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WO/2006/080409A1 |
Disclosed are a novel hydantoin racemase and a process for producing an optically active N-carbamylamino acid or an optically active amino acid using the hydantoin racemase. A novel hydantoin racemase isolated and purified from Bacillus ...
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WO/2006/076565A2 |
This application discloses a novel process for the conversion of a series of racemic propargylic alcohols to corresponding (R)-enantiomers. The application also discloses the enantio-selective esterification of a propargylic alcohol from...
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WO/2006/064213A2 |
Enzymatic and chemical processes for the preparation of certain of 3-phenyl-2-arylalkylthiopropionic acid derivatives which have utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated ...
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WO/2006/058595A1 |
The present invention is directed towards an asymmetric enzymic process for preparing optically active organic compounds. The process according to the invention is carried out in what are termed miniemulsions. The invention also relates ...
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WO/2006/053713A1 |
The invention relates to enzymatic methods for the production of (S)-butan-2-ol, enzymes for carrying out said method, nucleic acid sequences coding for said enzymes, expression cassettes containing the same, vectors and recombinant hosts.
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WO/2006/054437A1 |
A method for preparing an optically active compound, characterized in that it comprises hydrolyzing an optical isomer mixture with respect to the carbon atom being on the β-position to the carbon atom bonded to an esterificated hydroxyl...
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WO/2006/055528A2 |
The present disclosure provides enzymatic methods for generating stereoisomerically pure products by resolving a racemic mixture of N-protected β-lactams with a lipase from Candida antarctica with high stereospecificity. The presence of...
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WO/2006/046455A1 |
An efficient process for producing optically active alcohols, such as (R)-3-hydroxy-3-phenylpropanenitrile. In one aspect, there is provided a polypeptide isolated from a microbe belonging to the genus Candida, having the activity of asy...
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WO/2006/041062A1 |
Disclosed is a method for efficiently producing (4E)-5-chloro-2-isopropyl-4-pentenoate with high yield. Specifically, a compound represented by the formula (2) below is reacted with a base in the presence of a non-protic solvent, and the...
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WO/2006/037334A1 |
The inventors have identified polypeptides having lipase activity in anaerobic thermo-philic bacteria. Accordingly, the invention provides a process for hydrolyzing an ester bond in a substrate, which comprises treating the substrate wit...
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WO/2006/038698A1 |
A process for the production of optically active (S)- or (R) -β-amino acids represented by the general formula (II): (II) [wherein R is optionally substituted, alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aryl, or heteroaryl; and * rep...
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WO/2006/033705A1 |
A process for preparing a compound of formula (1) in enantiomerically enriched form, which comprises selective hydrolysis of the corresponding racemic compound (2) catalysed by an enzyme derived from a non-mammalian source and having est...
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WO/2006/032776A1 |
The invention concerns a method for partial or total inversion of the configuration of an amine enantiomer wherein the nitrogen of the amino group is directly bound to an asymmetric carbon atom bearing a hydrogen atom. The method consist...
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WO/2006/024502A2 |
The invention relates to a method for regioselective oxidation of a compound having a multiple methyl hydrocarbon chain branched by an enzyme system.
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WO/2006/021885A1 |
The invention relates to biocatalytic methods for preparing enantiomerically pure stereoisomers of 1-(2,6-dichloro-3-fluorophenyl)ethanol. Disclosed are methods of preparation of the desired (S)-enantiomer, which methods are based on a c...
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WO/2006/015716A2 |
The invention relates to a method for producing chiral, non-racemic, cis-configured cyclohexanols or cyclohexanol derivatives of formulae (la) and (Ib) wherein the radicals have the designations cited in the description, by means of enzy...
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WO/2006/015885A1 |
The processes of the present invention allow access to both enantiomeric series of non-natural &agr amino acids. In a first aspect of the invention, there is a process for resolving racemic non-natural &agr amino acids to provide an &agr...
