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Matches 151 - 200 out of 4,692

Document Document Title
WO/2011/057126
The invention provides compounds of formula (I) wherein u, d, v, m, n, R1, W, X, Y, and Z have any values defined herein, as well as salts thereof. The compounds have activity as anti-proliferative agents.  
WO/2011/054929
The invention relates to a method for producing triptolide from a suspension cell culture of Tripterygium sp., to a triptolide-enriched extract obtainable by means of extraction from the culture medium of an in vitro culture of dediffere...  
WO/2011/054929
The invention relates to a method for producing triptolide from a suspension cell culture of Tripterygium sp., to a triptolide-enriched extract obtainable by means of extraction from the culture medium of an in vitro culture of dediffere...  
WO/2011/048583
The present invention relates to a process for the preparation of mono-para- nitrobenzyl malonate Formula (II) or its salt.  
WO/2011/039268
A sustainable biosynthesizing of tetrodotoxin (TTX) based on seed culture of Vibrio spp is obtained from the mucus of various species of nemerteans (ribbon worms) (phylum Nemertea). The indispensable organisms are kept alive which extend...  
WO/2011/034217
Provided is a novel bioactive substance produced from tea leaves. A novel polyphenol derivative is produced by extraction of microorganism-fermented tea leaves obtained by culturing Aspergillus sp. (PK-1) bacteria using tea leaves.  
WO/2011/024711
A novel compound represented by general formula (1) and salts thereof, which are obtained by subjecting amycolamicin obtained from a microorganism belonging to the genus Amycolatopsis or a salt thereof to decomposition under acid conditi...  
WO/2011/021036
The invention relates to compounds of formula (I) wherein the variables are as defined in the description and their use in therapy.  
WO/2011/016102
The object aims to improve the durability of the enzymatic properties of formate dehydrogenase. The object can be achieved by utilizing a particular type of formate dehydrogenase which has a specific activity too high to be predicted fro...  
WO/2011/016351
The purpose of the present invention is to find compounds having a DNA synthase inhibitory effect and provide novel medicinal compositions (DNA synthase inhibitors, anticancer agents and antiinflammatory agents) using said compounds. Dis...  
WO/2011/011464
Improved constructs for increasing efficiency of transformation of thermophilic host cells for production of carbon-based products of interest and methods for producing carbon- based products of interest are provided.  
WO/2011/009899
Compounds of general formula (Ia) or (Ib) or (Ic) or (Id), wherein the R groups are each independently selected from the group consisting of hydrogen, acyl, alkyl, alkenyl, alkynyl, aryl, -CONH2, alkali metal, and sugar, and their use fo...  
WO/2011/010214
The present invention relates to a pharmaceutical composition comprising rifampicin and piperine with enhancement in bioavailability of rifampicin by piperine. The present invention further relates to process for preparing pharmaceutical...  
WO/2011/004008
Genetically modified strains of Streptomyces tsukubaensis (S. tsukubaensis) can be used for an improved fermentation process for the preparation of tacrolimus or a salt or derivative thereof by cultivation of these genetically modified s...  
WO/2010/139719
The invention relates to a method for the biocatalytic production of ambroxan by means of a polypeptide having the activity of a homofarnesol-ambroxan cyclase and representing a novel class of enzymes.  
WO/2010/139719
The invention relates to a method for the biocatalytic production of ambroxan by means of a polypeptide having the activity of a homofarnesol-ambroxan cyclase and representing a novel class of enzymes.  
WO/2010/140409
Disclosed is a pharmaceutical agent comprising demethyl polymethoxyflavonoid (that is a substance having an excellent physiologically active property) as an active ingredient, which can be produced by a process for which raw materials ar...  
WO/2010/130889
The present invention relates to a method for producing so-called second-generation alcohol from a lignocellulosic substrate, comprising the in-situ production of furfural in a controlled amount, and including at least the following step...  
WO/2010/130139
A kind of the ascorbic acid aryl acetate/propionate ester of formula (I), the preparation method and pharmaceutical composition thereof, such as L-ascorbic acid 6-O-(S)-ibuprofen ester. The ascorbic acid aryl acetate/propionate ester of ...  
WO/2010/131691
Disclosed is a compound useful as a therapeutic agent for tinea, protozoan infection and/or Pneumocystis pneumonia. Capnodiaceae strain No. 339855 is collected, and a polyketide compound is isolated from a culture of the bacterium. It is...  
WO/2010/129233  
WO/2010/129233
The present invention is directed to methods of treating a bacterial infection in a subject through the administration of a therapeutically effective amount of a glycopeptide antibiotic to a subject having a bacterial infection. The effe...  
WO/2010/126034
Disclosed are: a compound represented by structural formula (1) or a pharmacologically acceptable salt thereof; a histone acetylase inhibitor; a nuclear receptor transcription activation inhibitor; a deuteromycetes belonging to the genus...  
WO/2010/125891
For the purpose of treating/preventing disorders or diseases associated with estrogen deficiency, an extract from a hypha of Agaricus blazei Murrill and a brefeldin A component are utilized.  
WO/2010/122669
Disclosed are: a novel compound which has an excellent antibacterial activity against a wide variety of pathogenic bacteria including drug-resistant bacteria and bacteria causing pneumonia in domestic livestock, a tautomer of the compoun...  
WO/2010/123062
Disclosed is a process for producing (R)-3-quinuclidinol, which is a compound useful as an intermediate for the production of pharmaceutical agents, effectively and on an industrial scale. (R)-3-Quinuclidinol can be produced by reacting ...  
