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Matches 1 - 50 out of 3,969

Document Document Title
WO/2017/162667A1
The invention provides a new enzimatic process for the preparation of chiral carboxylic acids, their salts and acid derivatives of the general formula (I) by enzymatic hydrolysis of racemic carboxylic acid ester of the general formula (I...  
WO/2017/155025A1
Provided is a method for producing compound (1) or (6) by optical resolution using a specific hydrolase. (In the formula, R represents a protecting group of a carboxy group, R1 and R2 each independently represent a hydrogen atom or a pro...  
WO/2017/151573A1
Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deaminat...  
WO/2017/119514A1
[Problem] To provide a novel method for producing (2S, 3R, 4S)-4-hydroxyisoleucine. [Abstract] The present invention uses 4-hydroxyisoleucine dehydrogenase having one of the following substitutions in SEQ ID NO: 1: Arg is substituted wit...  
WO/2017/092197A1
Provided in the present invention is a method for the enzymatic resolution of an isavuconazole intermediate. Enantiomeric impurities in (2R,3S)-isavuconazole intermediate I are hydrolyzed to (2S,3S)-carboxylic acid by-product by nitrilas...  
WO/2017/038107A1
Provided are: a HasA-redoxin complex (a heme iron active-type HasA) which can asymmetrically oxidize only one of enantiomers of a secondary alcohol without the need of adding a coenzyme and has an asymmetric oxidization activity in an aq...  
WO/2017/033134A1
The present invention provides a process for the preparation of enantiomerically pure (R)- 1-(1-naphthyl)ethylamine of formula (IIa) by treating 1-acetylnaphthalene of formula (I) with R-selective transaminase enzyme in presence of amino...  
WO/2017/003721A1
The present invention is directed to processes for the preparation of lisdexamfetamine and related derivatives, wherein the processes comprise coupling to racemic or enantiomerically enriched amphetamine and wherein the resulting product...  
WO/2017/001907A1
A process for preparing Vilanterol includes a biocatalytic conversion of a ketone substrate to its corresponding alcohol, and then converting the obtained alcohol into Vilanterol. Polypeptides may be used for the biocatalytic conversion ...  
WO/2016/208709A1
A method for producing a 1-(acyloxy)alkyl carbamate derivative (III) using a fluorous alkyl carbonate derivative (I), and a fluorous alkyl carbonate derivative (I) and a method for producing the same. In the formulae: R1 represents a C1-...  
WO/2016/192694A1
The invention relates to a preparation method of (S)-l-(3-ethoxy-4-methoxyphenyl)- 2-(methylsulfonyl)-ethyl-amine (S)-l, or its N-acyl derivatives of general formula (S)-2. The amine (S)-l is the key intermediate in the synthesis of (S)-...  
WO/2016/130412A1
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzy...  
WO/2016/110708A1
There is described a process for the preparation of a stereospecific form of flurbiprofen, or a pharmaceutically acceptable salt thereof, which comprises subjecting a flurbiprofen ester, comprising a mixture (R)-(-)-flurbiprofen and (S)-...  
WO/2016/041535A1
The invention relates to a lyase and to a method for asymmetric synthesis of (S)-phenylacetylcarbinol. According to the invention, a lysase is provided in which the isoleucine is substituted at position no. 468 in the protein ApPDC-E469G...  
WO/2016/013225A1
[Problem] To provide a new method for producing a diphenyl sulfide derivative. [Solution] A method for producing a compound represented by general formula (5) by asymmetric hydrolysis of a compound represented by general formula (4) usin...  
WO/2015/166334A3
The invention consists of an esterase produced by the thermoacidophilic bacteria Acidicaldus sp. strain USBA-GBX-499, isolated from a thermal acid source from Los Nevados National Natural Park in Colombia. The specific activity of the es...  
WO/2015/078258A1
Provided is an omega-transaminase of R-configuration. The omega-transaminase of R-configuration has the amino acid sequences as shown in SEQ ID NO: 2, or has at least 80% identity to the amino acid sequences as shown in SEQ ID NO: 2, or ...  
WO/2015/071861A3
The current disclosure discloses stereo-selective bioreduction of keto intermediates of various pharmaceutically active compounds to their corresponding hydroxyl compounds by microbes.  
WO/2015/063796A3
The patent discloses herein a process for the chiral resolution of racemic cyclic and acyclic acetates to obtain (R)-alcohol. Further, it discloses the resolution of racemic cyclic and acyclic acetates to obtain enantiomerically pure (R)...  
WO/2015/063796A4
The patent discloses herein a process for the chiral resolution of racemic cyclic and acyclic acetates to obtain (R)-alcohol. Further, it discloses the resolution of racemic cyclic and acyclic acetates to obtain enantiomerically pure (R)...  
WO/2015/064453A1
The present invention addresses the problem of providing a simple method for producing, at a high yield, an optically active D-form and/or L-form amino acid derivative having a thiol group in a side chain. Provided are: a method for prod...  
WO/2015/055127A1
The present invention relates to an (R)-praziquantel preparation method, comprising steps of using (R,S)-tetrahydroisoquinoline-1-formate or salts thereof, or 1-(S)-tetrahydroisoquinoline-1-formate or salts thereof as a raw material to p...  
WO/2015/030010A1
 The present invention provides a method for producing an atropisomer of a pyrrole derivative having an exceptional mineralocorticoid receptor antagonizing effect, and an intermediate thereof. A method for producing an atropisomer of a...  
WO/2015/004015A1
The present invention relates to the biocatalyzed synthesis of enantiomerically pure (3R) and (3S)-methyl-1,2,3,4-tetrahydroquinoline. Said enantiomerically pure compounds are useful as chiral synthons in organic synthesis and, in partic...  
