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WO/2013/060292 |
Provided is R-praziquantel preparation method. Same utilizes the characteristics of biological enzyme of strong stereoselectivity, site-selectivity, and regioselectivity, of high resolution efficiency, of mild reaction conditions, and of...
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WO/2013/047767 |
The problem addressed by the present invention is to provide a means for producing an optically active tropic acid that is a compound useful as a synthesis starting material and intermediate for drugs and the like. The present invention ...
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WO/2013/030851 |
The present invention relates to a novel epoxide hydrolase enzyme which aims to achieve a high degree of resolution towards a broader range of substrates with high enantioselectivity and yields with minimal product inhibition. The invent...
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WO/2013/030851 |
The present invention relates to a novel epoxide hydrolase enzyme which aims to achieve a high degree of resolution towards a broader range of substrates with high enantioselectivity and yields with minimal product inhibition. The invent...
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WO/2013/014179 |
Subject of the invention is a process for the production of L-carnitine, wherein a β-lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into L-carnitine, wherein the process comprises an enzymatic conversion of the β-lactone...
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WO/2013/011295 |
A process for treating a mixture of R,R- and S,S- lactide is provided. The process involves contacting the mixture with an aliphatic alcohol and an enzyme in the presence of a ketone solvent to produce a mixture comprising aliphatic este...
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WO/2013/011298 |
A process for treating a mixture of R,R- and S,S- lactide is provided. The process involves contacting the mixture with an aliphatic alcohol and an enzyme to produce a mixture comprising aliphatic ester of lactic acid corresponding to on...
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WO/2012/167350 |
There is herein described a nanovesicle comprising a bilayer of porphyrin-phospholipid conjugates. Each porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid sid...
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WO/2012/165023 |
The present invention provides a practically suitable industrial method for producing an optically active α-substituted proline from a chain ketone compound by a short process under mild conditions. The present invention relates to a me...
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WO/2012/124639 |
Provided is a method for efficiently producing from a ketone compound an optically active amino compound useful as an intermediate of a drug, an agricultural chemical, or the like. Provided are: a polypeptide having amino transferase act...
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WO/2012/124513 |
The present invention enables the production of a D-amino acid at an improved efficiency by further modifying wild type D-succinylase to improve the D-form selectivity thereof. A modified D-succinylase obtained by, in the amino acid sequ...
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WO/2012/043622 |
Provided is a process for producing an optically active amino compound, which is a compound useful as an intermediate for a medicine, an agrochemical or the like, from a ketone compound with high efficiency. A polypeptide which has high ...
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WO/2012/043653 |
Provided is a method for economically and efficiently producing an optically active amino compound, which is useful as an intermediate for drugs, pesticides and so on, from a ketone compound. A novel polypeptide having a transaminase act...
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WO/2012/029819 |
The purpose of the present invention is to provide a novel hydrolase which can be used for efficiently producing a (1S,2S)-1-alkoxycarbonyl-2-vinylcyclopropanecarboxylic acid, which is a compound useful as an intermediate for the synthes...
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WO/2012/014953 |
A process for efficiently producing an optically active succinimide derivative which is a key intermediate for the production of (3R)-2'-(4-bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'(1'H)-
pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone...
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WO/2012/007445 |
This invention describes the use of mutarotase (also known as aldose-1-epimerase) in a process for carbohydrate crystallization. Preferably the carbohydrate is a reducing sugar, more preferably the carbohydrate is lactose. The mutarotase...
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WO/2012/001305 |
The present invention relates to a method for continuous regeneration of NADH from NAD+ by means of formate (HCO2 -) and a formate dehydrogenase enzyme FDH immobilized within a grafted polymer. It also relates to a system for detection o...
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WO/2012/002450 |
Disclosed is a novel D-succinylase which has high hydrolytic activity on N-succinyl-D-amino acid and is capable of producing D-amino acid with high yield on an industrial scale and in a period of time suitable for commercial production w...
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WO/2012/001305 |
The present invention relates to a method for continuous regeneration of NADH from NAD+ by means of formate (HCO2 -) and a formate dehydrogenase enzyme FDH immobilized within a grafted polymer. It also relates to a system for detection o...
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WO/2011/118450 |
Disclosed is a method for manufacturing an optically active N-methyl amino acid and/or an optically active N-methyl amino acid amide by using a fungal body of a microorganism belonging to the Mycoplana genus, or a substance obtained by p...
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WO/2011/106546 |
Processes utilizing treatment with Candida Antarctica lipase B ("CAL-B") or Candida Antarctica lipase A ("CAL-A") for desymmetiϊzation of a prochiral di-ester compound of formula (I): wherein R is a C1-C4 alkyl group, R1 is a hydrogen; ...
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WO/2011/100265 |
The present disclosure relates to the use of an amino acid dehydrogenase in combination with a cofactor regenerating system comprising a ketoreductase. In particular embodiments, the process can be used to prepare L-tert-leucine using a ...
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WO/2011/100265 |
The present disclosure relates to the use of an amino acid dehydrogenase in combination with a cofactor regenerating system comprising a ketoreductase. In particular embodiments, the process can be used to prepare L-tert-leucine using a ...
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WO/2011/092345 |
The present invention relates to a novel enzymatically catalyzed method for the production of asymmetric aromatic aldehydes in an aqueous reaction medium containing certain organic co-solvents.
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WO/2011/078172 |
A process for producing an optically active 3-substituted glutaric acid monoamide, characterized by mixing a mixed solution of an optically active 3-substituted glutaric acid monoamide represented by formula (2) (wherein * represents an ...
