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WO/2018/133844A1 |
The present invention provides a cytochrome P450 mutant protein and applications thereof. In particular, in the present invention, after the modification of key sites in the cytochrome P450 CYP716A47, the PPD production and the PPD/DM pr...
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WO/2018/126468A1 |
The present invention relates to a preparing method for an ursodesoxycholic acid by using a biological enzyme catalysis technology and 7β-hydroxysteroid dehydrogenase for preparation of the ursodesoxycholic acid. The method uses a 3α-h...
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WO/2018/126469A1 |
The present invention relates to a method for preparing ursodeoxycholic acid by using a biological enzyme catalysis technique and a 7β-steroid dehydrogenase for use in the preparation thereof. The method uses 3α-hydroxy-7 oxo-5β-chola...
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WO/2018/126466A1 |
The present invention relates to a method utilizing a biological enzyme catalysis technique for preparing 3α-hydroxy-7-oxo-5β-cholanoic acid and a 7α-steroid dehydrogenase for use in preparation thereof. The method uses chenodeoxychol...
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WO/2018/126467A1 |
A method which uses biological enzyme catalysis to prepare 3α-hydroxy-7-oxo-5β-cholanoic acid and 7α-steroid dehydrogenase for the preparation thereof. The method uses chenodeoxycholic acid as a substrate; in the presence of NAD, lact...
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WO/2018/120983A1 |
Provided are a Glycyrrhetinic acid-producing recombinant yeast strain, specifically the strain of deposit number CGMCC 13126, a preparation method for the strain, and uses of the strain in producing Glycyrrhetinic acid. The strain overex...
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WO/2018/062904A1 |
Disclosed are a composition for production of ginsenoside compound K using a high temperature-β-glycosidase and a high temperature-α-L-arabinofuranosidase, and a method for preparing ginsenoside compound k. The composition for producin...
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WO/2018/045946A1 |
A Poria cocos fermentation product. On the basis of the total weight of the Poria cocos fermentation product, the total amount of the following compounds (1) to (12) is no less than 0.15% by weight: (1) pachymic acid (PA), (2) dehydropac...
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WO/2018/036982A1 |
The invention relates to a further chemical-biocatalytic method for producing ursodeoxycholic acid from chenodeoxycholic acid after chemical oxidation to 3,7-diketo-ursodeoxycholic acid and after subsequent reaction with 7 beta-hydroxyst...
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WO/2018/028006A1 |
Provided are a mycobacterium neoaurum, a ketosteroid C27-monooxygenase derived from mycobacterium neoaurum, and application of the ketosteroid C27-monooxygenase. By adding expressions of SMO isoenzyme SMO1, SMO2 and/or SMO3 to mycobacter...
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WO/2018/012644A1 |
The present invention relates to a recombinant microorganism for producing a steviol glycoside and a method for producing a steviol glycoside. The recombinant microorganism for producing a steviol glycoside according to the present inven...
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WO/2017/220486A2 |
The present invention relates to a coupled biotransformation process of converting chenodeoxycholic acid (CDCA) and related compounds to ursodeoxycholic acid (UDCA) and related compounds. It also relates to the cloning, expression, and b...
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WO/2017/220486A3 |
The present invention relates to a coupled biotransformation process of converting chenodeoxycholic acid (CDCA) and related compounds to ursodeoxycholic acid (UDCA) and related compounds. It also relates to the cloning, expression, and b...
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WO/2017/214919A1 |
Provided are mycobacterium genetically-engineered bacteria and applications thereof in the preparation of a steroidal compound. The mycobacterium genetically-engineered bacteria are mycobacteria lacking of all of acyl-CoA dehydrogenase f...
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WO/2017/150723A1 |
Algae that generates a sterol and a sterol production method that uses the algae. According to the present invention, a sterol is produced by culturing algae, such as strain AJ7867 (FERM BP-22304) and strains derived therefrom, that has ...
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WO/2017/119795A1 |
The present invention relates to a novel Lactobacillus casei GFC1 strain (deposit number: KFCC18333P), a fermented ginseng extract using the strain, and a preparation method thereof. When the novel Lactobacillus casei GFC1 strain (deposi...
