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WO/2020/222717A1 |
The invention is related to an AG-08 coded novel structured molecule having cytotoxic features against cancer cells. The aim of the invention is to primarily synthesize the astragenol (AG) molecule from cycloastragenol (CA) and then from...
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WO/2020/215265A1 |
A method for preparing a mixture of rare ginsenosides Rh3 and Rk2 and a mixture thereof. In the method, Rg3 is used as a raw material, β-glucosidase is used for enzymatic preparation, an acidification reaction is performed after an enzy...
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WO/2020/161317A1 |
The present invention concerns a genetically modified bacterium and to its industrial application, in particular in the 1,2-dehydrogenation of steroids.
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WO/2020/155058A1 |
A method for preparing a radix codonopsis extract from a radix codonopsis leftover material, comprising: first adding water, cellulose, and β-glucosidase in the radix codonopsis leftover material; uniformly mixing and carrying out enzym...
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WO/2020/137706A1 |
[Problem] The purpose of the present invention is to provide a new method for producing a cycloastragenol analog from astragaloside IV. {Solution] A method for producing a cycloastragenol analog that includes a contact step that brings a...
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WO/2020/108327A1 |
A method of preparing tauroursodeoxycholic acid by biotransformation and an application thereof, comprising genetic codon optimization, engineered bacteria construction, engineered bacteria cultivation, substrate transformation, and prod...
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WO/2020/096905A1 |
Provided herein include methods of making mogroside compounds, e.g., Compound 1, compositions (for example host cells) for making the mogroside compounds, and the mogroside compounds made by the methods disclosed herein, and compositions...
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WO/2020/097588A1 |
Described in this application are enzymes (e.g., cucurbitadienol synthases (CDS), UDP- glycosyltransferases (UGT), C11 hydroxylases, epoxide hydrolases (EPH), squalene epoxidases, and/or cytochrome P450 reductases), host cells expressing...
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WO/2020/096907A1 |
Provided herein include methods of making mogroside compounds, e.g., Compound 1, compositions (for example, host cells) for making mogroside compounds, and the mogroside compounds made by the methods and compositions disclosed herein, co...
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WO/2020/076819A1 |
Genetically-modified cell capable of producing UDCA, cholic acid, and/or another UDCA precursor comprising at least one heterologous polynucleotide encoding an enzyme involved in a metabolic pathway that converts sugar to UDCA, cholic ac...
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WO/2020/072908A1 |
Aspects of the invention provide methods for producing one or more secondary metabolites from microbial culture. In various embodiments, the method comprises culturing a microbial cell producing a secondary metabolite for recovery from a...
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WO/2020/030799A1 |
A genetically-modified bacterium, for example of the class Actinobacteria, and the use of such a bacterium in the bioconversion of a steroidal substrate into a steroidal product of interest. A method of converting a steroidal substrate i...
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WO/2020/027456A1 |
The present invention relates to a novel Ceriporia lacerata-K1 strain (accession number KACC 83018BP, a culturing method therefor, and a composition comprising a culture thereof as an effective ingredient for prevention or treatment of d...
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WO/2020/022847A1 |
The present invention relates to a recombinant yeast strain having sterol productivity, a preparation method therefor and a use thereof and, more specifically, to: a recombinant yeast strain capable of producing cholesterol and cholester...
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WO/2019/182318A9 |
The invention relates to a method for preparing compound K by using ginseng sprouts, and an antioxidative and antibacterial composition containing compound K prepared thereby. In the present invention, various ginsenosides contained in g...
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WO/2019/224189A1 |
The present invention is related to an improved method for production of 7- dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention feature...
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WO/2019/224190A1 |
The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features...
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WO/2019/224188A1 |
The present invention is related to modified sterol acyltransferase enzymes with improved activity and/or specificity towards acylation of the vitamin D3 precursor 7-dehydrocholesterol (7-DHC) to be used in biotechnological production of...
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WO/2019/224187A1 |
The present invention is related to modified sterol acyltransferase enzymes with improved activity and/or specificity towards acylation of the vitamin D3 precursor 7-dehydrocholesterol (7-DHC) to be used in biotechnological production of...
