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Matches 1 - 50 out of 8,733

Document Document Title
WO/2019/153633A1
Provided are an alcohol dehydrogenase mutant and an application thereof in synthesis of diaryl chiral alcohol, belonging to the technical field of the biological engineering. The alcohol dehydrogenase mutant has good catalytic activity a...  
WO/2019/157383A2
A method of producing promorphinan, morphinan, nal-opioid, and nor-opioid alkaloid products through the increased conversion of a promorphinan alkaloid to a morphinan alkaloid. The method comprises contacting the promorphinan alkaloid wi...  
WO/2019/153183A1
The present invention relates to the technical field of genetic engineering, and provides a monooxygenase mutant, a preparation method therefor and an application thereof. The monooxygenase mutant has any one of the amino acid sequences ...  
WO/2019/153634A1
An alcohol dehydrogenase mutant and an application thereof in the synthesis of biaryl chiral alcohol. The alcohol dehydrogenase in the present invention is coupled to glucose dehydrogenase or formate dehydrogenase, and may be used for th...  
WO/2019/153632A1
Provided are an alcohol dehydrogenase mutant and an application thereof in synthesis of diaryl chiral alcohol, belonging to the technical field of the biological engineering. The alcohol dehydrogenase mutant has good catalytic activity a...  
WO/2019/150564A1
The present invention pertains to a method for synthesizing an oligodeoxynucleotide (ODN), said method comprising synthesizing an ODN which has a sulfonamide bonded thereto via a non-natural internucleotide linkage and using the thus syn...  
WO/2019/144920A1
A method for promoting the fermentation of Gluconobacter oxydans to produce D-sorbitol dehydrogenase and pyrroloquinoline. The method is such that: Gluconobacter oxydans is grafted to a fermentation culture medium, fermented and cultured...  
WO/2019/147865A1
Methods for catalyzing C-H insertion reactions using heme enzymes are described. The present disclosure provides a method for producing a C-H insertion product comprising providing an substrate having an sp3-hybridized C-H bond, a carben...  
WO/2019/140682A1
Provided are a ketoreductase mutant and an application thereof. The amino acid sequence of the ketoreductase mutant is an amino acid sequence obtained by mutating the amino acid sequence shown in SEQ ID NO: 1, and the mutation comprises ...  
WO/2018/027324A9
This disclosure relates to the production of opium poppy plants having high levels of thebaine. More particularly, the disclosure relates to the production of opium poppies having high levels of thebaine by simultaneously reducing the ex...  
WO/2019/128387A1
The present invention provides a method for preparing (S)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid and a derivative thereof by using enzymatic resolution, the method comprising the step of: using racemic 1,2,3,4-tetrahydroisoquin...  
WO/2019/130681A1
The present invention addresses the problem of providing a method for removing the hydroxyl group at the 8-position of a urolithin to produce a different urolithin. The present invention solves this problem by means of a method for produ...  
WO/2019/128006A1
Provided are mold OMK-25 for producing delta-lactone and an application thereof. Mold OMK-25 was deposited in China Center for Type Culture Collection on June 14, 2017 under a collection number of CCTCC M 2017339. Provided is a route for...  
WO/2019/130448A1
The present invention addresses the problem of providing a method for removing the hydroxyl group at the 8-position of a urolithin to produce a different urolithin. The present invention solves this problem by means of a method for produ...  
WO/2019/122421A1
The present application relates to processes for stereo- and regioselective reduction of cyclohexanones using a ketoreductase enzyme. Compounds prepared according to the disclosed processes are useful in the preparation of compounds for ...  
WO/2019/120132A1
A biosynthetic gene cluster-dis427 of Disorazole Z, the nucleotide sequence thereof is as shown in SEQ ID No. 1. An engineered strain DK1622::Km-Ptet-dis427 for heterologous expression of Disorazole Z is constructed by utilizing the gene...  
WO/2019/113710A1
Disclosed are methods for converting a substrate into a product benzylisoquinoline compound in a biosynthetic system involving the culturing of cells in a medium. The cells comprise a benzylisoquinoline uptake permease and a biosynthetic...  
