Title:
【発明の名称】インターフェロンγ誘導因子―2をコードする核酸
Document Type and Number:
Japanese Patent JP2000502903
Kind Code:
A
Abstract:
The present invention provides a polynucleotide (igif-2) which identifies and encodes a novel interferon gamma inducing factor-2 (IGIF-2) which was expressed in adenoid, brain, kidney, liver, lung, skin, synovium, and T-lymphocytes. The present invention also provides for antisense molecules. The invention further provides genetically engineered expression vectors and host cells for the production of purified IGIF-2; antibodies, antagonists and inhibitors; and pharmaceutical compositions and methods of treatment based on the polypeptide, its antibodies, antagonists and inhibitors. The invention specifically provides for use of the polypeptide as therapeutic for immuno-compromised individuals and as a positive control in diagnostic assays for the detection of aberrant IGIF-2 expression or altered leukocyte or lymphocyte activity.
Inventors:
Coleman, Roger
Cox, Benjamin Greem
Hawkins, Philip Earl
Cox, Benjamin Greem
Hawkins, Philip Earl
Application Number:
JP52448797A
Publication Date:
March 14, 2000
Filing Date:
December 20, 1996
Export Citation:
Assignee:
INCYTE PHARMACEUTICALS INC.
International Classes:
G01N33/53; A61K31/00; A61K38/00; A61K45/00; A61K48/00; A61P37/00; A61P43/00; C07K14/52; C07K14/54; C12N15/09; C12N15/19; C12P21/02; C12Q1/68; G01N33/566; (IPC1-7): C12N15/09; A61K38/00; A61K45/00; A61K48/00; A61P37/00; A61P43/00; C07K14/52; C12P21/02; C12Q1/68; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Youichi Oshima