Title:
【発明の名称】癌細胞における2―メトキシエストラジオール誘導アポトーシス
Document Type and Number:
Japanese Patent JP2000517299
Kind Code:
A
Abstract:
The present invention details methods for the treatment of cancer. In particular, it concerns the induction of apoptosis of cancer cells following treatment with methoxyestradiol. 2-methoxyestradiol (2-MeOE2) increase wild-type p53 levels in a human non-small lung cancer cell lines associated with accumulation of cyclin dependent kinase inhibitor p21WAF1/CIP1. Significant apoptotic cell death occurred after the drug treatment. Thus, 2-MeOE2 facilitates induction of p53-mediated apoptosis.
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Inventors:
Mukho Padiai, Tapas
Ross, Jack A.
Ross, Jack A.
Application Number:
JP50898198A
Publication Date:
December 26, 2000
Filing Date:
July 24, 1997
Export Citation:
Assignee:
BOARD OF REGENTS,THE UNIVERSITY OF TEXAS SYSTEM
International Classes:
A61K31/565; A61K38/00; A61K38/17; A61K48/00; A61P35/00; C12N5/10; C12Q1/68; C12N15/09; (IPC1-7): A61K48/00; A61K31/565; A61K38/00; A61P35/00; C12N5/10; C12N15/09; C12Q1/68
Attorney, Agent or Firm:
Shusaku Yamamoto