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WO/2023/247889A1 |
The present application relates to compounds and their use in health, in particular in the preventive or curative treatment of inflammatory diseases, microbial or bacterial infections or proliferative or neoplastic pathologies, linked to...
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WO/2023/037252A1 |
The present invention relates to an immobilized deacylase in cross-linked cell aggregates, a preparation method and use thereof in deacylation of echinocandins. The immobilization of deacyalse in cross-linked cell aggregates comprises th...
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WO/2022/180203A1 |
The invention relates to a virus particle comprising a lymphocytic choriomeningitis virus (LCMV) S segment and an LCMV L segment, wherein the S segment comprises an open reading frame encoding a glycoprotein derived from LCMV strain WE, ...
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WO/2022/056401A1 |
Compositions that inhibit the HIV-1 viral infectivity factor (Vif) and methods of use thereof are provided. The disclosed compositions have inhibitory activity against Vif function and restore A3G enzymatic activity. The disclosed compos...
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WO/2021/096298A1 |
The present invention relates to a penicillin G acylase mutant having increased cefazoline productivity and a use thereof, wherein Achromobacter sp. CCM 4824-derived penicillin G acylase mutants having unique mutation forms disclosed in ...
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WO/2021/054545A1 |
The present invention relates to a method for preparing a recombinant acremonium chrysogenum strain producing a high concentration of deacetoxycephalosporin C (DAOC), and a strain prepared by same method and, more specifically, to a meth...
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WO/2018/165881A1 |
Provided are cephalosporin C acylase mutants constructed by means of a point mutation method. The cephalosporin C acylase mutants have an amino acid sequence of SEQ ID NOs: 3-12. Compared with wild-type cephalosporin C acylase, the speci...
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WO/2018/038577A1 |
The present invention relates to a method for producing a recombinant Acremonium chrysogenum strain which produces 7-aminocephalosporanic acid at a high concentration, and to a strain produced using the method. More specifically, the pre...
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WO/2018/001034A1 |
A cephalosporin hydroxylase mutant, encoding DNA of the mutant, a method for using the mutant and an application thereof. An amino acid sequence of the cephalosporin hydroxylase mutant uses SEQ ID NO:2 as a reference sequence in a sequen...
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WO/2017/186864A1 |
The invention provides an improved process for producing β-lactam antibiotics catalyzed by an enzyme, which is immobilized onto a carrier, wherein the resulting β-lactam antibiotics are poorly soluble in the reaction media. The process...
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WO/2017/181809A1 |
Provided is a penicillin expandase mutant, wherein same takes SEQ ID NO: 2 of the sequence listing as the reference sequence, and has the mutations of at least one of threonine at position 42 and glutamine at position 126. Also provided ...
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WO/2017/178624A1 |
The present invention relates to a method to improve the production of a secondary metabolite catalyzed by a non-ribosomal peptide synthetase comprising contacting in a eukaryotic host a eukaryotic non-ribosomal peptide synthetase with a...
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WO/2017/143944A1 |
A penicillin G acylase mutant constructed by means of gene engineering; when compared with wild-type penicillin G acylase derived from Achromobacter sp.CCM 4824, the synthesis performance of the present penicillin G acylase mutant is gre...
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WO/2017/143945A1 |
Provided is a cephalosporin C acylase mutant constructed by means of a point mutation method, a gene for encoding said cephalosporin C acylase mutant, a plasmid comprising said gene, a microorganism for transforming said plasmid, and an ...
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WO/2016/046055A1 |
The present invention relates to the hemi sulfuric acid salt of D-phenylglycine methyl ester, to a method for the preparation of said salt and to the use of said salt in the enzymatic synthesis of antibiotics and of D-phenylglycine methy...
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WO/2015/071493A1 |
The invention relates to processes for the preparation of 7-amino-3- alkenylcephem-4-carboxylic acid of Formula 6 and the compounds of Formula 2 and 5 by using the enzymes p-nitrobenzyl esterase and penicillin G amidase. The processes ei...
