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Matches 151 - 200 out of 7,572

Document Document Title
WO/2011/091968A1
The invention relates to a method for producing racemic nebivolol of formula (I) from the enantiomer-pure compounds of formula (IVa) and (IVb), wherein racemic nebivolol is obtained by mixing enantiomer-pure d-nebivolol and I-nebivolol t...  
WO/2011/093185A1
Provided is a method for manufacturing a pyripyropene by culturing a microorganism, created by the introduction of a specific polynucleotide or a recombinant vector comprising same, together with an intermediate compound necessary for th...  
WO/2011/082365A3
Methods and systems for increasing the production of monatin in a multi-step equilibrium pathway are described. Tryptophan and pyruvate are added to a bioreactor to form a mixture comprising monatin and a plurality of intermediates via a...  
WO/2011/082365A2
Methods and systems for increasing the production of monatin in a multi-step equilibrium pathway are described. Tryptophan and pyruvate are added to a bioreactor to form a mixture comprising monatin and a plurality of intermediates via a...  
WO/2011/073956A2
This invention is related to bacterial engineering and the heterologous expression of useful compounds. In particular, the invention relates to a heterologous host that has been engineered for expression of a gene which is capable of pol...  
WO/2011/073956A3
This invention is related to bacterial engineering and the heterologous expression of useful compounds. In particular, the invention relates to a heterologous host that has been engineered for expression of a gene which is capable of pol...  
WO/2011/072287A3
The presently disclosed subject matter demonstrates that ThnG and ThnQ enzymes encoded by the thienamycin gene cluster in Streptomyces cattleya oxidize the C-2 and C-6 moieties of carbapenems, respectively. ThnQ stereospecifically hydrox...  
WO/2011/072287A2
The presently disclosed subject matter demonstrates that ThnG and ThnQ enzymes encoded by the thienamycin gene cluster in Streptomyces cattleya oxidize the C-2 and C-6 moieties of carbapenems, respectively. ThnQ stereospecifically hydrox...  
WO/2011/071396A1
Antifungal compounds, an antifungal compound extracted from Epicoccum purpurascens, also known as Epicoccum nigrum, methods of producing the antifungal compounds, isolates and compositions comprising the antifungal compounds, and methods...  
WO/2011/058446A3
The present invention relates to gene and protein sequences for a thebaine 6-O- demethylase from Papaver somniferum and methods of use therefor. The present invention also relates to gene and protein sequences for a codeine O-demethylase...  
WO/2011/057126A1
The invention provides compounds of formula (I) wherein u, d, v, m, n, R1, W, X, Y, and Z have any values defined herein, as well as salts thereof. The compounds have activity as anti-proliferative agents.  
WO/2011/054929A2
The invention relates to a method for producing triptolide from a suspension cell culture of Tripterygium sp., to a triptolide-enriched extract obtainable by means of extraction from the culture medium of an in vitro culture of dediffere...  
WO/2011/054929A3
The invention relates to a method for producing triptolide from a suspension cell culture of Tripterygium sp., to a triptolide-enriched extract obtainable by means of extraction from the culture medium of an in vitro culture of dediffere...  
WO/2011/048583A1
The present invention relates to a process for the preparation of mono-para- nitrobenzyl malonate Formula (II) or its salt.  
WO/2011/039268A1
A sustainable biosynthesizing of tetrodotoxin (TTX) based on seed culture of Vibrio spp is obtained from the mucus of various species of nemerteans (ribbon worms) (phylum Nemertea). The indispensable organisms are kept alive which extend...  
WO/2011/034217A1
Provided is a novel bioactive substance produced from tea leaves. A novel polyphenol derivative is produced by extraction of microorganism-fermented tea leaves obtained by culturing Aspergillus sp. (PK-1) bacteria using tea leaves.  
WO/2011/024711A1
A novel compound represented by general formula (1) and salts thereof, which are obtained by subjecting amycolamicin obtained from a microorganism belonging to the genus Amycolatopsis or a salt thereof to decomposition under acid conditi...  
WO/2011/021036A1
The invention relates to compounds of formula (I) wherein the variables are as defined in the description and their use in therapy.  
WO/2011/016102A1
The object aims to improve the durability of the enzymatic properties of formate dehydrogenase. The object can be achieved by utilizing a particular type of formate dehydrogenase which has a specific activity too high to be predicted fro...  
WO/2011/016351A1
The purpose of the present invention is to find compounds having a DNA synthase inhibitory effect and provide novel medicinal compositions (DNA synthase inhibitors, anticancer agents and antiinflammatory agents) using said compounds. Dis...  
WO/2011/011464A2
Improved constructs for increasing efficiency of transformation of thermophilic host cells for production of carbon-based products of interest and methods for producing carbon- based products of interest are provided.  
WO/2011/009899A3
Compounds of general formula (Ia) or (Ib) or (Ic) or (Id), wherein the R groups are each independently selected from the group consisting of hydrogen, acyl, alkyl, alkenyl, alkynyl, aryl, -CONH2, alkali metal, and sugar, and their use fo...  
WO/2011/010214A1
The present invention relates to a pharmaceutical composition comprising rifampicin and piperine with enhancement in bioavailability of rifampicin by piperine. The present invention further relates to process for preparing pharmaceutical...  
WO/2011/004008A1
Genetically modified strains of Streptomyces tsukubaensis (S. tsukubaensis) can be used for an improved fermentation process for the preparation of tacrolimus or a salt or derivative thereof by cultivation of these genetically modified s...  
