Title:
【発明の名称】ヒトBRCA2遺伝子のコード配列半数型
Document Type and Number:
Japanese Patent JP2001514887
Kind Code:
A
Abstract:
Five DNA and protein sequences have been determined for the BRCA2 gene, as have been ten polymorphic sites and their rates of occurrence in the normal alleles of BRCA2. The sequences BRCA (omil-5) and the ten polymorphic sites will provide accuracy and reliability for genetic testing. One skilled in the art will be able to avoid misinterpretations of changes in the gene and/or protein sequence, determine the presence of a normal sequence, and of mutations of BRCA2. This invention is also related to a method of performing gene therapy with BRCA2 (omil-5) coding sequences or fragments thereof. This invention is further related to protein therapy with BRCA2 (omil-5) proteins or their functional equivalents.
Inventors:
Patricia Di Murphy
Marga Be White
Mark Bee Rabin
Sherry jay olson
Matthew Yoshikawa
Joffrey M. Jackson
Tara Escandari
Brenda Schlier
Michael park
Marga Be White
Mark Bee Rabin
Sherry jay olson
Matthew Yoshikawa
Joffrey M. Jackson
Tara Escandari
Brenda Schlier
Michael park
Application Number:
JP2000509828A
Publication Date:
September 18, 2001
Filing Date:
August 14, 1998
Export Citation:
Assignee:
On Comed Incorporated
International Classes:
A61K38/00; A61K39/395; A61K48/00; A61P35/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12P21/02; C12P21/08; C12Q1/68; C12N15/09; G01N37/00; (IPC1-7): C12N15/09; A61K38/00; A61K39/395; A61K48/00; A61P35/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12Q1/68
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)