Title:
【発明の名称】1―フエニル―ベンズイミダゾール化合物及びこれをBAGA▲下A▼―レセプターモデュレーターとして使用する方法
Document Type and Number:
Japanese Patent JP2001502675
Kind Code:
A
Abstract:
The present invention relates to novel benzimidazole compounds, represented by general formula (I) in which o is 0, 1, 2 or 3; R1 represents an alkyl group, a phenyl group, or a monocyclic heterocyclic group, which groups may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkyl-alkyl, alkoxy, halogen, trifluoromethyl, cyano, amino and nitro; or R1 represents a cyano group or a group of the formula -alkyl-CO2R2, alkenyl-CO2R2, -CO-R2, -CO2(CH2)mR2, or -C(R3)=N-OR2, R11 represents a group of formula -CO2-R9, or R11 represents a group of general formula (II) in which n is 0, 1, 2 or 3; or R11 may represent a group of general formula (III), in which n is 0, 1, 2 or 3; the novel compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, such as for example anxiety, sleep disorders, anaestesia, memory disorders, and epilepsia or other convulsive disorders.
Inventors:
Toy Bar Rene
Wate Yen Frank
Wate Yen Frank
Application Number:
JP51885298A
Publication Date:
February 27, 2001
Filing Date:
October 21, 1997
Export Citation:
Assignee:
Neurosearch Actiesel Scab
International Classes:
C07D235/08; A61K31/415; A61K31/4184; A61K31/422; A61K31/4245; A61K31/4439; A61K31/4523; A61K31/454; A61K31/496; A61K31/5377; A61K31/551; A61P25/08; A61P25/22; A61P25/28; C07D235/06; C07D401/06; C07D401/10; C07D401/12; C07D401/14; C07D403/10; C07D405/04; C07D405/14; C07D413/04; C07D413/14; (IPC1-7): C07D235/08; A61K31/4184; A61K31/422; A61K31/4245; A61K31/4439; A61K31/4523; A61K31/454; A61K31/496; A61K31/5377; A61K31/551; A61P25/08; A61P25/22; A61P25/28; C07D401/10; C07D401/12; C07D401/14; C07D403/10; C07D405/04; C07D405/14; C07D413/04; C07D413/14
Attorney, Agent or Firm:
Mitsufumi Ezaki (3 others)