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WO/2006/015727A2 |
The invention relates to a method for producing, in essence, enantiomer-pure 3-hydroxycarboxylic acids or esters of general formula (III) by reacting racemic oxetan-2-ones of general formula (I) with compounds R3-OH of general formula (I...
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WO/2006/012789A1 |
A method for providing a guarantee of the quality of service (QoS) by a edge router which transfers the user service between a access network and a core network includes: establishing a classification of service flows; establishing plura...
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WO/2006/013399A1 |
The invention relates to pure enantiomer and in certain cases new racemic-isopropanol derivatives of the general Formula (I) and a process for the preparation thereof. The partly new and partly known compounds of the general Formula (I) ...
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WO/2006/013802A1 |
A process for the production of enantiomer-enriched compounds which comprises (1) bringing an enantiomer mixture into contact with a stereoselective dehydrogenase containing NAD+ (nicotinamide adenine dinucleotide) as coenzyme to oxidize...
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WO/2006/009338A1 |
The present invention relates to a new process for preparing optically active carboxylic acid derivatives by use of enzyme.
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WO/2006/008170A1 |
The invention relates to a novel compound (2R, 3R)-2 -hydroxy-3amino-3-aryl-propionamide according to formula (1), wherein aryl A represents a substituted or unsubstituted aromatic ring, and to a process for the preparation of said com...
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WO/2006/006851A2 |
The invention relates to a process for the preparation of an enantiomerically enriched ester or corresponding acid thereof by enzymatic conversion of the corresponding mixture of enantiomers. The enantiomerically enriched ester/acid has ...
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WO/2005/123932A2 |
There is provided a process for the preparation of an optically active carboxylic acid or an optically active carboxylic acid amide wherein a carboxylic acid amide having an alpha-carbon substituted with a heteroatom group is enantiosele...
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WO/2005/123921A1 |
There is provided a polypeptide having the following physical and chemical properties: (1) potency: stereoselectively reducing 1-chloro-3-hydroxyacetone with the use of NADH as a coenzyme to thereby produce (S)-3-chloro-1,2-propanediol; ...
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WO/2005/111227A1 |
The present invention relates to process for the preparing of optically active ester derivatives and their acid derivatives which are used intensively as important chiral intermediates from racemic β-hydroxybutyl ester derivatives. In m...
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WO/2005/102988A1 |
A method of separately collecting an optically active amino acid amide and an optically active amino acid from an aqueous solution containing the optically active amino acid amide and the optically active amino acid together with at leas...
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WO/2005/103280A1 |
A process for producing either a 3-benzamido-2-hydroxycarboxylic acid represented by 3-benzamido-2-hydroxy-3-phenylpropionic acid or a salt thereof. The process is safe and suitable for industrial production, and the target compound havi...
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WO/2005/100580A1 |
The present invention is directed to a regio-and stereoselective bioconversion of selected aliphatic dinitriles into corresponding cyanocarboxylic acids. More particularly, the present invention provides methods for the conversion of 2-i...
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WO/2005/100587A2 |
The invention provides yeast strains, and polypeptides encoded by genes of such yeast strains, that have enantiospecific 2,2-disubstituted epoxide hydrolase activity. The invention also features nucleic acid molecules encoding such polyp...
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WO/2005/100569A2 |
The invention provides yeast strains, and polypeptides encoded by genes of such yeast strains, that have enantiospecific styrene epoxide hydrolase activity. The invention also features nucleic acid molecules encoding such polypeptides, v...
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WO/2005/098018A1 |
A process is described for preparing the intermediate for synthesizing escitalopram and the pharmaceutically acceptable salts thereof from 4-(4-dimethylamino)-1-(4’-fluorophenyl)-1-(hydroxybutyl)-3
(acyloxymethyl) benzonitrile which, b...
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WO/2005/095602A1 |
This invention relates to S-hydroxynitrile lyase having excellent tolerance to heat, organic solvents, and the like, which is obtained by modifying at least one amino acid in the helix D3', helix A, and β-sheet 2 domains in the amino ac...
