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JPH0233353B2 |
1. Aqueous nutrient medium for the cultivation of microorganisms, characterised in that a component of the medium is a carbohydrate-free protein hydrolysate solution containing 0.2 to 5.0% cystein, which is prepared by hydrolysing horn, ...
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JPH02138195A |
NEW MATERIAL: A compounds of formula I (R is formula II, formula III). USE: Therapy and prevention of acune vulgaris, female thin hair, benign prostatomegaly, etc. PROCESS: By the aerobic fermentation of an assimilatory carbon source, a ...
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JPH02119795A |
PURPOSE: To obtain a product with a degraded side chain by using microorganisms produced in the presence of an oxygenic ring-degradation inhibitor of a sterol compound as a wild strain of the microorganism used for production of 17-C-ste...
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JPH0218071B2 |
A process for preparing 11 beta ,21-dihydroxy-2'-methyl-5' beta H-1,4-pregnadieno(16,17-d)-oxazole-3,20-dione, comprises fermenting 11 beta ,21-dihydroxy-2'-methyl-5' beta H-4-pregneno (16,17-d)-oxazole-3,20-dione with a living culture o...
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JPH0215197B2 |
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JPH027959B2 |
11-Methylene- DELTA 15-steroids of Formula I (I) wherein R1 is hydrogen or acyl and R2 is ethynyl, chloroethynyl or propynyl, are distinguished by a strong progestational activity and exhibit only a very low androgenic side effect.
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JPH027633B2 |
NEW MATERIAL:The primary alcohol derivative of phospholipid of formula I {A is group of formula II or formula III [R1 and R2 are -O-COR11 or -O-R12, or R1 and R2 in the group of formula II together form the group of formula IV (n is 11-1...
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JPH0216998A |
PURPOSE: To produce 12α-hydroxypregna-1,4-dien-3-one-20α-carboxylic acid or a salt thereof by culturing a specific bacterium in a culture medium containing deoxycholic acid and/or a salt thereof. CONSTITUTION: A bacterium, capable of p...
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JPH02360B2 |
3-enol ethers of 11 beta -hydroxy- DELTA 4-pregnene-3-ones are prepared by reacting triethylorthoacetate with an 11 beta -hydroxy- DELTA 4-pregnene-3-one in a solvent which is at least 40% by weight or more ethanol and 60% by weight or l...
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JPH0159879B2 |
1. Process for manufacturing 11 alpha-hydroxy-20 alpha-hydroxymethyl- 1,4-pregnadien-3-one, characterised in that 20 alpha-hydroxymethyl-1,4-pregnadien-3-one is fermented with a live culture of Aspergillus occhraceus which is capable of ...
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JPH0159880B2 |
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JPH0158199B2 |
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JPH0157960B2 |
The subject invention concerns a novel one-stage fermentation process for making the useful steroid intermediate 9-hydroxy-3-oxo-4,17(20)-pregnadiene-20-carboxylic acid (I). This process is significantly superior to the best prior art pr...
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JPH0152399B2 |
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JPH0151998B2 |
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JPH0150717B2 |
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JPH0150716B2 |
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JPH0149278B2 |
6 alpha -Methylprednisolone derivatives of Formula I (I) wherein R1 is 1-oxoalkyl of 2-6 carbon atoms or benzoyl and R2 is 1-oxoalkyl of 2-6 carbon atoms, are pharmacologically efficacious compounds, e.g., as antiinflammatories.
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JPH0149480B2 |
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JPH0148760B2 |
Methylene steroids of the formula wherein X is H, F or CH3; Y is hydroxymethylene, alkanoyloxymethylene or carbonyl; R1 is H, OH or alkanoyloxy; and R2 is H, OH or esterified OH, possess topical anti-inflammatory activity.
