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WO/2014/129538A1 |
The purpose of the present invention is to provide a method of efficiently producing an α-amino nitrile compound from a non-cyclic amine compound. The production method for an α-alkylamino nitrile compound according to the present inve...
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WO/2014/127438A1 |
The present invention relates to a recombinant enzyme from Aspergillus brasiliensis associated with the enzymatic epoxide hydrolysis process. The use of this recombinant enzyme allows chiral vicinal diols to be obtained from racemic epox...
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WO/2014/129537A1 |
The purpose of the present invention is to provide a novel mutant amino acid oxidase having an (R)-amine compound other than an amino acid as a substrate. Another purpose of the present invention is to provide an amine compound deracemiz...
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WO/2014/092496A1 |
The present invention relates to methods for preparing amino acid and amine having an optical activity. Both methods are configured such that α-keto acid is formed as a reaction intermediate so as to enable racemic amino acid or racemic...
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WO/2014/073673A1 |
Provided are: a protein complex capable of selectively and asymmetrically oxidizing one of enantiomers of a secondary alcohol without adding a coenzyme and having an asymmetric oxidation activity in a water-soluble solvent system in the ...
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WO/2014/045036A1 |
A process for producing a compound of formula (I) is provided. The process comprises reacting a mixture comprising a compound of formula (IIA) and a compound of formula (IIB) with an alkyl alcohol in the presence of a Candida antarctica ...
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WO/2014/041372A1 |
A lipase comprising a polypeptide or peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1-19 and the polynucleotides encoding the lipases is disclosed. The lipases and nucleic acid sequences encodi...
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WO/2014/024886A1 |
[Problem] To provide a novel method for producing methyl jasmonate having a high epi-isomer content. [Solution] A method for producing a methyl jasmonate isomer composition having an epi-isomer content of 20% or more, said method being c...
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WO/2014/013179A1 |
The invention relates to a method for the enzyme synthesis of the compound of formula (I), (7S)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) N-methyl methanamine. The invention is applicable to the synthesis of ivabradine and i...
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WO/2013/186540A1 |
A process for producing alkyl R-lactate from an initial compound comprising substructure (I) is provided. The process involves producing an intermediate comprising R,R- and S,S- lactide from the initial compound, wherein the initial comp...
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WO/2013/174848A2 |
An improved method for the preparation of treprostinil and its derivatives is described. In contrast to prior art, this method utilizes an easily scalable enzymatic resolution of a key intermediate for making these compounds. Another sig...
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WO/2013/154066A1 |
The problem addressed by the present invention is to efficiently produce an optically active bicyclic compound. The present invention efficiently produces an optically active bicyclic compound using an enzyme.
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WO/2013/127354A1 |
Provided is a (R)-praziquantel preparation method: utilizing the highly solid property, site and regioselectivity of an enzyme to catalyze a chemically synthesized racemate or an enantiomer in a derivative, conducting dynamic kinetic res...
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WO/2013/127356A1 |
Provided are a preparation method of (R) - praziquantel and an intermediate thereof. 1-alkylcarbamoyl-3，4-dihydroisoquinoline or 1-ester-3，4-dihydroisoquinoline are used as starting materials of the preparation method; the starting m...
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WO/2013/126337A1 |
The present disclosure provides a method for the stereospecific hydrolysis of racemic 1,1-dialkyloxycarbonylcyclopropanes.
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WO/2013/123240A1 |
The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.
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WO/2013/117585A1 |
Disclosed is a method for obtaining furan derivatives from D-glucose. In said method, A) D-glucose is transformed into D-fructose in an enzymatic process in which redox cofactors are used and regenerated, one of the two redox cofactors b...
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WO/2013/117251A1 |
Disclosed is a method for enzymatically regenerating the redox confactors NAD+/NADH und NADP+/NADPH in a one-pot reaction. In said method, one of the two redox cofactors is obtained in the reduced form thereof while the other redox cofac...
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WO/2013/117584A1 |
Disclosed is a method for enzymatically regenerating the redox confactors NAD+/NADH and NADP+/NADPH in a one-pot reaction. In said method, one of the two redox cofactors is obtained in the reduced form thereof while the other redox cofac...
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WO/2013/094499A1 |
Provided is a method for producing an optically-active α-substituted-β-amino acid represented by formula (2), the method involving a step in which an optical isomer mixture of an α-substituted-β-amino acid ester represented by formul...
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WO/2013/081100A1 |
Provided is a method for manufacturing adamantyl glycine at a good yield from inexpensive, readily available raw materials by fewer reaction steps than in the prior art. A method for obtaining adamantyl glycine by the following reaction.
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WO/2013/075239A1 |
Provided herein are diterpene synthases (diTPS) and methods for producing diterpenoids. Also provided herein are nucleic acid sequences encoding diTPS, diTPS amino acid sequences, diTPS proteins, vectors, cells, transgenic organisms, use...
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WO/2013/073679A1 |
The present invention provides a method for efficiently producing (2R,4R)-monatin polyvalent metal salt crystals which have good sweetness characteristics and a high storage stability. More specifically, the present invention provides a ...
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WO/2013/060292A1 |
Provided is R-praziquantel preparation method. Same utilizes the characteristics of biological enzyme of strong stereoselectivity, site-selectivity, and regioselectivity, of high resolution efficiency, of mild reaction conditions, and of...
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WO/2013/047767A1 |
The problem addressed by the present invention is to provide a means for producing an optically active tropic acid that is a compound useful as a synthesis starting material and intermediate for drugs and the like. The present invention ...
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WO/2013/030851A1 |
The present invention relates to a novel epoxide hydrolase enzyme which aims to achieve a high degree of resolution towards a broader range of substrates with high enantioselectivity and yields with minimal product inhibition. The invent...
