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WO/2024/026307A1 |
This disclosure provides biomarkers for diagnosing post-acute sequelae of COVID-19 (PASC). In some embodiments, the biomarker comprises phosphocreatine (PCr) recovery time. In some embodiments, the subject suffering from PASC has a longe...
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WO/2024/023641A1 |
The present invention relates to methods of identifying a subject for treatment with or treating a subject with a tricyclic AKR1C3 dependent KARS inhibitor of formula (I), or a pharmaceutically acceptable salt thereof. The methods may co...
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WO/2024/023368A1 |
The invention relates to a method for the prediction of an increase of dipeptidyl peptidase 3 (DPP3) in a critically ill patient. In particular, the method comprises providing a sample from said patient, determining a level of Dipeptidyl...
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WO/2024/023390A1 |
The present invention relates to a nanosensor comprising a porous nanoparticle with at least one pore, a marker located therein, and a molecular doorway, such that access to the outside of the pore is unblocked in the presence of scopola...
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WO/2024/023827A1 |
A method of activating an immune response against brain metastasis in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of an inhibitor of an MCP-1/CCR2/CCR4 axis...
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WO/2024/026115A2 |
The present invention is directed to a protein aggregation assay, and methods of use thereof.
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WO/2024/020646A1 |
Disclosed are methods for assessing the likelihood of a subject having resistance to coronavirus infection (eg a SARS-CoV-2 infection). More particularly, the present application discloses methods for assessing the likelihood of a subjec...
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WO/2024/025923A1 |
The present disclosure provides methods for assessing responsiveness or non-responsiveness to a therapeutic agent (e.g., ICB therapy and/or anti-angiogenic) in subjects having a cancer or tumor based on angio-immune panel signatures. The...
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WO/2024/025967A1 |
Methods, systems, and computer readable media for quantifying cells having expressed BCMA are provided. In aspects, a whole blood sample is mixed with a mixture of fluorophores to obtain a blood sample mixture, each fluorophore in the mi...
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WO/2024/021686A1 |
An ultra-sensitive nanopore structure, a chip, an analysis device, an amino acid detection method, a protein detection method, and a use. The ultra-sensitive nanopore structure relates to a nanopore (8); the pore diameter of the nanopore...
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WO/2024/020697A1 |
Provided are systems, cartridges, devices and methods for detecting a target analyte in a test sample. The system employs a multitude of magnetic sources for moving magnetic beads in a sequential movement through various portions of e.g....
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WO/2024/024180A1 |
An analysis assistance method for providing assistance in analysis of stained images of a specimen, the method comprising: a step for preparing a plurality of stained images that are obtained by staining a single specimen using different...
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WO/2024/024565A1 |
The present invention addresses the problem of providing an agent that suppresses cell aging and a drug that prevents or treats diseases and the like caused by cell aging. More specifically, the present invention is a cell aging suppress...
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WO/2024/026420A1 |
Systems and methods for the identification of auto-antibodies associated with central nervous system or psychiatric disease or disorders. Also disclosed herein are methods of treating central nervous system or psychiatric disease or diso...
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WO/2024/023144A1 |
The present invention relates to the field of optical imaging. More particularly, it relates to fluorescent probes targeting carbonic anhydrase nine (CA-IX) comprising near-infrared (NIR) dyes of the cyanine. The invention also relates t...
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WO/2024/023758A1 |
Provided herein are methods of precipitating proteins within compositions that contain a protein and a polysorbate. These methods allow for an accurate determination of the concentration or the amount of polysorbate within the composition.
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WO/2024/023770A1 |
Systems, methods and devices analyze a urine by generating a urine data matrix based on urine spectrum received by a light detector from a light source or urine spectra received by a light detector from light sources. The generated urine...
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WO/2024/025962A1 |
The present disclosure relates to treating tumor tissue using magneto-immunotherapy (Mag-IT) techniques. For example, a method may include administering a magnetotherapy treatment to tumor tissue of a subject and administering an immune ...
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WO/2024/025986A1 |
The invention provides pharmaceutical compositions of anti-PD-1 antibodies or antigen-binding fragments thereof with less than or equal to about 3.0 % oxidation of Met105 in the CDRH3 heavy chain region, and PH20 variants or fragments th...
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WO/2024/026413A2 |
Methods, systems and kits useful for the detection and diagnosis of neurodegenerative diseases including Alzheimer's Disease (AD)- and early-stage Parkinson's Disease-related pathology, and methods of preparing labeled immunocomplexes us...
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WO/2024/025968A1 |
The present disclosure provides methods of treating multiple myeloma in a patient in need thereof comprising administering a gamma secretase and a B-cell maturation antigen (BCMA)-directed therapy to the patient.
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WO/2024/022478A1 |
An antibody specifically binding to CB1 or an antigen-binding fragment thereof, a pharmaceutical composition comprising the antibody or the antigen-binding fragment thereof, a nucleic acid molecule encoding the antibody or the antigen-bi...
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WO/2024/023534A1 |
A sensor for sensing analytes in blood comprising plasma and erythrocytes, the sensor comprising: an analyte sensor configured to sense an analyte in the blood and to output a response corresponding to the sensed analyte; and a separatio...
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WO/2024/025891A1 |
Devices and techniques for a system for simultaneous contractile force and calcium/voltage transient measurement of engineered tissue are generally described. The system for simultaneous contractile force and calcium/voltage transient me...
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WO/2024/023320A1 |
The present invention relates to a method of physico-chemical analysis of a gas sample comprising a carrier gas in which chlorine gas is diluted, the physico-chemical analysis method comprising: a) a step of converting the chlorine of th...
