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Matches 101 - 150 out of 568

Document Document Title
WO/1998/048035A1
The present invention discloses a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.  
WO/1998/048034A1
The present invention discloses a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.  
WO/1998/048037A1
The invention relates to a method for controlling the solubility of a $g(b)-lactam nucleus having general formula (I) wherein R�0? is hydrogen or C�1-3? alkoxy; Y is CH�2?, oxygen, sulfur, or an oxidized form of sulfur; and Z is (a...  
WO/1998/039459A1
The invention relates to promoters of the genes glutamate desydrogenase, $g(b)-acetylhexosaminidase and $g(g)-actine and their use in systems of expression, secretion and anti-sens of filamentary funghi. The invention also relates to the...  
WO/1998/037179A2
The present invention describes the use of chemically defined media for the fermentative production of valuable compounds on an industrial scale. Microbial strains which are suitable for fermentation on an industrial scale using a chemic...  
WO/1998/027221A1
The present invention discloses a fermentative process for the production of penicillin G or V or cephalosporin G or V derivatives wherein certain derivatives of phenylbutyric acid are used as a side chain precursor. In said phenylbutyri...  
WO/1998/020120A1
New mutant penicillin G acylases preferably from $i(E. coli) are provided, exhibiting altered enzymatic activity. These penicillin G acylases are obtained by expression of a gene encoding said penicillin G acylase having an amino acid se...  
WO/1998/016648A2
A three-dimensional structure is described of a complex of isopenicillin N synthase (IPNS) with Fe and its substrate ACV. This structure is used to design modified enzymes IPNS, DAOCS, DACS, DAOC/DACS and other related enzymes of the pen...  
WO/1998/004732A1
Disclosed is a process for the synthesis of $g(b)-lactam antibacterials using soluble side chain esters in the presence of enzyme acylase. Also disclosed are novel esters useful as reactants in said process.  
WO/1998/002567A2
The present invention describes a process wherein $i(Acremonium) is used as a suitable and convenient organism for the production of N-acylated cephalosporin derivatives. In the process of the invention, a recombinant, acyltransferase-ex...  
WO/1998/002551A2
An improved process for the preparation of adipoyl cephalosporins via enzymatic ring expansion of adipoyl-6-aminopenicillinic acid, using a $i(Penicillium chrysogenum) transformant strain expressing modified expandase enzyme.  
WO/1997/040171A1
Process for producing the enzyme D-aminoacido oxydase of Rhodotorula gracilis in host cells. The process for the expression of the enzyme comprises isolating the complementary DNA corresponding to the messager RNA of the gene which codes...  
WO/1997/034902A1
The invention discloses a purification process through ultrafiltration and/or nanofiltration with the exclusion of molecular weights higher than 10,000 Dalton and preferably higher than 2,000 Dalton. By using this technique it is possibl...  
WO/1997/022610A1
The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a 'beta'-lactam core is acylated, the antibiotic i...  
WO/1997/020053A2
An overall process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a modified expandase enzyme.  
WO/1996/038580A1
An overall process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a Penicillium chrysogenum transformant strain expressing expandase.  
WO/1996/030540A2
Substrates for 'beta'-lactamase of general formula (I) in which one of X and Y is a fluorescent donor moiety and the other is a quencher (which may or may not re-emit); R' is selected from the group consisting of H, lower (i.e., alkyl of...  
WO/1996/023797A1
Process for the recovery of a 'beta'-lactam antibiotic from a mixture containing the ammonium salt of the 'beta'-lactam antibiotic and the ammonium salt of the corresponding 'beta'-lactam core by subjecting the mixture to a physical trea...  
WO/1996/023897A1
The invention relates to a process for the preparation of a 'beta'-lactam antibiotic by enzymatic acylation of a 'beta'-lactam core by means of an acylation agent, with the molar ratio between the 'beta'-lactam core and the acylation age...  
WO/1996/023796A1
Process for the recovery of cephalexin from a mixture containing cephalexin and 7-aminodesacetoxy cephalosporanic acid (7-ADCA), wherein a mixture of cephalexin and 7-ADCA, with a pH higher than 7, which apart from any solid cephalexin b...  
WO/1996/019569A1
An enzyme preparation that exhibits cephalosporin haloperoxidase activity is isolatable from a microorganism species of the Rathayibacter genus. This enzyme preparation can convert cephalexin to a halogenated cephalosporin antibiotic in ...  
WO/1996/016174A2
The present invention relates to an enzyme process for the one-step conversion of cephalosporin C or a derivative thereof into 7-aminocephalosporanic acid or a corresponding derivative thereof. The one-step conversion is effected using a...  
WO/1996/012031A1
According to the present invention, a process for the preparation of cyclosporin A comprising the steps of adding lower alkanol solvent to a culture fluid of a mutant of Tolypocladium inflatum and extracting the mixture; transferring the...  
WO/1996/010085A1
The present invention relates to biosynthesis 'beta'-lactam antibiotics. More specifically, the invention relates to processes of producing 'beta'-lactam antibiotics in vivo and in vitro. Also contemplated is a novel enzyme capable of ca...  
WO/1996/005318A1
New mutant 'beta'-lactam Penicillin G acylases are provided, exhibiting altered substrate specificities. These Penicillin G acylases are obtained by expression of a gene encoding said Penicillin G acylase and having an amino acid sequenc...  
