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WO/2024/033930A1 |
Methods of predicting response of a subject suffering from cancer to an anti-PD-1/L1 immunotherapy, as a monotherapy or combination therapy, comprising calculating a resistance score for factors expressed by the subject, summing the resi...
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WO/2024/035951A2 |
Provided are methods of monitoring a human subject receiving a T cell based therapy for HHV-6 reactivation in therapeutic T cells present in the subject. In some embodiments, the methods comprise obtaining from the subject a biological s...
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WO/2024/036234A1 |
Disclosed herein are systems and methods for screening variant libraries for activity. Also disclosed herein are high throughput methods for identifying candidate variant having gain of function biological activity in an assay. The discl...
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WO/2022/245230A9 |
The subject of the invention is a TaqPol-NeqSSB polymerase and its cloning method. Furthermore, the subject of the invention is an isolated recombinant plasmid, primers, and the application of the polymerase to replicate specific sequenc...
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WO/2024/032834A1 |
Method of prediction of gestational diabetes mellitus including both its milder and more severe form. Pregnant women are screened to determine the expression profile of two or more miRNAs in whole peripheral venous blood collected in the...
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WO/2024/034796A1 |
The present invention relates to an economical and efficient variant detection method and kit that detects multiple mutation sites simultaneously with a probe emitting the same fluorescence, thereby reducing the possibility of false nega...
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WO/2024/034622A1 |
The purpose of the present invention is to provide a means for selecting a subject-derived neoantigen. The above problem is solved by providing, for example, a method for selecting a subject-derived neoantigen, said method comprising: ...
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WO/2024/032020A1 |
The present invention relates to the field of recombinant protein technology, and particularly, to an enhanced monomeric StayGold protein and use thereof. The sequence of the enhanced monomeric StayGold protein is a mutant sequence of th...
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WO/2024/035082A1 |
The present invention relates to a biomarker composition for diagnosing small cell lung cancer, containing exosome-derived miRNAs as an active ingredient. Small cell lung cancer diagnosis and prognosis prediction accuracy has been analyz...
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WO/2024/035230A1 |
The present invention pertains to a multiple biomarker for cancer diagnosis and a use thereof and, specifically, to a composition for cancer diagnosis, comprising an agent for measuring the protein or mRNA expression levels of IGFI, KLK2...
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WO/2024/033461A1 |
The present invention relates to in vitro or ex vivo methods and kits for determining the viral or bacterial nature of an infection on the basis of a biological sample of a patient by identifying the change in the level of expression of ...
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WO/2024/036331A2 |
Methods to create barcoded influenza viruses without disrupting the function of the viral proteins and the proper packaging of the viral genome segments are described. The barcoded influenza viruses can be used within deep mutational sca...
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WO/2024/034207A1 |
[Problem] To increase an accuracy of counting colonies. [Solution] Provided is a colony counting device which uses an imaging unit to image each inspection individual illuminated by sequentially switching an illumination direction of an ...
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WO/2024/033411A1 |
The present application relates to methods for determining the location of a target sequence, such as an integrated and/or heterologous sequence, in the genomic DNA of a cell. The methods of the invention generally comprise the steps of ...
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WO/2024/031306A1 |
Provided are a dual-luciferase reporter gene detection system and use thereof. The detection system comprises Gaussia luciferase, Pleuromamma xiphias luciferase, and a substrate, and the substrate is coelenterazine or a derivative thereo...
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WO/2024/035653A1 |
Disclosed are kits and methods for detecting whether a patient with metastatic colorectal cancer should receive AVASTIN® (bevacizumab) in addition to chemotherapy.
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WO/2024/035721A1 |
Observing DNA-binding proteins interact with DNA substrates in real-time at the single-molecule level illuminates how proteins detect and bind to their targets at extraordinary detail. Accordingly, there is a need in the art for new tech...
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WO/2024/033381A1 |
The invention relates to the application of inhibition of transcription factor 4 (TCF4/ITF2) in the treatment of cancer. This in particular in combination therapy in conjunction with an immunotherapeutic compound (such as for treating ca...
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WO/2024/033422A1 |
The present invention relates to novel pore monomer conjugates, pore complexes formed from the conjugates and their uses in analyte detection and characterisation.
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WO/2024/033572A1 |
The present invention relates to the fields of life sciences, micro-organisms and degradation of polyolefins and/or polystyrenes. Specifically, the invention relates to an isolated specific enzyme or a fragment thereof, wherein said enzy...
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WO/2024/036106A1 |
A non-human animal comprising chimeric microglia and methods of performing blastocyst microglia complementation to produce such a non-human chimeric animal are disclosed. In particular, the disclosed methods can be used to produce a non-...
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WO/2024/033443A1 |
The present invention relates to novel pore monomer conjugates, pore complexes formed from the conjugates and their uses in analyte detection and characterisation.
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WO/2024/036319A2 |
A system for detecting multiple target polynucleotides in a sample, comprising: a RNA-guided nuclease; a plurality of guide molecules, each comprising a sequence capable of binding a target polynucleotide in the sample; and a plurality o...
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WO/2024/031860A1 |
Provided are a multi-gene methylation co-detection kit for colorectal cancer based on fluorescent quantitative PCR technology and clinical use thereof. By means of the co-detection of the methylation levels in TRGV9, TRDJ3, TRDC, FAM174B...