WO/2010/139719A2
The invention relates to a method for the biocatalytic production of ambroxan by means of a polypeptide having the activity of a homofarnesol-ambroxan cyclase and representing a novel class of enzymes.  
WO/2010/139719A3
The invention relates to a method for the biocatalytic production of ambroxan by means of a polypeptide having the activity of a homofarnesol-ambroxan cyclase and representing a novel class of enzymes.  
WO/2010/140409A1
Disclosed is a pharmaceutical agent comprising demethyl polymethoxyflavonoid (that is a substance having an excellent physiologically active property) as an active ingredient, which can be produced by a process for which raw materials ar...  
WO/2010/130889A3
The present invention relates to a method for producing so-called second-generation alcohol from a lignocellulosic substrate, comprising the in-situ production of furfural in a controlled amount, and including at least the following step...  
WO/2010/130139A1
A kind of the ascorbic acid aryl acetate/propionate ester of formula (I), the preparation method and pharmaceutical composition thereof, such as L-ascorbic acid 6-O-(S)-ibuprofen ester. The ascorbic acid aryl acetate/propionate ester of ...  
WO/2010/131691A1
Disclosed is a compound useful as a therapeutic agent for tinea, protozoan infection and/or Pneumocystis pneumonia. Capnodiaceae strain No. 339855 is collected, and a polyketide compound is isolated from a culture of the bacterium. It is...  
WO/2010/129233A9  
WO/2010/129233A2
The present invention is directed to methods of treating a bacterial infection in a subject through the administration of a therapeutically effective amount of a glycopeptide antibiotic to a subject having a bacterial infection. The effe...  
WO/2010/126034A1
Disclosed are: a compound represented by structural formula (1) or a pharmacologically acceptable salt thereof; a histone acetylase inhibitor; a nuclear receptor transcription activation inhibitor; a deuteromycetes belonging to the genus...  
WO/2010/125891A1
For the purpose of treating/preventing disorders or diseases associated with estrogen deficiency, an extract from a hypha of Agaricus blazei Murrill and a brefeldin A component are utilized.  
WO/2010/122669A1
Disclosed are: a novel compound which has an excellent antibacterial activity against a wide variety of pathogenic bacteria including drug-resistant bacteria and bacteria causing pneumonia in domestic livestock, a tautomer of the compoun...  
WO/2010/123062A1
Disclosed is a process for producing (R)-3-quinuclidinol, which is a compound useful as an intermediate for the production of pharmaceutical agents, effectively and on an industrial scale. (R)-3-Quinuclidinol can be produced by reacting ...  
WO/2010/115838A1
The present invention describes a process for the production of a valuable compound comprising a fermentation of a microbial strain on industrial scale comprising a non-repressing C-source and feeding at least one growth rate limiting nu...  
WO/2010/113175A3
The present invention provides an enzymatic process for the preparation of (S)-5-(4- Fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one by the reduction of 1-(4-Fluoro-phenyl)- 5-morpholin-4-yl-pentane-1,5-dione by using a suitable en...  
WO/2010/113725A1
Disclosed is a novel compound derived from the culture of an actinomycete and having an anti-tumor activity. Specifically disclosed is a compound represented by formula (I), (II), or (III), an optical isomer thereof, or a pharmaceuticall...  
WO/2010/113175A2
The present invention provides an enzymatic process for the preparation of (S)-5-(4- Fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one by the reduction of 1-(4-Fluoro-phenyl)- 5-morpholin-4-yl-pentane-1,5-dione by using a suitable en...  
WO/2010/104391A3
The invention relates to a method for preparing adipic acid, comprising - converting alpha-ketoglutaric acid (AKG) into alpha-ketoadipic acid (AKA), - converting alpha-ketoadipic acid into alpha-ketopimelic acid (AKP), - converting alpha...  
WO/2010/102063A2
A system for fermentation of biomass is disclosed. The system comprises a method for producing a fermentation product in a fermentation system from biomass that has been pre-treated and separated into a first component and a second compo...  
WO/2010/100236A1
The present invention relates to the production of recombinant microorganisms, in particular of the genus Gluconobacter, for production of 2-keto-L-gulonic acid (2-KGA) and/or L-ascorbic acid (hereinafter also referred to as Vitamin C), ...  
WO/2010/098103A1
Disclosed is microbe with the capacity to convert 50% or more of daidzein to equol in 24 hours, a food or medical composition that contains said microbe, a method of manufacturing equol using said microbe, and a nucleic acid fragment tha...  
WO/2010/092155A1
The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of ...  
WO/2010/089171A3
The invention relates to a method for the amination of at least one keto group in a multicyclic ring system comprising at least one keto group into an amino group, using at least one enzyme E having transaminase activity.  
WO/2010/089171A2
The invention relates to a method for aminizing at least one keto group in a multicyclical ring system comprising at least one keto group into an amino group, using at least one enzyme E having transaminase activity.  
WO/2010/090031A1
Disclosed is a method for producing an optically active succinimide derivative which is a key intermediate of (3R)-2'-(4-bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'(1'H)- pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone. The method for pr...  
WO/2010/079068A1
The present invention relates to novel phenylethanol dehydrogenase mutants, to a method for the manufacture thereof; to coded nucleic acid sequences therefor, to expression cassettes, to vectors and recombinant microorganisms that contai...  
WO/2010/078670A3
The present invention is directed to a process for the preparation of a fermentation broth. This fermentation broth contains - at least one lactic acid bacterium, abbreviated with LAB, that produces folate, - at least one propionic acid ...  

Matches 151 - 200 out of 7,572