Title:
【発明の名称】アリール置換オレフィン型アミン化合物を含む医薬組成物
Document Type and Number:
Japanese Patent JP2001512486
Kind Code:
A
Abstract:
Patients susceptible to or suffering from central nervous system disorders (e.g., Alzheimer's disease, Parkinson's disease, Tourette's syndrome, attention deficit disorder or schizophrenia) are treated by administering an effective amount of an aryl substituted olefinic amine compound of Formula (I): wherein X is C-R', C-OR', C-CH2-OR' wherein R' is selected from the group consisting of H, C1-C5 alkyl, an aromatic group containing species and alkyl-, halo-, or amino-substituted aromatic group containing species; E' is hydrogen or C1-C5 alkyl or halo substituted C1-C5 alkyl; E'' is C1-C5 alkyl or halo substituted C1-C5 alkyl; Z' and Z'' are each individually selected from the group consisting of hydrogen, C1-C5 alkyl, aryl rings, and can form a ring structure (a), A, A' and A'' are each individually selected from the group consisting of hydrogen, C1-C7 alkyl, and halo; m is 0 or 1; p is 0 or 1 with the proviso that when m or p is 0 then that E'' is hydrogen; and the wavy line in the structure represents a cis (Z) or trans (E) form of the compound. Exemplary compounds include (E)-N-methyl-4-[3-(benzyloxypyridin)yl]-3-buten-1-amine, (E)-N-methyl-4-[3-(5-phenoxypyridin)yl]-3-buten-1-amine, (E)-N-methyl-4-[3-(5-isopropoxypyridin)yl]-3-buten-1-amine, (E)-N-methyl-4-[3-(5-methoxymethylpyridin)yl]-3-buten-1-amine, and (E)-N-methyl-4-[3-(5-phenylpyridin)yl]-3-buten-1-amine.
Inventors:
Caldwell, William Scott
Dal, Gary Morris
Dobson, Grayland Page
Miller, Craig Harrison
Benkeriff, Meroane
Lippiero, Patrick Michael
Dal, Gary Morris
Dobson, Grayland Page
Miller, Craig Harrison
Benkeriff, Meroane
Lippiero, Patrick Michael
Application Number:
JP53680798A
Publication Date:
August 21, 2001
Filing Date:
February 19, 1998
Export Citation:
Assignee:
RJ Reynolds Tobacco Company
International Classes:
A61K31/44; A61P25/00; A61P25/16; A61P25/18; A61P25/28; A61P43/00; C07D213/38; C07D213/61; C07D213/65; C07D213/64; (IPC1-7): C07D213/65; A61K31/44; A61P25/00; A61P25/16; A61P25/18; A61P25/28; A61P43/00; C07D213/61
Attorney, Agent or Firm:
Nao Okuyama (3 others)