Title:
【発明の名称】免疫系による生きた被移植細胞の破壊を阻止する方法
Document Type and Number:
Japanese Patent JP2000500121
Kind Code:
A
Abstract:
This invention provides a method of inhibiting viable cells transplanted into a subject from being destroyed by the subject's immune system which comprises: a) containing the viable cells, or tissue comprising the viable cells, prior to transplantation within a device comprising a semipermeable membrane; and b) treating the subject with a substance which inhibits an immune system costimulation event in an amount effective to inhibit the subject's immune sytem from responding to said contained cells or tissue. In one embodiment, the substance which inhibits an immune system costimulation event is CTLA4. Also provided by this invention is a method of treating diabetes in a subject which comprises: a) containing viable insulin-producing cells, or tissue comprising such cells, within a device comprising a semipermeable membrane; b) transplanting an effective amount of such contained viable insulin-producing cells into the subject; and c) treating the subject with an effective amount of a substance which inhibits an immune system costimulation event.
Inventors:
Weber, Colin Jay
Hagler, Mary Kay
Linsley, Peter S
Cup, Judith A
Hagler, Mary Kay
Linsley, Peter S
Cup, Judith A
Application Number:
JP51371197A
Publication Date:
January 11, 2000
Filing Date:
September 27, 1996
Export Citation:
Assignee:
Emory University
BRISTOL-MYERS SQUIBB COMPANY
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K9/50; A61K31/00; A61K35/12; A61K35/30; A61K35/39; A61K35/407; A61K38/00; A61K38/17; A61K48/00; A61P3/00; A61P3/10; A61P37/00; A61P37/06; C12N5/071; (IPC1-7): A61K38/00; A61K9/50; A61K35/12; A61K35/30; A61K35/39; A61K35/407; A61K48/00; A61P3/10; A61P37/06
Attorney, Agent or Firm:
Takehiko Suzue (4 outside)