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WO/2012/175585 |
The present invention relates to a process for the preparation of 3'-thiosubstituted cephalosporins by enzymatic condensation of a nucleus with a phenylglycine derivative. Furthermore the present invention relates to a crystalline form o...
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WO/2012/175587 |
The present invention relates to a crystalline form of an intermediate for cefoperazone of formula (1 ) and to a process for the preparation thereof by enzymatic condensation of a 3'-thiosubstituted β-lactam nucleus with a phenylglycine...
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WO/2012/175587 |
The present invention relates to a crystalline form of an intermediate for cefoperazone of formula (1 ) and to a process for the preparation thereof by enzymatic condensation of a 3'-thiosubstituted β-lactam nucleus with a phenylglycine...
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WO/2012/113120 |
A new nucleotide sequence of xylose isomerase obtained from the metagenomic library of cattle rumen liquor and the amino acid sequence encoded thereof, vectors and transformants containing the said nucleotide sequence are provided. The s...
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WO/2011/161004 |
The present invention relates to an industrial scale fermentation process for the production of valuable compounds using microorganisms wherein ≥50% of the total energy input is delivered by injection of an oxygen containing gas and â‰...
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WO/2011/073166 |
The invention relates to a process for preparing cephradine, said process comprising converting D-dihydrophenylglycine (DHPG) into an activated form (DHPGa); and reacting 7-aminodesacetoxy-cephalosporanic acid (7-ADCA) with D- dihydrophe...
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WO/2011/073166 |
The invention relates to a process for preparing cephradine, said process comprising converting D-dihydrophenylglycine (DHPG) into an activated form (DHPGa); and reacting 7-aminodesacetoxy-cephalosporanic acid (7-ADCA) with D- dihydrophe...
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WO/2011/062563 |
Epithelial cell transforming sequence 2 (Ect2) is a potential oncogene. Our invention uncovers key mechanisms of Ect2 oncogenicity and the development of a relevant therapies by modulation of Ect2 expression.
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WO/2010/115838 |
The present invention describes a process for the production of a valuable compound comprising a fermentation of a microbial strain on industrial scale comprising a non-repressing C-source and feeding at least one growth rate limiting nu...
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WO/2010/072765 |
The present invention relates to a mutant prokaryotic penicillin G acylase derived from a wild-type penicillin G acylase characterized in that the mutant is having an amino acid substitution at one or more amino acid positions selected f...
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WO/2010/072765 |
The present invention relates to a mutant prokaryotic penicillin G acylase derived from a wild-type penicillin G acylase characterized in that the mutant is having an amino acid substitution at one or more amino acid positions selected f...
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WO/2010/055527 |
The present invention provides a stable and viable biocatalyst with high activity and operational stability and method of immobilization thereof. The immobilization process is based on the principle of entrapment of partially purified en...
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WO/2009/092727 |
Genetically modified Saccharomyces having the ability to synthesize non-ribosomal peptides and precursors thereof.
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WO/2009/016642 |
The present invention discloses isolation of Penicillin Acylase (PA) from Achromobacter sp CCM 4824 expressed in recombinant strain E. coli BL21 CCM 7394 bearing the recombinant plasmid pKXIPl and processing of PA into biocatalyst useful...
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WO/2009/013611 |
The present invention relates to a modified esterase with enhanced deacetylation activity for 7-ACA or its acyl amino derivative and cephalosporin C for the production of HACA and 3-deacetyl cephalosporin C, respectively, which carries o...
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WO/2008/110527 |
The present invention describes a process for the synthesis of a semi-synthetic β-lactam compound from a nucleus and a side chain selected from the group consisting of D-phenylglycine and D-dihydro-phenylglycine in the form of a side ch...
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WO/2007/096419 |
The present invention relates to a cephalosporin-producing microorganism characterized in that it has been transformed with a heterologous CefT gene and whereby the ratio of the cephalosporin production capacity of the microorganism tran...
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WO/2007/051355 |
A DNA sequence is for a recombinant D-amino acid oxidase with catalytic activity on cephalosporin C that is not less than 25% higher than that of its parent.
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WO/2007/038169 |
Disclosed herein are guanidinium containing compounds consisting of a core moiety with a plurality of side chains containing guanidinium groups. Such compounds have enhanced translocation across cellular membranes and epithelial tissues....
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WO/2007/038169 |
Disclosed herein are guanidinium containing compounds consisting of a core moiety with a plurality of side chains containing guanidinium groups. Such compounds have enhanced translocation across cellular membranes and epithelial tissues....
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WO/2007/023369 |
ABSTRACT The present invention relates to a mutant expandase-hydroxylase with increased activity and greater substrate specificity for Penicillin G and Phenyl acetyl 7-ADCA for the production of Phenyl acetyl - 7-ADCA and Deacetyl phenyl...
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WO/2007/016860 |
The present invention discloses Escherichia coli expression vector, as well as a method for steadily, high-efficiently expressing a required target protein in Escherichia coli using the expression vector. The expression vector is constru...
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WO/2007/016861 |
The present invention discloses a two-steps enzyme method for preparing 7-aminocephalosporanic acid from cephalosporin C, Wherein D-amino acid oxidase used is D-amino acid oxidase mutant of purified yeast Trigonopsis Variabilis, which ha...
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WO/2006/069984 |
The present invention relates to a process for the synthesis of cefaclor, which process comprises reacting 7-amino-3-chloro cephalosporanic acid (7-ACCA) with D- phenylglycine in activated form (PGa) in the presence of an enzyme in a rea...
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WO/2006/069984 |
The present invention relates to a process for the synthesis of cefaclor, which process comprises reacting 7-amino-3-chloro cephalosporanic acid (7-ACCA) with D- phenylglycine in activated form (PGa) in the presence of an enzyme in a rea...