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WO/2024/026314A1 |
Systems, methods, and devices are described herein for use in detecting and/or monitoring target extracellular vesicles ("EVs"), e.g., to detect and/or monitor treatment for a disease, e.g., for cancer, in a subject. The systems can incl...
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WO/2024/024512A1 |
Provided is a detection device capable of easily detecting an object to be detected in a sample. A detection device (6) according to an embodiment of the present invention is for detecting an antibody (92) in a sample (9) containing a ma...
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WO/2024/025482A1 |
The present invention relates to an optical sensor and kits containing the said sensor, that allows early diagnosis of Alzheimer's, Parkinson's, and dementia diseases in a short time in a simple, and selective way with high accuracy whil...
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WO/2024/026407A1 |
Multispecific constructs, e.g., bispecific constructs, which comprise an anti-B cell binding arm that specifically binds to a B-cell-specific cell surface marker such as CD20, CD19, CD21, CD24, or CD38, and a second binding arm that spec...
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WO/2024/025177A1 |
The present invention relates to an organ-on-a-chip having an inverted micro-weir structure, and use thereof. By using an organ-on-a-chip for evaluating drug efficacy and toxicity, provided in the present invention, the limitation of a c...
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WO/2024/026496A1 |
The present invention is directed to anti-PVRIG antibodies and stable liquid pharmaceutical formulations thereof. The present invention is directed to monotherapy and combination treatments with anti-PVRIG antibodies and anti-PD-1 antibo...
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WO/2024/025989A1 |
The invention provides pharmaceutical compositions of anti-PD-1 antibodies or antigen-binding fragments thereof with less than or equal to about 3.0 % oxidation of Met105 in the CDRH3 heavy chain region, and rHuPH20 or variants or fragme...
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WO/2023/114915A9 |
The invention provides compositions and methods comprising biomarker genes for identifying subjects that will respond to human MAP kinase kinase (MEK) inhibitor therapies, compositions and methods comprising biomarker genes for identifyi...
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WO/2024/023313A1 |
The invention relates to genetically engineered mouse models for multiple myeloma (MM) and their uses thereof for the development of multiple myeloma models as well as for the screening of compounds suitable for the treatment of multiple...
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WO/2024/026467A1 |
Described herein are 1,2-dioxetanes that are useful as chemiluminescent probes, diagnostic agents, and imaging agents. Also described herein are compositions containing such compounds and methods of using the same.
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WO/2024/023139A1 |
In the present invention, inventors used highly sensitive, immunoassay platform, to analyze combined cytokine profiles in serum of patients with Pulmonary Arterial Hypertension (PAH) ((EFFORT cohort). Thereafter, this approach allows to ...
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WO/2024/026465A1 |
Described in several example embodiments herein are engineered programmable pattern recognition compositions and uses thereof. In certain example embodiments, the engineered protein contains an NTPase of a Signal Transduction ATPases wit...
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WO/2024/025720A1 |
An apparatus for locating and venting pathogen cells in blood. A cassette has a plurality of thin holding chambers that are filled with blood drawn from a patient. A light source illuminates each of the holding chambers and passes light ...
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WO/2024/025712A1 |
A method for performing a screening includes illuminating a sample with light from a screen of a system at a first wavelength while the system is at a predetermined position with respect to the sample. The method also includes capturing ...
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WO/2024/025716A1 |
An operational unit for locating and neutralizing pathogen cells in blood includes a cassette which has a plurality of thin holding chambers that are filled with blood drawn from a patient. A light source illuminates the holding chambers...
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WO/2024/026114A1 |
Methods, systems, and apparatus, including computer programs encoded on computer storage media, for proteome mapping. One of the methods includes: identifying one or more target peptide sequences for a sample; estimating an elution order...
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WO/2024/025268A1 |
The present invention relates to a gas collection device, and aims to provide a gas collection device that is capable of providing gas concentration optimized for an analysis device by controlling the space where gas is diffused when col...
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WO/2024/023849A1 |
The present invention relates to IoT based breath analyser device. The device initially collects human breath through mouthpiece (100) into a silicon bag (104) enclosed with a hand compressor (103). The sampled breath is pushed into the ...
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WO/2024/025322A1 |
The present invention relates to an autonomous mobile system for detecting hazardous substances in the air, and comprises: a collection unit including a traveling part that autonomously travels under the control of an MCU, and a collecti...
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WO/2024/026384A1 |
The present disclosure is directed to antibodies binding to human endotrophin and methods for use of such antibodies to detect endotrophin in human samples.
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WO/2024/026109A1 |
The disclosed technology relates generally to compositions, methods, and system for utilizing paraxanthine alone and in combination for use in enhancing immune function and/or inhibiting inflammation through administration of a paraxanth...
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WO/2024/025963A1 |
Systems, methods, and compositions that incorporate, utilize, or are generated by an Al-based UniBind™ framework are described. The Al-based UniBind™ framework includes three major components: protein representation as a graph at the...
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WO/2024/023522A1 |
The present disclosure is based in part on studies that identify upregulation of markers in response to stimulation by an antigen (also referred to as activation induced markers) to detect antigen-specific immune cells, and uses thereof....
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WO/2024/021059A1 |
Provided is a non-human mammalian model expressing IL-8 and use thereof. Specifically, provided is a non-human mammalian model expressing IL-8. The non-human mammalian model expressing IL-8 can be better used to prepare a tumor-bearing n...
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WO/2024/025973A2 |
The disclosure provides devices, methods and systems for continuous dielectrophoresis cell sorting to isolate different populations of cells, and applications thereof.
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