【発明の名称】高分子量のポリマーを基剤とするプロドラッグ

Title:

【発明の名称】高分子量のポリマーを基剤とするプロドラッグ

Document Type and Number:

Japanese Patent JP2000517304

Kind Code:

A

Abstract:

The present invention is directed compositions of the formula: (I) wherein: D is a biologically active moiety; X is an electron withdrawing group; Y and Y' are independently O or S; R1 is selected from the group consisting of H, C1-6 alkyls, aryls, substituted aryls, aralkyls, heteroalkyls, substituted heteroalkyls and substituted C1-6 alkyls; (n) is an integer from 1 to about 12; and R2 is a polyalkylene oxide. In preferred embodiments, the prodrugs contain a polyethylene glycol having a molecular weight of at least about 20,000.

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Inventors:

Greenwald, Richard, Bee.
Pendri, Annapurna
Zao, Hong

Application Number:

JP51094998A

Publication Date:

December 26, 2000

Filing Date:

August 20, 1997

Export Citation:

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Assignee:

Enson Incorporated

International Classes:

A61K31/335; A61K31/337; A61K31/365; A61K31/395; A61K31/4745; A61K47/48; A61P43/00; C07D305/14; C07D307/77; C07D471/22; C07D491/22; C08G65/329; (IPC1-7): A61K47/48; A61K31/337; A61K31/365; A61K31/4745; A61P43/00

Domestic Patent References:

JPS6366196A	1988-03-24
JPS6289630A	1987-04-24

Foreign References:

WO1996023794A1	1996-08-08
WO1995011020A1	1995-04-27

Attorney, Agent or Firm:

Yusuke Hiraki (2 outside)

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