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JPH0148277B2 |
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JPH0147157B2 |
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JPH0147156B2 |
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JPH01252298A |
NEW MATERIAL:A compound expressed by formula I [R1 is H or acyl; R2 is H or expressed by formula II (R4WR7 is R1); R3 is (protected) carboxy]. EXAMPLE: A compound expressed by formula III. USE: Antibacterial agent. Preventive and remedy ...
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JPH01221391A |
NEW MATERIAL: A compd. of formula I (where R is OH or H; R1 and R2 are each =CH2 or -CH2O-; R3 is H, OH, HSO3O or HOCOCH2CH2CO2; R4 is OH, HOC15H30CO2, AcO or H; when R3 is H, a double bond does not exist in the cyclopentane ring; R5 is ...
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JPH01218600A |
PURPOSE: To carry out mass production of medicine, etc., having high safeness, by reacting 7 position of testosterone(TSS) using culture cell of the genus Marchantia under light irradiation. CONSTITUTION: An asexual bud of Marchantia suc...
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JPH01206999A |
PURPOSE: To produce pregneno-oxazoline used as an anti-inflammatory agent industrially advantageously by making 2'-substituted-4-pregnene-21-ol[17α,16α-d]- oxazonyl-3,20-dion contact with mixing-cultured germs grown sequentially among ...
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JPH0137120B2 |
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JPH0134038B2 |
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JPH01171496A |
PURPOSE: To improve the non-toxicity and safety of 9α-hydroxysteroid in high efficiency, by hydroxylating a specific steroid with a microbial cell, etc., in the presence of a 2-substituted-cyclopentanone. CONSTITUTION: A microbial cell ...
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JPH0132237B2 |
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JPH0132236B2 |
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JPH0128758B2 |
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JPH0121837B2 |
1-Hydroxy steroids of formula I (I) wherein R1 and R2 are independently hydrogen or alkanoyl of 1-8 carbon atoms are distinguished by strong progestational activity and only very minor androgenic side effects.
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JPH0121759B2 |
A process for preparing a 3 beta ,7 beta -dihydroxy- DELTA 5-steroid of the formula wherein Q is and R1 is hydrogen, trimethylacetyl, tert-butyldimethylsilyl, dimethyl-2-(3-methylbutyl)silyl or tribenzylsilyl, comprises fermenting a 3 be...
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JPH0121760B2 |
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JPH0120873B2 |
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JPH0120880B2 |
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JPH0120874B2 |
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JPH0120877B2 |
Androstane steroids are produced by microbiological conversion of a sterol substrate with a microorganism belonging to the genus Mycobacterium wherein the medium used contains at least 0.1% by weight of egg yoke as a dry weight.
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JPH0120879B2 |
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JPH0120878B2 |
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JPH0120876B2 |
1. Process for the manufacture of 12 alpha-hydroxysteroids of the general formula I see diagramm : EP0019162,P3,F1 in which X represents a hydrogen atom or a fluorine atom, R1 represents a hydrogen atom or a methyl group, and R2 represen...
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JPH0120875B2 |
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JPH0117679B2 |
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JPH0117678B2 |
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JPS6485099A |
PURPOSE: To obtain 9α-hydroxy-4-androstene-3,17-dione by decomposing the side chain of a naturally occurring sterol with new microorganisms belonging to the genus Mycobacterium. CONSTITUTION: An 1,2-steriod dehydrogenase-deleted strain ...
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JPS645880B2 |
Methylene steroids of the formula wherein X is H, F or CH3; Y is hydroxymethylene, alkanoyloxymethylene or carbonyl; R1 is H, OH or alkanoyloxy; and R2 is H, OH or esterified OH, possess topical anti-inflammatory activity.
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JPS6361000B2 |
In the prodn. of 11 beta-hydroxy-steroids of the pregnane series substd. in the 17 alpha-position by an acetal residue of the formula -3-CHR2-Or1 (I) (where R1 is alkyl opt. interrupted by an O-atom and R2 is H or alkyl; or R1+R2 is tetr...
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JPS6357437B2 |
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