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WO/2011/071058 |
Disclosed is an efficient industrial preparation method for an optically active 2-hydroxycycloalkane carboxylic acid ester that is useful as an intermediate for the production of pharmaceutical products. Specifically disclosed is a metho...
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WO/2011/068206 |
Disclosed is a process for producing D- or L-tert-leucine or D- or L-tert-leucineamide by reacting DL-tert-leucineamide with a biological catalyst selected from the group consisting of an enzyme capable of hydrolyzing DL-tert-leucineamid...
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WO/2011/066755 |
A process for preparing ethyl (3R, 5S)-dihydroxy-6-benzyloxy hexanoate via stereoselective microbial reduction is provided, which includes that ethyl 3,5-diketo-6-benzyloxy hexanoate is used as a substrate and a diketoreductase is used a...
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WO/2011/040700 |
The present invention relates to a method for producing alkyl lactate directly from ammonium lactate generated in a fermentation process. In detail, the present invention relates to a method for producing alkyl lactate directly from ammo...
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WO/2011/040700 |
The present invention relates to a method for producing alkyl lactate directly from ammonium lactate generated in a fermentation process. In detail, the present invention relates to a method for producing alkyl lactate directly from ammo...
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WO/2011/036233 |
The invention relates to a method for producing optically active 3-amino carboxylic acid ester compounds of general formula I, and the ammonium salts thereof, where R1 is alkyl, alkoxyalkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, o...
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WO/2011/034126 |
A process for preparing an optically active equol enantiomer using daidzein as the starting substance, characterized by including a step of conducting optical resolution that relies on asymmetric esterification by a lipase. By the proces...
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WO/2011/013340 |
Disclosed is a method for producing an optically active 3-substituted glutaric acid monoamide by subjecting a prochiral 3-substituted glutaric acid diamide to the action of an enzyme source which asymmetrically hydrolyzes prochiral 3-sub...
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WO/2010/151593 |
Stereospecific carbonyl reductases SCR1, SCR2, and SCR3 are described herein as are nucleotide sequences that encode these reductases. These stereospecific carbonyl reductases have anti-Prelog selectivity and have specificities that are ...
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WO/2010/151593 |
Stereospecific carbonyl reductases SCR1, SCR2, and SCR3 are described herein as are nucleotide sequences that encode these reductases. These stereospecific carbonyl reductases have anti-Prelog selectivity and have specificities that are ...
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WO/2010/134642 |
Disclosed is a method for preparing a protein complex comprising a first step for concentrating crude plant and animal proteins, a second step for entrapping said crude proteins in calcium alginate gel and causing aerial oxidizing before...
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WO/2010/123067 |
Disclosed is a process for producing an (S)-1-substituted propan-1-ol derivative which is a compound useful as an intermediate for the production of pharmaceutical agents, particularly (S)-3-chloro-1-(2-thienyl)propan-1-ol, effectively a...
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WO/2010/111622 |
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WO/2010/111622 |
The disclosure relates to engineered amidase polypeptides and processes of using the polypeptides for chiral resolution of amino acid amide compounds. The disclosure further relates to the polynucleotides that encode the engineered amida...
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WO/2010/100195 |
The invention relates to a method for stereoselectively, in particular enantioselectively, and enzymatically reducing keto compounds to the corresponding chiral hydroxy compounds, wherein the keto compounds are reduced using an enantiose...
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WO/2010/098505 |
Disclosed is a deracemization reaction of a mandelic acid derivative utilizing a biocatalyst, which is a process for producing an optically active mandelic acid derivative. Specifically disclosed is a process for producing optically acti...
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WO/2010/081053 |
The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes...
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WO/2010/081053 |
The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes...
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WO/2010/068994 |
A process for producing one or more chemical compounds comprising the steps of providing a bioelectrochemical system having an anode and a cathode separated by a membrane, the anode and the cathode being electrically connected to each ot...
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WO/2010/067613 |
Disclosed is an L-succinyl aminoacylase comprising (a) a protein coded by a gene consisting of the base sequence disclosed in sequence no. 1; (b) a protein consisting of the amino acid sequence disclosed in sequence no. 2; (c) a protein ...
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WO/2010/068756 |
There is provided a process for manufacture of optically-active, 2-(acyloxymethyl)-1,3-oxathiolanes of Formula (I) comprising a preparation of a racemic compound and an enzyme-catalyzed kinetic resolution of the enantiomers. The inventio...
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WO/2010/064744 |
The present invention relates to a microbial mutant in which the gene encoding transcription activator or the gene encoding dihydroxyacetone kinase in a microorganism having the ability to produce 1,3 -propanediol using glycerol as a car...
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WO/2010/058577 |
Disclosed is a method for producing an unsaturated aminocarboxylic acid derivative, which is useful as a pharmaceutical raw material, at low cost. Specifically, an unsaturated aminocarboxylic acid derivative is produced by hydrolyzing a...
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WO/2010/053050 |
Disclosed is an O-alkylserine which is useful as a pharmaceutical intermediate. Also disclosed is a process for producing an N-benzyl-O-alkylserine, which is a compound useful for the production of the O-alkylserine, on an industrial sc...
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WO/2010/050516 |
Disclosed is a method for producing an L-amino acid by allowing L-succinylase to act on a mixture of N-succinyl amino acid enantiomers in the coexistence of N-acylamino acid racemase to specifically hydrolyze the L-form. In particular, ...
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