Title:
【発明の名称】パクリタクセルの前駆物質化合物からの合成及びその製造方法
Document Type and Number:
Japanese Patent JP2001501578
Kind Code:
A
Abstract:
An efficient protocol for the synthesis of taxol, taxol analogs and their intermediates is described. The process incudes the attachment of the taxol A-ring side chain to baccatin III and for the synthesis of taxol and taxol analogs with variable A-ring side chain structures. A rapid and highly efficient esterification of O-protected isoserine and 3-phenylisoserine acids having N-benzyoloxycarbonyl groups to the C-13 hydroxyl of 7-O-protected baccatin III is followed by a deprotection-acylation sequence to make taxol, celphalomanninne and various analogs, including photoaffinity labeling candidates.
Inventors:
Sistie, Nicholas Jay.
Swindel, Charles S.
Chandler, Mad Habby.
Swindel, Charles S.
Chandler, Mad Habby.
Application Number:
JP50216197A
Publication Date:
February 06, 2001
Filing Date:
June 07, 1996
Export Citation:
Assignee:
Napro Biotherapeutics, Incorporated
Bryn Moor College
Bryn Moor College
International Classes:
C07C271/22; C07D305/14; C07F7/18; (IPC1-7): C07D305/14
Attorney, Agent or Firm:
Akira Asamura (3 outside)