【発明の名称】核酸輸送のための組成物及び方法 - Commonwealth Scientific and Industrial Research Organization

Title:

【発明の名称】核酸輸送のための組成物及び方法

Document Type and Number:

Japanese Patent JP2000506504

Kind Code:

A

Abstract:

The present invention provides a method for introducing nucleic acids into cells. The method involves exposing the cells to a compound having the formula in which: w is a nucleic acid x is a non-amino acid or non-peptide nucleic acid binding group y is a spacer having a chain length equivalent to 1-30 carbon-carbon single covalent bonds or is absent R4 is H or halogen or CH2O-R3; and R1, R2 and R3 are the same or different and are either hydrogen, methyl, ethyl, alkyl, alkenyl, hydroxylated alkyl, hydroxylated alkenyl groups or ether containing alkyl, alkenyl, hydroxylated alkyl or hydroxylated alkenyl groups optionally being an acyl group having a carbon chain length equivalent to 3-24 carbon atoms saturated or unsaturated, with the proviso that at least one of R1, R2 or R3 includes a group having a carbon chain of 3-24 carbon atoms saturated or unsaturated, or to a compound having the formula: w . . . y-y-NH-CH2-CH2O-R5 in which: w is a nucleic acid x is a non-amino acid or non-peptide nucleic acid binding group y is a space having a chain length equivalent to 1-30 carbon-carbon single covalent bonds or is absent R5 is alkyl, alkenyl, hydroxylated alkyl, hydroxylated alkenyl group or ether containing alkyl, alkenyl, hydroxylated alkyl or hydroxylated alkenyl group optionally being an acyl group having a carbon chain length equivalent to 3-24 carbon atoms saturated or unsaturated, with the proviso that R5 includes a group having a carbon chain of 3-24 carbon atoms saturated or unsaturated. The invention also relates to these compounds.

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Inventors:

Rocket, trevor john
Whitaker, Robert George
Cameron, Fiona Helen
Mogaddam, Minu Jalili
Carroll, Simon McEvan

Application Number:

JP52468297A

Publication Date:

May 30, 2000

Filing Date:

January 06, 1997

Export Citation:

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Assignee:

Commonwealth Scientific and Industrial Research Organization

International Classes:

A61K9/127; A61K31/70; A61K31/7088; A61K48/00; C07H21/00; C12N15/09; C07H21/02; C07H21/04; C12N5/10; C12N15/88; (IPC1-7): C07H21/00; A61K31/7088; A61K48/00; C12N5/10; C12N15/09

Attorney, Agent or Firm:

Masatake Shiga (1 person outside)

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