Title:
【発明の名称】レンチウイルス感染の治療および予防のための抗ウイルス剤としてのマクロファージ由来ケモカイン(MDC)
Document Type and Number:
Japanese Patent JP2001520002
Kind Code:
A
Abstract:
The present invention relates to therapeutic compositions of macrophage derived chemokine (MDC) and methods for treating and preventing infection by a lentivirus, particularly an immunodeficiency virus, particularly HIV, using MDC proteins, nucleic acids and/or derivatives or analogues thereof. The present invention further relates to methods for detection and prognosis of lenivirus infection, particularly HIV infection using MDC as a prognostic indicator. The present invention further provides MDC proteins, nucleic acids encoding such proteins, that have amino-terminal sequences that differ from other MDC isolates. Recombinant host cells and methods of production are also provided.
Inventors:
Debiko, Anthony El
Pal, Ranagit
Gallo, robert sea
Markham, Philip Day
Garzino-Demo, Alfredo
Pal, Ranagit
Gallo, robert sea
Markham, Philip Day
Garzino-Demo, Alfredo
Application Number:
JP2000511785A
Publication Date:
October 30, 2001
Filing Date:
September 16, 1998
Export Citation:
Assignee:
Akzo Novel N B
University of Maryland Biotechnology Institute
University of Maryland Biotechnology Institute
International Classes:
G01N33/569; A61K38/00; A61K48/00; A61P31/18; C07K14/52; C12N5/10; C12N15/00; C12P21/02; C12Q1/68; (IPC1-7): C12N15/00; A61K38/00; A61K48/00; A61P31/18; C07K14/52; C12N5/10; C12P21/02; C12Q1/68; G01N33/569
Attorney, Agent or Firm:
Yoshio Kawaguchi (3 outside)