Title:
【発明の名称】活性物質の制御された放出のための薬剤組成物
Document Type and Number:
Japanese Patent JP2001524950
Kind Code:
A
Abstract:
The invention relates to pharmaceutical compositions which can be administrated orally, allowing the controlled release of at least one active substance comprising a) the said at least one active substance, b) between 5 and 60% by weight, relative to the total weight of the composition, of at least one excipient, selected from inert matrices, hydrophilic matrices, lipid matrices, mixtures of inert matrices and of lipid matrices, mixtures of hydrophilic matrices and of inert matrices, with the exception of mixtures comprising a polyacrylic acid and at least one hydrophilic matrix of the cellulose type; c) between 5 and 50% by weight, relative to the total weight of the composition, of at least one alkalinizing agent soluble in an aqueous phase under physiological pH conditions, selected from alkali or alkaline-earth metal hydroxidcs, carbonates, bicarbonates and phosphates, sodium borate as well as the basic salts of organic acids. It also relates to processes for the preparation of said compositions, multi-layered pharmaceutical compositions comprising at least one layer with this composition, as well as processes for the preparation of said multi-layered composition.
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Inventors:
Fanara, Domenico
Belwale, Monique
Bouquet, Anne
Michelle Deleels
Belwale, Monique
Bouquet, Anne
Michelle Deleels
Application Number:
JP53995798A
Publication Date:
December 04, 2001
Filing Date:
March 13, 1998
Export Citation:
Assignee:
Yuseve, Societe Anonymous
International Classes:
A61K9/20; A61K9/22; A61K9/24; (IPC1-7): A61K9/22
Attorney, Agent or Firm:
Takashi Ishida (4 others)