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Matches 1 - 50 out of 8,682

Document Document Title
WO/2019/051046A1
[00018] Disclosed herein are methods that may be used for the synthesis of benzylisoquinoline alkaloids ("BIAs") such as thebaine and morphine and their derivatives. The methods disclosed can be used to produce thebaine, oripavine, codei...  
WO/2019/046954A1
A method for decontaminating a biological material contaminated with a trichothecene mycotoxin bearing a 3-hydroxy group, such as deoxynivalenol or vomitoxin, involves oxidation or epimerization of the 3-hydroxy group to convert the myco...  
WO/2019/050990A1
This present invention provides for a genetically modified host cell, or a cell-free system reactions, and related methods and materials for the biocatalytic production of an alkyl lactones from a hydroxy fatty acid, or natural alkyl lac...  
WO/2019/046941A1
Provided herein are methods and compositions for producing terpenoids in a host cell. In some cases, the terpenoids are cannabinoids.  
WO/2019/046183A1
The subject invention provides microbe-based products and efficient methods of producing them. In specific embodiments, methods are provided for symbiotic cultivation of Acinetobacter venetianus RAG1 and Bacillus subtilis B1, as well as ...  
WO/2019/044941A1
The purpose of the present invention is to provide a novel compound that has antibacterial activity against Mycobacterium avium and Mycobacterium intracellulare, which are pathogens implicated in MAC infection, and has a backbone structu...  
WO/2019/040585A1
Provided herein are improved methods of producing a derivative of PF1022A, for example a compound of Formula I: Formula I wherein R1 and R2 are each independently hydrogen or nitro, and at least one of R1 and R2 is nitro. In some embodim...  
WO/2019/034461A1
Described is a process of separating 2,5-diformylfuran from an aqueous mixture comprising dissolved 5-(hydroxymethyl)furfural, dissolved 2,5-diformylfuran and a buffer substance, comprising the step of (a) cooling down the mixture so tha...  
WO/2019/034717A1
Described is a process of biocatalytic oxidation of 5-(hydroxymethyl)furfural to 2,5-diformylfuran. The invention furthermore relates to the use of a specific compound as a constituent of a two phase system for biocatalytic oxidation of ...  
WO/2019/029408A1
Provided are a streptovaricin derivative, a preparation method therefor, and an application thereof, pertaining to the field of bio-pharmaceuticals. The novel streptovaricin derivative 1-4 is obtained by using Streptomyces spectabilis XW...  
WO/2019/028671A1
Provides is a method for preparing levetiracetam. The method comprises producing (R/S)-α-ethyl-2-oxo-1-pyrrolidine acetate under the action of an alkaline reagent using 2-bromobutyrate and 2-pyrrolidinone as raw materials, performing re...  
WO/2019/028390A1
The present disclosure provides systems and methods for increasing production of an alkaloid product through the epimerization of a (S)-1-benzylisoquinoline alkaloid to a (R)-1-benyzlisoquinoline alkaloid via an engineered epimerase in a...  
WO/2019/019529A1
Provided are a Comamonas testosteroni strain and the use of same in the synthesis of 5-hydroxymethyl furoic acid. The strain is Comamonas testosteroni SC1588, deposited at the China Centre for Type Culture Collection, CCTCC for short, on...  
WO/2019/013573A2
The present invention suggests: a newly shown biosynthesis pathway using the production of homoserine as an intermediate stage for the preparation of 2-hydroxy gamma butyrol acetone (HGBL) and a precursor thereof, 2,4-dihydroxybutanoic a...  
WO/2019/012058A1
The invention provides a genetically modified bacterial cell capable of improved iron-sulfur cluster delivery, characterized by a modified gene encoding a mutant Iron Sulfur Cluster Regulator (IscR) as well as one or more transgenes enco...  
WO/2019/011947A1
The present invention relates to the field of bio-production of ectoine. There is a need in the art for ectoine production methods allowing its highly efficient synthesis and secretion. The solution proposed in the present invention is t...  
