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Matches 151 - 200 out of 322

Document Document Title
JPH11502832A
Process for the recovery of ampicillin from a mixture containing ampicillin and 6-aminopenicillic acid (6-APA), in which a mixture of ampicillin and 6-APA, with a pH higher than 7, which apart from any solid ampicillin being present is h...  
JP2771244B2
beta -lactams having a 6-D- alpha -aminophenylacetamido side chain are prepared in high yield by enzymatic reaction of a 6-amino beta -lactam with a D,L-phenylglycine derivative, preferably at temperatures between 0 and 25 DEG C.  
JPH10506287A
The present invention relates to the biosynthesis of beta-lactam antibiotics. More specifically, the invention relates to processes of producing beta-lactam antibiotics in vivo and in vitro. Also contemplated is a novel enzyme capable of...  
JP2688065B2
Compounds of the formula I: wherein R is a carboxy group or a carboxylate anion, R2 represents a hydroxy protecting group or hydrogen atom, R1 represents one of certain defined organic groups, useful as antibiotics, are prepared by hydro...  
JP2688053B2
Compounds of the formula I : wherein R1 represents a hydroxy protecting group and R2 represents a carboxy protecting group, useful as intermediates for the preparation of penem antibiotics, are prepared by hydrolysing a compound of the f...  
JP2655790B2
Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed Penicillium chrysogenum str...  
JP2590158B2
Corn steep liquor, i.e. the aqueous liquid obtained when corn (maize) is digested with warm water to soften and swell the corn grain, is subjected to a treatment comprising separating the water from the corn, initially adjusting the pH o...  
JP2572751B2
2-(Allenyl)penicillins antibiotics and intermediates thereto are disclosed. The antibiotics have the formula oror a mixture of the two, wherein:R1 is hydrogen or a methyl group;R2 is hydrogen, an amino-protecting group or a C1 to C20 acy...  
JPH08256789A
To efficiently obtain the subject antibiotic substance without generating by products by reacting 6-aminopenicillanic acid or 7-aminocephalosporanic acid with amides in the presence of a penicillin acrylase and an enzyme inhibitor under ...  
JP2540143B2
DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes coding for one or more enzymes involved i...  
JPH08242884A
To obtain penicillin and cephalosporin that are stable and can be readily purified in high yield by carrying out the reaction of 6-amino-penicillanic acid or 7-amino-cephalosporanic acid with an amide in the presence of an immobilized pe...  
JPH0829108B2
A process for producing a variety of chemical products, e.g., ethanol, by fermentation in which the product is removed from the fermentation medium as it is formed by liquid-liquid extraction using an extractant for the product which is ...  
JPH082311B2
A composition comprising immobilized cells having enzyme activity, the cells being immobilized by means of a fixed, insoluble, crosslinked polymer obtained by curing a curable prepolymer material selected from the group consisting of pol...  
JPH0787788B2
The present invention comprises novel DNA compounds that encode isopenicillin N synthetase and also comprises related methods, transformants, and polypeptides. The novel isopenicillin N synthetase-encoding DNA, together with its associat...  
JPH07507959A
(57) [Summary] Since this publication is application data before electronic filing, summary data is not recorded.  
JPH07231794A
PURPOSE: To produce a penem compound useful as an antibacterial agent in high yield and purity by the enzymatic hydrolysis of a penem ester with a lipase or an acylase in an alcoholic solution. CONSTITUTION: A penem ester of formula I (R...  
JPH0773499B2
The present invention comprises novel DNA com­pounds that encode isopenicillin N synthetase. The invention also comprises methods, transformants, and polypeptides related to the novel DNA compounds. The novel isopenicillin N synthetase-...  
JPH0771490B2
A composition comprising immobilized cells having enzyme activity, the cells being immobilized by means of a fixed, insoluble, crosslinked polymer obtained by curing a curable prepolymer material selected from the group consisting of pol...  
JPH07502168A
PCT No. PCT/DK92/00388 Sec. 371 Date May 12, 1994 Sec. 102(e) Date May 12, 1994 PCT Filed Dec. 18, 1992 PCT Pub. No. WO93/12250 PCT Pub. Date Jun. 24, 1993.The present invention relates to an improved method for the preparation of certai...  
JPH07501207A
Described is a method for the fermentative production of cephalosporin C, the fermentation solution being filtered during fermentation through a cross-flow filtration system. The filtrate obtained from the fermenter can be used again.  
JPH0698009B2
A process for preparing phenylalanine which comprises contacting phenylpyruvic acid or phenylpyruvate with immobilized whole cells having transaminase activity in the presence of an amine donor. Ruptured or permeabilized cells, with the ...  
JPH06504947A
The present invention relates to a process for separating, from each other, one non-dissolved catalyst from one or more other non-dissolved components present in a reaction mixture. The separation is obtained by using a catalyst having a...  
JPH06105682A
PURPOSE: To provide a method for enhancing the production of a fermentable β-lactam antibiotic and to obtain a composition therefor. CONSTITUTION: This DNA sequence contains a reading frame encoding δ-(L-α- aminoadipyl)-cysteinyl-D-va...  
JPH0612997B2  
JPH05304994A
PURPOSE: To provide a continuous type penicillin extraction device for rapidly extracting a raw material for producing penicillin antibiotics including penicillin G in a stable pH region, and to provide the extraction method. CONSTITUTIO...  
