Title:
【発明の名称】トコール含有混合物からのトコールの分離方法
Document Type and Number:
Japanese Patent JP2002501915
Kind Code:
A
Abstract:
The invention relates to method for separating tocotrienol from a first tocol admixture by heating the first tocol admixture composed of a tocotrienol, at least one tocopherol, a fatty acid, and an esterifying compound to esterify the fatty acid to produce a second tocol admixture composed of the tocotrienol, the tocopherol, the esterified fatty acid, and the unesterified fatty acid; distilling the second tocol admixture with the esterified fatty acid to remove the unesterified fatty acid from the second tocol admixture to produce a third tocol admixture composed of the tocotrienol and the tocopherol, with substantially removed unesterified fatty acid; distilling the third tocol admixture for a sufficient time and temperature to substantially remove the tocotrienol and tocopherol from the third tocol admixture to produce a fourth tocol admixture composed of the removed tocotrienol, tocopherol, and a non-tocol component; and extracting the tocotrienol from the fourth tocol admixture with an extraction solvent composed of a polar, organic solvent that is miscible with water to produce a two phase system composed of a first phase containing the majority of the extraction solvent and the second phase, wherein the selectivity of the extraction solvent for tocotrienol with respect to the tocopherol is greater than unity, and removing the first phase from the second phase, with the proviso that the extraction solvent is not a neat alcohol. The invention further relates to compositions produced by the methods of the present invention.
Inventors:
Sumner, Charles E. Jr.
Monsieur, John Dee.
Kernel, Jeffrey S.
Foster, Mary K.
Monsieur, John Dee.
Kernel, Jeffrey S.
Foster, Mary K.
Application Number:
JP2000529327A
Publication Date:
January 22, 2002
Filing Date:
January 26, 1999
Export Citation:
Assignee:
Eastman Chemical Company
International Classes:
A61K31/352; A61K31/355; C07D311/72; (IPC1-7): C07D311/72; A61K31/355
Domestic Patent References:
| JPH072827A | 1995-01-06 | |||
| JPS61268677A | 1986-11-28 | |||
| JPS61151186A | 1986-07-09 | |||
| JPS6153280A | 1986-03-17 |
Foreign References:
| WO1996014311A1 | 1996-05-17 | |||
| WO1997021697A1 | 1997-06-19 | |||
| US5660691A | 1997-08-26 |
Attorney, Agent or Firm:
Takashi Ishida (4 others)