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WO/2006/061425 |
The present invention describes the transformation of a microorganism that does not naturally produce a beta-lactam compound with polynucleotides involved in the biosynthesis of beta-lactam compounds and the use of such transformed micro...
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WO/2006/040313 |
The present invention relates to a mutant expandase that is a variant of a model polypeptide with expandase activity whereby the mutant expandase has an at least 2-fold improved in vitro expandase activity towards adipyl-6-APA in compari...
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WO/2005/075652 |
It is intended to produce a modified peptide having an enhanced glutaryl-7-aminosephalosporanic acid (GL-7-ACA) acylase activity (i.e., a modified GGT) by using &gammad -glutamyltranspeptidase (GGT) which is an enzyme widely occurring in...
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WO/2005/054452 |
The invention relates to a new class of isolated, single or multiple mutated glutaryl amidases from Pseudomonas SY-77, or a functional part, derivative or analogue thereof. The invention also relates to a method for preparing 7-aminoceph...
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WO/2005/019468 |
Deacetoxy/deacetylcephalosporin C synthase (DAOC/DACS) modified to reduce the hydroxylation activity and in particular DAOC/DACS modified to reduce the hydroxylation activity and further modified to improve the ring expanding activity.
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WO/2005/014821 |
A CPC acylase mutant of the present invention has an improved reactivity and specific activity to CPC, which can be efficiently employed for directly preparing 7-ACA from CPC by a one-step enzymatic method.
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WO/2005/003367 |
The present invention describes a process for preparing cephradine, said process comprising reacting 7-aminodesacetoxy cephalosporanic acid (7-ADCA) with D-dihydrophenylglycine in activated form (DHa) in the presence of an enzyme in a re...
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WO/2004/113508 |
The invention is concerned with a bioprocess for the production of a ceph-3-em compound selected from the group consisting of desacetoxycephalosporin C, deacetylcephalosporin C and cephalosporin C in P. chrysogenum. The invention is also...
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WO/2004/111241 |
The present invention relates to a novel enzyme having Penicillin G acylase activity, characterised by a. an initial Synthesis/Hydrolysis ratio (S/Hini) of at least 50% above the S/Hini of Penicillin G acylase of E. coli and b. an initia...
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WO/2004/069848 |
This invention provides amidases, polynucleotides encoding the amidases, methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides enzymes having secondary amidase activity, e.g., having ac...
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WO/2004/069848 |
This invention provides amidases, polynucleotides encoding the amidases, methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides enzymes having secondary amidase activity, e.g., having ac...
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WO/2004/062558 |
The present invention describes a process for the preparation of β-lactam antibiotics, cephalexin and ampicillin, wherein the β-lactam nucleus is acylated with an acylating agent, D-phenylglycine, by means of a reaction biocatalyzed by...
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WO/2004/050893 |
The invention relates to a method for producing cephalexin with the aid of a penicillin amidase that is immobilized on a pearl-shaped, cross-linked and hydrophilic copolymer that binds to ligands having nucleophilic groups.
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WO/2004/039997 |
A process for preparing the 7-(1-H-tetrazol-1-yl) acetamide-3-(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl-3-cep
hem-4-carboxylic acid or cefazolin, comprising catalysing the acylation of the amino β-lactam, the 7-amino-3-[5methyl-1,3,4-t...
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WO/2004/026902 |
The present invention relates to isolated nucleic acid molecules which code for a new protein from Acremonium chrysogenum, to vectors which comprise such a nucleic acid molecule, to Acremonium chrysogenum host cells which have been trans...
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WO/2004/020649 |
An enzymatic process under thermodynamical control for preparing b-lactams, by coupling the 7-amino group of a cephalosporin nucleus with the carboxylic function of an acetic acid derivative consisting of a residue with p-electrons, a sh...
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WO/2004/020652 |
An enzymatic process under kinetical control for preparing ß-lactams, by coupling the 7-amino group of 7-ACA with the carboxylic function of TZH activated as methyl- or ethylester. The process comprises using a penicillin amidase or a-a...
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WO/2004/020572 |
The present invention discloses a bioreactor apparatus with an expandable surface area which is useful for culturing cells. A method for culturing cells is also included in the invention. The method comprises providing a container and a ...
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WO/2004/020651 |
An enzymatic process under kinetical control for preparing β-lactams, by coupling the 7-amino group of a cephalosporin nucleus with the carboxylic function of an acetic acid derivative consisting of a residue with &pgr -electrons, a sho...
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WO/2004/020650 |
An enzymatic process under kinetical control for preparing b-lactams, by coupling the 7-amino group of a cephalosporin nucleus with the carboxylic function of an acetic acid derivative consisting of a residue with p-electrons, a short sp...
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WO/2003/076640 |
A process for the preparation of cephalosporin acid derivatives comprises the step of enzymatically converting cephalosporin C into 7 cephalosporin acid derivatives in the presence of two biocatalysts, wherein one biocatalyst comprises c...
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WO/2003/076640 |
A process for the preparation of cephalosporin acid derivatives comprises the step of enzymatically converting cephalosporin C into 7 cephalosporin acid derivatives in the presence of two biocatalysts, wherein one biocatalyst comprises c...
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WO/2003/064613 |
This invention provides amidases, polynucleotides encoding the amidases, methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides enzymes having secondary amidase activity, e.g., having ac...
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WO/2003/064613 |
This invention provides amidases, polynucleotides encoding the amidases, methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides enzymes having secondary amidase activity, e.g., having ac...
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WO/2003/062430 |
The present invention relates to host cells transformed with a nucleic acid sequence encoding a eukaryotic xylose isomerase obtainable from an anaerobic fungus. When expressed, the sequence encoding the xylose isomerase confers to the ho...
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