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WO/2013/014179A1 |
Subject of the invention is a process for the production of L-carnitine, wherein a β-lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into L-carnitine, wherein the process comprises an enzymatic conversion of the β-lactone...
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WO/2013/011295A1 |
A process for treating a mixture of R,R- and S,S- lactide is provided. The process involves contacting the mixture with an aliphatic alcohol and an enzyme in the presence of a ketone solvent to produce a mixture comprising aliphatic este...
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WO/2013/011298A1 |
A process for treating a mixture of R,R- and S,S- lactide is provided. The process involves contacting the mixture with an aliphatic alcohol and an enzyme to produce a mixture comprising aliphatic ester of lactic acid corresponding to on...
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WO/2012/167350A1 |
There is herein described a nanovesicle comprising a bilayer of porphyrin-phospholipid conjugates. Each porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid sid...
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WO/2012/165023A1 |
The present invention provides a practically suitable industrial method for producing an optically active α-substituted proline from a chain ketone compound by a short process under mild conditions. The present invention relates to a me...
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WO/2012/124513A1 |
The present invention enables the production of a D-amino acid at an improved efficiency by further modifying wild type D-succinylase to improve the D-form selectivity thereof. A modified D-succinylase obtained by, in the amino acid sequ...
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WO/2012/124639A1 |
Provided is a method for efficiently producing from a ketone compound an optically active amino compound useful as an intermediate of a drug, an agricultural chemical, or the like. Provided are: a polypeptide having amino transferase act...
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WO/2012/043622A1 |
Provided is a process for producing an optically active amino compound, which is a compound useful as an intermediate for a medicine, an agrochemical or the like, from a ketone compound with high efficiency. A polypeptide which has high ...
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WO/2012/043653A1 |
Provided is a method for economically and efficiently producing an optically active amino compound, which is useful as an intermediate for drugs, pesticides and so on, from a ketone compound. A novel polypeptide having a transaminase act...
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WO/2012/029819A1 |
The purpose of the present invention is to provide a novel hydrolase which can be used for efficiently producing a (1S,2S)-1-alkoxycarbonyl-2-vinylcyclopropanecarboxylic acid, which is a compound useful as an intermediate for the synthes...
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WO/2012/014953A1 |
A process for efficiently producing an optically active succinimide derivative which is a key intermediate for the production of (3R)-2'-(4-bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'(1'H)-
pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone...
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WO/2012/007445A1 |
This invention describes the use of mutarotase (also known as aldose-1-epimerase) in a process for carbohydrate crystallization. Preferably the carbohydrate is a reducing sugar, more preferably the carbohydrate is lactose. The mutarotase...
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WO/2012/001305A2 |
The present invention relates to a method for continuous regeneration of NADH from NAD+ by means of formate (HCO2 -) and a formate dehydrogenase enzyme FDH immobilized within a grafted polymer. It also relates to a system for detection o...
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WO/2012/002450A1 |
Disclosed is a novel D-succinylase which has high hydrolytic activity on N-succinyl-D-amino acid and is capable of producing D-amino acid with high yield on an industrial scale and in a period of time suitable for commercial production w...
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WO/2011/118450A1 |
Disclosed is a method for manufacturing an optically active N-methyl amino acid and/or an optically active N-methyl amino acid amide by using a fungal body of a microorganism belonging to the Mycoplana genus, or a substance obtained by p...
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WO/2011/106546A1 |
Processes utilizing treatment with Candida Antarctica lipase B ("CAL-B") or Candida Antarctica lipase A ("CAL-A") for desymmetiϊzation of a prochiral di-ester compound of formula (I): wherein R is a C1-C4 alkyl group, R1 is a hydrogen; ...
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WO/2011/100265A2 |
The present disclosure relates to the use of an amino acid dehydrogenase in combination with a cofactor regenerating system comprising a ketoreductase. In particular embodiments, the process can be used to prepare L-tert-leucine using a ...
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WO/2011/092345A1 |
The present invention relates to a novel enzymatically catalyzed method for the production of asymmetric aromatic aldehydes in an aqueous reaction medium containing certain organic co-solvents.
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WO/2011/078172A1 |
A process for producing an optically active 3-substituted glutaric acid monoamide, characterized by mixing a mixed solution of an optically active 3-substituted glutaric acid monoamide represented by formula (2) (wherein * represents an ...
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WO/2011/071058A1 |
Disclosed is an efficient industrial preparation method for an optically active 2-hydroxycycloalkane carboxylic acid ester that is useful as an intermediate for the production of pharmaceutical products. Specifically disclosed is a metho...
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WO/2011/068206A1 |
Disclosed is a process for producing D- or L-tert-leucine or D- or L-tert-leucineamide by reacting DL-tert-leucineamide with a biological catalyst selected from the group consisting of an enzyme capable of hydrolyzing DL-tert-leucineamid...
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WO/2011/066755A1 |
A process for preparing ethyl (3R, 5S)-dihydroxy-6-benzyloxy hexanoate via stereoselective microbial reduction is provided, which includes that ethyl 3,5-diketo-6-benzyloxy hexanoate is used as a substrate and a diketoreductase is used a...
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WO/2011/040700A2 |
The present invention relates to a method for producing alkyl lactate directly from ammonium lactate generated in a fermentation process. In detail, the present invention relates to a method for producing alkyl lactate directly from ammo...
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WO/2011/036233A1 |
The invention relates to a method for producing optically active 3-amino carboxylic acid ester compounds of general formula I, and the ammonium salts thereof, where R1 is alkyl, alkoxyalkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, o...
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