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Matches 651 - 700 out of 8,105

Document Document Title
WO/2006/047891A1
This invention relates to novel biologically active polycyclic aromatics produced by cultivation of Micromonospora echinospora ssp. challisensis NRRL 12255. The invention also relates to their pharmaceutically acceptable salts, prodrugs ...  
WO/2006/048550A1
The invention relates to a gamma-undecenolactone of formula (i), wherein a lactonic cycle can carry an unsaturation between carbon N°2 and carbon N°3 and is preferably saturated, RI is a possibly substituted C7 alkenyl or alkynyl group...  
WO/2006/048551A1
The inventive method for stereoselectively preparing a (R) or (S) gamma-lactone consists in microbially biosynthesising gamma-lactone, wherein said biosynthesis is carried out from a substrate selected from C5 to C20 fatty acids with the...  
WO/2006/046152A2
The invention provides a method for the heterologous expression of a secondary metabolite encoded by a biosynthetic pathway. Also provided is a method for introducing a large sized DNA molecule into the chromosome of a heterologous host ...  
WO/2006/046314A1
Microbe (Penicillium citrinum FKI-1938, FERM ABP-10149) belonging to the genus Penicillium citrinum and capable of producing substance FKI-1938A and/or substance FKI-1938B and/or substance FKI-1938B’ and/or substance FKI-1938C is incub...  
WO2006031661A3
Although macrolide compounds are insoluble in water, surprisingly high part of the product was found in the liquid phase of the fermentation broth. Therefore, processing the entire fermentation broth, i.e. the suspension obtained by cult...  
WO/2006/046130A2
The invention relates to a process for the preparation of pure pravastatin or a salt thereof using adsorption matrices. The invention also relates to pharmaceutical compositions that include the pure pravastatin and the use of the compos...  
WO2003066871A3
Isolated nucleic acid and amino acid sequences for phenylalanine aminomutase enzyme and methods for purifying this enzyme are provided. Methods for altering biosynthesis of compounds in plant cell cultures are also provided. In particula...  
WO/2006/038218A1
The present invention discloses the manufacture of MPA by fermentation under optimal fermentation parameters using a new strain of Penicillium arenicola.  
WO2005100569A3
The invention provides yeast strains, and polypeptides encoded by genes of such yeast strains, that have enantiospecific styrene epoxide hydrolase activity. The invention also features nucleic acid molecules encoding such polypeptides, v...  
WO/2006/035770A1
[PROBLEMS] To provide a process for synthesizing natural compound derivatives useful in random high-throughput screening (HTS), the search for drugs or agricultural chemicals, the search for lead compounds of drugs or agricultural chemic...  
WO/2006/034567A1
This invention relates to methods of inhibiting growth and/or proliferation of a neoplastic cell, and methods of treating neoplasms using the farnesylated dibenzodiazepinone compound of Formula I. The invention includes pharmaceutical co...  
WO2004081176A3
A method for biotransformation of organic compounds using non-prokaryotic microalgae is disclosed. The method is useful to biotransform a chemical precusor compound, preferably a heterocyclic compound, to a chemically distinct final prod...  
WO2005108590A3
The invention relates to a method for producing the optically active alkanols of formula (I), wherein n is an integer of from 0 to 5; Cyc represents an optionally substituted, mononuclear or polynuclear, saturated or unsaturated, carbocy...  
WO2006015811A3
The invention relates to a dihydrocoumarin that has been technically produced by the biotransformation of coumarin and to associated production variants that are carried out with the aid of isolated enzymes and/or microorganisms. Pure co...  
WO2004053065A3
Domains of disorazole polyketide synthase and polynucleotides encoding them are provided. Methods to prepare disorazoles in pharmaceutically useful quantities are described, as are methods to prepare disorazole analogs and other polyketi...  
WO/2006/032232A2
The invention relates to novel genes from lysolipin-producing microorganisms, to novel gene clusters formed from novel and/or known genes of these microorganisms, to expression products of these genes, to a transformation vehicle contain...  
WO/2006/031664A1
The invention is a simple process for separation of tacrolimus and its analogues, ascomycin and tsucubamycin B and preparation of enough pure crystalline tacrolimus. The process takes advantage of surprising properties of tacrolimus and ...  
WO/2006/031661A2
Although macrolide compounds are insoluble in water, surprisingly high part of the product was found in the liquid phase of the fermentation broth. Therefore, processing the entire fermentation broth, i.e. the suspension obtained by cult...  
WO/2006/031665A1
Mycophenolic acid can be isolated from fermentation broth easily with low consumption of organic solvents to produce mycophenolic acid that is surprisingly high in purity. The process can be accomplished by addition of a suitable base to...  
WO/2006/030909A1
A process for producing 2-hydroxy-4-substituted pyridines microbiologically; novel microbes; and novel compounds. Specifically, a process for the production of 2-hydroxy-4-substituted pyridines by making a microbe or a product of treatme...  
WO/2006/031008A1
The present invention provides a novel microorganism capable of metabolizing isoflavone. More particularly, the invention provides a novel microorganism capable of metabolizing daidzein and genistein into dihydrodaidzein and dihydrogenis...  
WO/2006/031007A1
The present invention provides a novel microorganism capable of metabolizing dihy- drodaidzein into equol. More particularly, the invention provides Eggerthella sp. microorganism capable of metabolizing dihydrodaidzein into equol under a...  
WO/2006/024582A1
The present invention relates to a process for the preparation of mycophenolate mofetil (MMF) in which an ester of mycophenolic acid (MPA) with a low-molecular- weight aliphatic alcohol is transesterif ied with N- (2- hydroxyethyl) morph...  