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WO/2024/033659A1 |
The invention relates to a method of preparing a nucleic acid library for sequencing comprising selecting for nucleic acid fragments greater than 5 kb in length from a fragmented nucleic acid sample using paramagnetic Solid Phase Reversi...
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WO/2024/035844A1 |
Provided herein are methods, compositions, and kits for reducing capture of analytes from a biological sample on a spatial array on areas not covered by a biological sample.
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WO/2024/036192A2 |
The present invention relates to the field of virology. More specifically, the present invention provides compositions and methods for assessing the severity of and treating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or...
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WO/2024/031508A1 |
The present invention relates to a method for detecting multiple target nucleic acids, and in particular, to a method for achieving rapid detection and simultaneous typing of various pathogenic microorganisms by utilizing digital magneti...
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WO/2024/033421A2 |
The present invention relates to novel pore monomer conjugates, pore complexes formed from the conjugates and their uses in analyte detection and characterisation.
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WO/2024/032486A1 |
The present invention relates to a CREPT mutant and use thereof in the inhibition of tumor growth. In particular, the present invention relates to a protein obtained by replacing a residue at position 134 of SEQ ID NO: 4 with a residue t...
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WO/2024/032321A1 |
The present invention belongs to the field of molecular biology. A TouchDown PCR detection method for detecting the expression level of circular RNA. The method comprises: extracting total RNA from a human liver cancer cell line HepG2 ce...
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WO/2024/033063A1 |
The invention relates to a method for predicting whether a subject with cancer can successfully be treated with an immunotherapy. The method is based on measuring the TGFbeta and/or the MAPK pathway activity in a sample obtained from the...
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WO/2024/036134A2 |
Embodiments are directed to an apparatus comprising a support to receive a biological sample and a plurality of reagents. The plurality of reagents can include a plurality of first agents configured to bind to a pre-active peptide portio...
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WO/2024/036304A1 |
The present disclosure relates in some aspects to recombinant polymerases, variant PumA1 polymerases, and compositions thereof. Also provided herein are methods of using the recombinant polymerases and/or variant PumA1 polymerases for nu...
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WO/2024/033450A1 |
The present invention relates to methods and kits for the collection, preservation and storage of analytes of interest present in biological test samples (biofluid samples). In particular, the present invention relates to means to collec...
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WO/2024/033790A1 |
The present disclosure describes methods, kits, and systems for digesting polyribonucleotides. The method involves selectively forming oligonucleotide (e.g., DNA:RNA or RNA:RNA) duplexes with single-stranded target RNA and then using seq...
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WO/2024/036068A1 |
Disclosed herein are methods for classifying a cell present in a sample, such as a tumor, of a subject, comprising: sequencing bulk DNA from first and second (e.g., tumor and healthy) a subject's tissue samples; classifying somatic varia...
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WO/2024/031805A1 |
The present invention relates to the field of bioengineering, and specifically, to an integrated extraction kit. The integrated extraction kit comprises a kit body, an extraction part, and an amplification part. The extraction part compr...
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WO/2024/031801A1 |
Provided are a photoresponsive nucleic acid aptamer, a photoactivable DNA polymerase, a kit, a method for preparing the photoactivable DNA polymerase, a method for activating the photoactivable DNA polymerase, and use of the photoactivab...
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WO/2024/034576A1 |
This method for culturing a cancer organoid includes culturing the cancer organoid on the top surface or inside of a cell structure in a medium free from extracellular matrix, wherein the cell structure contains cells constituting the st...
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WO/2024/035638A1 |
The present disclosure provides methods for classifying and treating gastrointestinal tumors in a patient based on tumor-associated mycobiota. Also disclosed herein are methods for determining the prognosis of patients suffering from GI ...
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WO/2024/033174A1 |
The invention provides a method which allows the separation of different workflow steps for barcoding of target nucleic acids and therefore providing optimal reaction conditions for each workflow step, especially for template switching r...
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WO/2024/032828A2 |
Disclosed in the present invention are a method for detecting a nucleic acid on the basis of a DNA nanorobot, and the use thereof in a kit or a biosensor. According to the detection method, a padlock probe and a DNAzyme strand are design...
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WO/2024/029755A1 |
The present invention relates to an animal model of Charcot-Marie-Tooth disease caused by K141N or K141T mutations in HSPB8. In this animal model expressing the K141N or K141T mutant HSPB8 protein, symptoms of Charcot-Marie-Tooth disease...
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WO/2024/031031A2 |
There is provided amino acid recognizers with improved binding properties, allowing for more structural information to be obtained from polypeptides based on the kinetics of on-off binding between recognizer and polypeptide. An amino aci...
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WO/2024/030919A1 |
Provided herein are methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers comprising an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable mo...
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WO/2024/027119A1 |
Provided are a nucleic acid sequencing system and a sequencing control method. The nucleic acid sequencing system comprises a biochemical reaction apparatus (10), a sample loading apparatus (20), a detection apparatus (30), and a transfe...
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WO/2024/027265A1 |
The present invention belongs to the technical field of biological detection, and provides a method for detecting the enzyme activity of cytochrome CYP8B1, and a kit. According to the present invention, when the enzyme activity of the cy...
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WO/2024/029988A1 |
The present invention relates to a composition, kit and information provision method for predicting coronary collateral circulation by using cell-free DNA through determination of the methylation level of differentially methylated region...
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WO/2024/030431A1 |
A biological test system has receptacles for a variety of removable electro-mechanical biological blood test-based elements having multiple features such as lancets or strips. Testing is through an analysis biological test processor that...
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