Title:
【発明の名称】抗転移剤及び抗新生物剤としての、RU(▲III▼)アニオン複合体の新規な塩
Document Type and Number:
Japanese Patent JP2000514424
Kind Code:
A
Abstract:
A salt of an anionic complex of Ru(III) with an ammonium cation fof formula (I),where R1, R2 and R3, equal or different from each other, are selected from the group consisting of H, C1-C6 alkyl, linear or branched, saturated or unsaturated, C3-C7 cycloalkyl, phenyl and aryl; or NR1R2R3 is a 5-7-membered nitrogen-containing heterocycle, saturated or unsaturated, optionally containing one or more O, S and/or N atoms, said nitrogen atom being optionally substituted with a C1-C4 alkyl, aryl or benzyl residue; said nitrogen-containing heterocycle being optionally condensed with a benzo group and/or substituted with C1-C4 alkyl, C1-C4 alkoxyl, C1-C4 alkylthio, aryl or benzyl groups; where R4 and R5, equal or different from each other, are selected from the group consisting of H, C1-C6 alkyl, C3-C7 cycloalkyl, phenyl and aryl or R4 and R5 form, together with the S atom, a 4-7-membered heterocycle. Furthermore the process for the preparation of said salts, the pharmaceutically compositions containing the same and their use as antimetastatic and antineoplastic agents are described.
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Inventors:
Mestroni Giovanni
Arescio Enzo
Sava Gianni
Arescio Enzo
Sava Gianni
Application Number:
JP50383998A
Publication Date:
October 31, 2000
Filing Date:
June 30, 1997
Export Citation:
Assignee:
Sigea Society A Responsor Billita Limitata
International Classes:
A61P35/00; C07F15/00; A61K31/555; (IPC1-7): C07F15/00; A61K31/555; A61P35/00
Attorney, Agent or Firm:
Yamashita