WO/2019/117612A1
The present invention relates to a microorganism variome which is capable of extracellular heme generation, and more specifically, to a metabolically engineered microorganism variome which is capable of extracellular heme generation and ...  
WO/2019/109170A1
Disclosed are methods for converting a first morphinan alkaloid compound into a second morphinan alkaloid compound in the presence of a neopinone isomerase enzyme under reaction conditions permitting the conversion of the first alkaloid ...  
WO/2019/098598A1
The specification relates to a method for producing coumestrol by using cultured roots of leguminous plants and a method for preparing a leguminous plant extract having an increased coumestrol amount. A method according to one aspect of ...  
WO/2019/013573A9
The present invention suggests: a newly shown biosynthesis pathway using the production of homoserine as an intermediate stage for the preparation of 2-hydroxy gamma butyrol acetone (HGBL) and a precursor thereof, 2,4-dihydroxybutanoic a...  
WO/2019/076021A1
Provided is a preparation method for hesperetin, comprising: suspending hesperidin or neohesperidin in water, and adding a sodium hydroxide solution until the hesperidin or neohesperidin is completely dissolved to obtain a substrate prep...  
WO/2019/032235A3
The present invention relates to the production of eriodictyol via bioconversion.  
WO/2019/071000A1
Disclosed herein are microorganism and methods that can be used for the synthesis of cannabigerolic acid (CBGA) and cannabinoids. The methods disclosed can be used to produce CBGA, Δ9-tetrahydrocannabinolic acid (THCA), cannabidiolic ac...  
WO/2019/070992A1
Metastable state spore incubation mixing systems are described. An example system includes a spore container to store spores, a nutrient container, an arrangement of valves and tubes, a reciprocating pump, a mixing tube, and a holding ta...  
WO/2019/013573A3
The present invention suggests: a newly shown biosynthesis pathway using the production of homoserine as an intermediate stage for the preparation of 2-hydroxy gamma butyrol acetone (HGBL) and a precursor thereof, 2,4-dihydroxybutanoic a...  
WO/2019/056467A1
A Burkholderia strain, specifically Burkholderia glathei ECU 0712, the deposit number thereof being CGMCC No. 14464. The strain or an extract thereof serving as a biocatalyst is applicable in catalyzing the asymmetric oxidation of a thio...  
WO/2019/051046A1
[00018] Disclosed herein are methods that may be used for the synthesis of benzylisoquinoline alkaloids ("BIAs") such as thebaine and morphine and their derivatives. The methods disclosed can be used to produce thebaine, oripavine, codei...  
WO/2019/046954A1
A method for decontaminating a biological material contaminated with a trichothecene mycotoxin bearing a 3-hydroxy group, such as deoxynivalenol or vomitoxin, involves oxidation or epimerization of the 3-hydroxy group to convert the myco...  
WO/2019/050990A1
This present invention provides for a genetically modified host cell, or a cell-free system reactions, and related methods and materials for the biocatalytic production of an alkyl lactones from a hydroxy fatty acid, or natural alkyl lac...  
WO/2019/046941A1
Provided herein are methods and compositions for producing terpenoids in a host cell. In some cases, the terpenoids are cannabinoids.  
WO/2019/046183A1
The subject invention provides microbe-based products and efficient methods of producing them. In specific embodiments, methods are provided for symbiotic cultivation of Acinetobacter venetianus RAG1 and Bacillus subtilis B1, as well as ...  
WO/2019/044941A1
The purpose of the present invention is to provide a novel compound that has antibacterial activity against Mycobacterium avium and Mycobacterium intracellulare, which are pathogens implicated in MAC infection, and has a backbone structu...  
WO/2019/040585A1
Provided herein are improved methods of producing a derivative of PF1022A, for example a compound of Formula I: Formula I wherein R1 and R2 are each independently hydrogen or nitro, and at least one of R1 and R2 is nitro. In some embodim...  