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WO/2005/095628A1 |
Disclosed is a method for producing chiral, secondary alcohols of formula (I), wherein A represents an aromatic, heterocyclic, or alicyclic ring or a ring system with 4 to 20 C atoms, n represents 0, 1, 2, 3, 4, or 5, R represents haloge...
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WO/2005/095629A1 |
Process for the preparation of an enantiomerically enriched ester, which comprises subjecting a mixture of enantiomers of the corresponding secondary alcohol, in the presence of an acyl donor, to an enantioselective enzymatic conversion,...
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WO/2005/093081A1 |
The present invention relates to a process for preparing, in particular, enantiomerically enriched L-&agr -amino acids, in particular those of the general formula (I). In this connection, the process according to the invention uses 2-ket...
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WO/2005/085184A1 |
[PROBLEMS] To provide a process for the synthesis of cyclopentenenitrile derivatives through conjugate addition of a nitrile derivative to an &agr ,β-unsaturated ketone whereby cyclopentenenitrile derivatives, particularly those capable...
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WO/2005/085462A1 |
The invention relates to a process for the preparation of a enantiomerically enriched β2-amino acid comprising the steps of reacting a stereoselective hydrolytic enzyme with a mixture of enantiomers of a β 2-amino acid ester and collec...
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WO/2005/075650A1 |
It is intended to provide a novel amidase which is useful in producing an optically active amino acid, in particular, a D-amino acid and a process for producing the same. Namely, a novel D-amidase isolated and purified from Arthrobacter ...
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WO2001032847A9 |
The present invention relates to a novel strain, Pseudomonas aeruginosa, the gene encoding esterase, and the method for the production of RAM from (R,S)-ester using this esterase. In detailly described, this invention discloses the novel...
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WO/2005/064006A1 |
The present invention relates to optically active heteroaromatic β -hydroxy esters of formula (I) useful in the synthesis of epothilone derivatives, to beta-keto esters of formula (IV) used to produce these intermediates by means of an ...
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WO2004106534B1 |
The present invention relates to a new process for the preparation of optically active alcohols represented by the general formula 2 and their esters represented by the general formula 3 in scheme 1. In more detail, this invention relate...
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WO/2005/054186A2 |
The present invention relates to methods of preparing a stereoisomerically enriched compound of formula (I), wherein R6 is hydrogen, comprising treating a compound of formula (I), wherein R6 is chosen from C1-C10 alkyl, C2-C10 alkenyl, C...
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WO/2005/049816A2 |
The invention relates to an NADPH-dependent oxidoreductase from yeast, Mestchnikowia species for example, particularly Metschnikowia zobellii, an enzymatic method for enantioselective reduction of organic keto compounds to form correspon...
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WO/2005/044973A2 |
A process for easily producing optically active alcohols which are (R)-3-hydroxypentanenitrile, an optically active 3-hydroxybutanoic ester, and an optically active 1-phenylethanol derivative; and a novel enzyme useful for the production...
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WO/2005/040076A1 |
Process for the preparation of an alkynol with formula HC=C-C(OH)-R2 (formula 2) wherein R2 represents methyl, halomethyl or ethyl, wherein the corresponding silyl-protected alkynol ester with formula 1 (1) wherein R1 represents H, or an...
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WO/2005/038036A1 |
The invention relates to a method for hydrolysing fluorinated epoxy comprising one or several CF3 groups consisting in treating an epoxy in the presence of a protein exhibiting epoxy hydrolysis (EH) activity with respect to CF3 epoxies i...
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WO/2005/033076A1 |
This invention relates to a method of preparing (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine, a key intermediate compound for the synthesis of certain inhibitor compounds, including the step of enzyme catalysed enantioselective esterific...
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WO2004022764A9 |
The present invention relates to a process for the preparation of enantiomerically enriched organic compounds. In particular, the present invention relates to an enzymatically operating process, in which, in a coupled enzymatic reaction ...
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