Title:
【発明の名称】腫瘍壊死因子レセプター-1誘導性アポトーシスおよびCD-95誘導性アポトーシスの新規なインヒビターである、I-FLICE
Document Type and Number:
Japanese Patent JP2001511011
Kind Code:
A
Abstract:
The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of TNFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human I-FLICE-1 or I-FLICE-2 protein. I-FLICE-1 or I-FLICE-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of I-FLICE-1 or I-FLICE-2 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.
Inventors:
Ni, Gian
Rosen, Craig A.
Dixit, Bishbaem.
Gents, Liner El.
Kenny, Joseph Jay.
Rosen, Craig A.
Dixit, Bishbaem.
Gents, Liner El.
Kenny, Joseph Jay.
Application Number:
JP53461098A
Publication Date:
August 07, 2001
Filing Date:
January 21, 1998
Export Citation:
Assignee:
Human Genome Sciences, Inc.
The Regents of the University of Michigan
The Regents of the University of Michigan
International Classes:
A61K38/00; A61K45/00; A61P43/00; C07H21/02; C07H21/04; C07K1/00; C07K14/00; C07K14/52; C07K16/40; C07K17/00; C12N1/15; C12N15/09; C12N1/19; C12N1/20; C12N1/21; C12N5/10; C12N9/64; C12N9/99; C12N15/12; C12N15/78; C12P21/02; C12P21/06; C12Q1/02; C12Q1/68; (IPC1-7): C12N15/09; A61K38/00; A61P43/00; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/64; C12Q1/68
Attorney, Agent or Firm:
Shusaku Yamamoto