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Matches 651 - 700 out of 4,675

Document Document Title
WO/2004/089958
Provided is a method for crystallization and purification of a macrolide such as tacrolimus, sirolimus, pimecrolimus, or everolimus that includes the step of providing a combination of a macrolide, and a polar solvent, dopolar aprotic so...  
WO/2004/090094
The invention relates to proteins that have an enzymatic activity for reducing substituted alkanones, such as 3-methylamino-1-(2-thienyl)-propane-1-on. The invention also relates to nucleic acids that encode these proteins, to nucleic ac...  
WO/2004/090147
A method of purifying an aqueous amide compound solution, which comprises filtering an aqueous solution containing an amide compound obtained with a biocatalyst through an ultrafiltration membrane having a fractional molecular weight of ...  
WO/2004/087938
Novel substances PF1270A, PF1270B and PF1270C represented by the following formula (1) or pharmacologically acceptable salts thereof; a process for producing the same; and a pharmaceutical composition comprising at least one thereof as a...  
WO/2004/087909
2-Hydroxyisoflavanone dehydratase substantially having the amino acid sequence represented by SEQ ID NO:1 is isolated from licorice. Further, a polynucleotide encoding 2-hydroxyisoflavanone dehydratase of the SEQ ID NO:2 is obtained. Fur...  
WO/2004/087932
The present invention relates to a method for preparing (2S,3R) alkyl trans-3-phenylglycidate or (2R,3S) methyl trans-3-phenylglycidate comprising:- enzymatic resolution by trans-esterification of ± methyl trans-3-phenylglycidate with e...  
WO/2004/087935
The invention relates to a fermentation process for the preparation of substantially pure pravastatin. The process provides a method of producing pravastatin by microbial hydroxylation of compactin (ML-236B) by maintaining a concentratio...  
WO/2004/087940
Process for producing enantiopure β-amino acid derivatives corresponding to general formula (I) R1-NZ-CHR2-CH2-COOR3 (I) in which R1 and R2 independently denote organic residues optionally forming a cyclic substituent, R3 denotes H or a...  
WO/2004/081219
The present invention relates to a novel and efficient chemoenzymatic process of preparation of optically active trans alkyl phenylglycidates. The invention particularly discloses a novel process for the chemoenzymatic synthesis of two e...  
WO/2004/081176
A method for biotransformation of organic compounds using non-prokaryotic microalgae is disclosed. The method is useful to biotransform a chemical precusor compound, preferably a heterocyclic compound, to a chemically distinct final prod...  
WO/2004/078978
Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vec...  
WO/2004/077944
It is intended to provide a nematocide which is extracted and purified form a culture liquid of a fungus belonging to the genus Aspergillus sp. Namely, a nematocide characterized by containing, as the active ingredient, an organic acidic...  
WO/2004/078951
It has been required to economically produce a large amount of an optically active &gammad -lactone derivative (for example, pantolactone) which is useful as an intermediate in synthesizing a useful substance such as a drug. To achieve t...  
WO/2004/076676
A method for the production of partially esterified (meth)acrylic acid esters of polyalcohols and the use thereof.  
WO/2004/071382
The present invention relates to substituted heterocycles, processes for their preparation, and their use in medicaments, especially for the treatment of inflammatory disease, i.e. asthma, or cancer.  
WO/2004/069845
The present invention provides a novel method for producing compound of formula (I) or any of its salt form, by solid state fermentation, optionally using fed-batch technique by culturing microorganisms capable of producing the compound ...  
WO/2004/070045
A process for producing an optically active 6-formyl-1,4-benzodioxin-2-carboxylic acid derivative represented by the general formula (3): (wherein R3 is C1-6 alkyl), which comprises reacting a compound represented by the general formula ...  
WO/2004/065591
This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by ...  
WO/2004/064745
Processes for preparing racemic and optically pure 3,6-dihydro-2H-pyrans of formulae H, I, N and O are described. These compounds may be further transformed into compounds of formulae J, K, L, M, P, Q, S, T, U, V, Y and Z with potential ...  
WO/2004/065607
By culturing Pleurotaceae Panus rudis K-3574 strain (FERM BP-8265), a compound RS-K3574 represented by the following formula (I) is produced as a physiologically active substance showing an activity of inhibiting ubiquitin activating enz...  
WO/2004/062558
The present invention describes a process for the preparation of β-lactam antibiotics, cephalexin and ampicillin, wherein the β-lactam nucleus is acylated with an acylating agent, D-phenylglycine, by means of a reaction biocatalyzed by...  
WO/2004/063383
This invention relates to ionic liquids and their use as solvents in biocatalysis. According to a first aspect of the invention there is provided a method of carrying out an enzyme-catalysed reaction comprising providing a liquid reactio...  
WO/2004/061116
Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vec...  
WO/2004/058976
The present invention relates to the biosynthesis of polyketides and derives from the cloning of nucleic acids encoding a polyketide synthase and other associated proteins involved in the synthesis of the polyketide borrelidin. Materials...  
WO/2004/056998
A gene cluster has open reading frames which encode polypeptides sufficient to direct the synthesis of a safracin molecule.  
WO/2004/057011
Antibiotics caprazamycin D and caprazamycin G represented by the following general formula (I) are obtained by culturing Streptomyces sp. MK730−62F2 (Accession No. FERM BP−7218). Caprazamycins D and G show excellent antimicrobial act...  
