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WO/2002/059561A2 |
The methods of the invention allow for the construction and/or use of modular computational models to accurately predict the therapeutic properties, including both therapeutic potency and one or more ADMET properties, of all or part of a...
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WO/2002/055996A1 |
The present invention is directed to a method for determining the surface activity properties of an amphiphilic substance, such as a drug, the method including a step wherein the surface tension of an aqueous solution of the said substan...
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WO/2002/052248A1 |
A method of obtaining a measure of the stickiness of heated particulate solids (40) includes pouring a sample of the particulate solids (40) onto a generally horizontal support (12) and allowing it to freely form its own angle of repose....
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WO/2002/042740A1 |
A method for testing cleaning effect of a compound or compositions is disclosed. The method comprises: (a) Preparing a liquid sample of less than 10 ml comprising the test compound, (b) applying liquid sample to a stained surface, (c) ap...
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WO/2002/039090A2 |
A method for isolating surface tension effects and/or yield stress of a fluidflowing in a U-shaped tube wherein one or both legs of the U-shaped tube is monitored over time for the changing height of the respective fluid columns therein....
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WO/2002/025245A1 |
The invention relates to a method and device for detecting an analyte in a sample holder (PT). According to the invention, at least one liquid is provided in the sample holder, and the analyte is contained in and/or on top of a liquid, g...
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WO/2002/023158A1 |
The invention relates to a measuring device for measuring the diffusion of a gaseous substance on the surface of a material (8), which measuring device includes a body (1), in which there is a first contact surface and a second contact s...
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WO/2002/018937A1 |
The invention relates to a device and method for the measurement of lateral intrinsic forces from living materials, in particular in cell layers or tissue structures.
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WO/2002/014876A2 |
The invention relates to a test unit for the discovery and/or identification of stable formulations, containing the following components: at least one agent which is poorly soluble or insoluble in a dispersion medium, at least one formul...
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WO/2002/014836A2 |
Apparatus and methods for evaluating the rheological properties of Newtonian and non-Newtonian liquids and melts employs the principle of capillary breakup following rapid stretching of the fluid between two plates.
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WO/2002/006518A1 |
The present invention relates to high-throughput systems (100) and methods to prepare a large number of component combinations, at varying concentrations and identities, at the same time, and high-throughput methods to test tissue barrie...
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WO/2002/005356A1 |
A lamp with an LED light source (3) comprises several unhoused LEDs and a projection optic. The LED dice are arranged on a circuit board made from thermally conducting material, or on a board together with a control circuit and preferabl...
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WO/2002/004922A1 |
A method for determining ink receptivity on surfaces is disclosed. The method may be used to predictably and reliably screen suitable substrate coating compositions (and/or substrates) or alternately suitable ink compositions in printing...
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WO/2002/001919A1 |
A dissolution testing system comprises a vessel plate on which a plurality of vessels are mounted. Each vessel including a lateral wall having an outer surface around which a plurality of flexible heater elements are attached. Each heate...
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WO/2001/098751A1 |
The invention concerns a method for determining the surface tension of a comminuted solid based on different experimental measurements and different mathematical equations. Said method uses the principle of capillary rise of a probe liqu...
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WO/2001/096833A1 |
The object of the invention is a method for determining the air pollution by measuring the surface tension of rainwater or from water melted from snow. The object of the invention is also a device for measuring continuously or from taken...
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WO/2001/088960A2 |
A method for mask-free molecular or atomic patterning of surfaces of reactive solids is disclosed. Molecules adsorb at surfaces in patterns, governed by the structure of the surface, the chemical nature of the adsorbate, and the adsorbat...
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WO/2001/081890A2 |
A biosensor (10) has a hydrogel (30) in a rigid and preferably biocompatible enclosure (20). The hydrogel (30) includes an immobilized analyte binding molecule (ABM) and an immobilized analyte. The immobilized analyte competitively binds...
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WO/2001/069201A1 |
The invention concerns a method for measuring the permeability of a coating (3) on a plastic wall (1) to low molecular weight gases, wherein the diffusion coefficient and/or solubility coefficient of the coating (3) relative to the low m...
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WO/2001/057492A1 |
There is disclosed a method of rheometry and to a corresponding rheometer apparatus having particular application to the manufacturing of polymers. The invention provides a method of studying the properties of a polymer. A rheometer havi...
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WO/2001/057515A2 |
This invention relates to a method and apparatus of determining the concentration of analytes in sample using an extraction device whereby the concentration of analytes of interest can be determined from the diffusion coefficient for sai...
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WO/2001/053798A1 |
A method of measuring the surface configuration of a liquid surface, e.g. to measure surface tension. Liquid samples are confined in wells, e.g. of a multi-well microtitle plate, and a light beam is passed through the sample offset from ...
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WO2000046597A9 |
A dissolution test sample holder (10) for testing topical formulations for dermal and/or transdermal drug delivery is disclosed. The holder (10) has a cylindrical tubular body (12) with an end cap (22) removably attached to one end (14)....
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WO/2001/046493A1 |
The present invention relates to diamond microstructures that are suitable for use in biochemical synthesis and analysis. The microstructures have a surface that is modified by oxidising to be hydrophilic.
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WO/2001/044785A1 |
The method for measuring viscosity is based on observation of the relaxation of a drop of a sample (A) which is initially compressed between two plates (7,8) normally without any contact therewith due to a gaseous layer which is blown th...
