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WO/2024/081782A1 |
Disclosed herein are methods to develop, assay and identify high efficiency antibodies and high efficiency antibody fragments that target histone post-translation modifications or DNA modifications. Improved genomic mapping assays using ...
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WO/2024/081570A1 |
Aspects of the present disclosure relate to creating a graph, such as a directed-acyclic-graph (DAG), which represents the causal links in a biological process. In aspects, a researcher can establish the graph to incorporate the complexi...
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WO/2024/078503A1 |
The present invention relates to the field of roadbed dynamic response model testing; provided are a cumulative roadbed deformation simulation test system and a method, having full service environment and traffic load action, and directe...
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WO/2024/077355A1 |
The present disclosure relates to use of tear fluid neuropeptide Y (NPY) level for diagnosis, prognosis, assessment and therapy stratification of corneal nerve damage or loss, corneal neuropathy, corneal neuropathic pain, corneal neuralg...
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WO/2024/079069A1 |
Herein is reported a method for classifying cells in a cell mixture, wherein the mixture comprises T-cells and B-cells, comprising the steps of first applying at least labelled antibodies binding to F-actin, MHCII and CD3 to the cell mix...
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WO/2024/054298A3 |
The disclosed subject matter relates to detecting radiation exposure via Raman Spectroscopy. Described herein, for example, are methods comprising: collecting a Raman signal from a sample; and processing the Raman signal to determine a p...
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WO/2023/060210A9 |
Molecules, test kits, test kit components and methods for detecting and measuring different first and second antibodies in a test sample using a single test are provided herein. A method includes the steps of obtaining the test specimen ...
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WO/2024/078621A1 |
Disclosed are a nanopore mutant protein and a use thereof. The nanopore mutant protein comprises one or more amino acids of the wild-type PHT nanopore protein as represented by SEQ ID NO: 1 being mutated into other amino acids, or knocko...
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WO/2024/077856A1 |
Provided in the present invention is the use of a TBX family transcription factor as a target in the preparation of a drug for treating ophthalmic diseases. In the present invention, the TBX family transcription factor is used as a targe...
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WO/2024/015310A3 |
The invention features a composition including (i) pro-parathyroid hormone (pro-PTH); and (ii) an antibody that specifically binds to pro-PTH.
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WO/2024/081807A2 |
Disclosed herein are methods, compositions, systems, and kits related to functional testing of polypeptide-target interactions, such as antigen/immune receptor interactions, in a single-cell format.
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WO/2024/079079A1 |
Soil Monitoring Soil testing apparatus (101), for use in determining an indicator of soil health, comprises a probe (102) having a penetrating tip (107) for insertion in soil (100) to be tested, a sensor (106) operatively connected to th...
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WO/2024/080878A1 |
Disclosed is a system (100) and a method for monitoring a snowpack formed from an accumulation of snow layers (901, 902a, 902b). The system comprises: at least one device (110) for transmitting electromagnetic signals and acoustic signal...
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WO/2024/077097A1 |
Blood and lung infections are a worldwide health problem with approximately five million deaths each year. Early treatment could help save lives, but better tests to identify these infections are needed. This invention identifies pathoge...
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WO/2024/077256A1 |
The present invention discloses methods and platforms for generating protein binding proteins with specificity for native peptide-MHC (pMHC) complexes. The pMHC binding proteins can be used in bi-specific antibodies or for generating CAR...
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WO/2024/077135A1 |
Provided herein are MAGEA1 immunogenic peptides, binding proteins recognizing MAGEA1 immunogenic peptides, and uses thereof.
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WO/2024/074114A1 |
A hepatitis c virus test kit. The hepatitis c virus test kit comprises a first antibody, a second antibody, a third antibody and a fourth antibody for detecting a hepatitis c virus core antigen. The kit has high sensitivity, good stabili...
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WO/2024/076983A1 |
According to some embodiments, a system for monitoring nutrient levels in the body of a tree is provided, the system comprising; a sensing component comprising a sensor implanted into the tissue of the tree to generate a dataset that cor...
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WO/2024/076805A2 |
A method for producing a positive antigen-based control for detecting a pathogen which includes providing a culture fluid having a pathogen with a first detectable antigen, wherein the culture fluid has a first concentration of the first...
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WO/2024/073802A1 |
A method for detection of a nerve agent in a sample, which method comprises (a) irradiating an optical sensing element, the optical sensing element comprising a fluorescent sensing compound provided on a substrate, and measuring the lumi...
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WO/2024/075838A1 |
A pulmonary fibrosis model that includes a co-culture system containing alveolar organoids and pulmonary fibroblasts that express a reporter gene when converted into myofibroblasts, wherein, when the alveolar organoids are injured, the p...
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WO/2024/075783A1 |
One embodiment of the present invention provides a method for quantifying reactive NOx, which is an NOx source that could contribute to the generation of nitroso compounds. Another embodiment of the present invention provides a formulati...
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WO/2024/075811A1 |
The present invention estimates intestinal information about a subject with high accuracy from components contained in gas generated from excrement of the subject. This intestinal information estimation system comprises a detection contr...
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WO/2024/077088A1 |
A pathogen detection method. A sample that potentially contains a pathogen is collected. A triangle wave form output is produced. A signal associated with the triangle wave form is transmitted from a voltage-controlled oscillator over a ...
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WO/2024/077134A1 |
Provided herein are FRAME immunogenic peptides, binding proteins recognizing FRAME immunogenic peptides, and uses thereof.
