Title:
【発明の名称】融合性リポソーム組成物および方法
Document Type and Number:
Japanese Patent JP2001504093
Kind Code:
A
Abstract:
A fusogenic liposome composition for delivering a liposome-entrapped compound into the cytoplasm of a target cell is described. The liposomes have an outer surface coating of chemically releasable hydrophilic polymer chains which shield hydrophobic polymers on the liposome outer surface. Release of the hydrophilic polymer chains exposes the hydrophobic polymers for interaction with outer cell membranes of the target cells to promote fusion of the liposome with the target cells. Also disclosed is a method for using the composition to deliver a compound to target cells, and a method for selecting suitable hydrophobic polymers for use in the composition.
Inventors:
Martin, Francis Jay.
Zalipsky, Samuel
Zalipsky, Samuel
Application Number:
JP51862998A
Publication Date:
March 27, 2001
Filing Date:
October 10, 1997
Export Citation:
Assignee:
Arza Corporation
International Classes:
A61K9/127; A61K47/30; A61K48/00; A61P35/00; (IPC1-7): A61K9/127; A61K47/30; A61K48/00
Attorney, Agent or Firm:
Shusaku Yamamoto