JPH05199897A
PURPOSE: To modulate the number and/or size of organelles by the treatment such an altering the expression of proteins existing in the organelles, thereby modulate the production of secondary metabolites such as of penicillin or cephalos...  
JPH05192162A
PURPOSE: To provide a DNA fragment coding δ-(L-α-aminoadipyl)-L-cystyl-D- valine synthetase (ACVS enzyme) gene originated from Acremonium.chrysogenum, and the ACVS enzyme using for the same and a method for producing a β-lactam antibi...  
JPH05502592A
A transformant selection system has been developed, particularly for a beta -lactam producing strain, more particularly for P. chrysogenum, by the complementation of a mutation of said beta -lactam producing strain by a homologous select...  
JPH0526461B2
PURPOSE:To improve the productivity of an antibiotic substance, by cultivating a miroorganism capable of producing the antibiotic substance under irradiation with light within a specific wavelength region. CONSTITUTION:A microorganism ca...  
JPH05501651A
A new oxido reductase enzyme activity obtainable from P. chrysogenum, involved in the production of beta -lactams, the set of genes encoding said enzyme activity, and a method to enhance said production by using the above-mentioned oxido...  
JPH03133384A
PURPOSE: To obtain a DNA compound encoding isopenicillin N:acylCoa acyltransferase activity and giving a gene related to the production of penicillins. CONSTITUTION: This DNA compound contains an isolated DNA sequence encoding the isopen...  
JPH0336509B2
The invention relates to a corn-steeping process. In this process the temperature of the steeping water decreases from silo to silo and the cycling ratio is comprised between 0.8 and 1.2 m3 per ton of commercial corn. The Corn-Steep obta...  
JPH0257919B2
A process for immobilizing enzyme-containing microbial cells by contacting such cells with an aqueous agar solution containing from about 1.0 to 8.0% sulfate moiety on a weight/weight basis, contacting a solution of inorganic sodium salt...  
JPH0158952B2
PURPOSE:In preparing antibiotics by cultivating microorganisms, to improve the productivity of antibiotics, by carrying out the cultivation under irradiation of light rays containing no ultraviolet light with <=a specific wave length. CO...  
JPH01304896A
PURPOSE: To convert a β-lactam compound to other compound by protecting the carboxy group at 2nd position as the corresponding phenylacetyloxymethylester form, enzymatically hydrolyzing the compound and removing a protecting group. CONS...  
JPH0154999B2  
JPH01503037A
The extraction of water soluble antibiotics containing a phenolic or carboxylic group from an aqueous solution or fermentation broth using a N-C8-C14 alkyl pyrrolidone extractant and the process involving the extraction of said antibiotic.  
JPH0146110B2
1. A process for immobilizing enzymatically active formulations, wherein a suspension containing precipitated silica or silica hydrogel is prepared, and then a porous filler and the enzymatically active formulation are incorporated into ...  
JPH01218599A
PURPOSE: To enhance enzymatic biosyntheses at a low cost by bringing a cytoclasis preparation of an organism capable of producing ≥1 species of penicillin, cephalosporin and cephamycin to act on an amino acid mixture. CONSTITUTION: Cep...  
JPS6339232B2
An aqueous dispersion of a biologically-active protein bound to polyurethane is formed by (a) admixing the protein and an isocyanate-capped liquid polyurethane prepolymer to form a solution; and (b) dispersing the solution in water.  
JPS63185393A
6 beta -(L- alpha -Aminoadipoyl)-2 alpha -vinyl-2 beta -methylpenam-3-carboxylic acid is provided in an enzymatic process converting delta -(L- alpha -aminoadipoyl)-L-cysteinyl-D- gamma , delta -didehydroisoleucine with isopenicillin N s...  
JPS63137696A
PURPOSE: To obtain the titled compound, having excellent antimicrobial action and inhibitory activity against β-lactamases and useful as medicines and veterinary drugs, by cultivating a specific microorganism belonging to the genus Stre...  
JPS6363393A
N-(3-Carboxyphenylacetyl)-L-cysteinyl-D-valine and N-(3--carboxyphenylacetyl)-L-cysteinyl-D-modified-valine dipeptides are substrates for isopenicillin N synthetase conversion to penams e.g. 2-vinyl-2-methylpenam, 2-allenylpenam and 2-me...  
JPS6260079B2
This invention relates to certain novel alpha -amino- or alpha -formyl- alpha -(p-acyloxyphenyl)acetamidocephalosporanic acids which are useful as antibacterial agents.  
JPS62265980A
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.  
JPS6247516B2
Acrylonitrile polymer containing amino groups and having a porous structure containing micro-pores with an average size of from 50 to 2000 ANGSTROM and pore volume of not less than 0.2 cm3/g is prepared by reducing an acrylonitrile polym...  
JPS6243679B2  
JPS62164686A
A compound of Formula II:wherein R is hydrogen or an alkyl group and R' is an alkoxy group, and salts and esters thereof.  
JPS6231919B2  
JPS6219160B2
This invention relates to certain novel alpha -amino- or alpha -formyl- alpha -(p-acyloxyphenyl)acetamidocephalosporanic acids which are useful as antibacterial agents.  

Matches 151 - 200 out of 322