Title:
【発明の名称】抗病原性ペプチドおよびこれらを含む組成物
Document Type and Number:
Japanese Patent JP2000506128
Kind Code:
A
Abstract:
Peptides which have a net positive charge and none or only a partial a-helix configuration were found to have a non-hemolytic selective cytolytic activity. The peptides may be derived from natural peptides such as pardaxin and mellitin and fragments thereof in which L-amino acid residues are replaced by corresponding D-amino acid residues, and cyclic derivatives of the foregoing, or are diastereomers of linear peptides composed of varying ratios of at least one positively charged amino acid and at least one hydrophobic amino acid, and in which at least one of the amino acid residues is a D-amino acid, and preferably at least one third of the sequence is composed of D-amino acid residues. Pharmaceutical compositions comprising the non-hemolytic cytolytic peptides can be used for the treatment of several diseases caused by pathogens including antibacterial, fungal, viral, mycoplasma and protozoan infections and for the treatment of cancer.
Inventors:
Shy, yechel
Oren, Zibu
Oren, Zibu
Application Number:
JP52995497A
Publication Date:
May 23, 2000
Filing Date:
February 20, 1997
Export Citation:
Assignee:
Yeda Research and Development Company Limited
International Classes:
A61K38/00; A61K31/00; A61K38/04; A61K38/17; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P33/00; A61P35/00; C07K14/00; C07K14/435; C07K14/46; C07K; (IPC1-7): C07K14/46; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P33/00; A61P35/00; A61K38/00
Attorney, Agent or Firm:
Akira Asamura (3 outside)