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WO/2019/013464A1 |
The present invention relates to a method for treating biological tissue, a laser treatment device and an atmospheric pressure mass spectrometry imaging system. The method comprises the steps of: a) preparing a pretreatment material solu...
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WO/2019/008391A1 |
An ion guide is disclosed that comprises a plurality of electrodes arranged to form a multipole ion guide and one or more rigid support members. The plurality of electrodes comprises one or more groups of electrodes, and each group of el...
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WO/2019/008488A1 |
Systems and methods described herein relate to a mass spectroscopy system having multipole ion guides that can receive ions from an ion source for transmission to downstream mass analyzers, while preventing unwanted ions from being trans...
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WO/2019/008492A1 |
Apparatus, systems, and methods in accordance with various aspects of the applicant's teachings provide for improved interfaces for providing a sample flow from a sample conduit (e.g., an analytical conduit or capillary), including those...
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WO/2019/003188A1 |
A system and method is described for characterizing glycopeptides which includes a first quadrupole mass filter, a multipole rod set of an ion guide, a lens electrode, an ExD device and a mass analyzer. The multipole rod set is adapted t...
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WO/2019/003365A1 |
In this invention, a reference sample is repeatedly measured under the control of an analysis control unit (94) while a CD voltage applied by a CD voltage adjustment unit (96) to a conversion dynode (61) of the detection unit (6) is minu...
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WO/2019/003456A1 |
The present invention provides an ion guiding device and an ion guiding method. The ion guiding device comprises a first electrode assembly, the first electrode assembly comprising two parallel electrode units arranged along a spatial ax...
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WO/2019/006188A1 |
Here we demonstrate rapid, calibrated, mechanical measurements of single cells using quantitative deformability cytometry (q-DC). Cells are driven to deform through micron-scale constrictions at rates of thousands of cells per minute by ...
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WO/2019/002127A1 |
Provided is a method for determining, in a sample, enrichments of a first and at least one second stable-labeled tracer of at least one target substance including glucose, the first tracer and the second tracer having the same or similar...
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WO/2019/000699A1 |
An ion source (200), comprising: two reaction gas inlet apparatus (250), which are disposed at an inlet end and an outlet end of a reaction ionization tube (210) respectively. Also disclosed is a novel chlorine/bromine isotope mass spect...
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WO/2018/235735A1 |
Provided is an evaluation system provided with: a means for ionizing a gas injected into a vacuum vessel; a means for forming an electric field causing a phase change, by applying to an electrode in the vacuum vessel a voltage obtained b...
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WO/2018/236934A2 |
Systems, methods, apparatuses, and computer programs encoded on a computer storage medium, allow for matching advertisements with content, with advertisement and content formats including text, image, audio, video, and animation, by mean...
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WO/2018/234245A1 |
The invention relates to a device and method for the partial for the partial transfer of a liquid sample, comprising multiple components and to a method for the online determination and analysis of these components of a liquid sample com...
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WO/2018/229724A2 |
Disclosed is an ionization apparatus 10 for ionizing an analyte S, comprising an inlet E, an outlet A, a first electrode 1, a second electrode 2 and a dielectric element 3. The first electrode 1, second electrode 2 and the dielectric ele...
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WO/2018/231631A1 |
Apparatus (e.g., ion source), systems (e.g., residual gas analyzer), and methods provide extended life and improved analytical stability of mass spectrometers in the presence of contamination gases while achieving substantial preferentia...
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WO/2018/232170A1 |
Methods of ion mobility spectrometry are provided in which a sample material is modified by exposing the sample material to physical stress to produce a modified material, ions are generated from the modified material to produce generate...
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WO/2018/227201A1 |
A multi-port laser device used to create multiple laser induced plasma filaments positioned in a useful position in spatial relationship to another filament or filaments, such as interconnecting with each other.
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WO/2018/227079A1 |
Method and devices are provided for imaging a surface, such as a biological tissue sample, by mass spectrometry. In certain aspects, devices of the embodiments allow for the placement and collection of a plurality of spatially separated ...
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WO/2018/224049A1 |
Provided in the present invention are an ion mobility analyzer and an analysis method, the analyzer comprising: an ion source, a first migration/analysis region which is provided with an ion inlet, a second migration/analysis region whic...
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WO/2018/224050A1 |
The present invention provides an ion migration rate analysis device and analysis method. The analysis device comprises: an ion source; two parallel electrodes, wherein a migration region is formed therebetween, the migration region has ...
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WO/2018/225423A1 |
A mass spectrometer, provided with: an ionization unit for ionizing a sample; a nozzle unit having an inflow port 3a, which is connected to the ionization unit by a flow tube and through which the ionized sample flows in, and an outflow ...
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WO/2018/224307A1 |
The invention relates to a method for ionizing gaseous samples by means of dielectric barrier discharge and for subsequently analysing the produced sample ions in an analysis appliance, in particular a mass spectrometer or an ion mobilit...
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WO/2018/223111A1 |
A mass spectrometer having a triple ionization interface for ionizing sample components is provided. The ionization interface of the mass spectrometer includes a means for ionizing sample components via electrostatic ionization, atmosphe...
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WO/2018/219575A1 |
The invention relates to a method for analyzing a gas by mass spectrometry, comprising the following steps: exciting ions of the gas to be analyzed in an FT ion trap, recording a first frequency spectrum (FS1) in a first measurement time...
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WO/2018/218308A1 |
The present invention relates generally to components of scientific analytical equipment, and to complete items of analytic equipment. More particularly, the invention relates to apparatus and methods useful for detecting an ion in mass ...
