Title:
【発明の名称】新規のモルフォゲン応答性シグナルトランスデューサーおよびその使用方法
Document Type and Number:
Japanese Patent JP2001501096
Kind Code:
A
Abstract:
A novel gene, DD-10, and its encoded polypeptide chain, DD-10, expressed during early onset of morphogen-induced mammalian tissue morphogenesis, now has been discovered. Accordingly, the invention identifies a new gene which is a novel biological marker of cell differentiation and tissue morphogenesis, particularly of chondroblast or osteoblast cell differentiation and bone tissue morphogenesis. Disclosed are: (a) methods and compositions for screening for and producing morphogen analogs; (b) novel morphogen analogs; (c) downstream inducers of morphogenesis; (d) a novel marker for evaluating morphogen or morphogen analog dosing; and (e) therapeutic methods and compositions using these analogs and/or downstream inducers.
Inventors:
Hiroshi Takeda
Hidenori Ichijo
Sampass, Coober Tea.
Hidenori Ichijo
Sampass, Coober Tea.
Application Number:
JP51587298A
Publication Date:
January 30, 2001
Filing Date:
September 24, 1997
Export Citation:
Assignee:
Creative Bio Molecule's, Inc.
International Classes:
C12N15/09; A61K38/00; A61K48/00; A61P19/00; C07K14/475; C07K14/51; C12N5/10; C12Q1/02; C12Q1/68; (IPC1-7): C12N15/09; A61K38/00; A61K48/00; A61P19/00; C07K14/475; C07K14/51; C12N5/10; C12Q1/02; C12Q1/68
Attorney, Agent or Firm:
Shusaku Yamamoto