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WO/2008/061418A1 |
A procedure and equipment thereof useful in clearly solid state fermentation of Radix pueraria to co-produce ethanol and Radix pueraria flavones and to utilize Radix pueraria fibers. Said procedure comprises steps of: providing Radix pue...
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WO/2008/059466A1 |
The present invention relates to a novel mutant strain of Penicillium citrinum ATCC 38065 and a process for producing compactin of Formula (I) using the novel mutant strain of Penicillium citrinum ATCC 38065.
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WO/2008/035187A2 |
A method of reducing a ketone to a chiral secondary alcohol. The method includes providing an alcohol dehydrogenase from Agromyces sp. and adding a ketone to the alcohol dehydrogenase to produce a chiral secondary alcohol. An organic sol...
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WO/2008/032140A1 |
The present invention is related to new compound that’s belong to new family of antibiotic clinical structure, to the Streptomyces SPBS46 producing to it’s prepration process, to the pharmaceutical cosmetic food or feed composition a...
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WO/2008/029942A1 |
The object is to find a gene for an enzyme capable of directly controlling the amount of activated cytokinin synthesized and provide a transformed plant having a controlled cytokinin level by using the gene. Disclosed is a transformed pl...
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WO/2008/028654A1 |
The present invention relates to the production of optically active amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.
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WO/2008/026883A1 |
The present invention relates to methods for producing mycophenolic acid using urea as a nitrogen source. More particulary, the present invention provides the method for producing mycophenolic acid by culturing PeniciIlium brevi-compactu...
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WO/2008/025826A1 |
The present invention discloses a chemoenzymatic process for the preparation of an iminocyclitol corresponding to formula (I), (II), (III) or (IV), wherein: R1 and R2 are the same or different, and independently selected from the group c...
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WO/2008/021699A2 |
A method for obtaining improved yields of isoflavones from spent fermentation beer produced by Actinomycetes grown on leguminous plant materials is demonstrated. This method involves conversion of isoflavone biotransformation products to...
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WO2007105280A9 |
Disclosed is a process for producing a novel acylated epigallocatechin gallate derivative in which an acyl group is introduced selectively and efficiently to epigallocatechin gallate. A process for producing an acylated derivative of epi...
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WO/2008/016133A1 |
The object is to find an enzyme capable of phosphorylating a compound such as (2R)-2-amino-2-methyl-4-[5- (5-phenylpentanoyl)thiophen-2-yl]butan-1-ol in vivo and provide a method for phosphorylating the compound, a method for screening f...
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WO/2008/000416A1 |
The present invention relates to microorganisms genetically engineered to reduce carbon source diversion throughout the bioconversion of a carbon source, such as e.g. sorbitol, into biomass. Processes for generating such microorganisms a...
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WO/2008/002600A2 |
The present invention relates to a sahnosporamide A composition and methods of making salinosporamide A and analogs thereof. The present invention also relates to methods of identifying 2OS proteasome inhibiting agents.
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WO2007082402B1 |
The process according to the invention for regioselective N(5)-formylation of (6S)-5,6,7,8-tetrahydropteroic acid and derivatives thereof which are defined in formula (I) is characterized in that an aqueous buffer solution having a pH of...
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WO/2008/000415A1 |
The present invention relates to microorganisms genetically engineered to reduce carbon source diversion throughout the bioconversion of a carbon source, such as e.g. sorbitol, into biomass. Processes for generating such microorganisms a...
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WO/2008/002665A1 |
The present invention provides a method of preparing acid metabolites, such as mycophenolic acid, and a strain of Penicillium sp. with accession number CCM 8364 for use in such method, which method produces mycophenolic acid at increased...
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WO/2007/147801A1 |
The present invention provides a fermentative process for the synthesis of simvastatin by providing a host capable of incorporating the 2,2-dimethylbutyrate side chain into simvastatin, i.e. by customizing a polyketide synthase gene opti...
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WO/2007/148514A1 |
Disclosed is a method for synthesis of a 4-hydroxy-2-quinoline by using an enzyme under clean and mild conditions in a simple manner. More specifically, disclosed is a method for synthesis of a 4-hydroxy-2-quinoline by conducting unimole...
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WO/2007/148412A1 |
An FKI-3389 substance is produced by culturing a microorganism (NITE ABP-244), which is a filamentous bacterium and has an ability to produce the FKI-3389 substance, in a medium, accumulating the FKI-3389 substance in the culture and iso...
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WO/2007/144368A2 |
The invention relates to the preparation of phenolics derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives with the glucose moiety of sucrose. The production of said phenolics derivatives is a...
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WO/2007/141945A1 |
[PROBLEMS] To provide a simple process for production of epitheaflagallin and epitheaflagallin-3-O-gallate which can be used in a food directly, and a process for production of a beverage containing epitheaflagallin and epitheaflagallin-...
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WO/2007/142222A1 |
Disclosed is an effective method for producing pyridoxamine by employing a fermentation technique. Pyridoxamine is one of the substances having a vitamin B6 activity and is useful as a pharmaceutical agent or an intermediate for the synt...
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WO/2007/139871A2 |
The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.
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WO/2007/137510A1 |
A bacillus pumilus strain for high yield of tetramethylpyrazine, named as Bacillus pumilus RX3-17, deposited with China Center for Type Culture Collection under the deposit number CCTCC M 206043 on 19 Apr. 2006. The strain, isolated from...
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WO/2007/137816A1 |
The invention relates to a process for the preparation of intermediates, which can suitably be used in the preparation of active pharmaceutical ingredients, in particular in the preparation of HMG-CoA reductase inhibitors, more in partic...
