Title:
【発明の名称】新規な脂質キナーゼ
Document Type and Number:
Japanese Patent JP2000517165
Kind Code:
A
Abstract:
The invention relates to a novel lipid kinase which is part of the PI3 Kinase family. PI3 Kinases catalyze the addition of phosphate to inositol generating inositol mono, di and triphosphate. Inositol phosphates have been implicated in regulating intracellular signaling cascades resulting in alternations in gene expression which, amongst other effects, can result in cytoskeletal remodeling and modulation of cellular motility. More particularly the invention relates to a novel human PI3 Kinase, p110Delta which interacts with p85, has a broad phosphinositide specificity and is sensitive to the same kinase inhibitors as PI3 Kinase p110A. However, in contrast to previously identified PI3 Kinases which show a ubiquitous pattern of expression, p110Delta is selectively expressed in leucocytes. Importantly, p110Delta shows enhanced expression in most melanomas tested and therefore may play a crucial role in regulating the metastatic property exhibited by melanomas. The identification of agents that enhance or reduce p110Delta activity may therefore prevent cancer metastatis.
Inventors:
Burt Van Hasebroek
Michael Derek Waterfield
Michael Derek Waterfield
Application Number:
JP50030598A
Publication Date:
December 26, 2000
Filing Date:
May 30, 1997
Export Citation:
Assignee:
Ludwig Institute for Cancer Research
International Classes:
G01N33/50; A61K31/7052; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P35/00; C07K16/40; C12N5/10; C12N9/12; C12N15/09; C12N15/54; C12P21/08; C12Q1/68; G01N33/15; G01N33/53; (IPC1-7): C12N15/09; A61K31/7052; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P35/00; C07K16/40; C12N5/10; C12N9/12; C12Q1/68; G01N33/15; G01N33/50; G01N33/53
Attorney, Agent or Firm:
Takayoshi Matsunaga (1 outside)