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WO/2018/220398A1 |
A method of analysing peptides and/or proteins directly from a surface of a tissue sample is disclosed. The method comprises directing a spray of solvent droplets (13) from a sprayer device (10) onto a surface of the tissue sample (20). ...
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WO/2018/223025A1 |
The method presented herein includes acquiring a mass spectrum of a molecule that includes mass spectrum peaks corresponding to a precursor ion and fragment ions. The method also includes identifying at least a portion of the fragment io...
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WO/2018/223138A1 |
A method includes receiving proteomic data for each of a plurality of identified post-translational modification (PTM) sites. A pairwise correlation of co PTM is computed among each respective pair of the identified PTM sites. The method...
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WO/2018/220742A1 |
This sample plate for a solid sample comprises a plate-like body (2) and a lid (3). The body (2) has a recess (21) that has a bottom surface center that protrudes in a cylindrical shape so as to form a sample stage (21a). The lid (3) has...
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WO/2018/220768A1 |
In the present invention, a biological sample is placed on a sample table 8. The sample table 8 includes a tray 82, a heater 83 and a temperature sensor 84. A placement surface 821 on which the biological sample is to be placed is formed...
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WO/2018/222593A1 |
Calibrants and methods of making the same include using mixtures of multifunctional core compounds or multifunctional dendrimers that are functionalized to yield a set of discrete compounds which cover a range of collisional cross sectio...
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WO/2018/222345A1 |
The present disclosure establishes new dissociation parameters that may be used to determine the collision energy (CE) needed to achieve a desired extent of dissociation for a given analyte precursor ion using collision cell type collisi...
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WO/2018/215552A1 |
The invention relates to a mass spectrometer for determining macroscopic particle masses, said spectrometer allowing molecules to visible particles in particular to be spectroscoped. The mass spectrometer comprises a particle source for ...
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WO/2018/217778A1 |
An integrated sample processing system including an analyzer and a mass spectrometer is disclosed. The integrated sample processing system can perform multiple different types of detection, thereby providing improved flexibility and bett...
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WO/2018/215737A1 |
A Time of Flight mass analyser is disclosed comprising: at least one ion mirror ((34) for reflecting ions; an ion detector (36) arranged for detecting the reflected ions; a first pulsed ion accelerator (30) for accelerating an ion packet...
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WO/2018/211112A1 |
The MALDI mass spectrometry method comprises the provision of a test composition comprising an analyte, a matrix material, a solvent for the matrix material and an antisolvent, which facilitates crystallization of the matrix material on ...
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WO/2018/211714A1 |
The present invention provides a data acquisition method for a mass spectrometer, comprising the steps of: 1. providing at least one ion source for generating ions; 2. not fragmenting or less fragmenting the ions when a collision cell is...
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WO/2018/211611A1 |
In the present invention, an ion detector (4) is provided with a shield electrode (42) between an aperture plate (41) and a conversion dynode (43). The shield electrode (42) has a straight traveling particle blocking wall (42a) positione...
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WO/2018/210108A1 |
The present invention relates to a reaction control and mass spectrometry station for joint use with respect to an in situ pool of an X-ray expressing apparatus. The reaction control and mass spectrometry station comprises a reacting gas...
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WO/2018/207903A1 |
The present invention provides an electrospray ionization device comprising a probe member for contacting and thereby capturing a sample, and a voltage application member configured to apply a voltage to the probe member. The probe membe...
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WO/2018/207842A1 |
A mass spectrometer according to one embodiment of the present invention is provided with a sample stage (12a), a spectrometry unit (50), an ion beam source (20), an assist energy source (40) and a laser light source (30). The sample sta...
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WO/2018/207606A1 |
Provided is a spray chamber including a specimen introduction opening portion into which is introduced a gas flow containing specimen droplets that have been atomized by means of a nebulizer, a discharge opening portion which discharges ...
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WO/2018/208810A1 |
A quadrupole ion trap apparatus includes a main electrode, a first end-cap electrode, a second end-cap electrode, and a phase-controlled waveform synthesizer.The phase-controlled waveform synthesizer generates a main RF waveform for the ...
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WO/2018/208318A1 |
An ion detector for secondary ion mass spectrometer, the detector having an electron emission plate coupled to a first electrical potential and configured to emit electrons upon incidence on ions; a scintillator coupled to a second elect...
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WO/2018/203082A1 |
A multi-reflecting time of flight mass analyser is disclosed in which the ion flight path is maintained relatively small and the duty cycle is made relatively high. Spatial focussing of the ions in the dimension (z-dimension) in which th...
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WO/2018/197814A1 |
The invention relates to an analysis plate (10) comprising at least one analysis zone intended to receive a sample to be analyzed by mass spectrometry according to the MALDI-TOF technique, of the type comprising at least one test face (1...
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WO/2018/198386A1 |
The present invention provides an ion guiding device and guiding method, comprising a plurality of ring electrodes with a same size disposed in parallel; wherein a connection line of centers of the plurality of ring electrodes is defined...
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WO/2018/193637A1 |
The present invention discloses an ion guide device and associated method as well as a mass spectrometer. A pair of parallel electrode assemblies, among the electrode assemblies surrounding a spatial axis to form an ion transmission chan...
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WO/2018/189544A1 |
A MALDI ion source is disclosed comprising: a target plate (2) having a front surface (4), a rear surface (6), and at least one sample receiving well (9) for receiving a liquid sample or at least one sample receiving channel (8) extendin...
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WO/2018/189365A1 |
The present invention relates to a method for single-cell imaging mass spectrometry (MS) by correlating an optical image of a cell sample with an MS image. The method of the invention is in particular useful in research to test concomita...
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