WO/2010/115838
The present invention describes a process for the production of a valuable compound comprising a fermentation of a microbial strain on industrial scale comprising a non-repressing C-source and feeding at least one growth rate limiting nu...  
WO/2010/113175
The present invention provides an enzymatic process for the preparation of (S)-5-(4- Fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one by the reduction of 1-(4-Fluoro-phenyl)- 5-morpholin-4-yl-pentane-1,5-dione by using a suitable en...  
WO/2010/113725
Disclosed is a novel compound derived from the culture of an actinomycete and having an anti-tumor activity. Specifically disclosed is a compound represented by formula (I), (II), or (III), an optical isomer thereof, or a pharmaceuticall...  
WO/2010/113175
The present invention provides an enzymatic process for the preparation of (S)-5-(4- Fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one by the reduction of 1-(4-Fluoro-phenyl)- 5-morpholin-4-yl-pentane-1,5-dione by using a suitable en...  
WO/2010/104391
The invention relates to a method for preparing adipic acid, comprising - converting alpha-ketoglutaric acid (AKG) into alpha-ketoadipic acid (AKA), - converting alpha-ketoadipic acid into alpha-ketopimelic acid (AKP), - converting alpha...  
WO/2010/102063
A system for fermentation of biomass is disclosed. The system comprises a method for producing a fermentation product in a fermentation system from biomass that has been pre-treated and separated into a first component and a second compo...  
WO/2010/100236
The present invention relates to the production of recombinant microorganisms, in particular of the genus Gluconobacter, for production of 2-keto-L-gulonic acid (2-KGA) and/or L-ascorbic acid (hereinafter also referred to as Vitamin C), ...  
WO/2010/098103
Disclosed is microbe with the capacity to convert 50% or more of daidzein to equol in 24 hours, a food or medical composition that contains said microbe, a method of manufacturing equol using said microbe, and a nucleic acid fragment tha...  
WO/2010/092155
The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of ...  
WO/2010/089171
The invention relates to a method for the amination of at least one keto group in a multicyclic ring system comprising at least one keto group into an amino group, using at least one enzyme E having transaminase activity.  
WO/2010/089171
The invention relates to a method for aminizing at least one keto group in a multicyclical ring system comprising at least one keto group into an amino group, using at least one enzyme E having transaminase activity.  
WO/2010/090031
Disclosed is a method for producing an optically active succinimide derivative which is a key intermediate of (3R)-2'-(4-bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'(1'H)- pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone. The method for pr...  
WO/2010/079068
The present invention relates to novel phenylethanol dehydrogenase mutants, to a method for the manufacture thereof; to coded nucleic acid sequences therefor, to expression cassettes, to vectors and recombinant microorganisms that contai...  
WO/2010/078670
The present invention is directed to a process for the preparation of a fermentation broth. This fermentation broth contains - at least one lactic acid bacterium, abbreviated with LAB, that produces folate, - at least one propionic acid ...  
WO/2010/079675
The objective is to develop a method for effectively manufacturing a novel bicyclic aromatic hydroxycarboxylic acid by using an enzyme which regiospecifically oxidizes bicyclic aromatic hydroxycarboxylic acid, and to develop a novel bicy...  
WO/2010/078670
The present invention is directed to a process for the preparation of a fermentation broth. This fermentation broth contains - at least one lactic acid bacterium, abbreviated with LAB, that produces folate, - at least one propionic acid ...  
WO/2010/073757
Disclosed are: an useful use application of a cashew apple; and an active ingredient which is derived from a naturally occurring material and has beneficial activities including an α-amylase inhibition activity, a lipase inhibition acti...  
WO/2010/072323
The present invention relates to a method for producing optically active cyclic depsipeptides comprising lactic acid and phenyl lactic acid and having 24 ring atoms, by means of both representatives of the Rosellinia and Coniolariella ge...  
WO/2010/072600
The present invention relates to a novel method for selectively isolating polyketide biosynthesis genes from metagenomes. Furthermore, the nucleic and amino acid sequences of the PKS cluster of psymberin and expression systems for produc...  
WO/2010/073404
The purpose of this object is to provide a valuable use of cashew apple. Another purpose of this object is to provide an active ingredient which originates in a natural material and has useful activities such as an α-amylase inhibitory ...  
WO/2010/068756
There is provided a process for manufacture of optically-active, 2-(acyloxymethyl)-1,3-oxathiolanes of Formula (I) comprising a preparation of a racemic compound and an enzyme-catalyzed kinetic resolution of the enantiomers. The inventio...  
WO/2010/068756
There is provided a process for manufacture of optically-active, 2-(acyloxymethyl)-1,3-oxathiolanes of Formula (I) comprising a preparation of a racemic compound and an enzyme-catalyzed kinetic resolution of the enantiomers. The inventio...  
WO/2010/053950
The present invention relates to microorganisms capable of producing isolable amounts of styrene and/or 7-methyl-l,3,5-cyclooctatriene (MCOT) and uses thereof. The present invention also relates to methods for biosynthetically preparing ...  
WO/2010/053950
The present invention relates to microorganisms capable of producing isolable amounts of styrene and/or 7-methyl-l,3,5-cyclooctatriene (MCOT) and uses thereof. The present invention also relates to methods for biosynthetically preparing ...  

Matches 151 - 200 out of 4,692