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WO/2024/076668A1 |
Improved methods and systems for image acquisition of small aquatic organisms at high resolution are disclosed. The methods and systems disclosed herein provide taxonomical classification of the small aquatic organisms through captured i...
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WO/2024/074133A1 |
Provided is a protein marker Nell-1, which is present in a person's blood sample in an amount that is correlated with neurodegenerative disorders such as Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI), and Parkinson's Disease ...
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WO/2024/076967A1 |
The present invention provides compositions and methods for reducing the level and/or activity of a TET protein, for treating or preventing a disease and disorder associated with an increased level and/or activity of a TET protein, for r...
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WO/2024/075847A1 |
Provided is a non-specific reaction inhibitor which comprises a copolymer having a constituent unit A derived from 2-methacryroyloxyethyl phosphorylcholine and exhibiting a specific property X measured by Fourier transform infrared spect...
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WO/2024/074617A1 |
Circulatory failure generates hypoxia and leads to accumulation of reductive species in tissue and circulatory failure monitoring tools are needed but rare. Cardiopulmonary bypass (CPB) is known to promote brief circulatory failure durin...
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WO/2024/075123A1 |
A method of screening and/or monitoring a patient for cancer that is detectable in urine, comprising : obtaining a urine sample from the patient; acquiring an electrochemical signal generated j ointly by redox molecules in the urine samp...
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WO/2024/076411A1 |
Methods of assessing the suitability of a fluorochrome panel for use in a flow cytometric protocol analyzing a biological sample are provided. Methods of interest include, with a processor, receiving an initial fluorochrome panel, a plur...
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WO/2024/077074A1 |
The present disclosure provides biological sensors that may be used to test for the presence or absence of an analyte. These biological sensors are prepared using additive manufacturing techniques to construct the base sensor shape and t...
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WO/2024/076210A1 |
The present invention relates to methods for screening for a drug that interferes with or modulates binding between amyloid proteins and screening for a target domain of the drug. According to a method for screening for a candidate mater...
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WO/2024/077068A1 |
A method, assay, and kit for detecting a biomarker comprising: obtaining or having obtained a biological sample from the subject suffering from Sjogren's syndrome; and assaying a biological sample obtained from the subject for the presen...
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WO/2024/076801A2 |
A method and corresponding kit for detecting Sjögren's Disease or predicting labial salivary gland biopsy results. The method includes evaluating an individual for the presence of one or more peptides or whole proteins or fragments ther...
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WO/2024/073796A1 |
The present invention relates to cell permeant particles. In particular, the present invention relates to plasma-treated particles or plasma-synthesised particles that are capable of migrating across the membranes of live cells.
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WO/2024/073794A1 |
The present disclosure generally relates to the surprising discovery that subjects likely to respond to treatment with an 11β-HSD1 inhibitor can be selected for treatment based on a comparison between a baseline level of a tau protein i...
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WO/2024/074685A1 |
The inventors hypothesized that each type of liver injury can be revealed by a specific profile of HSA posttranslational modifications. Therefore, the aim of inventors was to study the pattern of albumin isoforms in rats intoxicated with...
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WO/2024/076280A1 |
A water recycling device comprises a filtration tank (100) for receiving and filtering processed wash water from a water consumption device, such as a washing machine or a dishwasher, a manifold (200) provided with a plurality of inlets ...
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WO/2024/074812A1 |
A sensor is provided for measuring an environmental condition. The sensor includes a sensing element having a resistance and a capacitance which are sensitive to the environmental condition; a first measurement circuit for determining th...
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WO/2024/076605A1 |
Provided herein are multilineage cardiovascular organoids and methods of generating the same. In some aspects, provided herein is a system comprising a plurality of multilineage cardiovascular organoids derived from embryoid bodies. The ...
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WO/2024/076942A1 |
A fuel sensor for a vehicle includes a housing, a fuel composition sensor element disposed within the housing, and two removable and interchangeable fuel connector modules attached to the housing. The fuel composition sensor element comp...
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WO/2024/074991A1 |
A milking system (1) is provided for sampling (4) and analysing (5) milk, which comprises a milking device, a sampling device to extract a milk sample, and an analysis device for the sample. The analysis device comprises a cassette (7) w...
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WO/2024/075029A1 |
The present invention relates to methods, devices and systems for diagnosis, detection, monitoring, and treatment of traumatic brain injury The methods, devices and systems include detection of salivary biomarkers associated with brain i...
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WO/2024/077040A1 |
An impactor sample collection apparatus includes an inlet and a first impaction stage downstream of the inlet, the first impaction stage defining a longitudinal first axis. A second impaction stage is downstream of the first impaction st...
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WO/2024/073834A1 |
Methods and apparatus for capturing exhaled aerosols containing a target analyte of interest from breath, retaining the exhaled aerosols including the target analyte of interest in droplet form, and allowing the target analyte of interes...
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WO/2024/074826A1 |
The invention relates to a method for detecting, staging, monitoring or prognosing a liver disease in a subject. The method comprises measuring the concentration of 2-pentanone, 4-methyl-1- pentene and/or 1-hexene, indole, dimethyl selen...
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WO/2024/077274A1 |
Provided here are cell culture system with tunable stiffness comprising a biocompatible polydimethyl siloxane substrate and a polyelectrolyte multilayer. Also provided here are methods of making and using these systems as research and/or...
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WO/2024/075662A1 |
One purpose of the present disclosure is to provide a method for testing for the presence/absence of a stroke. The method for testing for the presence/absence of a stroke includes a step of measuring the presence/absence of at least on...
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