WO/1996/002663A1
'beta'-Lactam derivatives can advantageously by synthesized by an enzymatic reaction of the parent amino 'beta'-lactam with the corresponding acylating agent at constantly high concentrations of said reactants.  
WO/1995/034675A1
The present invention provides an improved method for enzymatic acylation to prepare semisynthetic 'beta'-lactam antibiotics by the application of modulators to suppress the hydrolysis of the acylating agent more than the synthesis of th...  
WO/1995/029253A1
DNA encoding the late enzymes involved in the synthesis of the antibiotic cephamycin have been isolated and purified. The particular enzymes are involved in the late steps of cephamycin biosynthesis. These DNA's have been sequenced and c...  
WO/1995/012680A1
A mutant CC acylase wherein at least one amino acid at the A1a49, Met164, Ser166, Met174, Glu358, Met465, Met506, or Met750 position of the animo acid sequence of the native CC acylase is replaced by a different amino acid, a DNA coding ...  
WO/1995/004148A1
An overall efficient process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via 2-(carboxyethylthio)acetyl- and 3-(carboxymethylthio)propionyl-7-ADCA, using a Penicillium chrysogenum transformant strai...  
WO/1995/004149A1
An overall efficient process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via 3-(carboxyethylthio)propionyl-7-ADCA, using a Penicillium chrysogenum transformant strain expressing expandase in conjunc...  
WO/1995/003420A1
Process for the preparation of a beta-lactam derivative, wherein in an enzymatic reaction a beta-lactam nucleus is coupled to D-phenylglycine amide, and the enzyme, the solid phenylglycine and the beta-lactam derivative are separated out...  
WO/1994/018209A1
Provided is a process for isolating cefaclor from an acylation reaction mixture by adding anthraquinone-1,5-disulfonic acid to the mixture. The acid highly selectively precipitates with cefaclor so that isolation and recovery is streamli...  
WO/1993/023164A1
The present invention relates to a method of separating a particulate solid catalyst from a chemical reaction mixture which further comprises at least one other solid component, either during the reaction or after the reaction.  
WO/1993/012250A1
The present invention relates to an improved method for the preparation of certain $g(b)-lactam antibiotics by enzymatic acylation or by deprotection of a protected intermediate.  
WO/1993/008287A1
Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed $i(Penicillium chrysogenum)...  
WO/1993/005158A1
An important intermediate for preparing cephalosporin antibiotics, 7-aminodesacetoxy cephalosporanic acid (7-ADCA), is prepared by a novel bioprocess in which a transformed $i(Penicillium chrysogenum) strain is cultured in the presence o...  
WO/1993/004188A1
Described is a method for the fermentative production of cephalosporin C, the fermentation solution being filtered during fermentation through a cross-flow filtration system. The filtrate obtained from the fermenter can be used again.  
WO/1992/017600A1
An enzymatic means for hydrolyzing the ester of certain cephalosporins is provided herein.  
WO/1992/017496A1
The invention relates to a DNA sequence with a nucleotide sequence encoding a polypeptide in a host cell having Cephalosporin C synthetase (DAC acetyltransferase) activity which is the last enzyme in the synthesis of cephalosporins. Embo...  
WO/1992/012782A1
The present invention relates to a process for separating, from each other, one non-dissolved catalyst from one or more other non-dissolved components present in a reaction mixture. The separation is obtained by using a catalyst having a...  
WO/1992/001061A1
beta-Lactam derivatives are synthesized by an enzymatic reaction of the parent amino beta-lactam with the corresponding acylating agent, the concentration of the acylating agent plus the concentration of beta-lactam derivative in the rea...  
WO/1991/019788A1
A new oxido reductase enzyme activity obtainable from P. chrysogenum, involved in the production of beta-lactams, the set of genes encoding said enzyme activity, and a method to enhance said production by using the above-mentioned oxido ...  
WO/1991/009136A1
Synthesis of semi-synthetic monobactamic or beta-lactamic antibiotics by using derivatives stabilized by various methods of penicillin G acylase from various microbial sources according to a thermodynamically controlled strategy in monop...  
WO/1990/012110A1
An enzymatic process for the production of 7-amino cephalosporanic acid from cephalosporine C is disclosed. The process is a two-stage enzymatic reaction which can be performed in a single reactor. The invention further includes a mutant...  
WO/1988/000203A1
The extraction of water soluble antibiotics containing a phenolic or carboxylic group from an aqueous solution or fermentation broth using a N-C8-C14 alkyl pyrrolidone extractant and the process involving the extraction of said antibiotic.  
WO/1986/004087A1
A Trigonopsis variabilis D-amino acid oxidase in substantially pure form and active against cephalosporin C. This D-amino acid oxidase is isolated from Trigonopsis variabilis by a method which is performed in three steps, namely: (a) aci...  
JP2023095798A
To develop CPC acylase with an excellent enzymatic activity for cephalosporin C (CPC).Disclosed herein are a polypeptide having a cephalosporin C (CPC) acylase activity and use thereof. More specifically, provided are a mutant CPC acylas...  
JP6046941B2
The present invention relates to host cells transformed with a nucleic acid sequence encoding a eukaryotic xylose isomerase obtainable from an anaerobic fungus. When expressed, the sequence encoding the xylose isomerase confers to the ho...  
JP6048980B2
The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least 75% sequence identity to the amino acid sequence set out in SEQ ID NO...  

Matches 101 - 150 out of 568