Title:
【発明の名称】アルキルアミノベンゾチアゾールおよび―ベンゾキサゾール誘導体
Document Type and Number:
Japanese Patent JP2000503667
Kind Code:
A
Abstract:
The present invention concerns the radiolabelled compounds of formula the N-oxide forms, the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein X is O or S; n is 2, 3, 4 or 5; R<1> is hydrogen, C1-6alkyl, C1-6alkyloxy or halo; R<2> is hydrogen, C1-6alkyl, phenyl, phenylC1-6alkyl or phenylcarbonyl; R<3> and R<4> each independently are selected from hydrogen, halo, nitro, C1-6alkyl, C1-6alkyloxy, haloC1-6alkyl, aminosulfonyl, mono- or di(C1-4alkyl)aminosulfonyl; or R<3> and R<4> may also be taken together to form a bivalent radical of formula -CH=CH-CH=CH- , characterized in that the compound has at least one halo which is a radioactive isotope of iodine, bromine or fluorine, or has at least one <11>C-atom or tritium atom ; it further relates to a process of marking dopamine D4 receptor sites and a process for imaging an organ.
Inventors:
Kennis, Ludo Edmund Giosephine
Mertens, Josephus Carolus
Peters, Sergeil Maria Aloysius
Mertens, Josephus Carolus
Peters, Sergeil Maria Aloysius
Application Number:
JP54053597A
Publication Date:
March 28, 2000
Filing Date:
May 02, 1997
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
A61K31/00; A61K31/42; A61K31/421; A61K31/423; A61K31/495; A61K31/496; A61K51/00; A61P25/00; A61P25/18; A61P43/00; C07B59/00; C07D263/28; C07D263/58; C07D277/82; (IPC1-7): C07D263/28; A61P25/18; A61K31/423; A61K31/496; A61K51/00; C07D277/82
Attorney, Agent or Firm:
Heiyoshi Odashima (1 person outside)