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WO/2017/108799A1 |
The present invention is related to production of a sterol mix in a modified yeast cell, wherein the amount of zymosterol present in said mix is dramatically reduced or abolished via modification of sterol acyltransferase activity within...
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WO/2017/089408A1 |
The present invention relates to an enzymatic method for producing deconjugated bile acids from bile.
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WO/2017/075257A3 |
Disclosed herein are compounds having structural Formula (I), or salts thereof. These compounds are useful as sweet tasting agents and/or sweetness enhancers. Also disclosed are compositions comprising the present compounds and methods o...
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WO/2017/075257A2 |
Disclosed herein are compounds having structural Formula (I), or salts thereof. These compounds are useful as sweet tasting agents and/or sweetness enhancers. Also disclosed are compositions comprising the present compounds and methods o...
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WO/2017/069565A1 |
The present invention relates to a method for selectively producing ginsenoside Rd, which is originally present in a trace amount in ginseng, from panaxadiol-based saponins in ginseng and, more specifically, to a method capable of obtain...
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WO/2017/069561A1 |
The present invention relates to a method for selectively producing ginsenoside F2, compound Mc, and compound O, which is originally present in ginseng in trace amounts, from saponins of ginseng and, more specifically, to a method capabl...
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WO/2017/069569A1 |
The present invention relates to a method for selectively producing compound K and compound Y, which are originally present in trace amounts in ginseng, from saponins of ginseng and, more specifically, to a method capable of obtaining de...
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WO/2017/057851A1 |
The present invention relates to a ginsenoside fatty acid ester compound, a method for preparing same, and a cosmetic composition comprising same and, more specifically, to a ginsenoside fatty acid ester compound, modified into a fatty a...
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WO/2017/057852A1 |
The present invention relates to a ginsenoside fatty acid ester compound, a method for preparing same, and a cosmetic composition comprising same and, more specifically, to a ginsenoside fatty acid ester compound, modified into a fatty a...
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WO/2017/020143A1 |
Provided is a method of biosynthesizing a functional lipid using a nano-magnetically immobilized enzyme for continuous targeted catalysis of a phospholipid in soybean oil, comprising: applying nano-magnetically immobilized phospholipid e...
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WO/2016/119756A1 |
Provided are a mutant protein of glycosyltransferase and uses thereof. Specifically, by using homology alignment and site-directed mutagenesis, a new mutant protein of glycosyltransferase is discovered. The mutant protein is a non-natura...
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WO/2016/090622A1 |
Provided are a hydroxyacyl-coenzyme A dehydrogenase gene and an acyl-coenzyme A thiolase gene, and a genetically-engineered bacteria and a use thereof. The hydroxyacyl-coenzyme A dehydrogenase gene encodes a protein (i) or (ii) as follow...
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WO/2016/066738A1 |
Generally, the present invention relates to the field of steroid hydroxylation. More specifically, the present invention relates to a method for the 21-hydroxylation of steroids in cells. It also relates to cells expressing a steroid 21-...
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WO/2016/064007A1 |
The present invention relates to: a method for producing rubusoside from stevioside by using a Lactobacillus plantarum strain, which is a type of Lactobacillus; a composition, to be used in the method, for producing rubusoside, containin...
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WO/2016/056610A1 |
The present invention provides a method for manufacturing 7-dehydrocholesterol (7-DHC), the method being characterized by culturing, in a culture medium, a labyrinthulean micro-organism that produces 7-DHC and that has decreased stero...
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WO/2016/050890A3 |
Methods for recombinant and enzymatic production of mogroside compounds and compositions containing mogroside compounds are provided by this invention.
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WO/2016/042267A1 |
The invention concerns a method for producing a compound of interest of the sterol biosynthesis pathway in a eukaryotic organism or a derivative of a compound of the sterol biosynthesis pathway in said eukaryotic organism, in particular ...
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WO/2016/039359A1 |
The present invention relates to: a terpenoid derivative which is capable of activating a Keap1/Nrf2/ARE signaling pathway and has an excellent anti-inflammatory activity and an excellent cell-protecting activity; and a sustained-release...
