Title:
【発明の名称】イムノフィリン由来ドメインとのキメラタンパク質用の多量体化剤としてのラパマイシンの合成誘導体
Document Type and Number:
Japanese Patent JP2000505475
Kind Code:
A
Abstract:
New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains. The compounds are of the formula M<1>-L-M<2> where M<1> and M<2> are independently moieties of formula (II), (a) or (b), in which B<1>, B<2>, B<3>, R<1>, R<2>, n, W, X and Y are as defined.
Inventors:
Holt, Dennis A.
Keenan, Terence Pea
Guo, Tao
Labourd, Edgard
Yang, Wu
Keenan, Terence Pea
Guo, Tao
Labourd, Edgard
Yang, Wu
Application Number:
JP53113997A
Publication Date:
May 09, 2000
Filing Date:
February 28, 1997
Export Citation:
Assignee:
Ariad Gene Therapeutics Incorporated
International Classes:
A61K31/00; A61K31/4427; A61K31/445; A61K31/495; A61P37/00; A61P37/06; C07D207/16; C07D211/60; C07D401/12; C07D401/14; C07D405/12; (IPC1-7): C07D211/60; C07D401/14
Domestic Patent References:
| JPH05306289A | 1993-11-19 |
Foreign References:
| US5162333A | 1992-11-10 | |||
| WO1994018317A1 | 1994-08-18 |
Attorney, Agent or Firm:
Hirose Shoichi