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Matches 651 - 700 out of 7,576

Document Document Title
WO/2005/014834A1
The invention relates to transgenic plant cells expressing nucleic acid molecules which encode polypeptides with expoxygenase activity wherein said cells naturally contain high levels of linoleic acid; plants comprising said cells and me...  
WO/2005/012498A3
Methods and materials for producing porphyrins are described. In particular, microorganisms that contain one or more exogenous nucleic acids are described that produce porphyrins in high yield.  
WO/2005/012498A2
Methods and materials for producing porphyrins are described. In particular, microorganisms that contain one or more exogenous nucleic acids are described that produce porphyrins in high yield.  
WO/2005/009391A2
Fermentation of a nutrient medium with a eubacterium Streptomyces sp. yields a novel antibacterial compound of structure (I).  
WO/2005/005618A1
The present invention related to the microorganism for producing pravastatin and the process for producing pravastatin using the microorganism. The Micropolyspora roseoalba CGMCC 0624 of the present invention has a stronger tolerance to ...  
WO/2005/003137A1
The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie wit...  
WO/2005/000042A1
It is intended to provide a composition containing a lactic acid-bacterium producing equol characterized by containing a lactic acid bacterium belonging to the genus Lactococcus that is capable of metabolizing at least one daidzein compo...  
WO/2005/001105A1
A method for producing monatin, characterized in that it comprises treating a liquid to be treated containing monatin and impurities with a non-polar resin containing an aromatic ring to thereby separate monatin from the liquid to be tre...  
WO/2004/110439A1
This invention relates to novel biologically active polyene oxazoles of Formula (I), their pharmaceutically acceptable salts and derivatives, and to methods of obtaining them. One method for obtaining the compounds is by cultivation of S...  
WO/2004/111230A1
To obtain nemadictin as C-13 hydroxylnemadictin to which a saccharide can add, a strain capable of producing C-13 hydroxylnemadictin is constructed by modifying nemadictin aglycon biosynthesis genes. Further, a C-13 glycosylnemadictin-pr...  
WO/2004/111255A1
The invention encompasses a process for purifying a fermentation broth by providing a fermentation broth; adjusting the pH of the fermentation broth; isolating a filtrate from the fermentation broth; and passing the filtrate through a ca...  
WO/2004/111205A1
Provided is a Streptomyces sp. CJPV 975652 (KCCM-10497) capable of converting compactin to pravastatin and a method for producing pravastatin using a strain of Streptomyces sp. CJPV 975652 (KCCM-10497), which includes: culturing the stra...  
WO/2004/108944A1
A method for producing an optically active chroman-carboxylate, which comprises esterifying one antipode of a racemic chroman-carboxylic acid in the presence of a biocatalyst in a solvent containing an alcohol, separating the unreacted o...  
WO/2004/106557A2
The present invention provides a method for producing thiamin products using a microorganism containing a mutation that causes it to overproduce and release thiamin products into the medium. Biologically pure cultures of the microorganis...  
WO/2004/104205A2
The present invention relates to a process for preparing a chiral indole ester by enzymatic resolution using a lipase from Pseudomonas fluorescens as the catalyst for the enantioselective hydrolysis of an ester.  
WO/2004/104008A1
The invention relates to an enzymatic process for the production of an intermediate, bicyclic-heteroaryl-2-carboxylic acid, of the formula (I) wherein X and Y are defined in the specification and which are useful in the preparation of be...  
WO/2004/104206A1
The invention provides a compound of the formula (I). Furthermore, the invention provides a process for the production of a compound of formula (I). The present invention also provides a process for the production of natamycin by a Strep...  
WO/2004/100649A2
Plant material enriched in secondary metabolites is produced in tissue culture under conditions that organogenically produce a proliferation of shoots and leafy material, and harvesting the leafy material and shoots while in a green, act...  
WO/2004/101803A2
The disclosure describes the production of anticancer agent LL-D45042, having the structure (I) by fermentation, to methods for the recovery and concentration of this anticancer agent from crude solutions, and to processes for the purifi...  
WO/2004/099174A2
A continuous process for the process for the enzyme-catalyzed preparation of cyclic ester oligomers from linear ester oligomers. The process may use a linear or recirculating reactor.  
WO/2004/096188A1
A structure containing polyhydroxyalkanoate and a magnetic substance includes an external phase part containing polyhydroxyalkanoate and an internal phase part contained in the external phase part, at least one of the external phase part...  
WO/2004/094645A1
Staurosporine of the formula (I) is recovered from a fermentation broth in a process comprising an ultrafiltration and a diafiltration step.  
WO/2004/092389A2
New processes for improving the manufacture of clavams e.g. clavulanic acid. Novel DNA sequences and new microorganisms capable of producing increased amounts of clavulanic acid are also disclosed.  
WO/2004/089958A2
Provided is a method for crystallization and purification of a macrolide such as tacrolimus, sirolimus, pimecrolimus, or everolimus that includes the step of providing a combination of a macrolide, and a polar solvent, dopolar aprotic so...  
WO/2004/090094A2
The invention relates to proteins that have an enzymatic activity for reducing substituted alkanones, such as 3-methylamino-1-(2-thienyl)-propane-1-on. The invention also relates to nucleic acids that encode these proteins, to nucleic ac...  