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WO/2016/023933A1 |
The invention relates to novel 3α-hydroxysteroid dehydrogenase mutants, to sequences which code for these enzyme mutants, to methods for producing the enzyme mutants, and to the use thereof in enzymatic reactions of cholic acid compound...
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WO/2016/016213A1 |
The invention relates to novel 7β-hydroxysteroid dehydrogenase mutants, to sequences encoding said enzyme mutants, to methods for the preparation of the enzyme mutants and to their use in enzymatic reactions of cholic acid compounds, an...
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WO/2016/013030A3 |
The present invention relates to novel steroidal compounds of formula (I), process for preparation of the same and composition comprising these compounds.
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WO/2015/200831A3 |
The present disclosure relates generally to the identification of enzymes within the cyclopamine biosynthesis pathway as well as to engineering transgenic plants or organisms for the production of cyclopamine.
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WO/2015/197698A3 |
The invention relates to novel biocatalytic processes, comprising the whole cell reduction of dehydrocholic acid (DHCS) compounds, novel 7ß-hydroxysteroid dehydrogenase mutants, to the sequences encoding said enzyme mutants, to methods ...
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WO/2015/197698A2 |
The invention relates to novel biocatalytic processes, comprising the whole cell reduction of dehydrocholic acid (DHCS) compounds, novel 7ß-hydroxysteroid dehydrogenase mutants, to the sequences encoding said enzyme mutants, to methods ...
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WO/2015/188742A3 |
A group of glycosyltransferases and a use thereof are disclosed in the present invention. Specifically, the use of glycosyltransferase gGT29-7 and a polypeptide derived therefrom in catalytic glycosylation of a terpenoid and in synthesiz...
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WO/2015/188742A2 |
The present invention relates to a group of glycosyltransferases and a use thereof. Specifically, the use of glycosyltransferase gGT29-7 and a polypeptide derived therefrom in catalytic glycosylation of a terpenoid and in synthesizing ne...
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WO/2015/167282A1 |
The present invention relates to a uridine diphosphate (UDP)-glycosyltransferase protein which has glycosylation activity for a hydroxyl group at the C-20 position of a protopanaxadiol (PPD)- or protopanaxatriol (PPT)-type ginsenoside, a...
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WO/2015/162305A1 |
The present invention relates to a recombinant microorganism which is capable of expressing a cytochrome P450 reductase (CPR) and, optionally, a cytochrome P450 enzyme (CYP) and which is capable of overexpressing a Ice2p comprising the a...
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WO/2015/131798A1 |
Provided is a nicotinamide adenine dinucleotide (NADPH)-cytochrome P450 reductase and a use thereof. Also provided is a polynucleotide encoding the NADPH-cytochrome P450 reductase, an expression vector and a host cell which express the N...
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WO/2015/128534A1 |
The invention relates to bacterial strains of the species M. smegmatis with the activity 3-ketosteroid-9α-hydroxylase inactivated or with the activities 3-ketosteroid-9α-hydroxylase and 3-ketosteroid-∆1-dehydrogenase, and to the use ...
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WO/2015/115775A1 |
The present invention relates to a method for bioconverting ginsenoside Rb1 into ginsenoside F2 by using Ralstonia pickettii LSA71 strain. Particularly, the Ralstonia pickettii LSA71 strain isolated from Codonopsis lanceolata rhizosphere...
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WO/2015/111155A1 |
An 11β-hydroxysteroid such as hydrocortisone is produced using protein (a1), (b1), or (c1). (a1) A protein containing an amino acid sequence of SEQ ID NO: 43. (b1) A protein containing an amino acid sequence in which one or several amin...
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WO/2015/108058A1 |
The present invention provides a method for manufacturing 7-dehydrocholesterol, the method being characterized by deleting, replacing or adding at least one base in a gene that is present on the chromosomal DNA in a parent strain and ...
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WO/2015/102022A3 |
The present invention relates to an improved process for the preparation of abiraterone acetate. More specifically the invention relates to a process for the preparation of abiraterone acetate free from dimer and other impurities.
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