Title:
【発明の名称】抗原性構造ペプチド、抗原性および免疫原性化合物、およびHCV感染を検出、予防及び治療するための使用
Document Type and Number:
Japanese Patent JP2001522352
Kind Code:
A
Abstract:
The invention concerns a structural peptide, identified by antibodies directed against a polypeptide, comprising the 2-45 amino acid sequence of the N-terminal end of the Core or nucleocapsid (p21) protein of the hepatitis C virus (HCV), excluding any protein or peptide compound comprising or consisting of the N-terminal end. The invention is characterized in that it comprises a tertiary structure consisting of at least a first peptide fragment having a secondary structure in alpha helix, a second peptide fragment having secondary structure in alpha helix and a third peptide bond fragment linking the two alpha helices, these two alpha helices being substantially perpendicular to each other in space. This peptide can be used for detecting antibodies directed against the p21 protein of HCV, for detecting all of part of the RNA of HCV and for preparing a diagnostic, prophylactic or therapeutic composition for detecting, preventing or treating an HCV infection.
Inventors:
Michele Jolivet
Phunin, Francois
Dalbon, Pascal
Ladaviere, Laurent
Lakuu, Xavier
Phunin, Francois
Dalbon, Pascal
Ladaviere, Laurent
Lakuu, Xavier
Application Number:
JP53824198A
Publication Date:
November 13, 2001
Filing Date:
March 05, 1998
Export Citation:
Assignee:
BAEO MERYU
International Classes:
G01N33/576; A61K38/00; A61K39/12; A61P31/12; C07K14/18; C07K16/10; C12Q1/70; (IPC1-7): C07K14/18; A61K38/00; A61K39/12; A61P31/12; C07K16/10; C12Q1/70; G01N33/576
Attorney, Agent or Firm:
Masatake Shiga (8 outside)