WO/2004/090147A1
A method of purifying an aqueous amide compound solution, which comprises filtering an aqueous solution containing an amide compound obtained with a biocatalyst through an ultrafiltration membrane having a fractional molecular weight of ...  
WO/2004/087938A1
Novel substances PF1270A, PF1270B and PF1270C represented by the following formula (1) or pharmacologically acceptable salts thereof; a process for producing the same; and a pharmaceutical composition comprising at least one thereof as a...  
WO/2004/087909A1
2-Hydroxyisoflavanone dehydratase substantially having the amino acid sequence represented by SEQ ID NO:1 is isolated from licorice. Further, a polynucleotide encoding 2-hydroxyisoflavanone dehydratase of the SEQ ID NO:2 is obtained. Fur...  
WO/2004/087932A2
The present invention relates to a method for preparing (2S,3R) alkyl trans-3-phenylglycidate or (2R,3S) methyl trans-3-phenylglycidate comprising:- enzymatic resolution by trans-esterification of ± methyl trans-3-phenylglycidate with e...  
WO/2004/087935A2
The invention relates to a fermentation process for the preparation of substantially pure pravastatin. The process provides a method of producing pravastatin by microbial hydroxylation of compactin (ML-236B) by maintaining a concentratio...  
WO/2004/087940A2
Process for producing enantiopure β-amino acid derivatives corresponding to general formula (I) R1-NZ-CHR2-CH2-COOR3 (I) in which R1 and R2 independently denote organic residues optionally forming a cyclic substituent, R3 denotes H or a...  
WO/2004/081219A1
The present invention relates to a novel and efficient chemoenzymatic process of preparation of optically active trans alkyl phenylglycidates. The invention particularly discloses a novel process for the chemoenzymatic synthesis of two e...  
WO/2004/081176A2
A method for biotransformation of organic compounds using non-prokaryotic microalgae is disclosed. The method is useful to biotransform a chemical precusor compound, preferably a heterocyclic compound, to a chemically distinct final prod...  
WO/2004/078978A1
Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vec...  
WO/2004/077944A1
It is intended to provide a nematocide which is extracted and purified form a culture liquid of a fungus belonging to the genus Aspergillus sp. Namely, a nematocide characterized by containing, as the active ingredient, an organic acidic...  
WO/2004/078951A1
It has been required to economically produce a large amount of an optically active &gammad -lactone derivative (for example, pantolactone) which is useful as an intermediate in synthesizing a useful substance such as a drug. To achieve t...  
WO/2004/076676A1
A method for the production of partially esterified (meth)acrylic acid esters of polyalcohols and the use thereof.  
WO/2004/071382A2
The present invention relates to substituted heterocycles, processes for their preparation, and their use in medicaments, especially for the treatment of inflammatory disease, i.e. asthma, or cancer.  
WO/2004/069845A1
The present invention provides a novel method for producing compound of formula (I) or any of its salt form, by solid state fermentation, optionally using fed-batch technique by culturing microorganisms capable of producing the compound ...  
WO/2004/070045A1
A process for producing an optically active 6-formyl-1,4-benzodioxin-2-carboxylic acid derivative represented by the general formula (3): (wherein R3 is C1-6 alkyl), which comprises reacting a compound represented by the general formula ...  
WO/2004/065591A1
This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by ...  
WO/2004/064745A2
Processes for preparing racemic and optically pure 3,6-dihydro-2H-pyrans of formulae H, I, N and O are described. These compounds may be further transformed into compounds of formulae J, K, L, M, P, Q, S, T, U, V, Y and Z with potential ...  
WO/2004/065607A1
By culturing Pleurotaceae Panus rudis K-3574 strain (FERM BP-8265), a compound RS-K3574 represented by the following formula (I) is produced as a physiologically active substance showing an activity of inhibiting ubiquitin activating enz...  
WO/2004/062558A2
The present invention describes a process for the preparation of β-lactam antibiotics, cephalexin and ampicillin, wherein the β-lactam nucleus is acylated with an acylating agent, D-phenylglycine, by means of a reaction biocatalyzed by...  
WO/2004/063383A1
This invention relates to ionic liquids and their use as solvents in biocatalysis. According to a first aspect of the invention there is provided a method of carrying out an enzyme-catalysed reaction comprising providing a liquid reactio...  
WO/2004/061116A2
Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vec...  
WO/2004/058976A2
The present invention relates to the biosynthesis of polyketides and derives from the cloning of nucleic acids encoding a polyketide synthase and other associated proteins involved in the synthesis of the polyketide borrelidin. Materials...  
WO/2004/056998A1
A gene cluster has open reading frames which encode polypeptides sufficient to direct the synthesis of a safracin molecule.  
WO/2004/057011A1
Antibiotics caprazamycin D and caprazamycin G represented by the following general formula (I) are obtained by culturing Streptomyces sp. MK730−62F2 (Accession No. FERM BP−7218). Caprazamycins D and G show excellent antimicrobial act...  
WO/2004/055021A1
The invention relates to spirobenzofuranlactam derivatives of formula (I) that are formed by the microorganism Stachybotris atra ST002348, DSM 14952 during fermentation, methods for the production thereof, the use thereof for producing a...  

Matches 651 - 700 out of 7,576