WO/2019/014395A8
The present invention includes systems, methods and compositions for the generation of water- soluble cannabinoids in yeast, and other plant cell suspension cultures as well as novel water- soluble cannabinoid compounds. The present inve...  
WO/2019/011192A1
Provided by the present invention are an aminopeptidase for catalyzed synthesis of dipeptide and a preparation method and application therefor. Said aminopeptidase is an amino acid sequence shown in SEQ ID NO: 2; For the preparation of t...  
WO/2019/014490A1
The present disclosure relates to the production of cannabinoids in yeast. In one aspect there is provided a genetically modified yeast comprising: one or more GPP producing genes and optionally, one or more GPP pathway genes; two or mor...  
WO/2019/014395A1
The present invention includes systems, methods and compositions for the generation of water- soluble cannabinoids in yeast, and other plant cell suspension cultures as well as novel water- soluble cannabinoid compounds. The present inve...  
WO/2019/007146A1
Provided are an aminotransferase, a mutant, and applications of the aminotransferase and the mutant in preparation of sitagliptin. According to the applications, bacteriophages obtained by performing fermentation culture on recombinant e...  
WO/2019/001548A1
Provided is a method for preparing fucoxanthin by fermental cultivation of Nitzschia laevis, comprising the following process steps: step A: preparation of a seed solution; step B: fermental cultivation: transferring the seed solution to...  
WO/2018/229306A9
The invention relates to recombinant host cells that expresses one or more genes encoding a cytochrome P450 enzyme capable of N-demethylating and/ O-demethylating reticuline and/or derivatives thereof, and also methods of producing a N-d...  
WO/2018/229306A1
The invention relates to recombinant host cells that expresses one or more genes encoding a cytochrome P450 enzyme capable of N-demethylating and/ O-demethylating reticuline and/or derivatives thereof, and also methods of producing a N-d...  
WO/2018/229305A1
The invention relates to norcoclaurine synthases and substrate binding sites having one or more site-specific mutation which increase the activity, when compared to the wild type synthase, of the condensation of 4-HPAA and dopamine to (S...  
WO/2018/229322A1
The present invention relates to an enzymatic composition and the development of an enzymatic cascade for the production of 2,5-furanodicarboxylic acid (FDCA) from 5-methoxymethylfurfural (MMF). The cascade is triggered by oxidation of M...  
WO/2018/218903A1
A method for preparing troxerutin ester using whole cell catalysis, which falls within the fields of biological catalysis and pharmaceutical chemistry. The method specifically comprises the following steps: evenly mixing troxerutin and a...  
WO/2018/217855A1
The present disclosure includes genetically engineered, non-pathogenic Streptomyces bacterium with exogenous, non-native Thaxtomin A (ThxA) biosynthetic gene clusters conferring the genetically engineered, non-pathogenic Streptomyces bac...  
WO/2018/212626A1
The present invention relates to a recombinant microorganism having an enhanced ability to produce heme, coproporphyrin III (Copro III), and uroporphyrin III (Uro III), and a method for producing heme, coproporphyrin III, and uroporphyri...  
WO/2018/212624A1
The present invention relates to a 11-lipoxygenase consisting of the amino acid sequence represented by SEQ ID NO: 1; or a composition for producing 11-hydroxyfatty acid, hepoxilin D3, or trioxilin D3, comprising the 11-lipoxygenase and ...  
WO/2018/207930A1
A recombinant microorganism is provided which has a gene encoding pyridoxine oxidase and a gene encoding pyridoxamine synthetase having enzymatic activity for synthesizing pyridoxamine from pyridoxal, wherein the gene encoding pyridoxine...  
WO/2018/207931A1
A recombinant microorganism is provided which has a gene encoding pyridoxine dehydrogenase, a gene encoding pyridoxamine synthetase having enzymatic activity for synthesizing pyridoxamine from pyridoxal, and a gene encoding an amino acid...  
WO/2018/207888A1
The present invention provides a method for simply and efficiently producing ramelteon, which is a sleep-inducing agent. According to the present invention, ramelteon can be produced through a few steps including a step in which (E)-2-[1...  
