635 |
Four new genes, and the enzymes that they encode, are disclosed, which are present in Propionibacterium freudenreichii, and which are involved in at least five steps in the biosynthetic pathway of vitamin B12. The four enzymes are: A: co...
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WO/2004/011661 |
Compounds represented by the following general formula (I), pharmacologically acceptable salts thereof or hydrates of the same: (I) wherein W represents (1) , (2) or (3) ; and R3, R7, R16, R17, R20, R21 and R21’ are the same or differe...
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WO/2004/007709 |
The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and ...
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WO/2004/007750 |
The invention provides polypeptides having a monooxygenase activity, polynucleotides encoding these enzymes, the use of such polynucleotides and polypeptides. In one aspect, the invention provides polypeptides having a monooxygenase acti...
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WO/2004/007510 |
A novel chemical substance capable of inducing the morphogenesis and growth promotion of marine large green algae; a process for producing the novel chemical substance with the use of a microorganism; and an algae culture medium comprisi...
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WO/2004/005275 |
The present invention provides a novel method for producing compound of formula (I), its acid form or any salt form, where R¿1? is H or CH¿3?, by solid state fermentation using fed-batch technique by culturing microorganisms capable of...
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WO/2004/005292 |
The invention relates to novel antibiotics against Vibrio anguillarum and the applications thereof in cultures of fish, crustaceans, molluscs and other aquaculture activities. Five diketopiperazines with activity against Vibrio anguillar...
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WO/2004/005311 |
The invention provides a compound of formula (I) and pharmaceutically acceptable salts thereof. Processes for the isolating of this bafilomycin metabolite from a novel Micromonospora species, pharmaceutical compositions containing this m...
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WO/2004/003213 |
A process for producing a lactone which comprises culturing Candida sorbophila in a culture medium containing at least one member selected from the group consisting of hydroxyfatty acids, hydroxyfatty acid derivatives, and hydrolyzates o...
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