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WO/2019/169027A3 |
The present invention provides host cells and methods for making mogrol glycosides, including Mogroside V (Mog. V), Mogroside VI (Mog. VI), Iso-Mogroside V (Isomog. V), and glycosylation products that are minor products in Siraitia grosv...
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WO/2019/178980A1 |
A method for preparing gynostemma pentaphylla makino saponin LVI, XLVI, L, LI, Damulin A or Damulin B. In said method, Gynostemma cardiospermum Cogn.ex Oliv is used as a raw material to prepare a high content of target product by means o...
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WO/2019/182318A1 |
The invention relates to a method for preparing compound K by using ginseng sprouts, and an antioxidative and antibacterial composition containing compound K prepared thereby. In the present invention, various ginsenosides contained in g...
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WO/2019/169027A2 |
The present invention provides host cells and methods for making mogrol glycosides, including Mogroside V (Mog. V), Mogroside VI (Mog. VI), Iso-Mogroside V (Isomog. V), and glycosylation products that are minor products in Siraitia grosv...
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WO/2019/163601A1 |
The purpose of the present invention is to provide a transgenic plant in which 7-dehydrocholesterol, which is a precursor to active VD3, is produced in an increased amount, and a technique for using the same. This problem is solved by pr...
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WO/2019/136924A1 |
A method for promoting the suspension cell growth of momordica grosvenori and improving the content of mogroside V by means of salt stress, comprising: controlling the concentration of potassium ions to be 100-2,000 mg/kg in a process of...
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WO/2019/114157A1 |
Provided is a method for enzymatically converting and producing 9α-hydroxyandrost-4-ene-3,17-dione, the method comprising the steps of: expressing, in E. coli BL21, an oxidative subunit KshA, a reductive subunit KshB, and a subunit KshC...
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WO/2019/104608A1 |
Disclosed is a method for the enzyme catalysis synthesis of ginsenoside Rh2. The method produces ginsenoside Rh2 by using ginsenoside Rg3 as a substrate, and adding a glucosidase derived from Terrabacter ginsenosidimutans to perform a ca...
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WO/2019/078359A1 |
Provided is a method for producing a sterol. A sterol is produced by culturing a microorganism of the class Labyrinthulomycetes, which is capable of producing the sterol and has been modified so as to lower the activity of 24-dehydrochol...
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WO/2019/078410A1 |
The present invention relates to a method for preparing ginsenosides 20(S)-Rg3 or 20(S)-Rh2 by using a novel ginsenoside glycosidase, in order to obtain, with high efficiency, a highly pure ginsenoside 20(S)-Rg3 or 20(S)-Rh2. The prepara...
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WO/2019/017722A3 |
The present invention relates to a method for producing a ginsenoside from a Gynostemma pentaphyllum-derived adventitious root. Specifically, the present invention relates to a method for producing a ginsenoside from a Gynostemma pentaph...
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WO/2018/234479A3 |
The present invention relates to a method for preparing bile acid derivatives with a protected hydroxyl group in position 3, the method comprising the contacting of a bile acid derivative, having an unprotected 3-alpha-hydroxyl group, wi...
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WO/2019/025029A3 |
The present invention relates to the provision of an enzymatic method for the preparation of 1 β, 3α,7α,12α-tetrahydroxy bile acid (Formula I). The enzymatic method of the present invention is advantageous over conventional synthetic...
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WO/2019/017722A2 |
The present invention relates to a method for producing a ginsenoside from a Gynostemma pentaphyllum-derived adventitious root. Specifically, the present invention relates to a method for producing a ginsenoside from a Gynostemma pentaph...
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WO/2019/010971A1 |
A preparation method for dehydroepiandrosterone, comprising: in a protective atmosphere, adding potassium tert-butoxide to tert-butanol, stirring evenly, adding 4-androstenedione to obtain a mixture, and adding the mixture dropwise to a ...