WO/2019/034461A1
Described is a process of separating 2,5-diformylfuran from an aqueous mixture comprising dissolved 5-(hydroxymethyl)furfural, dissolved 2,5-diformylfuran and a buffer substance, comprising the step of (a) cooling down the mixture so tha...  
WO/2019/034717A1
Described is a process of biocatalytic oxidation of 5-(hydroxymethyl)furfural to 2,5-diformylfuran. The invention furthermore relates to the use of a specific compound as a constituent of a two phase system for biocatalytic oxidation of ...  
WO/2019/029408A1
Provided are a streptovaricin derivative, a preparation method therefor, and an application thereof, pertaining to the field of bio-pharmaceuticals. The novel streptovaricin derivative 1-4 is obtained by using Streptomyces spectabilis XW...  
WO/2019/028671A1
Provides is a method for preparing levetiracetam. The method comprises producing (R/S)-α-ethyl-2-oxo-1-pyrrolidine acetate under the action of an alkaline reagent using 2-bromobutyrate and 2-pyrrolidinone as raw materials, performing re...  
WO/2019/028390A1
The present disclosure provides systems and methods for increasing production of an alkaloid product through the epimerization of a (S)-1-benzylisoquinoline alkaloid to a (R)-1-benyzlisoquinoline alkaloid via an engineered epimerase in a...  
WO/2019/019529A1
Provided are a Comamonas testosteroni strain and the use of same in the synthesis of 5-hydroxymethyl furoic acid. The strain is Comamonas testosteroni SC1588, deposited at the China Centre for Type Culture Collection, CCTCC for short, on...  
WO/2019/013573A2
The present invention suggests: a newly shown biosynthesis pathway using the production of homoserine as an intermediate stage for the preparation of 2-hydroxy gamma butyrol acetone (HGBL) and a precursor thereof, 2,4-dihydroxybutanoic a...  
WO/2019/012058A1
The invention provides a genetically modified bacterial cell capable of improved iron-sulfur cluster delivery, characterized by a modified gene encoding a mutant Iron Sulfur Cluster Regulator (IscR) as well as one or more transgenes enco...  
WO/2019/011947A1
The present invention relates to the field of bio-production of ectoine. There is a need in the art for ectoine production methods allowing its highly efficient synthesis and secretion. The solution proposed in the present invention is t...  
WO/2019/014395A8
The present invention includes systems, methods and compositions for the generation of water- soluble cannabinoids in yeast, and other plant cell suspension cultures as well as novel water- soluble cannabinoid compounds. The present inve...  
WO/2019/011192A1
Provided by the present invention are an aminopeptidase for catalyzed synthesis of dipeptide and a preparation method and application therefor. Said aminopeptidase is an amino acid sequence shown in SEQ ID NO: 2; For the preparation of t...  
WO/2019/014490A1
The present disclosure relates to the production of cannabinoids in yeast. In one aspect there is provided a genetically modified yeast comprising: one or more GPP producing genes and optionally, one or more GPP pathway genes; two or mor...  
WO/2019/014395A1
The present invention includes systems, methods and compositions for the generation of water- soluble cannabinoids in yeast, and other plant cell suspension cultures as well as novel water- soluble cannabinoid compounds. The present inve...  
WO/2019/007146A1
Provided are an aminotransferase, a mutant, and applications of the aminotransferase and the mutant in preparation of sitagliptin. According to the applications, bacteriophages obtained by performing fermentation culture on recombinant e...  
WO/2019/001548A1
Provided is a method for preparing fucoxanthin by fermental cultivation of Nitzschia laevis, comprising the following process steps: step A: preparation of a seed solution; step B: fermental cultivation: transferring the seed solution to...  
WO/2018/229306A9
The invention relates to recombinant host cells that expresses one or more genes encoding a cytochrome P450 enzyme capable of N-demethylating and/ O-demethylating reticuline and/or derivatives thereof, and also methods of producing a N-d...  

Matches 1 - 50 out of 8,733