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WO/2024/038967A1 |
An ANKS1A-A355D protein variant is found in Alzheimer's disease patients, and unlike a normal ANKS1A protein, is unable to induce the cell membrane expression of an LRP1 receptor, and thus is unable to efficiently remove toxic proteins s...
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WO/2024/038863A1 |
Provided are an assay method and a reagent for improving the long-term stability of the measurement value of a biological substance. The assay method and the reagent are characterized by adding, to a reaction solution, a nonionic surfa...
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WO/2024/038445A1 |
A system and method of predicting disposition of a mental disorder of a subject may include obtaining a Lymphoblastoid Cell Line (LCL) assay of the subject; calculating a gene expression profile of the subject based on the LCL assay, whe...
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WO/2024/038266A1 |
The invention relates to a viral vector production system. More specifically, the present invention relates to a set of nucleotide sequences comprising sequences encoding heterologous envelope proteins that facilitates the production of ...
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WO/2024/040123A1 |
The present disclosure relates generally to methods and systems of producing Schwann cells from pluripotent stem cells under fully defined conditions. The Schwann cells produced by the disclosed methods find applications as models of the...
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WO/2024/040115A2 |
Antibodies that interact with FcγRIIa are described. Methods of detecting the amount of FcγRIIa on platelets in a sample using antibodies to FcγRIIa are described. Methods of treating a selected subject at risk of thrombosis with an a...
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WO/2024/037663A1 |
A natural gas pipeline, a filling method for an explosion suppression component, and an explosion suppression experiment method. The natural gas pipeline comprises a pipeline body and an explosion suppression component, wherein the explo...
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WO/2024/038901A1 |
The present invention provides: a biomarker for detecting liver disease at high accuracy and noninvasively or minimally invasively; a kit, a method, and a program for detecting liver disease at high accuracy and noninvasively or minimall...
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WO/2024/037966A1 |
The invention relates to a method for assessing corrosion phenomena on at least one metal element (1) of a concrete structure (2) covered at least in regions with a material (3) that is electrolytically conductive or can be made electrol...
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WO/2024/039068A1 |
A solution state measurement device is disclosed. The solution state measurement device comprises: a probe having a measurement unit with at least one open surface so as to measure the state of a solution; a mesh arranged on a path throu...
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WO/2024/038099A1 |
The present invention relates to a sampling device for collecting microorganisms from aquatic environments by chemotaxis comprising: a housing, at least one electronic control unit interacting with the housing / connected to the housing;...
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WO/2024/039553A1 |
In an aspect, there is provided a method (100) that includes: obtaining a physics-based ocean simulation model (102) that specifies multiple simulation parameters, obtaining data characterizing an ocean in a geographical region, determin...
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WO/2024/038338A1 |
Described herein is a multilayered article comprising a functionalized porous substrate. Such functionalized porous substrates can be used in the detection of analytes, wherein a reagent matrix comprising: (1) a plurality of first captur...
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WO/2024/032700A1 |
Anti-PVRIG antibodies and antigen-binding fragments thereof, are provided, as are related compositions and methods. The antibodies bind to human PVRIG receptor and can block the interaction between the PVRL2 ligand on one cell with PVRIG...
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WO/2024/034315A1 |
A target substance detection device 1 comprises a target-substance-including base material 10 and a sensor body 20. The target-substance-including base material 10 includes: a base material 12, to the surface of which is immobilized at l...
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WO/2024/035703A1 |
The porosome is the main secretory structure of the eukaryotic cell. Presented herein are compositions and methods for the control and regulation of the porosome structure. Including a method of porosome-associated-protein and interactin...
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WO/2024/031149A1 |
The present invention provides methods and kits for the determination of oxidative status and/or the detection of myeloperoxidase in a faecal sample. The methods and kits may find application in diagnosing and/or determining the severity...
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WO/2024/034730A1 |
The present invention comprises: a rainfall detection part having a raindrop sensor so as to detect rainfall; a water intake opening/closing part which includes a water intake cover, a limit switch and a cover position detection sensor, ...
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WO/2024/035023A1 |
The present invention provides: a Bax protein variant in which lysine at position 128, lysine at position 190, or lysines at positions 128 and 190 in a Bax protein is(are) substituted with arginine; a method for increasing the half-life ...
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WO/2024/033447A1 |
Aspects of the disclosure relate to protein pore complexes and their uses in analyte detection and characterisation. The disclosure is based, in part, on nanopore complexes formed by CsgG-like pores and one or more auxiliary proteins, wh...
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WO/2024/033930A1 |
Methods of predicting response of a subject suffering from cancer to an anti-PD-1/L1 immunotherapy, as a monotherapy or combination therapy, comprising calculating a resistance score for factors expressed by the subject, summing the resi...
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WO/2024/033652A1 |
The invention provides, in some aspects, peptides, kits comprising the same and methods of using such peptides for diagnosing/treating type 1 diabetes (T1D) and latent autoimmune diabetes in adults (LADA) and methods of determining the t...
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WO/2024/034261A1 |
[Problem] To acquire appearance data and information about moisture content. [Solution] This solid-state imaging device comprises an imaging element and a processing circuit. The imaging element has, in a single pixel array, a visible-li...
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WO/2024/036234A1 |
Disclosed herein are systems and methods for screening variant libraries for activity. Also disclosed herein are high throughput methods for identifying candidate variant having gain of function biological activity in an assay. The discl...
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WO/2024/032896A1 |
The invention relates to a method for investigating bioequivalence of a topically applied or appliable test substance with respect to a reference substance, the method comprising: evaluating whether there is bioequivalence of the test su...