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WO/2019/012095A1 |
The invention relates to ketoreductases and the use thereof. The ketoreductases of the invention are particularly useful for enzymatically catalyzing the reduction of ketones to chiral or non-chiral secondary alcohols and oxidation of ch...
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WO/2018/234479A2 |
The present invention relates to a method for preparing bile acid derivatives with a protected hydroxyl group in position 3, the method comprising the contacting of a bile acid derivative, having an unprotected 3-alpha-hydroxyl group, wi...
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WO/2018/227644A1 |
Provided is a method for catalyzing steroidal biological transformation. In the method, sodium alginate-grafted cyclodextrin immobilized cells are used as a catalyst, so as to implement the cyclic utilization of a cyclodextrin medium, th...
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WO/2018/204483A3 |
Provided herein include methods of making mogroside compounds, e.g., Compound 1, compositions (for example host cells) for making the mogroside compounds, and the mogroside compounds made by the methods disclosed herein, and compositions...
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WO/2018/227940A1 |
A method for preparing ursodeoxycholic acid via a chemical-enzymatic process, comprising: adding hyodeoxycholic acid to a first organic solvent, and oxidising under the effect of an oxidising agent to obtain 6-oxo-lithocholic acid; addin...
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WO/2018/210208A1 |
Provided are a glycosyltransferase, a mutant, and an in vitro glycosylation method. The method comprises the steps of: transferring a glycosyl group of a glycosyl donor to a hydroxyl group at the C-3 position of a tetracyclic triterpenoi...
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WO/2018/204483A2 |
Provided herein include methods of making mogroside compounds, e.g., Compound 1, compositions (for example host cells) for making the mogroside compounds, and the mogroside compounds made by the methods disclosed herein, and compositions...
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WO/2018/133844A1 |
The present invention provides a cytochrome P450 mutant protein and applications thereof. In particular, in the present invention, after the modification of key sites in the cytochrome P450 CYP716A47, the PPD production and the PPD/DM pr...
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WO/2018/126468A1 |
The present invention relates to a preparing method for an ursodesoxycholic acid by using a biological enzyme catalysis technology and 7β-hydroxysteroid dehydrogenase for preparation of the ursodesoxycholic acid. The method uses a 3α-h...
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WO/2018/126469A1 |
The present invention relates to a method for preparing ursodeoxycholic acid by using a biological enzyme catalysis technique and a 7β-steroid dehydrogenase for use in the preparation thereof. The method uses 3α-hydroxy-7 oxo-5β-chola...
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WO/2018/126466A1 |
The present invention relates to a method utilizing a biological enzyme catalysis technique for preparing 3α-hydroxy-7-oxo-5β-cholanoic acid and a 7α-steroid dehydrogenase for use in preparation thereof. The method uses chenodeoxychol...
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WO/2018/126467A1 |
A method which uses biological enzyme catalysis to prepare 3α-hydroxy-7-oxo-5β-cholanoic acid and 7α-steroid dehydrogenase for the preparation thereof. The method uses chenodeoxycholic acid as a substrate; in the presence of NAD, lact...
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WO/2018/120983A1 |
Provided are a Glycyrrhetinic acid-producing recombinant yeast strain, specifically the strain of deposit number CGMCC 13126, a preparation method for the strain, and uses of the strain in producing Glycyrrhetinic acid. The strain overex...
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WO/2018/062904A1 |
Disclosed are a composition for production of ginsenoside compound K using a high temperature-β-glycosidase and a high temperature-α-L-arabinofuranosidase, and a method for preparing ginsenoside compound k. The composition for producin...
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WO/2018/045946A1 |
A Poria cocos fermentation product. On the basis of the total weight of the Poria cocos fermentation product, the total amount of the following compounds (1) to (12) is no less than 0.15% by weight: (1) pachymic acid (PA), (2) dehydropac...
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WO/2018/036982A1 |
The invention relates to a further chemical-biocatalytic method for producing ursodeoxycholic acid from chenodeoxycholic acid after chemical oxidation to 3,7-diketo-ursodeoxycholic acid and after subsequent reaction with 7 beta-hydroxyst...
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