Title:
【発明の名称】眼の神経損傷の処置に(2-イミダゾリン-2-イルアミノ)キノキサリンを使用する方法
Document Type and Number:
Japanese Patent JP2001503370
Kind Code:
A
Abstract:
A method according to which neuroprotection is conferred upon ocular nerve cells by administration of a drug of formula (I) to the optic nerve and/or retina of a mammal within a period prior to or following an insult to ocular nerve cells but prior to cell death, wherein the 2-imidazolin-2-ylamino group may be in either the 5- or 6-position of the quinoxaline nucleus; x, y and z may be in any of the remaining 5-, 6-, 7- or 8-positions and are selected from hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl; and R is an optional substituent in either the 2-or 3-position of the quinoxaline nucleus and may be hydrogen, lower alkyl or lower alkoxy is disclosed.
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Inventors:
Wheeler, Larry A
Waldmassy, Elizabeth
Rye, Ronald Kay
Waldmassy, Elizabeth
Rye, Ronald Kay
Application Number:
JP50445497A
Publication Date:
March 13, 2001
Filing Date:
June 17, 1996
Export Citation:
Assignee:
Allergan Sails Incorporated
International Classes:
C07D403/12; A61K31/495; A61K31/498; A61P27/02; (IPC1-7): A61K31/498; A61P27/02
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)