WO/2018/205563A1
A method for producing tetrahydropyrimidine by fermenting recombinant Corynebacterium glutamicum. The recombinant Corynebacterium glutamicum is obtained by overexpressing, in Corynebacterium glutamicum, an aspartokinase gene lysC of whic...  
WO/2018/206590A1
The invention provides a novel class of natural azaphilone pigments, called atrorosins, and methods for their production. The methods for the production of atrorosins include production by fermentation using a fungal species belonging to...  
WO/2018/205846A1
A method for extracting highly-effective natural plant anthocyanidin, which relates to the technical field of bioengineering. The method comprises the steps of: hydrolyzing anthocyanin; by using sodium bicarbonate or potassium bicarbonat...  
WO/2018/204859A1
In an aspect, the disclosure provides methods for making neurotransmitters in a host organism. The neurotransmitters can be cannabinoids and derivatives of cannabinoids. The host cells can be microalgae, fungi or other host cells. In a r...  
WO/2018/199814A1
The invention relates to microbiology and biotechnology. The unicellular algae strain Mallomonas kalinae SX-1 VKPM AI-23, a producer of fucoxanthin, a carotenoid having antioxidant activity, has been deposited at the Federally Funded Ins...  
WO/2018/200888A1
The present disclosure provides genetically modified host cells that produce a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative. The present disclosure provides methods of synthesizing...  
WO/2018/183706A8
The subject invention concerns materials and methods for alkene reduction of compounds, such as levoglucosenone (LGO) and (,S)-Y-hydroxymethyl-a,P-butenolide (HBO), using an alkene reductase enzyme. In one embodiment, a method of the inv...  
WO/2018/183706A1
The subject invention concerns materials and methods for alkene reduction of compounds, such as levoglucosenone (LGO) and (,S)-Y-hydroxymethyl-a,P-butenolide (HBO), using an alkene reductase enzyme. In one embodiment, a method of the inv...  
WO/2018/172401A1
The invention relates to fungal cells for the production of FDCA. The fungal cell has genetic modification that reduces specific 2,5-furandicarboxylic acid (FDCA) decarboxylating monooxygenase activity in the cell, as compared to a corre...  
WO/2018/169055A1
It is known that foods containing a carbohydrate, e.g., starch, in a large amount generate acrylamide upon heating at high temperatures. Some documents state that acrylamide is formed by the Maillard reaction of an amino acid, e.g., aspa...  
WO/2018/159957A1
The present invention relates to a method for selective and effective synthesis of equol, dehydroequol, 5-hydroxy-equol, and 5-hydroxy-dehydroequol from daidzein or genistein, using recombinant Escherichia coli bacteria in which Slackia ...  
WO/2018/154048A1
The invention provides an improved method of isolating the 3-(E)-isomer of an unsaturated carboxylic acid from a mixture of corresponding (E/Z)isomers. More particularly, the present invention relates to an improved method for the biocat...  
WO/2018/157021A1
A Squalene Hopene Cyclase (SHC) isolated from Gluconobacter morbifer is provided as are variants and a method for using the G. morbifer SHC to biocatalytxcally convert homofarnesol to ambroxan.  
WO/2018/149282A1
Disclosed is a method for heterologous expression of an epothilone, comprising introducing an epothilone gene cluster into host bacteria, while supplementing an epothilone precursor synthesis pathway combining with the introduction of th...  
WO/2018/148848A1
A method and cell line for producing phytocannabinoids and phytocannabinoid analogues in yeast. The method applies, and the cell line includes, a yeast cell transformed with a polyketide synthase CDS and a cytosolic prenyltransferase CDS...  
WO/2018/145342A1
Disclosed in the present invention is a method for preparing dihydrodaidzein, comprising the following steps: (1) using the compound represented by formula I as a raw material for an oxidation reaction to prepare a compound represented b...  
WO/2018/142109A1
The present invention relates to a process of producing a monoterpene and/or derivatives thereof. The process comprises the steps of: a) providing a host microorganism genetically engineered to express a bacterial monoterpene synthase (m...  

Matches 1 - 50 out of 8,682