WO/2015/005341A1
 This method for manufacturing an optically active fluorolactic acid derivative is characterized in asymmetrically reducing a fluoropyruvic acid derivative (or a hydrate of a fluoropyruvic acid derivative) using an α-keto acid dehydro...  
WO/2015/001330A1
A process for producing alkyl R-lactate and alkyl S,S-lactyllactate is provided. The process comprises:(a) admixing (i) a first mixture comprising R,R-and S,S-lactide with (ii) a second mixture comprising a C1-C8 alkyl alcohol, the corre...  
WO/2014/209230A1
The invention provides methods of making enantiopure vicinal diols and α-hydroxyketones by biocatalysis with high yield, purity, and substrate scope, e.g., by one-pot biocatalysis. For example, in some embodiments, the invention provide...  
WO/2014/148929A1
The method of enzymatic resolution of the racemic derivative of α- methylserine involves acylation of N-blocked-a-substituted serine ester in a homogeneous system with the use of an acyl group donor in a solvent selected from among pola...  
WO/2014/140006A1
The present invention relates to a process for the enzymatic enantioselective synthesis of 3-hydroxy- glutaric acid esters of formula 1 with R 1being alkyl, aryl, or substituted alkyl, as well as the use compounds of formula 1 in the syn...  
WO/2014/131996A1
A method for the enzymatic synthesis of the compound of formula (I). Use thereof in the synthesis of ivabradine and of the pharmaceutically acceptable acid addition salts thereof.  
WO/2014/131247A1
Provided is a method for synthesizing levo-praziquantel, comprising subjecting a chemically synthesized raceme or a certain enantiomer to a dynamic kinetic resolution catalyzed with a nitrile hydratase to produce an optically pure chiral...  
WO/2014/129538A1
 The purpose of the present invention is to provide a method of efficiently producing an α-amino nitrile compound from a non-cyclic amine compound. The production method for an α-alkylamino nitrile compound according to the present i...  
WO/2014/127438A1
The present invention relates to a recombinant enzyme from Aspergillus brasiliensis associated with the enzymatic epoxide hydrolysis process. The use of this recombinant enzyme allows chiral vicinal diols to be obtained from racemic epox...  
WO/2014/129537A1
 The purpose of the present invention is to provide a novel mutant amino acid oxidase having an (R)-amine compound other than an amino acid as a substrate. Another purpose of the present invention is to provide an amine compound derace...  
WO/2014/092496A1
The present invention relates to methods for preparing amino acid and amine having an optical activity. Both methods are configured such that α-keto acid is formed as a reaction intermediate so as to enable racemic amino acid or racemic...  
WO/2014/073673A1
Provided are: a protein complex capable of selectively and asymmetrically oxidizing one of enantiomers of a secondary alcohol without adding a coenzyme and having an asymmetric oxidation activity in a water-soluble solvent system in the ...  
WO/2014/045036A1
A process for producing a compound of formula (I) is provided. The process comprises reacting a mixture comprising a compound of formula (IIA) and a compound of formula (IIB) with an alkyl alcohol in the presence of a Candida antarctica ...  
WO/2014/041372A1
A lipase comprising a polypeptide or peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1-19 and the polynucleotides encoding the lipases is disclosed. The lipases and nucleic acid sequences encodi...  
WO/2014/030106A3
The present invention relates to a process for producing an optically active (2S,3S)-3- hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4 (5H)-one (Cis-lactam). More particularly, this invention relates to a process for making...  
WO/2014/024886A1
[Problem] To provide a novel method for producing methyl jasmonate having a high epi-isomer content. [Solution] A method for producing a methyl jasmonate isomer composition having an epi-isomer content of 20% or more, said method being c...  
WO/2014/013179A1
The invention relates to a method for the enzyme synthesis of the compound of formula (I), (7S)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) N-methyl methanamine. The invention is applicable to the synthesis of ivabradine and i...  
WO/2013/186540A1
A process for producing alkyl R-lactate from an initial compound comprising substructure (I) is provided. The process involves producing an intermediate comprising R,R- and S,S- lactide from the initial compound, wherein the initial comp...  
WO/2013/174848A2
An improved method for the preparation of treprostinil and its derivatives is described. In contrast to prior art, this method utilizes an easily scalable enzymatic resolution of a key intermediate for making these compounds. Another sig...  
WO/2013/174848A3
A method for the preparation of treprostinil and its derivatives is described. In contrast to prior art, this method utilizes an easily scalable enzymatic resolution of a key intermediate for making these compounds. Another significant i...  
WO/2013/154066A1
The problem addressed by the present invention is to efficiently produce an optically active bicyclic compound. The present invention efficiently produces an optically active bicyclic compound using an enzyme.  
WO/2013/127354A1
Provided is a (R)-praziquantel preparation method: utilizing the highly solid property, site and regioselectivity of an enzyme to catalyze a chemically synthesized racemate or an enantiomer in a derivative, conducting dynamic kinetic res...  
WO/2013/127356A1
Provided are a preparation method of (R) - praziquantel and an intermediate thereof. 1-alkylcarbamoyl-3,4-dihydroisoquinoline or 1-ester-3,4-dihydroisoquinoline are used as starting materials of the preparation method; the starting m...  
WO/2013/126337A1
The present disclosure provides a method for the stereospecific hydrolysis of racemic 1,1-dialkyloxycarbonylcyclopropanes.  
WO/2013/123240A1
The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.  
WO/2013/117585A1
Disclosed is a method for obtaining furan derivatives from D-glucose. In said method, A) D-glucose is transformed into D-fructose in an enzymatic process in which redox cofactors are used and regenerated, one of the two redox cofactors b...  

Matches 1 - 50 out of 3,969