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JP3156735B2 |
PURPOSE: To provide a strain of microorganism capable of converting in high yield a highly concentrated precursor into 3α-hydroxy-7-keto-5β-cholanic acid, 3α-hydroxy-7,12-diketo-5β-cholanic acid, or 3α, 12α-dihydroxy-7-keto-5β-cho...
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JP3137645B2 |
Described is a method of preparing 17-oxosteroids by the fermentative oxidation of 17 beta -hydroxysteroids, characterized in that a bacterial culture of the species Mycobacterium spec. NRRL B-3805, Mycobacterium spec. NRRL B-3683, Mycob...
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JP2001031572A |
To obtain the subject medicine having excellent neurocladism action on central nervous cells, especially aged central nervous cells and useful as a therapeutic agent including an antidemential agent for neurodegenerative diseases by incl...
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JP3133327B2 |
A pharmaceutical composition conatining at least one C3-OH ether or fatty acid monoester of 7B-hydroxycholesterol selected from the group consisting of the ethers or esters of palmitic, oleic, hexenoic, decenoic and arachindonic acids or...
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JP2000319287A |
To obtain a new compound capable of inhibiting developing sialyl- Lewis-X on leukocyte surface and useful as an anti-inflammatory agent. This compound is a compound of the formula (R is an ethyl, normal propyl or isopropyl), e.g. MK13089...
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JP2000511404A |
Use is provided for a 7alpha-hydroxy or 7-oxo substituted 3beta-hydroxy-steroid possessing the carbon skeleton of cholesterol, androsterone, pregnenolone or estradiol, or an analogue thereof substituted independently at one or both of th...
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JP3082973B2 |
The present invention provides microorganisms of the genus Bacillus capable of predominantly producing 3a,7a-dihydroxy-12-keto-5b-cholanic acid from 3a,7a,12a-trihydroxy-5b-cholanic acid and mutant strains thereof and use of such microor...
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JP3084586B2 |
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JP3039604B2 |
PURPOSE: To obtain an active fraction from Cordyceps capable of inhibiting activation of human mesangial cells, improving IgA nephritis and preventing onsets of uremia. CONSTITUTION: This active fraction of Cordyceps has a structure expr...
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JP3034602B2 |
PCT No. PCT/DE91/00620 Sec. 371 Date Jun. 18, 1992 Sec. 102(e) Date Jun. 18, 1992 PCT Filed Jul. 30, 1991 PCT Pub. No. WO92/03571 PCT Pub. Date Mar. 5, 1992.A process for the production of 4-pregnene-3,20-dione and its derivatives of gen...
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JP3030306B2 |
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JP2000501940A |
PCT No. PCT/EP96/05729 Sec. 371 Date Sep. 30, 1998 Sec. 102(e) Date Sep. 30, 1998 PCT Filed Dec. 10, 1996 PCT Pub. No. WO97/21830 PCT Pub. Date Jun. 19, 1997The invention relates to a microbial method of in vitro transformation of a ster...
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JP2992830B2 |
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JPH11318436A |
To measure the biocompatibility of a lipophilic substance in a cell culture test by preparing a dispersion comprising a nanoemulsion containing the lipophilic substance in an aqueous phase and subsequently adding the dispersion to a cell...
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JPH11308991A |
To economically obtain a steroid useful as a medicine or the like by incubating a sterol compound in the presence of protein(s) produced by a specific process under such conditions as to enable a steroid to be oxidized and the resulting ...
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JP2963711B2 |
Genetically engineered host cells containing new expression cassettes are provided which are able to carry out biochemical oxidations of steroids. In particular the oxidation is carried out with cells into which DNA has been introduced w...
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JP2887689B2 |
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JPH1175863A |
To obtain a polypeptide useful for e.g. preventing, diagnosing and treating adult diseases such as osteoporosis caused by active vitamin D3 level drop and having the activity of the subject enzyme catalyzing the final stage of vitamin D3...
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JP2855538B2 |
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JPH11500615A |
PCT No. PCT/FR96/00089 Sec. 371 Date Aug. 8, 1997 Sec. 102(e) Date Aug. 8, 1997 PCT Filed Jan. 19, 1996 PCT Pub. No. WO96/25512 PCT Pub. Date Aug. 22, 1996A Chrysosporium strain No. CBS 123.95, mutants and derivatives thereof, and a meth...
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JPH10234396A |
To obtain the subject compound useful as an active ingredient, etc., of an antitumor agent by culturing a bacterium belonging to the genus Penicillium and having a production capability of a physiologically active substance, Soyasapogeno...
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JP2779662B2 |
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JP2779774B2 |
PURPOSE: To simplify the purification process for the reaction mixture by acylating only a specific primary hydroxy group in the saccharide moiety of a steryl glucoside selectively. CONSTITUTION: A steryl glucoside of a general formula: ...
