Title:
【発明の名称】免疫系による生きた被移植細胞の破壊を阻止する方法
Document Type and Number:
Japanese Patent JP2002501548
Kind Code:
A
Abstract:
This invention provides a method of inhibiting viable cells transplanted into a subject from being destroyed by the subject's immune system which comprises: a) containing the viable cells, or tissue comprising the viable cells, prior to transplantation within a device comprising a semipermeable membrane; and b) treating the subject with a substance which inhibits an immune-system costimulation event in an amount effective to inhibit the subject's immune system from responding to said contained cells or tissue. In one embodiment, the substance which inhibits an immune-system costimulation event is CTLA4. Also provided by this invention is a method of treating diabetes in a subject which comprises: a) containing viable insulin-producing cells, or tissue comprising such cells, within a device comprising a semipermeable membrane; b) transplanting an effective amount of such contained viable insulin-producing cells into the subject; and c) treating the subject with an effective amount of a substance which inhibits an immune-system costimulation event.
Inventors:
Webber, Colin Jay
Hagler, Mary, Kay
Linthree, Peter S
Cup, Judith, A
Safrey, Susan A
Hagler, Mary, Kay
Linthree, Peter S
Cup, Judith, A
Safrey, Susan A
Application Number:
JP54956799A
Publication Date:
January 15, 2002
Filing Date:
March 26, 1999
Export Citation:
Assignee:
Emori University
BRISTOL-MYERS SQUIBB COMPANY
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K9/00; A61K9/50; A61K35/39; A61K38/00; A61K38/17; A61K45/00; A61K48/00; A61P3/10; A61P43/00; C07K14/705; C12N5/071; A61K35/12; (IPC1-7): A61K45/00; A61K9/00; A61K9/50; A61K38/00; A61K48/00; A61P3/10; A61P43/00
Attorney, Agent or Firm:
Takehiko Suzue (4 outside)