WO/2004/055021
The invention relates to spirobenzofuranlactam derivatives of formula (I) that are formed by the microorganism Stachybotris atra ST002348, DSM 14952 during fermentation, methods for the production thereof, the use thereof for producing a...  
WO/2004/053065
Domains of disorazole polyketide synthase and polynucleotides encoding them are provided. Methods to prepare disorazoles in pharmaceutically useful quantities are described, as are methods to prepare disorazole analogs and other polyketi...  
WO/2004/053110
The invention relates to Corynebacterium ammoniagenes CJXSP 0201 KCCM 10448 producing 5'-xanthylic acid. More specifically, the invention relates to Corynebacterium ammoniagenes CJXSP 0201 KCCM 10448 which is a mutant strain of Corynebac...  
WO/2004/052829
A process for easily producing from an inexpensive material an optically active 3-hydroxypropionic ester derivative useful as an intermediate for medicines. The process, which is for producing an optically active 3-hydroxypropionic ester...  
WO/2004/053125
By substituting an amino acid residue at least at one position participating in the efficient formation of (2R,4R)-monatin (100-position, 180- to 183-positions, 243-position and 244-position) in the amino acid sequence of wild type D-ami...  
WO/2004/050862
Riboflavin-producing Bacillus subtilis which is resistant to threonine analogue, and a method for producing riboflavin using the Bacillus subtilis are provided.  
WO/2004/050890
It is intended to provide a novel process for producing a 12-membered macrolide compound 11107D having an antitumor activity via biological conversion. The 12-membered macrolide compound 11107B represented by the formula (I), which is a ...  
WO/2004/050889
Disclosed is a method for the enzymatic synthesis of flavonoid esters and flavonoid derivatives, according to which a) a reaction medium containing an organic solvent, a glycosylated flavonoid or aglycone flavonoid, an acyl group donor, ...  
WO/2004/050684
Methods for improving secondary metabolite production by modulating certain genes involved in secondary metabolite production, including genes encoding CreA, AreA, GanB, Gna3, FadA, Gna1, Gpa1, RfeH, An09, PacC, Lys14, LovU, Ste7, Pde2, ...  
WO/2004/050795
Methods and compositions are disclosed for the preparation of free radical scavenging polymers and polymer films functionalized with antioxidants. Enzymatic and chemical tailoring of monomers with antioxidants followed by enzymatic polym...  
WO/2004/048590
The present invention relates to a process for producing a compound of formula (I); said process comprising the steps of: a) subjecting a compound of formula (II) to an enzymatic diastereomeric resolution in the presence of a suitable am...  
WO/2004/045600
The present invention relates to the finding of potentiality of aromatic polyketide intermediates in drug development and, in specific, use of these compounds in development of antiviral or anticancer medicines.  
WO/2004/046368
It is intended to provide a novel compound having an excellent antibacterial activity, a microorganism producing this compound, a process for producing the compound, a medicinal composition (in particular, an antibacterial agent) contain...  
WO/2004/044180
A method for the production of a polyketide by fermentation comprising the steps of growing a culture of a polyketide-producing organism at a pH value conducive to cell growth for a time sufficient to generate the producing culture, lowe...  
WO/2004/044211
The invention relates to cells and to a method for the production of R-$g(a)-liponic acid by fermentation. The inventive host organism strain, which is suitable for fermentative production of R-$g(a)-liponic acid, is characterized in tha...  
WO/2004/044214
A microorganism capable producing a substance FKI−1033 represented by the following formula: is cultured in a medium to accumulate the FKI−1033 in the culture medium and then the FKI−1033 is collected from the culture medium. Becau...  
WO/2004/044213
The invention provides a PHA copolymer including at least a 3-hydroxy-&ohgr -carboxyalkanoic acid represented by a formula (19) or (32) and simultaneously at least a unit represented by a formula (2) or a formula (3) in a molecule, a pre...  
WO/2004/040955
There is provided a microbiological one-step method for the manufacture of ascorbic acid. The method comprises use of the operon expressing 2-ketogluconate dehydrogenase in naturally occurring microorganisms and microorganisms transforme...  
WO/2004/039993
The present invention relates to a polynucleotide sequence encoding a pyranosone dehydratase. The present invention further relates to a method for producing transgenic plants which are resistant to pathogens, particularly fungal pathoge...  
WO/2004/034810
The invention relates to animal food additives containing a vitamin B6, a method for producing said additives, animal food compounds containing the inventive additive and a method for introducing said additives into the animal food compo...  
WO/2004/035760
Three gene clusters that together encode albicidin biosynthesis, the complete gene DNA sequences, and the deduced protein sequences for the enzymes and methods for using the DNA sequences are disclosed and discussed as well as methods fo...  
WO/2004/035010
The present invention features methods of producing B6 vitamers that involve culturing an organism overexpressing an enzyme that catalyzes a step in the biosynthesis of a B6 vitamer under conditions such that a B6 vitamer is produced. Th...  
WO/2004/033703
A novel macrophage foam cell formation inhibitor FKA−25 which is a substance inhibiting the formation of mouse−origin macrophage foam cells. Pseudobotrytis sp. FKA−25, which is a strain belonging to the genus Pseudobotrytis and cap...  
WO/2004/033702
Microorganisms belonging to the genus Streptomyces and being capable of producing K99−5278A, K99−5278B and K99−5278C, which are drugs efficacious against infection with so−called fungi such as molds and yeasts, are cultured in a ...  

Matches 651 - 700 out of 4,675