WO2005100578A3
The invention provides yeast strains, and polypeptides encoded by genes of such yeast strains, that have enantiospecific meso-epoxide hydrolase activity. The invention also features nucleic acid molecules encoding such polypeptides, vect...  
WO2005100587A3
The invention provides yeast strains, and polypeptides encoded by genes of such yeast strains, that have enantiospecific 2,2-disubstituted epoxide hydrolase activity. The invention also features nucleic acid molecules encoding such polyp...  
WO/2006/018211A1
The present invention relates to a process for the production of isoprenoids, in particular Coenzyme Q-10 by microorganisms. More particularly, the present invention relates to a process for increased production of Coenzyme Q-10 by micro...  
WO/2006/019209A1
The invention relates to a method and apparatus for compensating the lens shading phenomenon in image sensor. The invention first stores an inputted compensation reference value, identifies a center pixel using digital image signals rece...  
WO2004015119A3
This invention relates to processes for the preparation of ansamitocins, in particular ansamitocins that can be converted to maytansinol.  
WO/2006/015811A2
The invention relates to a dihydrocoumarin that has been technically produced by the biotransformation of coumarin and to associated production variants that are carried out with the aid of isolated enzymes and/or microorganisms. Pure co...  
WO/2006/015727A2
The invention relates to a method for producing, in essence, enantiomer-pure 3-hydroxycarboxylic acids or esters of general formula (III) by reacting racemic oxetan-2-ones of general formula (I) with compounds R3-OH of general formula (I...  
WO2005047509A8
The present invention relates to Mycobacterium ulceran virulence plasmid, pMUM001 and particularly to a cluster of genes carried by this plasmid that encode polyketide synthases (PKSs) and polyketide-modifying enzymes necessary and suffi...  
WO/2006/010246A1
A gene encoding a littorine mutase/hydroxylase has been isolated and characterized. The gene is used in processes of altering alkaloid biosynthesis. Transgenic plants containing the gene have been produced and used for the production of ...  
WO/2006/012277A2
biocatalytic process for preparing enantiomerically enriched pramipexole and pramipexole precursors are disclosed.  
WO/2006/011156A1
A novel fermentation fed batch process for producing the immunosuppressant, Tacrolimus (FK-506), using the mutant microorganism Streptomyces sp. utilizing vegetative oil as sole source of carbon in production medium, is provided herewith.  
WO/2006/009518A1
There is provided a new strain, i.e. the alternaria alternata var. monosporus ST­026R CGMCC No.0899, and its use in the production of paclitaxel. The invention also provides a method for the production of paclitaxel by using the strain ...  
WO/2006/009276A1
A polypeptide participating in the biosynthesis of pladienolide as a macrolide compound; a DNA coding for such a polypeptide; a variant thereof; a transformant in which part or the whole of such a DNA or variant thereof has been incorpor...  
WO2004035010A3  
WO/2006/010117A2
Methods and compositions are provided for production of flavonoids in microbial hosts. The compositions comprises a set of genes which encode for enzymes involved in one or more steps in the biosynthetic pathway for the conversion of phe...  
WO2005020883A3
A process of the large-scale fermentation of a highly productive ansamitocin-producing strains. A method for isolating crude ansamitocins. A method for purifying ansamitocins.  
WO/2005/123933A1
A process for preparing the compound of formula (II) by reacting the compound of formula (I) with an enzyme that can hydrolyze the ester bond: formula (I) and (II) where * indicates a chiral center, R1 and R2 each independently represent...  
WO/2005/121327A2
A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with I module, and a cytochrome P450 hydroxylase is described. Also provided are novel Streptomyces species and metho...  
WO/2005/118777A3
The invention relates to a novel strain Saccharothrix actinomycete SA 103 deposited at CNCM on 16th February 2004, number I-3160 or a mutant strain thereof; a method and a medium for selection of said strain; and a method for the product...  
WO/2005/118777A2
The invention relates to a novel strain Saccharothrix actinomycete SA 103 deposited at CNCM on 16th February 2004, number I-3160 or a mutant strain thereof; a method and a medium for selection of said strain; and a method for the product...  
WO/2005/116061A2
The invention relates to DNA sequences coding for polypeptides which, in turn, participate in the enzymatic biosynthesis of polyketide compounds, and to amino acid sequences of said polypeptides. The invention also relates to the use of ...  
WO/2005/116200A2
The present invention provides polypeptides involved in cryptophycin biosynthesis and the nucleic acid molecules that encode such polypeptides. The nucleic acid molecules and polypeptides of the invention or variants thereof can be used ...  
WO2005080549A3
The invention relates to the use of trioxacarcins as agents for treating infections caused by fungi, parasites, viruses or bacteria. The invention also relates to the novel trioxacarcin derivatives as such, to drugs containing them or th...  
WO/2005/116200A3
The present invention provides polypeptides involved in cryptophycin biosynthesis and the nucleic acid molecules that encode such polypeptides. The nucleic acid molecules and polypeptides of the invention or variants thereof can be used ...  
WO/2005/112951A1
It is intended to provide an antitumor agent, which has established a strengthened function selectivity of acting exclusively on caner cells, lessened side effects, mastery of drug tolerance and so on, and has an activity of inducing cel...  
WO/2005/111214A1
The present invention relates to an ethanol producing microbial strain, such as Saccharomyces cerevisiae strain, being able to grow and produce ethanol from lignocellulosic hydrolysates comprising growth inhibiting compounds of the group...  

Matches 651 - 700 out of 8,105