Title:
【発明の名称】PDE III、PDE IVおよびTNF阻害剤としてのイミド類
Document Type and Number:
Japanese Patent JP2000502350
Kind Code:
A
Abstract:
1. Use of a compound of the formula in which: one of R<1> and R<2> is R<3>-X and the other is hydrogen, nitro, cyano, trifluoromethyl, carbo(lower)alkoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, lower alkyl, alkylamino, lower alkoxy, halo, HF2CO, F3CO or R<3>-X-; R<3> is monocycloalkyl, bicycloalkyl or benzocycloalkyl of up to 18 carbon atoms, tetrahydropyran or tetrahydrofuran; X is a carbon-carbon bond, -CH2-, -O- or -N=; R<5> is (i) o-phenylene, unsubstituted or substituted with 1 or more substituents each selected independently from nitro, cyano, halo, trifluoromethyl, carbo(lower)alkoxy, acetyl, or carbamoyl, unsubstituted or substituted with lower alkyl, acetoxy, carboxy, hydroxy, amino, lower alkylamino, lower acylamino, aminoalkyl, or lower alkoxy; (ii) the vicinally divalent residue of pyridine, pyrrolidine, imidizole, naphthalene, or thiophene, wherein the divalent bonds are on vicinal ring carbon atoms; (iii) a vicinally divalent cycloalkyl or cycloalkenyl of 4-10 carbon atoms, unsubstituted or substituted with one or more substituents each selected independently from the group consisting of nitro, cyano, halo, trifluoromethyl, carbo(lower)alkoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, lower alkylamino, lower alkyl, lower alkoxy, or phenyl; (iv) vinylene di-substituted with lower alkyl; or (v) ethylene, unsubstituted or monosubstituted or disubstituted with lower alkyl; R<6> is -CO-, -CH2- or -CH2CO-; Y is -COZ, -CN, -OR<8>, lower alkyl or aryl, Z is -NH2, -OH, -NHR, -R<9>, or -OR<9>; R<8> is hydrogen or lower alkyl; R<9> is lower alkyl or benzyl, and n has a value of 0, 1, 2, or 3, wherein the term "lower" denotes from 1 to 6 carbon atoms, for the manufacture of a medicament for treating cancer.
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Inventors:
Muller, George, W
Mary shire
Mary shire
Application Number:
JP52385897A
Publication Date:
February 29, 2000
Filing Date:
December 24, 1996
Export Citation:
Assignee:
Celgene Corporation
International Classes:
A61K31/00; A61K31/403; A61K31/4035; A61P1/00; A61P1/04; A61P11/06; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P29/00; A61K31/40; A61P31/00; A61P31/12; A61P35/00; A61P37/00; A61P43/00; C07D209/46; C07D209/48; (IPC1-7): C07D209/48; A61P1/04; A61P17/06; A61P19/02; A61P29/00; A61P31/12; A61P35/00; A61P37/00; A61P43/00; A61K31/4035; C07D209/46
Attorney, Agent or Firm:
Mikio Hatta (3 outside)