Title:
【発明の名称】ファルネシルタンパク質トランスフェラーゼの阻害剤
Document Type and Number:
Japanese Patent JP2000508631
Kind Code:
A
Abstract:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
Inventors:
Graham, Samuel El
Williams, Theresa M
Way, Ji Jong S
Williams, Theresa M
Way, Ji Jong S
Application Number:
JP53534897A
Publication Date:
July 11, 2000
Filing Date:
March 27, 1997
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
A61K31/00; A61K31/4427; A61K31/445; A61K31/4465; A61K31/4523; A61K31/454; A61P1/00; A61P1/16; A61P9/00; A61P13/00; A61P13/12; A61P27/00; A61P27/02; A61P31/00; A61P31/10; A61P35/00; A61P43/00; C07D401/06; (IPC1-7): C07D401/06; A61K31/454; A61P1/16; A61P9/00; A61P13/12; A61P27/02; A61P31/10; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)