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WO/2013/113646A1 |
The present invention relates to the preparation of β-lactam antibiotics comprising contacting 4-hydroxyphenylglycine or phenylglycine, cysteine and valine with a non-ribosomal peptide synthetase and subsequent cyclization using an isop...
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WO/2013/105030A1 |
The present invention relates to a mutant hydroxylase with increased activity and greater substrate specificity towards phenylacetyl-7-ADCA derivatives for the production of phenylacetyl-7-HACA derivatives, which carries one or more amin...
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WO/2012/175585A1 |
The present invention relates to a process for the preparation of 3'-thiosubstituted cephalosporins by enzymatic condensation of a nucleus with a phenylglycine derivative. Furthermore the present invention relates to a crystalline form o...
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WO/2012/175587A2 |
The present invention relates to a crystalline form of an intermediate for cefoperazone of formula (1 ) and to a process for the preparation thereof by enzymatic condensation of a 3'-thiosubstituted β-lactam nucleus with a phenylglycine...
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WO/2012/113120A1 |
A new nucleotide sequence of xylose isomerase obtained from the metagenomic library of cattle rumen liquor and the amino acid sequence encoded thereof, vectors and transformants containing the said nucleotide sequence are provided. The s...
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WO/2011/161004A1 |
The present invention relates to an industrial scale fermentation process for the production of valuable compounds using microorganisms wherein ≥50% of the total energy input is delivered by injection of an oxygen containing gas and â‰...
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WO/2011/073166A2 |
The invention relates to a process for preparing cephradine, said process comprising converting D-dihydrophenylglycine (DHPG) into an activated form (DHPGa); and reacting 7-aminodesacetoxy-cephalosporanic acid (7-ADCA) with D- dihydrophe...
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WO/2011/062563A1 |
Epithelial cell transforming sequence 2 (Ect2) is a potential oncogene. Our invention uncovers key mechanisms of Ect2 oncogenicity and the development of a relevant therapies by modulation of Ect2 expression.
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WO/2010/115838A1 |
The present invention describes a process for the production of a valuable compound comprising a fermentation of a microbial strain on industrial scale comprising a non-repressing C-source and feeding at least one growth rate limiting nu...
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WO/2010/072765A2 |
The present invention relates to a mutant prokaryotic penicillin G acylase derived from a wild-type penicillin G acylase characterized in that the mutant is having an amino acid substitution at one or more amino acid positions selected f...
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WO/2010/055527A1 |
The present invention provides a stable and viable biocatalyst with high activity and operational stability and method of immobilization thereof. The immobilization process is based on the principle of entrapment of partially purified en...
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WO/2009/092727A1 |
Genetically modified Saccharomyces having the ability to synthesize non-ribosomal peptides and precursors thereof.
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WO/2009/016642A1 |
The present invention discloses isolation of Penicillin Acylase (PA) from Achromobacter sp CCM 4824 expressed in recombinant strain E. coli BL21 CCM 7394 bearing the recombinant plasmid pKXIPl and processing of PA into biocatalyst useful...
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WO/2008/110527A1 |
The present invention describes a process for the synthesis of a semi-synthetic β-lactam compound from a nucleus and a side chain selected from the group consisting of D-phenylglycine and D-dihydro-phenylglycine in the form of a side ch...
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WO/2007/096419A1 |
The present invention relates to a cephalosporin-producing microorganism characterized in that it has been transformed with a heterologous CefT gene and whereby the ratio of the cephalosporin production capacity of the microorganism tran...
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WO/2007/051355A1 |
A DNA sequence is for a recombinant D-amino acid oxidase with catalytic activity on cephalosporin C that is not less than 25% higher than that of its parent.
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WO/2007/038169A2 |
Disclosed herein are guanidinium containing compounds consisting of a core moiety with a plurality of side chains containing guanidinium groups. Such compounds have enhanced translocation across cellular membranes and epithelial tissues....
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WO/2007/023369A1 |
ABSTRACT The present invention relates to a mutant expandase-hydroxylase with increased activity and greater substrate specificity for Penicillin G and Phenyl acetyl 7-ADCA for the production of Phenyl acetyl - 7-ADCA and Deacetyl phenyl...