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WO/2007/134836A1 |
The present invention pertains to the production of secondary metabolites and particularly to the production of lipstatin. Lipstatin, a potent inhibitor of the pancreas lipase, is reported to be useful in the treatment and/or prevention ...
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WO/2007/132937A1 |
Seven kinds of novel antibiotics could be produced by culturing a strain named Microbispora sp. A34030 strain (deposited under the accession number of FERM BP-10505 under Budapest Treaty) which had been isolated from a soil sample. The s...
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WO/2007/128469A1 |
The invention relates to a process for the preparation of an enantiomerically enriched nitrile by reacting an epihalohydrin (derivative) with Br- and CN- in the presence of an enantioselective haloalcohol dehalogenase. The process of the...
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WO2007103389A9 |
This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using thes...
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WO/2007/118320A1 |
The present invention provides a scalable process for producing a concentrate containing a mass of a farnesylated dibenzodiazepinone by fermenting in an aqueous culture medium a strain of a microorganism that is capable of producing the ...
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WO/2007/113268A1 |
The present invention relates to 4,5-dihydromacbecin analogues according to the formula (IA) or (IB) below, or a pharmaceutically acceptable salt there of: wherein: R1 represents H or CONH2. that are useful, e.g. in the treatment of canc...
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WO/2007/113270A1 |
The present invention relates to 15-0-desmethylmacbecin analogues according to the formula (IA) or (IB) below, or a pharmaceutically acceptable salt thereof: wherein: R1 and R2 either both represent H or together they represent a bond (i...
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WO/2007/114125A1 |
Disclosed is a process for production of an N-(monohydroxy-2-adamantyl)-phthalimide derivative, which is a compound useful as an intermediate for the production of a functional resin or pharmaceutical, in a high yield and at a low cost. ...
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WO/2007/112299A2 |
Disclosed and claimed herein are novel biocatalysts for converting racemic mixtures of amino acids to an enantiomerically pure (S) form of the amino acid, methods for their use, and the enantiomerically enriched products of such biocatal...
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WO/2007/111203A1 |
Disclosed is a triprenyl phenol compound having a thrombolysis-enhancing activity. Also disclosed is a process for production of the triprenyl phenol compound. The triprenyl phenol compound is represented by the general formula (II) or (...
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WO/2007/108108A1 |
The invention is directed to a novel stemphone compound in which a microorganism which belongs to the genus Aspergillus and has an ability to produce a stemphone compound selected from the group consisting of stemphone D compound, stemph...
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WO/2007/102936A2 |
This invention provides genes and their encoded proteins, involved in the biosynthesis of farnesyl dibenzodiazepinones, including ECO-04601. The invention relates to expression vectors comprising the genes and to host cells transformed w...
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WO/2007/102396A1 |
Disclosed is a method for production of a labeled sphingolipid, comprising reacting a sphingolipid or lysosphingolipid with an aliphatic carboxylic acid having a label selected from the group consisting of a substance capable of forming ...
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WO/2007/099107A1 |
A process for the production of an optically enriched oxazolidinone of the formula (2a) or (2b), by reacting an epoxide of the formula (1 ) with cyanate in the presence of halo- hydrin dehalogenase.
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WO/2007/097106A1 |
By using sclareol as a substrate, a dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]-furan intermediate is efficiently produced. As a result of intensive studies with the aim of isolating and identifying a microorganism having a character...
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WO/2007/095696A1 |
The present invention relates to polyketide xanthones of the kibdelone class and their use as antibacterial and anticancer agents is described. Methods of preparing kibdelone compounds, pharmaceutical compositions containing them, and th...
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WO2006113147B1 |
Herein is disclosed a method of generating ascorbic acid from yeast transformed with a mannose epimerase. In a further embodiment, the yeast can be further transformed with a myoinositol phosphatase. In the method, the transformed yeast ...
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WO/2007/084808A2 |
Methods for preparing substantially non-antigenic polymers having lone electron pair-containing moieties in high purity are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of...
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WO2007028239B1 |
The isolation and identification of two O-methyltransferases from the hops plant (Humulus lupulus L.), designated as OMT1 (SEQ ID NO. 1) and OMT2 (SEQ ID NO. 3) is described.
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WO/2007/078263A2 |
Technical solution is related to industry production microorganism Streptomyces toxytricini CCM 7349 and method of lipstatin biotechnology preparation by this strain. Production strain listed above with use of two step vegetative inoculu...
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WO/2007/074060A1 |
The invention relates to a method for production of optically active (1S)-3-chloro-1-(2-thienyl)-propan-1-ol of formula (I), wherein 3-chloro-1 -(2-thienyl)-propan-1-one of formula (II) is reduced in a medium to give the compound of form...
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WO2007035693A9 |
Novel isonitrile biosynthetic enzymes isnA and isnB which together possess a catalytic activity of converting an amine-containing compound to an isonitrile-containing compound are described. The genes that encode such enzymes, recombinan...
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WO/2007/074070A1 |
The invention relates to a method for producing optically active alkanols of formula (I), in which n represents a whole number from 0 to 5; Cyc represents an optionally substituted, mononuclear or polynuclear, saturated or unsaturated, c...
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WO/2007/068498A1 |
The invention relates to a process for the preparation of δ-lactones by reacting acetaldehyde and a substituted acetaldehyde in the presence of an aldolase, preferably a DERA from Escherichia coli, from Bacillus subtilis or from a Geoba...
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WO/2007/067698A2 |
The invention concerns a method having the steps of: combining an aqueous fermentation broth containing ansamitocins with a water-immiscible solvent and a water-soluble solvent to form an organic layer and an aqueous layer, wherein: (i) ...
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