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WO/2024/036178A2 |
Provided is an adapter comprising an antibody binding domain (AbBD) that specifically binds and crosslinks to an immunoglobulin Fab region, where the AbBD is a variant of a Protein A domain D and has an amino acid replacement/modificatio...
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WO/2024/031196A1 |
Aptamers specific for L-lactate are provided. Also provided are biosensors comprising such aptamers and methods for detecting L-lactate using such aptamers and/or biosensors. Also provided is a method for multiplexed detection of L-lacta...
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WO/2024/035726A1 |
Methods and devices to capture and analyze aerosolized particles including protein biomarkers and their truncated proteoforms characteristic of a disease, including a respiratory disease, in exhaled breath to enable rapid detection of di...
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WO/2024/035342A1 |
The present disclosure provides an antigen-binding molecule comprising a single domain antibody sequence that binds to B7-H3. It also discloses a chimeric antigen receptor (CAR) construct comprising said antigen-binding molecule, encodin...
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WO/2024/036292A2 |
In various aspects, microfluidic devices, systems, kits, and methods of using quantitative ferrohydrodynamic cell separation devices are provided for quantifying antigen-binding capacity and isolating target cells. The method includes pr...
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WO/2024/035612A1 |
A method of determining a raw score of a pathology slide from a tissue sample includes receiving, by a regression system, a plurality of first slide features corresponding to the pathology slide, calculating, by the regression system, on...
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WO/2024/035230A1 |
The present invention pertains to a multiple biomarker for cancer diagnosis and a use thereof and, specifically, to a composition for cancer diagnosis, comprising an agent for measuring the protein or mRNA expression levels of IGFI, KLK2...
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WO/2024/035369A1 |
The invention relates to an easy and portable decision support system, which is based on the determination of the gas types measured directly from the live bovine uterus using sensor technology, and is created with devices, methods and s...
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WO/2024/033332A1 |
The present invention relates to methods for identifying alternative target peptides of a binding moiety.
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WO/2024/034371A1 |
Labels (2a, 2b) in a first label group and labels (2c, 2d) in a second label group have different labeling properties from one another. Each particle group includes a plurality of particle subgroups (a to d) that differ from each other i...
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WO/2024/035834A1 |
A method for automatically calibrating a sensor for a residual gas analyzer includes measuring a known sample by the sensor and obtaining data measurements at a first mass unit. A peak model function is fitted to the data to determine an...
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WO/2024/032823A1 |
A use of a new highly toxic amyloid oligomer Aβo*3F as a target for diagnosing Alzheimer's disease (AD) in the early stage and the middle-late stage and mild cognitive impairment (MCI) caused by AD. The Aβo*3F specifically binds to a 3...
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WO/2024/033769A1 |
The present invention relates to a process for assessing the biodegradability of complex organic mixtures such as pharmaceutical compositions allowing the understanding of the fate of complex products that cannot be assessed by the stand...
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WO/2024/031136A1 |
The present disclosure relates to the remediation of contaminated materials, and, in particular, to a method that supports remediation processes which involve the use of sorbents. The disclosure relates to an improved method for determin...
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WO/2024/035389A1 |
Method and apparatus for eliminating oxygen in the filling of a flexible bag with a beverage utilizing sources of inert gas, vacuum, and beverage. A filling head regulates the injection of inert gas and applies a vacuum to the flexible b...
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WO/2024/033604A1 |
The present invention relates to the electrochemical sensing of proteins using shotgun biotin tagging of proteins prior to their interfacial immunocapture and enzyme tag recruitment.
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WO/2024/035653A1 |
Disclosed are kits and methods for detecting whether a patient with metastatic colorectal cancer should receive AVASTIN® (bevacizumab) in addition to chemotherapy.
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WO/2024/035192A1 |
The present invention relates to a biomarker for diagnosing immune-related diseases, a composition and kit for detecting the biomarker for diagnosing immune-related diseases, and a method for diagnosing immune-related diseases using same...
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WO/2024/032485A1 |
The present invention relates to a non-phosphorylated and non-ubiquitinated CREPT protein and use thereof. Specifically, the present invention relates to a protein that is obtained by modifying CREPT or a homologous protein thereof. The ...
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WO/2024/033422A1 |
The present invention relates to novel pore monomer conjugates, pore complexes formed from the conjugates and their uses in analyte detection and characterisation.
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WO/2024/034749A1 |
An abnormal egg detection service system, according to one embodiment of the present invention, comprises: an abnormal egg detector for detecting an abnormal egg; a user device for receiving the abnormal egg detection result; and a serve...
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WO/2024/034888A1 |
The present invention relates to a microfluidic device capable of confirming sustained anticancer activity of a drug and the enhanced permeability and retention (EPR) effect of a nanoparticle formulation of the drug, and a method for con...
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WO/2024/035239A1 |
A urine analysis method comprises the steps of: preparing a urine test kit to include information about a urine test patient by tagging the urine test kit including an NFC tag on an NFC reader connected to a manager terminal; inserting, ...
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WO/2024/036106A1 |
A non-human animal comprising chimeric microglia and methods of performing blastocyst microglia complementation to produce such a non-human chimeric animal are disclosed. In particular, the disclosed methods can be used to produce a non-...
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WO/2024/034747A1 |
The urine analysis apparatus comprises: a seating part having a urine test kit seated therein; at least one light-emitting unit provided on the inner side surface of the seating part so as to irradiate light at a test sheet of a bending-...
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