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WO/2007/016861A1 |
The present invention discloses a two-steps enzyme method for preparing 7-aminocephalosporanic acid from cephalosporin C, Wherein D-amino acid oxidase used is D-amino acid oxidase mutant of purified yeast Trigonopsis Variabilis, which ha...
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WO/2007/016860A1 |
The present invention discloses Escherichia coli expression vector, as well as a method for steadily, high-efficiently expressing a required target protein in Escherichia coli using the expression vector. The expression vector is constru...
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WO/2006/069984A2 |
The present invention relates to a process for the synthesis of cefaclor, which process comprises reacting 7-amino-3-chloro cephalosporanic acid (7-ACCA) with D- phenylglycine in activated form (PGa) in the presence of an enzyme in a rea...
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WO/2006/061425A2 |
The present invention describes the transformation of a microorganism that does not naturally produce a beta-lactam compound with polynucleotides involved in the biosynthesis of beta-lactam compounds and the use of such transformed micro...
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WO/2006/040313A2 |
The present invention relates to a mutant expandase that is a variant of a model polypeptide with expandase activity whereby the mutant expandase has an at least 2-fold improved in vitro expandase activity towards adipyl-6-APA in compari...
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WO/2005/075652A1 |
It is intended to produce a modified peptide having an enhanced glutaryl-7-aminosephalosporanic acid (GL-7-ACA) acylase activity (i.e., a modified GGT) by using &gammad -glutamyltranspeptidase (GGT) which is an enzyme widely occurring in...
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WO/2005/054452A2 |
The invention relates to a new class of isolated, single or multiple mutated glutaryl amidases from Pseudomonas SY-77, or a functional part, derivative or analogue thereof. The invention also relates to a method for preparing 7-aminoceph...
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WO/2005/019468A1 |
Deacetoxy/deacetylcephalosporin C synthase (DAOC/DACS) modified to reduce the hydroxylation activity and in particular DAOC/DACS modified to reduce the hydroxylation activity and further modified to improve the ring expanding activity.
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WO/2005/014821A1 |
A CPC acylase mutant of the present invention has an improved reactivity and specific activity to CPC, which can be efficiently employed for directly preparing 7-ACA from CPC by a one-step enzymatic method.
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WO/2005/003367A2 |
The present invention describes a process for preparing cephradine, said process comprising reacting 7-aminodesacetoxy cephalosporanic acid (7-ADCA) with D-dihydrophenylglycine in activated form (DHa) in the presence of an enzyme in a re...
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WO/2004/113508A1 |
The invention is concerned with a bioprocess for the production of a ceph-3-em compound selected from the group consisting of desacetoxycephalosporin C, deacetylcephalosporin C and cephalosporin C in P. chrysogenum. The invention is also...
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WO/2004/111241A1 |
The present invention relates to a novel enzyme having Penicillin G acylase activity, characterised by a. an initial Synthesis/Hydrolysis ratio (S/Hini) of at least 50% above the S/Hini of Penicillin G acylase of E. coli and b. an initia...
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WO/2004/069848A2 |
This invention provides amidases, polynucleotides encoding the amidases, methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides enzymes having secondary amidase activity, e.g., having ac...
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WO/2004/062558A2 |
The present invention describes a process for the preparation of β-lactam antibiotics, cephalexin and ampicillin, wherein the β-lactam nucleus is acylated with an acylating agent, D-phenylglycine, by means of a reaction biocatalyzed by...
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WO/2004/050893A1 |
The invention relates to a method for producing cephalexin with the aid of a penicillin amidase that is immobilized on a pearl-shaped, cross-linked and hydrophilic copolymer that binds to ligands having nucleophilic groups.
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WO/2004/039997A1 |
A process for preparing the 7-(1-H-tetrazol-1-yl) acetamide-3-(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl-3-cep
hem-4-carboxylic acid or cefazolin, comprising catalysing the acylation of the amino β-lactam, the 7-amino-3-[5methyl-1,3,4-t...
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