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JP2779855B2 |
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JPH1099094A |
To effectively obtain the subject products having various kinds of medicinal efficacy by culturing a Prevotella S-1 strain in a ginseng-containing culture medium to produce protopanaxadiol metabolites in the culture medium and subsequent...
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JP2719377B2 |
9 alpha -hydroxy-17-keto steroids are prepared by fermenting steroids having a C-17 side chain of 5-10 carbon atoms inclusive, with the novel Mycobacterium species CBS 482.86. Starting from various substrates containing a 5-10 C carbon c...
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JP2702201B2 |
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JP2689144B2 |
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JP2689140B2 |
PURPOSE:To obtain a purified novel 3-beta-hydroxysteroid oxidase having specific enzymatic characteristics by making a culture of Rhodococcus equi MIL 1037 strain separated from soil. CONSTITUTION:Rhodococcus equi MIL 1037 strain (FERM p...
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JPH09511902A |
The invention relates to new compounds, WF15604 substances or salts thereof, having antifungal activity and inhibitory activity on cholesterol biosynthesis, to a process for the preparation thereof and to a pharmaceutical composition com...
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JP2680870B2 |
The present invention involves processes for 1,2-dehydrogenation of DELTA 4-3-keto C21-hemiester steroids of formula (I) (I) with Arthrobacter simplex or Bacterium cyclooxydans to produce the corresponding DELTA 1,4-3-keto C21 hemiester ...
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JPH09202797A |
To obtain the subject new compound which is a specific 5α-reductase inhibiting compound having a steroid structure derived from a microorganism of the genus Aspergillus and inhibiting actions on 5α-reductases and useful as a preventing...
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JP2627915B2 |
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JP2623285B2 |
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JP2622700B2 |
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JP2622712B2 |
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JPH0967393A |
To obtain the subject new compound having 5 α-reductase inhibiting action and useful as a preventing or treating medicine for prostatic hypertrophy from cultured products obtained by culturing dicephalosterol producing bacterium belongi...
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JPH099990A |
PURPOSE: To efficiently convert a cholesterol analog into a steroid hormone raw material by utilizing a microorganism. CONSTITUTION: A Gram-negative aerobic bacillus is reacted with a cholesterol analog in a medium containing water super...
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JPH08511163A |
PCT No. PCT/NL94/00135 Sec. 371 Date Nov. 28, 1995 Sec. 102(e) Date Nov. 28, 1995 PCT Filed Jun. 10, 1994 PCT Pub. No. WO94/29453 PCT Pub. Date Dec. 22, 1994Disclosed is a new gene which codes for a NADPH cytochrome P450 oxidoreductase f...
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JPH08245686A |
PURPOSE: To obtain a new bioactive substance having eliminating activity of a bonding site of scaly leaf of Chamaecyparis obtusa and useful as a herbicide and a phytohormone agent, etc., by culturing Cryptosporiopsis-abietina having absc...
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JP2525049B2 |
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JP2517894B2 |
PURPOSE: To obtain the subject strain useful for bioreactor, etc., containing a localized signal sequence to an N-end microsome and a C-end maturation type mitochondrial P450, having a plasmid to manifest ferredoxin and its reduc tase. C...
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JP2500543B2 |
PURPOSE:To obtain a new plasmid capable of expressing a chimera P450 of a localized signal sequence to N-terminal microsome and the C-terminal matured and mitochondria type P450. CONSTITUTION:An expression plasmid capable of mass-produci...
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JPH0892114A |
PURPOSE: To obtain the short chain saponin expected to have a new pharmacological effect different from those of conventional saponins by a specific tissue- culture method from a medicinal ginseng plant body. CONSTITUTION: A callus induc...
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JPH0824596B2 |
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JPH0859690A |
PURPOSE: To obtain a novel compound, absisterol-A, which is useful as a herbicide or a plant growth regulator, by culturing a microorganism capable of producing absisterol-A, Cryptosporiopsis abietina and collecting the product from the ...
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JPH0815433B2 |
The invention relates to a biocatalytic process for the conversion of organic substances, especially those of low solubility in water. The invention is characterised in that enzymes, prokaryotic and eukaryotic cells or combinations of en...
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JPH088876B2 |
A process for the production of 4-androstene-3,17-dione and 1,4-androstadiene-3,17-dione of the general formula wherein . . . . . symbolizes a single bond or a double bond, characterized in that ergosterol is fermented with a culture of ...
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JPH082311B2 |
A composition comprising immobilized cells having enzyme activity, the cells being immobilized by means of a fixed, insoluble, crosslinked polymer obtained by curing a curable prepolymer material selected from the group consisting of pol...
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JPH07121230B2 |
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