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WO/2001/044789A1 |
The invention provides apparatus and methods for formulation mixing and measurement to produce rank orders of solubility of chemicals. A control sample (14) is passed through a capillary electrochromatography tube (26) to separate the ch...
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WO/2001/038850A2 |
For intrinsic dissolution testing, a drug pellet (i.e., the dissolution test sample) is retained within a cylindrical recess in a sample holder that is placed at the bottom of a dissolution vessel containing an appropriate dissolution me...
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WO/2001/036908A2 |
A measurement equipment monitoring system (30) includes a shaft centerline offset measurement device (40) and a shaft height measurment device (50) connected by electrical conduits (EC) to a control/display console (60). Console (60) inc...
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WO/2001/002834A1 |
The invention relates to a micro-fabricated device for the measurement of the solubility or the rate of dissolution of a sample. Specifically the invention relates to an automated device for the determination of these parameters on large...
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WO/2000/053840A1 |
A hydrophilic fiber which has a composition such that a polyolefin constitutes 30 % or more of a circumference of the cross section of a fiber, characterized in that it has a hydrophilicity of 30 seconds or less as measured according to ...
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WO2000009988A9 |
Workable set-ups for rapidly measuring permeability of micro-perforated films have been developed, using both static and flow-thru methods. The static method simulates normal package conditions and thus the data obtained is useful for de...
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WO/2000/040946A1 |
The invention relates to a method for the location-resolved, simultaneous detection of adhesion and friction and optionally of other material properties of a sample surface (30) to be examined. To this end a raster probe (1) is used whic...
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WO/2000/040923A1 |
The object of the invention is a measuring device for measuring small forces and displacements having in a body (1) of the device a detector means comprising a light source (4) and a position-sensitive detector (5), and a sensing means c...
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WO/2000/037935A1 |
A matric potential responder which includes a liquid absorbing swellable non-liquid material (115) held within a housing (114) of a ceramic material which provides for transfer of matric potential from an outside material environ such as...
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WO/2000/033052A1 |
A surface signal control probe high in resolution, rigidity, and bending elasticity which can be used for a scanning probe microscope and a highly accurate surface signal control probe for inputting and outputting signals which can be us...
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WO/2000/031527A2 |
A method and system for cleaning the silicon microlenses (100) in an electron-beam microcolumn in situ. The microlenses individually are heated by passing a current (I) through each microlens. The current is utilized to heat the microlen...
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WO/2000/012997A1 |
The present invention relates to a device and a method for determining the composition of a fluid (37) in which a sample of the fluid (37) being tested is drawn by capillary action between two sides (27', 27'') of a hollow cavity (25) wh...
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WO/2000/013012A1 |
Disclosed is a device for in vitro active substance release from a solid medicament form, consisting of a mini-basket with a bottom and a top part, wherein the bottom part (mini-basket) and the top part (lid) of the mini-basket are made ...
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WO/2000/005564A1 |
The present invention relates to an imbibition measuring apparatus for determining the wettability of powders from different materials, comprising a bulk material receptacle, a receptacle for a measuring liquid and a device for determini...
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WO/2000/000814A1 |
Apparatus for measuring the angle of contact between a drop of liquid (16) and the surface of a specimen (16) has a light source (10) in the form of a high intensity LED which projects light on to the drop (16) and identifying means in t...
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WO/2000/000815A1 |
The present invention provides a practical, reliable, quick, accurate method and system for determining a surface tension-related characteristic of a liquid-containing composition, wherein the surface tension-related characteristic is de...
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WO/1999/061896A1 |
The adsorption speed of proteins from solutions on surfaces in the area of boundary layers is frequently so high that a depletion of the proteins results in the boundary layer. As a result, the entire reaction is transfer-dependent thus ...
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WO/1999/057539A1 |
A method for determining ink receptivity on surfaces is disclosed. The method may be used to predictably and reliably screen suitable substrate coating compositions (and/or substrates) or alternately suitable ink compositions in printing...
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WO/1999/056105A1 |
An $i(in vitro) skin irritation test uses biomembranes made of one or more layers formed from proteins (12) and/or lipid (10) and optionally including cholesterol (14). The layers are formed by passing a substrate (22) through a Langmuir...
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WO/1999/051981A1 |
The invention relates to a method for automatically testing and controlling the surface-active contents in aqueous solutions used in a process. According to said method, the following operations are carried out under control of a program...
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WO/1999/030129A1 |
The invention concerns a method for characterising complex fluids such as emulsions, gels, surfactant solutions and others and appliances resulting therefrom for characterising said fluids on the basis of the process used. The characteri...
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WO/1999/029435A2 |
The invention relates to a method for producing a surface coating in addition to the utilization of surface coatings in order to increase the surface tension of articles. The invention is characterized in that the surface coating can be ...
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WO/1999/028437A1 |
The invention relates to a system and method for assessing simulated biological dissolution of a pharmaceutical formulation and absorption of a pharmaceutically active compound therefrom. The system comprises a dissolution chamber and a ...
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WO/1999/024868A1 |
A method for mask-free molecular or atomic patterning of surfaces of reactive solids is disclosed. A molecular-scale pattern of adsorbate molecules is used in place of the conventional macroscopic 'mask'. Molecules adsorb at surfaces in ...
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WO/1999/021002A1 |
An artificial capillary testing apparatus (ACTA) is provided for evaluation of gas transport/exchange properties of a fluid. A sample fluid, having a known or measured partial gas pressure, is introduced from a gas-tight dispenser into a...
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